scholarly journals An Efficient Therapy Strategy under a Novel HIV Model

2011 ◽  
Vol 2011 ◽  
pp. 1-19 ◽  
Author(s):  
Chunming Zhang ◽  
Xiaofan Yang ◽  
Wanping Liu ◽  
Lu-Xing Yang
Keyword(s):  
Optimal Control ◽  
Human Immunodeficiency Virus ◽  
Immune System ◽  
Virus Spread ◽  
Hiv Model ◽  
Hiv Virus ◽  
Therapy Strategy ◽  
Spread Model ◽  
Immunodeficiency Virus ◽  
The Cost

By incorporating the chemotherapy into a previous model describing the interaction of the immune system with the human immunodeficiency virus (HIV), this paper proposes a novel HIV virus spread model with control variables. Our goal is to maximize the number of healthy cells and, meanwhile, to minimize the cost of chemotherapy. In this context, the existence of an optimal control is proved. Experimental results show that, under this model, the spread of HIV virus can be controlled effectively.

scholarly journals PENERAPAN MODEL ARIMA DALAM PERAMALAN ANAK USIA 5–14 Th YANG TERINFEKSI HIV DI INDONESIA

2019 ◽  
Vol 1 (1) ◽  
pp. 74-82
Author(s):  
Wigid Hariadi ◽  
Sulantari Sulantari
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune System ◽  
Arima Model ◽  
Hiv Disease ◽  
Human Immune System ◽  
The Public ◽  
Number Of Children ◽  
Hiv Virus ◽  
Immunodeficiency Virus ◽  
Human Immune

Human Immunodeficiency Virus (HIV) is dangerous diseases for humans, and until now has not found a cure. Virus HIV is attacks the human immune system so that someone is susceptible to disease. This causes if someone is infected with HIV, then the person can experience an danger condition, it will even effect is death. In recent years, the number of children aged 5 – 14 years old that infected with HIV continues to increase. Therefore the author was moved to write about the application of the ARIMA model in forecasting the number of children aged 5 – 14 years old that infected with HIV in Indonesia by 2023. With the hope that the public or the govermment can find out the potential dangers of HIV disease, especially in children aged 5 – 14 years old. So that the public and govermment can jointly eradicate the spread of the HIV virus, especially in chidren. the result are obtained that the model that is suitable for use in forecasting is the ARIMA(0,1,2) models, with error value obtained is 0.057429. with the forecast value of the number of children aged 5 – 14 years old that infected with HIV in Indonesia from 2019 – 2023 in a row is : 570.82, 647.12, 734.14, 823.85, 944.83.

Nonlinear incidence Human immunodeficiency virus infection model with optimal control

2020 ◽  
Vol 34 (11) ◽  
pp. 2050100
Author(s):  
David Yaro ◽  
Aly R. Seadawy ◽  
Dianchen Lu
Keyword(s):  
Optimal Control ◽  
Human Immunodeficiency Virus ◽  
Evolutionary Dynamics ◽  
Control Strategies ◽  
Cellular Level ◽  
Infection Model ◽  
Hiv Model ◽  
Immunodeficiency Virus ◽  
Infected Cells ◽  
Horizontal Spread

Mathematical modeling plays a crucial role in understanding the dynamics of Human immunodeficiency virus (HIV) disease. Most models deal with the vertical and horizontal spread of disease, but few studies have focused on the evolutionary dynamics of HIV at the cellular level. In this paper, we present an HIV model to analyze the dynamics of HIV infection at the cellular level to produce more natural results. We present a detailed stability analysis of disease-free and viral-persistence equilibrium in the system. In addition, sensitivity analysis and optimal control strategies are used to analyze the role of antiretroviral drug therapy and dietary supplements in controlling the concentration of infected cells and viruses.

scholarly journals Intracranial Arterial Dissection Related to HIV Infection

2005 ◽  
Vol 11 (4) ◽  
pp. 387-391 ◽  
Author(s):  
D. Lefeuvre ◽  
L. Liebenberg ◽  
A. Taylor
Keyword(s):  
Human Immunodeficiency Virus ◽  
Subarachnoid Haemorrhage ◽  
Vessel Wall ◽  
False Aneurysm ◽  
Hiv Positive ◽  
Pathological Study ◽  
Hiv Virus ◽  
Immunodeficiency Virus ◽  
The Right ◽  
Wall Injury

There are many reasons for patients infected with human immunodeficiency virus (HIV) to develop cerebrovascular disease. The HIV virus itself however may be a cause of vessel wall pathology. We present a clinical and pathological study of a patient who was HIV positive and presented with a subarachnoid haemorrhage. Cerebral angiography and later histology confirm that there was extensive vessel wall injury with dissection and a false aneurysm of the right middle cerebral artery.

scholarly journals Recent advances in understanding HIV evolution

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 597 ◽  
Author(s):  
Sophie M. Andrews ◽  
Sarah Rowland-Jones
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune System ◽  
Reverse Transcriptase ◽  
Viral Diversity ◽  
Recent Advances ◽  
Technological Advances ◽  
Generation Times ◽  
Immunodeficiency Virus ◽  
Shed Light ◽  
Hiv Evolution

The human immunodeficiency virus (HIV) evolves rapidly owing to the combined activity of error-prone reverse transcriptase, recombination, and short generation times, leading to extensive viral diversity both within and between hosts. This diversity is a major contributing factor in the failure of the immune system to eradicate the virus and has important implications for the development of suitable drugs and vaccines to combat infection. This review will discuss the recent technological advances that have shed light on HIV evolution and will summarise emerging concepts in this field.

scholarly journals Identification of HIV virus in Najaf city, Iraq

2020 ◽  
Vol 11 (3) ◽  
pp. 4866-4871
Author(s):  
Thualfakar Hayder Hasan ◽  
Raad A. Al-Harmoosh ◽  
Huda Jameel Baker Al-khilkhali
Keyword(s):  
Immune System ◽  
Central Africa ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Human Immune System ◽  
Hiv Virus ◽  
Immunodeficiency Virus ◽  
Mucus Membrane ◽  
Elisa Technique ◽  
Human Immune

Acquired Immune Deficiency Syndrome (ADIS) is a disease of the human immune system that results in a decline in the efficiency of the human immune system step by step to leave people exposed to many infections and tumours. It caused by the Human Immunodeficiency Virus (HIV). The first appeared of HIV in West Central Africa in the late 19th or early 20th century. The direct contact from personal mucus membrane or bloodstream and physical fluid (blood, vaginal semen fluid and breastfeeding milk) containing the virus is the unique viral transmission route. Out of 80 blood samples were taken from different areas of Najaf city, Iraq, for ages from 20 to 60 years (males and females) to the period from 1/1/2019 to 19/12/2019. The surface antigen of the HIV was detected by the ELISA technique and mini VIDAS by a virus-specific kit. Out of 80 different patients by physical examination infected with ADIS: HIV viruses were the most incidences with 12 isolates (15%) while, there were 66 isolates (82.5%) were belonged to other infections and two strains (2.5%) were negative to any viral infection.

scholarly journals Development Model of Family Empowerment and Peer Group Support in Independence of Caring on Indonesian’s Migrant Worker (TKI) Infected by HIV

Jurnal NERS ◽  
2016 ◽  
Vol 10 (2) ◽  
pp. 265 ◽  
Author(s):  
Nursalam Nursalam ◽  
Ah. Yusuf ◽  
Ika Yuni Widyawati ◽  
Candra Panji Asmoro
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune System ◽  
Peer Support ◽  
Migrant Workers ◽  
Peer Group ◽  
Group Support ◽  
Family Empowerment ◽  
Immunodeficiency Virus ◽  
The Family ◽  
Work Abroad

Introduction: Human Immunodeficiency Virus (HIV) is a retrovirus that infects cells of the immune system, destroying or damaging the function of cells of the immune system. This makes the immune system becomes weaker, and people become more liable to infection. A lot of new detected HIV transmission source comes from former workers who work abroad. The challenge in dealing the number of transmission performed comprehensive care of patients and their family empowerment and peer support groups. The aimed of this study was to develop the ability of a family of Indonesian Workers who are infected with HIV and Peer Support Group in independence of care. Methods: This study was used an explanatory design and quasy-experimental. Population in this study were the closest family who care for patients infected with HIV during work abroad as migrant workers in East Java. Samples were selected using simple random sampling technique. The independent variable was the peer group and family support, the dependent variable is the level of independence of care on the respondent. Data were collected using a questionnaire that has been tested for validity and reliability and results were tested using the Wilcoxon Signed Rank Test with alpha ≤0.05. Results: The results showed that this method can improve the independence of the family of the HIV-infected client care during labor as migrant workers abroad with a significance value of p=0.004. Conclusion: Empowerment of family and peer group support can be used to increase the independence of families and patients in the treatment of HIV-infected patients during work abroad as migrant workers. Future studies are expected to use a larger sample.Keywords: empowerment of the family, peer group support, independence treatment, TKI (Indonesian Labor), Human Immunodeficiency Virus (HIV)

scholarly journals Developing AIDS – The Dangerous Conjugation and Transformation of HIV : An In-depth Analysis

1970 ◽  
pp. 157-166
Author(s):  
K Bulbul Sarwar
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune System ◽  
Opportunistic Infections ◽  
White Blood Cells ◽  
The Body ◽  
New Drugs ◽  
Research Issues ◽  
Depth Analysis ◽  
Immunodeficiency Virus ◽  
Hiv Aids

HIV/AIDS spreads so quickly and so destructively that it supersedes all disasters ever attacks human civilization. No branch of scientists can declare them aloof or abstain from it. So the agriculturists are very closely concern with its research-issues, nutritional remedies and agro-based care. We know, HIV stands for human immunodeficiency virus. It is the virus that causes AIDS. A member of a group of viruses called retroviruses, HIV infects human cells and uses the energy and nutrients provided by those cells to grow and reproduce. AIDS stands for acquired immunodeficiency syndrome. It is a disease in which the body's immune system breaks down and is unable to fight off infections, known as "opportunistic infections," and other illnesses that take advantage of a weakened immune system. Opportunistic infections are various in types and it needs not only the care from health professionals rather it deserves agriculturists, nutritionists and social scientists to combat together. When a person is infected with HIV, the virus enters the body and lives and multiplies primarily in the white blood cells. These are immune cells that normally protect us from disease. The hallmark of HIV infection is the progressive loss of a specific type of immune cell called T-helper, or CD4 cells. As the virus grows, it damages or kills these and other cells, weakening the immune system and leaving the person vulnerable to various opportunistic infections and other illnesses ranging from pneumonia to cancer. Understanding how the human immunodeficiency virus (HIV) works inside the human cell gives all scientists important ways about how to attack it at its most vulnerable points and clues to start research. Knowing the secrets of how the virus functions and reproduces itself -- a process called its ‘life-cycle'- can help scientists design new drugs and nutritional supplements those are more effective at suppressing HIV and support the affected lives. This study will draw a clear and easy-to-understand picture for every scientist, obviously the agriculturists too, being alert and keeping their lives safe from this fatal conjugation of HIV and help to invent natural and/or plant remedies to prevent or suspend HIV's aggression, as long as we concern. Key words: HIV, AIDS, retro virus, HIV viral transformation. DOI = 10.3329/jard.v5i1.1473 J Agric Rural Dev 5(1&2), 157-166, June 2007

scholarly journals Optimal Control of Virus Spread under Different Conditions of Resources Limitations

Information ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 214
Author(s):  
Paolo Di Giamberardino ◽  
Daniela Iacoviello
Keyword(s):  
Optimal Control ◽  
Cost Function ◽  
Virus Spread ◽  
Human Virus ◽  
Positive Diagnosis ◽  
Control Actions ◽  
The People ◽  
Different Types ◽  
The Cost ◽  
Instantaneous Control

The paper addresses the problem of human virus spread reduction when the resources for the control actions are somehow limited. This kind of problem can be successfully solved in the framework of the optimal control theory, where the best solution, which minimizes a cost function while satisfying input constraints, can be provided. The problem is formulated in this contest for the case of the HIV/AIDS virus, making use of a model that considers two classes of susceptible subjects, the wise people and the people with incautious behaviours, and three classes of infected, the ones still not aware of their status, the pre-AIDS patients and the AIDS ones; the control actions are represented by an information campaign, to reduce the category of subjects with unwise behaviour, a test campaign, to reduce the number of subjects not aware of having the virus, and the medication on patients with a positive diagnosis. The cost function considered aims at reducing patients with positive diagnosis using as less resources as possible. Four different types of resources bounds are considered, divided into two classes: limitations on the instantaneous control and fixed total budgets. The optimal solutions are numerically computed, and the results of simulations performed are illustrated and compared to put in evidence the different behaviours of the control actions.

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