scholarly journals Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Krista A. Delviks-Frankenberry ◽  
Chawaree Chaipan ◽  
Rachel Bagni ◽  
Kathleen Wyvill ◽  
Robert Yarchoan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Chronic Fatigue ◽  
Human Prostate Cancer ◽  
Xenotropic Murine Leukemia ◽  
Fatigue Syndrome ◽  
Related Virus ◽  
Hiv 1 ◽  
Murine Leukemia

Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus reported to be associated with human prostate cancer and chronic fatigue syndrome. Since retroviruses cause various cancers, and XMRV replication might be facilitated by HIV-1 co-infection, we asked whether certain patients with HIV-associated lymphomas are infected with XMRV. Analysis of PMBCs and plasma from 26 patients failed to detect XMRV by PCR, ELISA, or Western blot, suggesting a lack of association between XMRV and AIDS-associated lymphomas.

scholarly journals The tale of xenotropic murine leukemia virus-related virus

2012 ◽  
Vol 93 (5) ◽  
pp. 915-924 ◽  
Author(s):  
Harriet C. T. Groom ◽  
Kate N. Bishop
Keyword(s):  
Murine Leukemia Virus ◽  
Prostate Cancer Patient ◽  
Leukemia Virus ◽  
Chronic Fatigue ◽  
Xenotropic Murine Leukemia ◽  
Fatigue Syndrome ◽  
Related Virus ◽  
Potential Association ◽  
The Media ◽  
Murine Leukemia

In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic murine leukemia virus-related virus (XMRV), this was potentially the third class of retrovirus to be pathogenic in humans. XMRV made a more dramatic impact on the wider scientific community, and indeed the media, in 2009 when it was reported to be present in a remarkably high proportion of patients with chronic fatigue syndrome as well as a significant, albeit smaller, proportion of healthy controls. The apparent strong link to disease and the fear of a previously unknown retrovirus circulating in the general population lead to a surge in XMRV research. Subsequent studies failed to find an association of XMRV with disease and, in most cases, failed to find the virus in human samples. In 2011, the case against XMRV and human disease strengthened, ending with several decisive publications revealing the origin of the virus and demonstrating contamination of samples. In this review, we outline the passage of research on XMRV and its potential association with disease from its isolation to the present day, where we find ourselves at the end of a turbulent story.

scholarly journals A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

mBio ◽  
2012 ◽  
Vol 3 (5) ◽  
Author(s):  
Harvey J. Alter ◽  
Judy A. Mikovits ◽  
William M. Switzer ◽  
Francis W. Ruscetti ◽  
Shyh-Ching Lo ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Xenotropic Murine Leukemia ◽  
Fatigue Syndrome ◽  
Related Virus ◽  
Murine Leukemia ◽  
Polytropic Murine Leukemia Virus

ABSTRACT The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection. IMPORTANCE Chronic fatigue syndrome/myalgic encephalomyelitis has an estimated prevalence of 42/10,000 in the United States, with annual direct medical costs of $7 billion. Here, the original investigators who found XMRV and pMLV (polytropic murine leukemia virus) in blood of subjects with this disorder report that this association is not confirmed in a blinded analysis of samples from rigorously characterized subjects. The increasing frequency with which molecular methods are used for pathogen discovery poses new challenges to public health and support of science. It is imperative that strategies be developed to rapidly and coherently address discoveries so that they can be carried forward for translation to clinical medicine or abandoned to focus resource investment more productively. Our study provides a paradigm for pathogen dediscovery that may be helpful to others working in this field.

scholarly journals Xenotropic Murine Leukemia Virus–Related Virus Prevalence in Patients with Chronic Fatigue Syndrome or Chronic Immunomodulatory Conditions

2010 ◽  
Vol 202 (10) ◽  
pp. 1478-1481 ◽  
Author(s):  
Timothy J. Henrich ◽  
Jonathan Z. Li ◽  
Donna Felsenstein ◽  
Camille N. Kotton ◽  
Robert M. Plenge ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Chronic Fatigue ◽  
Virus Prevalence ◽  
Xenotropic Murine Leukemia ◽  
Fatigue Syndrome ◽  
Related Virus ◽  
Murine Leukemia
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