scholarly journals Synthesis and Structural Studies of Transition Metal Complexes with Bidentate Schiff Base Derived from 3-Acetyl-6-methyl-(2H)-pyran-2,4(3H)-dione

2011 ◽  
Vol 8 (s1) ◽  
pp. S245-S252 ◽  
Author(s):  
Praveen S. Mane ◽  
Sanjiv M. Salunke ◽  
Balagi S. More
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Octahedral Geometry ◽  
Ligand Field ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
Dehydroacetic Acid ◽  
Ligand Field Parameters

The solid complexes of Cu(II), Ni(II), Co(II), Mn(II) and Fe(III) with Schiff base ligands derived from heterocyclic compounds 3-acetyl-6-methyl-(2H)-pyran-2,4(3H)-dione (Dehydroacetic acid) ando-chloroaniline were synthesized and characterized by elemental analysis, conductance, magnetic, thermal, UV-Vis and1H-NMR spectroscopy. The ligand field parameters have been evaluated for Cu(II), Ni(II), Co(II), Mn(II) and Fe(III) complexes which suggest an octahedral geometry for each of them. The magnetic moment and spectral data suggest the dimeric nature of Mn(II) complexes with octahedral geometry. The fungicidal activities of the ligands and their metal complexes have been screened in vitro againstAspergillus nigerand the percentage inhibition of the metal complexes is found to be increased considerably then that of their corresponding ligands and the order is Cu>Ni>Fe>Mn>Co.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

scholarly journals SYNTHESIS, MOLLUSCICIDALAND ANTIMICROBIAL POTENTIALITIES OF IRON TRIAD MONONUCLEAR METAL COMPLEXES INCORPORATING TRIDENTATE ASYMMETRICAL SCHIFF BASE LIGANDS CONTAINING SOFT SULFUR COORDINATING ATOM

2019 ◽  
pp. 103-113
Author(s):  
AMAL M ALOSAIMI ◽  
INES EL MANNOUBI ◽  
SAMI A ZABIN
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Metal Ion ◽  
Lethal Dose ◽  
Analytical Techniques ◽  
Central Metal ◽  
Schiff Base Ligands ◽  
Molluscicidal Activity

Objective: This work aimed at synthesizing tridentates asymmetrical Schiff base ligands containing sulfur atom and using them for preparing metal complexes with the iron triad metals. The prepared compounds were assayed in vitro for antimicrobial potential and in vivo molluscicidal activity. Methods: The unsymmetrical tridentate Schiff bases (SL1, SL2, and SL3) were prepared using 2-aminothiophenol as primary amine and condensed with 2-carboxybenzaldehyde, 2-hydroxy-1-naphthaldehyde, and 7-formyl-8-hydroxyquinoline. These ligands were used in preparing metal complexes with iron triad metals. The synthesized Schiff base ligands and their corresponding metal complexes were characterized and their proposed structures were confirmed using different physical and spectroscopic analytical techniques. All ligands and their corresponding metal complexes were assayed against different bacterial and fungal strains using the agar disk-diffusion technique. The molluscicidal activity was performed according to the standard reported methods as cited in the literature and by observing the toxicity and lethal dose according to the WHO guidelines. Results: The synthesized ligands behave as tridentate (NOS) ligands and form mononuclear complexes with the general formula [M(SL)2] with an octahedral geometry around the central metal ion. Metal complexes were non-electrolytic in nature. The in vitro antibacterial and antifungal examination results showed weak activity of the ligands, and there was enhanced activity with the complexes. The in vivo molluscicidal activity of the tested compounds showed good activity. Conclusion: The targeted compounds were prepared successfully, characterized, and showed some biological activity but lower than the standard reference drugs.

scholarly journals Synthesis and Spectroscopic and Antimicrobial Studies of Schiff Base Metal Complexes Derived from 2-Hydroxy-3-methoxy-5-nitrobenzaldehyde

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
K. R. Joshi ◽  
A. J. Rojivadiya ◽  
J. H. Pandya
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Dilution Method ◽  
Aspergillus Clavatus ◽  
Schiff Base Ligands ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Schiff Base Metal Complexes ◽  
Broth Dilution

Two new series of copper(II) and nickel(II) complexes with two new Schiff base ligands 2-((2,4-dimethylphenylimino)methyl)-6-methoxy-4-nitrophenol and 2-((3,4-difluorophenylimino)methyl)-6-methoxy-4-nitrophenol have been prepared. The Schiff base ligands were synthesized by the condensation of 2-hydroxy-3-methoxy-5-nitrobenzaldehyde with 2,4-dimethylaniline or 3,4-difluoroaniline. The ligands and their metal complexes have been characterized by IR, 1H NMR, mass and electronic spectra and TG analysis. The Schiff base ligands and their metal complexes were tested for antimicrobial activity against Gram positive bacteria Staphylococcus aureus, and Streptococcus pyogenes and Gram negative bacteria Escherichia coli, and Pseudomonas aeruginosa and fungus Candida albicans, Aspergillus niger, and Aspergillus clavatus using Broth Dilution Method.

scholarly journals Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

2020 ◽  
Vol 32 (7) ◽  
pp. 1768-1772
Author(s):  
Anita Rani ◽  
Manoj Kumar ◽  
Hardeep Singh Tuli ◽  
Zahoor Abbas ◽  
Vinit Prakash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Analytical Techniques ◽  
Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

scholarly journals Synthesis Characterization and Antimicrobial Activity Studies of Some Transition Metal Complexes Derived from 3-Chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Vivekanand D. Biradar ◽  
B. H. M. Mruthyunjayaswamy
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Esr Spectra ◽  
Mass Spectral Data ◽  
Tetrahedral Geometry ◽  
Donor Ligand ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr

A series of new coordination complexes of Cu(II), Co(II), Ni(II), Zn(II), Hg(II), Mn(II), and Fe(III) with the Schiff base 3-chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide (HL) have been synthesized and characterized by elemental analysis, electrical conductivity measurements, IR spectra,1H NMR, mass spectral data, electronic spectra, magnetic susceptibility, ESR spectra, TGA, and Powder XRD data. The Schiff base behaves as tridentate ONO donor ligand and forms the complexes of the type ML2(metal-ligand) stoichiometry for Cu(II), Co(II), Ni(II), and Mn(II) complexes and ML stoichiometry for Zn(II), Hg(II), and Fe(III) complexes. All the complexes are colored and nonelectrolytes. It is found that Cu(II), Co(II), Ni(II), Mn(II) and Fe(III) complexes have exhibited octahedral geometry whereas Zn(II) and Hg(II) complexes exhibited tetrahedral geometry. The ligand and its metal complexes have been screened for their antibacterial activity againstE. coliandS. aureusand antifungal activity againstA. nigerandA. flavus.

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