scholarly journals High-sensitivity determination of 2-chlorovinylarsonous acid in biomedical samples for retrospective detection of exposure to lewisite upon antidotal therapy

2011 ◽  
Vol 26 (1) ◽  
pp. 1-10 ◽  
Author(s):  
N. L. Koryagina ◽  
E. S. Ukolova ◽  
E. I. Savel’eva ◽  
N. G. Voitenko ◽  
O. I. Orlova ◽  
...  
Keyword(s):  
Blood Cells ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Single Injection ◽  
High Sensitivity ◽  
Rat Urine ◽  
First Time ◽  
Antidotal Therapy

A procedure for determination of the lewisite metabolite 2-chlorovinylarsonous acid (CVAA) in biomedical samples, involving derivatization of the latter with propane-1,3-dithiol and head-space solid-phase microextraction of the derivative on a 100-μm PDMS fiber followed by GC-MS, was applied for the first time to analysis ofin vivosamples. The detection limits of CVAA in urine, plasma and red blood cells were 0.1, 1.0 and 10 ng/ml, respectively. Upon exposure to lewisite at a dose of 1.6 mg/kg, CVAA could be detected in rat urine for about three months. Study of the effect of a single injection of the antidote unithiol on the CVAA excretion profile revealed more active CVAA excretion during the first two days after the injection, compared to that observed in the absence of antidotal therapy.

Combined headspace single-drop microextraction and solid-phase microextraction for the determination of phenols as their methyl ethers by gas chromatography-mass spectrometry

2017 ◽  
Vol 9 (46) ◽  
pp. 6590-6598 ◽  
Author(s):  
Archana Jain ◽  
Soumitra Soni ◽  
Kishan Reddy-Noone ◽  
Aradhana K. K. V. Pillai ◽  
Krishna K. Verma
Keyword(s):  
Solid Phase Microextraction ◽  
Solid Phase ◽  
High Sensitivity ◽  
Large Mass ◽  
Gas Chromatography Mass Spectrometry ◽  
Gas Chromatograph ◽  
Single Drop ◽  
Single Drop Microextraction ◽  
Single Drop Extraction

A combination of headspace large volume single drop extraction and solid phase microextraction permitted attainment of high sensitivity by transferring an overall large mass of analytes into a gas chromatograph.

New solid phase microextraction fiber based on an eggshell membrane coating for determination of polycyclic aromatic hydrocarbons

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86477-86484 ◽  
Author(s):  
Mohammad Jabbari ◽  
Habib Razmi
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Eggshell Membrane ◽  
Spme Fiber ◽  
Polycyclic Aromatic ◽  
Membrane Coating ◽  
First Time

In this work, we introduced a novel soluble eggshell membrane protein (SEP) coating for the fabrication of a solid phase microextraction (SPME) fiber for the first time.

In Vivo Solid-Phase Microextraction with in Vitro Calibration: Determination of Off-Flavor Components in Live Fish

2013 ◽  
Vol 85 (4) ◽  
pp. 2328-2332 ◽  
Author(s):  
Ziwei Bai ◽  
Alexandre Pilote ◽  
Pallab Kumer Sarker ◽  
Grant Vandenberg ◽  
Janusz Pawliszyn
Keyword(s):  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Flavor Components ◽  
Live Fish

Rapid and high-sensitivity determination of phenylarsine oxide in environmental samples by a new technique: solid-phase microextraction followed by corona discharge ion mobility spectrometry

2019 ◽  
Vol 11 (47) ◽  
pp. 5969-5975
Author(s):  
Sajad Asadi ◽  
Bozorgmehr Maddah
Keyword(s):  
Corona Discharge ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Environmental Samples ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
High Sensitivity ◽  
Phenylarsine Oxide ◽  
A New Technique

A new, rapid and sensitive method using solid-phase microextraction coupled with corona discharge ion mobility spectrometry was employed for determining phenylarsine oxide in environmental samples after derivatization with 1,3-propanedithiol.

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