scholarly journals Atypical Creutzfeldt-Jakob Disease Evolution after Electroconvulsive Therapy for Catatonic Depression

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Iria Grande ◽  
Juan Fortea ◽  
Ellen Gelpi ◽  
Itziar Flamarique ◽  
Marc Udina ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Disease Duration ◽  
Psychiatric Symptoms ◽  
Psychiatric Admission ◽  
Disease Evolution ◽  
Clinical Recovery ◽  
Jakob Disease ◽  
Magnetic Resonance Imaging Mri ◽  
Electroencephalogram Eeg ◽  
Codon 129

We describe a case report of an 80-year-old woman who presented with symptomatology compatible with an episode of major depression with catatonia. After psychiatric admission, electroconvulsive therapy (ECT) was applied, but symptoms progressed with cognitive impairment, bradykinesia, widespread stiffness, postural tremor, and gait disturbance. After compatible magnetic resonance imaging (MRI), diffusion changes, and electroencephalogram (EEG) findings the case was reoriented to Creutzfeldt-Jakob disease (CJD). The genetic study found a methionine/valine heterozygosity at codon 129 of the prion protein gene PrPSc. On followup, a significant clinical recovery turned out. For this reason, EEG and MRI were repeated and confirmed the findings. The patient subsequently demonstrated progressive clinical deterioration and died 21 months later. The diagnosis was verified postmortem by neuropathology. The vCJD subtype MV2 is indeed characterized by early and prominent psychiatric symptoms and a prolonged disease duration however no frank clinical recovery has before been reported.

Cerebrospinal Fluid Biomarker-Based Diagnosis of Sporadic Creutzfeldt-Jakob Disease: A Validation Study for Previously Established Cutoffs

2017 ◽  
Vol 43 (1-2) ◽  
pp. 71-80 ◽  
Author(s):  
Franc Llorens ◽  
André Karch ◽  
Ewa Golanska ◽  
Matthias Schmitz ◽  
Peter Lange ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Negative Correlation ◽  
Disease Duration ◽  
Population Sample ◽  
Clinical Accuracy ◽  
Jakob Disease ◽  
And Control ◽  
Fluid Biomarker ◽  
Prnp Codon ◽  
Codon 129

Background: Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions. Methods: We analyzed 14-3-3, tau, p-tau levels, and the p-tau/tau ratio in a population sample collected from Polish hospitals including nondementia, dementia, and definite sCJD cases and validated their parameters according to previously established cutoffs. Additionally, the correlation between biomarkers and disease duration as well as the influence of the PRNP129 polymorphism are reported. Results: The tau levels and p-tau/tau ratios differed considerably between sCJD and clinically characterized non-CJD cases (p < 0.001). p-tau was only elevated in sCJD when compared to cases without dementia (p < 0.05). Tau and the p-tau/tau ratio showed a sensitivity of 95 and 100%, respectively, in detecting sCJD cases. A negative correlation between tau levels and disease duration, but not the timing of lumbar puncture was observed. Conclusion: The present findings confirmed the value of the p-tau/tau ratio as a robust sCJD biomarker and suggest a role for tau as prognostic marker.

scholarly journals Using Deep Learning algorithms to detect the success or failure of the Electroconvulsive Therapy (ECT) sessions

2021 ◽  
Vol 34 (1) ◽  
Author(s):  
Usef Faghihi ◽  
Cyrus Kalantarpour
Keyword(s):  
Deep Learning ◽  
Electroconvulsive Therapy ◽  
Healthcare Professionals ◽  
Learning Algorithms ◽  
Mental Healthcare ◽  
Machine Learning Algorithms ◽  
Professional Needs ◽  
Magnetic Resonance Imaging Mri ◽  
Electroencephalogram Eeg ◽  
Depression Disorder

Major Depression Disorder (MDD) is a big problem in our society. MDD can cause suicide and take families apart. When treatment with medications fail, mental healthcare professionals, use Electroconvulsive Therapy (ECT) to treat patients with MDD. During an ECT session, electroencephalogram (EEG) signals let the mental healthcare professionals record patients' brain activities which are helpful to decide whether the treatment was successful. However, there is no standard way to know how and with what intensity a healthcare professional needs to apply electroshock to treat patients with MDD. So far, to our knowledge, researchers have used multi-parametric magnetic resonance imaging (MRI) techniques combined with statistical methods and/or linear machine learning algorithms to predict patients’ responses to ECT. However, the aforementioned methods are very expensive and time-consuming. In this study, we will be using Deep learning algorithms to detect the effectiveness of ECT sessions based on the EEG.

scholarly journals A rare case of sporadic Creutzfeldt-Jakob disease in an 83 years old female

2021 ◽  
Vol 8 (2) ◽  
pp. 279
Author(s):  
Medo M. Kuotsu ◽  
Arjun Bal Kallupurakkal ◽  
Nyamnyei Konyak ◽  
Keisham Jaya Chanu ◽  
Vikie-o Khruomo ◽  
...  
Keyword(s):  
Prion Disease ◽  
Alpha Helix ◽  
Cellular Prion Protein ◽  
Progressive Dementia ◽  
Extrapyramidal Signs ◽  
Control And Prevention ◽  
Weighted Magnetic Resonance Imaging ◽  
Jakob Disease ◽  
Magnetic Resonance Imaging Mri ◽  
Electroencephalogram Eeg

Sporadic Creutzfeldt-Jakob disease is a rare invariably fatal neurodegenerative prion disease. Prion disease are associated with the conversion of alpha-helix rich cellular prion protein (PrPC) into a beta-structure rich insoluble conformer scrapie isoform (PrPSc) thought to be infectious isoform. Here we present a case of an 83 years old woman with findings of rapidly progressive dementia, cognitive disturbance, myoclonic jerks and extrapyramidal signs (cogwheel rigidity). Following a series of clinical and diagnostic (diffusion-weighted magnetic resonance imaging (MRI) brain, electroencephalogram (EEG)) examination she was diagnosed with sporadic Creutzfeldt-Jakob disease based on Centers for disease control and prevention (CDC) criteria.

scholarly journals Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer’s and Creutzfeldt–Jakob Disease: A Micromorphological Pilot Study on 20 Brains

2021 ◽  
Vol 22 (4) ◽  
pp. 2099
Author(s):  
Nikol Jankovska ◽  
Tomas Olejar ◽  
Radoslav Matej
Keyword(s):  
Prion Protein ◽  
Fluorescent Microscopy ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Key Characteristics ◽  
Jakob Disease ◽  
Immunohistochemical Methods ◽  
Confocal Fluorescent Microscopy ◽  
Codon 129

Alzheimer’s disease (AD) and sporadic Creutzfeldt–Jakob disease (sCJD) are both characterized by extracellular pathologically conformed aggregates of amyloid proteins—amyloid β-protein (Aβ) and prion protein (PrPSc), respectively. To investigate the potential morphological colocalization of Aβ and PrPSc aggregates, we examined the hippocampal regions (archicortex and neocortex) of 20 subjects with confirmed comorbid AD and sCJD using neurohistopathological analyses, immunohistochemical methods, and confocal fluorescent microscopy. Our data showed that extracellular Aβ and PrPSc aggregates tended to be, in most cases, located separately, and “compound” plaques were relatively rare. We observed PrPSc plaque-like structures in the periphery of the non-compact parts of Aβ plaques, as well as in tau protein-positive dystrophic structures. The AD ABC score according to the NIA-Alzheimer’s association guidelines, and prion protein subtype with codon 129 methionine–valine (M/V) polymorphisms in sCJD, while representing key characteristics of these diseases, did not correlate with the morphology of the Aβ/PrPSc co-aggregates. However, our data showed that PrPSc aggregation could dominate during co-aggregation with non-compact Aβ in the periphery of Aβ plaques.

The Three Glycotypes in the London Classification System of Sporadic Creutzfeldt-Jakob Disease Differ in Disease Duration

2021 ◽  
Author(s):  
Blair Ney ◽  
Dhamidhu Eratne ◽  
Victoria Lewis ◽  
Luke Ney ◽  
Qiao-Xin Li ◽  
...  
Keyword(s):  
Classification System ◽  
Disease Duration ◽  
Jakob Disease

scholarly journals Pulvinar sign in a case of anti-HU paraneoplastic encephalitis

2016 ◽  
Vol 29 (6) ◽  
pp. 436-439 ◽  
Author(s):  
Pierre-Luc Gamache ◽  
Maude-Marie Gagnon ◽  
Martin Savard ◽  
François Émond
Keyword(s):  
Magnetic Resonance Imaging ◽  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Clinical Manifestations ◽  
Resonance Imaging ◽  
Paraneoplastic Encephalitis ◽  
Jakob Disease ◽  
Magnetic Resonance Imaging Mri ◽  
Work Up

This article reports the case of a 68-year-old patient with anti-HU antibodies paraneoplastic encephalitis. The clinical manifestations were atypical and the paraclinical work-up, notably the magnetic resonance imaging (MRI) showing bilateral posterior thalamic hyperintensities (pulvinar sign), misleadingly pointed towards a variant Creutzfeld–Jakob disease. After presenting the case, the differential diagnosis of the pulvinar sign is discussed along with other important diagnostic considerations.

scholarly journals Extra-pontine myelinolysis secondary to hypernatremia induced by postpartum water restriction

2017 ◽  
Vol 30 (1) ◽  
pp. 84-87 ◽  
Author(s):  
A Chhabra ◽  
R Kaushik ◽  
RM Kaushik ◽  
D Goel
Keyword(s):  
Postpartum Period ◽  
Resonance Imaging ◽  
Water Restriction ◽  
Delta Waves ◽  
Steady Improvement ◽  
Pontine Myelinolysis ◽  
History Of ◽  
Magnetic Resonance Imaging Mri ◽  
Electroencephalogram Eeg ◽  
Progressive Weakness

A young adult female with restricted water intake during the postpartum period presented with history of progressive weakness, dizziness and tendency to fall with generalized slowing of movement. On examination, patient was anaemic, febrile and stuporous. Investigations revealed hypernatremia, delta waves in electroencephalogram (EEG) and features suggestive of extra-pontine myelinolysis on magnetic resonance imaging (MRI) of brain. After correcting hypernatremia and instituting anti-cholinergic therapy, there was a gradual but steady improvement in neurological symptoms of the patient over a period of one week and the patient was discharged in a conscious, oriented and ambulant state. As such, neuroimaging findings can be crucial in diagnosing hypernatremic encephalopathy in the postpartum period.

scholarly journals Sporadic Creutzfeldt-Jakob disease: a case report of long disease duration and difficulties in confirming the diagnosis with short literature review

2021 ◽  
Vol 59 (3) ◽  
pp. 327-334
Author(s):  
Anna Karolina Stanowska ◽  
Barbara Wach ◽  
Izabela Herman-Sucharska ◽  
Dariusz Adamek
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Disease Duration ◽  
Jakob Disease

Codon 129 Polymorphism Specific Cerebrospinal Fluid Proteome Pattern in Sporadic Creutzfeldt−Jakob Disease and the Implication of Glycolytic Enzymes in Prion-Induced Pathology

2010 ◽  
Vol 9 (11) ◽  
pp. 5646-5657 ◽  
Author(s):  
Joanna Gawinecka ◽  
Jana Dieks ◽  
Abdul R. Asif ◽  
Julie Carimalo ◽  
Uta Heinemann ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Glycolytic Enzymes ◽  
Jakob Disease ◽  
Codon 129
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