scholarly journals Mcl-1 Expression Is Up-Regulated in Malignancies of the Parotid Gland

2011 ◽  
Vol 30 (5) ◽  
pp. 229-233 ◽  
Author(s):  
Gregor Heiduschka ◽  
Boban M. Erovic ◽  
Johannes Pammer ◽  
Ulana Kotowski ◽  
Alexandra Kaider ◽  
...  
Keyword(s):  
Overall Survival ◽  
Retrospective Study ◽  
Statistical Analysis ◽  
Parotid Gland ◽  
Poor Prognosis ◽  
Malignant Tumors ◽  
Gland Tumor ◽  
Parotid Gland Tumor ◽  
Apoptotic Protein ◽  
Pleomorphic Adenomas

The anti-apoptotic protein Mcl-1 is highly expressed in various types of malignant tumors. Overexpression is reported to correlate with poor prognosis and disease progression. We report the expression levels of Mcl-1 in tumor samples of the parotid gland. A retrospective study containing 108 patients was performed. A tissue microarray of six malignancies of the parotid gland and pleomorphic adenoma as control was constructed. Parotid gland tumor samples were immunohistochemically stained for Mcl-1 and expression intensities were assessed. Statistical analysis included correlation to patients' clinical data and comparison of malignancies to the adenoma.All malignancies had significantly higher expression of Mcl-1 than the pleomorphic adenomas. The intensity, however, had no significant correlation to overall survival.Our immunohistochemical findings indicate that parotid gland malignancies produce high levels of Mcl-1 protein. Therefore, Mcl-1 might serve as a predictive co-marker in tumors of the parotid gland.

Parotid Gland Tumors in Northern Greece: A 7-year Retrospective Study of 207 Patients

2020 ◽  
Vol 74 (6) ◽  
pp. 1-5
Author(s):  
Alexandros Poutoglidis ◽  
Nikolaos Tsetsos ◽  
Sotiria Sotiroudi ◽  
Georgios Fyrmpas ◽  
Frideriki Poutoglidou ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Parotid Gland ◽  
Positive Association ◽  
Complication Rates ◽  
Gland Tumor ◽  
Northern Greece ◽  
Recurrence Rates ◽  
Parotid Gland Tumors ◽  
Parotid Gland Tumor ◽  
Epidemiological Characteristics

Introduction: Parotid gland neoplasms represent a heterogenous group of tumors, either benign or malignant. The diagnosis and management of parotid gland tumors is complicated by their relative infrequency and their diverse biologic behavior. The purpose of this study is to investigate the epidemiological characteristics, the recurrence rates and the surgical approach employed for parotid gland tumors in Northern Greece. Material and methods: This is a single-center retrospective study. All patients admitted in the ENT clinic of “G. Papanikolaou” General Hospital of Thessaloniki from January 2012 to June 2019 with the diagnosis of parotid gland tumor were included in the study. Patients with incomplete charts and patients that underwent revision surgeries were excluded. Chi-squared tests were used to assess the associations between variables. Results: A total of 207 patients with a mean age of 54.97 (range 16-91) were included in the study. Benign neoplasms accounted for 87.9% of the cases. Warthin's tumor was the most common neoplasm encountered, with an incidence of 46.8%, followed by pleomorphic adenoma (31,9%). There was a higher incidence of parotid gland tumors in males and smokers (p=0.025, p=0.001 respectively). The majority of the patients were treated with an extracapsular resection (60.4%) or with a partial superficial parotidectomy (22.6%). In 12 cases (5.7%), there was a recurrence of the lesion. The most common complications encountered were facial nerve injury, Frey syndrome and hematoma formation. Conclusions: Parotid gland tumors typically benign, non-aggressive tumors, more frequently seen in men than women. There is a positive association between smoking and parotid gland tumor development. Comprehensive information regarding recurrence and complication rates are presented.

scholarly journals Giant Cell Carcinosarcoma of the Parotid Gland With a PLAG 1 Translocation in Association With a Pleomorphic Adenoma With HMGA2 Translocation

2020 ◽  
Vol 154 (6) ◽  
pp. 811-815
Author(s):  
Levon Katsakhyan ◽  
Virginia A LiVolsi ◽  
Ara A Chalian ◽  
Paul J Zhang
Keyword(s):  
Salivary Gland ◽  
In Situ Hybridization ◽  
Parotid Gland ◽  
Giant Cell ◽  
Pleomorphic Adenoma ◽  
De Novo ◽  
Sarcomatous Component ◽  
Gland Tumor ◽  
Parotid Gland Tumor

Abstract Objectives Carcinosarcomas of the salivary gland are rare neoplasms and have been described arising de novo or in association with pleomorphic adenoma (PA). PLAG1 and HMGA2 translocations are known to occur in PAs and carcinomas ex PA but are mutually exclusive. Methods We report a case of a carcinosarcoma in the parotid gland of a 77-year-old man with unusual anaplastic sarcomatoid giant cell morphology. Results Microscopically, a small separate PA was found adjacent to the carcinosarcoma. By conventional notion, the PA and carcinosarcoma would be considered related, as carcinosarcomas are well known to arise from PAs (carcinosarcoma ex PA). However, fluorescence in situ hybridization (FISH) assay demonstrated PLAG1 translocation in the carcinosarcoma and HMGA2 translocation in the separate PA. Conclusions These findings support that the carcinosarcoma likely originated from another PA with a PLAG1 translocation or de novo but not from the coexisting PA harboring a different translocation. To our knowledge, the case is the first to demonstrate PLAG1 translocation by FISH in a sarcomatous component of any parotid gland tumor, which may help better classify these tumors. In addition, multiple PAs are commonly found in the salivary gland, and to our knowledge, our case is the first to demonstrate that the same parotid gland can host PAs and PA-related tumors with different translocations.

Accessory parotid gland tumor: a case report

1997 ◽  
Vol 24 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Arata Horii ◽  
Yuichiro Honjo ◽  
Michihiro Nose ◽  
Masayoshi Ozaki ◽  
Jun-Ichi Yoshida
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Gland Tumor ◽  
Parotid Gland Tumor ◽  
Accessory Parotid Gland

scholarly journals A case of a parotid gland tumor which was enlarged from the hard and soft palate to the pharyngeal region.

1994 ◽  
Vol 40 (3) ◽  
pp. 470-472
Author(s):  
Kouki TAMAYAMA ◽  
Jun-ichi MURAKAMI ◽  
Hiroto KIMURA ◽  
Toru AKITAYA ◽  
Keiichi IGARASHI ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Soft Palate ◽  
Gland Tumor ◽  
Parotid Gland Tumor ◽  
Pharyngeal Region

scholarly journals Pattern of distribution of different salivary gland tumors; a retrospective study in NICRH, Dhaka

2016 ◽  
Vol 15 (1) ◽  
pp. 95-98
Author(s):  
Afroza Khanam ◽  
Gulshan Akhter ◽  
Md. Abdur Rahman
Keyword(s):  
Salivary Gland ◽  
Retrospective Study ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Major Salivary Gland ◽  
Gland Tumor ◽  
Minor Salivary Gland Tumors ◽  
Malignant Salivary Gland Tumors

Background: Salivary gland tumors are rare, generally benign and affect both major and minor salivary glands.Objective: To find out the pattern of distribution of different benign and malignant salivary gland epithelial tumors and their relation to age and sex in a tertiary care center in Bangladesh.Methodology: This is a retrospective study. Details of epithelial salivary gland tumors were obtained from department of ENT, National institute of cancer & research hospital (NICRH), Dhaka, Bangladesh from the period January 2009 to December 2012 (3 years).Result: A total number of 261 cases presenting with both benign and malignant salivary gland tumors were analyzed according to gender, age and histopathological findings. There were 130 (49.84%) males and 131 (50.19%) females with the male female ration of 1: 0.99. Age of study population ranged from 10 to 70 years with the mean age 40.78. Percentage of benign salivary gland tumors was 73.94% and malignant salivary gland tumor 26.05%. Among major salivary gland tumors, no sublingual tumors were found and parotid gland tumors were the commonest. Whereas, among minor salivary gland tumors palatal minor salivary tumors were common.Conclusion: Parotid gland was the most common site of origin of both benign and malignant salivary gland tumors. Histopathologically, pleomorphic adenoma was the most common benign salivary gland tumor and mucoepidermoid carcinoma was the most frequent malignant neoplasm. Adenoid cystic carcinoma was common minor salivary gland tumor.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.90-94

scholarly journals Superficial Parotidectomy by Retrograde Facial Nerve Dissection

2017 ◽  
Vol 10 (1) ◽  
pp. 25-27
Author(s):  
Narendra Vikram Gurung ◽  
D Shrestha ◽  
A Acharya ◽  
A Gurung ◽  
S Shrestha ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Facial Nerve ◽  
Head And Neck Neoplasms ◽  
Complication Rate ◽  
Gland Tumor ◽  
Superficial Parotidectomy ◽  
Salivary Fistula ◽  
Parotid Tumors ◽  
Parotid Gland Tumor

Introduction: Tumors of the salivary gland are relatively uncommon and represent less than two percentage of all head and neck neoplasms. Parotid gland tumor comprises 85% of the salivary gland tumors of which 80% are being benign. Superficial parotidectomy is the commonest procedure done for parotid tumors which can be performed by either anteretrograde or retrograde facial nerve dissection technique.Methods: Outcome of 60 patients after superficial parotidectomy with retrograde facial nerve dissection has been studied.Results: Total of 60 patients had been studied. Complications like facial nerve weakness, Freys syndrome, salivary fistula, and wound infection were taken into account. Among them, 13.33% patients developed temporary facial nerve weakness, followed by temporary salivary fistula, 1.6%. None of the patients developed any severe complication.Conclusion: Superficial parotidectomy by retrograde facial nerve dissection is an easy technique to carry out with low complication rate and without compromising surgical outcome.Journal of Gandaki Medical CollegeVol. 10, No. 1, 2017, page: 25-27

Castelman’s disease of the parotid gland – case report

2020 ◽  
Vol 9 (2) ◽  
pp. 62-65
Author(s):  
Paweł Krawczyński ◽  
Wojciech Brzoznowski
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Lymph Nodes ◽  
Histopathological Examination ◽  
Lymphoproliferative Disease ◽  
Castleman Disease ◽  
Disease Entity ◽  
Gland Tumor ◽  
Parotid Gland Tumor

Castleman disease is a rare lymphoproliferative disease occurs most often in lymph nodes located in the chest. The extra-nodal form concerns 25% of diagnosed cases of this disease entity. We present the case of Castelman disease localized in the parotid gland in a 15-year-old boy, confirmed by histopathological examination, clinically progressing as a right parotid gland tumor.

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