scholarly journals Primitive Neuroectodermal Tumor of the Liver: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Eduardo Cambruzzi ◽  
Enilde Eloena Guerra ◽  
Hamilton Cardoso Hilgert ◽  
Herbert Jorge Schmitz ◽  
Vinícius Lopes Silva ◽  
...  
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Soft Tissues ◽  
Young Patients ◽  
Neuroectodermal Tumor ◽  
Solid Mass ◽  
Resected Liver ◽  
The Central Nervous System ◽  
Right Lobe ◽  
Upper Abdominal ◽  
The Right

Primary liver sarcomas represent a rare group of neoplasias, with angiosarcoma being the most common histological type. Primitive neuroectodermal tumor (PNET) represents a high malignant neoplasia that usually affects the central nervous system and soft tissues. An 18-year-old male patient was admitted with clinical complains of pain in the right upper abdominal quadrant. The clinical evaluation revealed a solid mass in the right hepatic lobe. On the gross examination of the resected liver specimen, the right lobe of the liver was replaced by a yellow-red solid mass measuring 21 cm in its largest dimension. On the histopathology, a tumor composed of small round blue cells with little cytoplasm and round nuclei was identified. The lesion revealed positive immunoexpression for vimentin and CD99 and negative immunostaining for desmin, CD45, cytokeratin, and neuroblastoma protein, suggesting, then, the diagnosis of PNET. Although it is an unusual tumor, it should be considered in the differential diagnosis of liver masses, especially in young patients.

A case of peripheral primitive neuroectodermal tumor of the ovary

2004 ◽  
Vol 14 (2) ◽  
pp. 370-372 ◽  
Author(s):  
K.-J. Kim ◽  
B.-W. Jang ◽  
S.-K. Lee ◽  
B.-K. Kim ◽  
S.-L. Nam
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Soft Tissues ◽  
Case Reports ◽  
The Body ◽  
Neuroectodermal Tumor ◽  
Pelvic Cavity ◽  
Age Group ◽  
Peripheral Primitive Neuroectodermal Tumor ◽  
Children And Young Adults ◽  
The Right

Peripheral primitive neuroectodermal tumor (PNET) belongs to the PNET/Ewing's sarcoma family. PNET is a small round cell tumor of putative neuroectoderm origin and is the second most common sarcoma among children and young adults. It may occur anywhere in the body and within any age group; however, it is most likely to occur in the bone and soft tissues. There have been a small number of case reports of PNET arising in the ovary. We presented a case of PNET arising in the right ovary of an 18-year-old woman. The tumor was metastased to the lymph nodes of the pelvis and para-aorta at surgical staging. We had persecuted Taxol/carboplatin chemotherapy, pelvic cavity radiotherapy, and Vincristine/Actinomycink, Cyclophosphamide/Doxorubicin (VACA). She died after 10 months due to septic shock.

scholarly journals Melanotic Neuroectodermal Tumor of Infancy

2018 ◽  
Vol 142 (11) ◽  
pp. 1358-1363 ◽  
Author(s):  
Brian S. Soles ◽  
Allecia Wilson ◽  
David R. Lucas ◽  
Amer Heider
Keyword(s):  
Differential Diagnosis ◽  
Local Recurrence ◽  
Soft Tissues ◽  
Malignant Neoplasm ◽  
Neck Region ◽  
Neuroectodermal Tumor ◽  
Growth Potential ◽  
Incomplete Resection ◽  
The Central Nervous System ◽  
Blue Cell

Context.— Melanotic neuroectodermal tumor of infancy, albeit rare and generally regarded as benign, is an important tumor to recognize because of its rapid growth, potential for local recurrence, and small round blue cell morphology, which can lead to misdiagnosis of a malignant neoplasm. Objective.— To review its clinical presentation and immunomorphologic findings, and discuss common entities in the differential diagnosis. Data Sources.— The study involved PubMed searches, including multiple review articles, case studies, retrospective studies, selected book chapters, and University of Michigan cases. Conclusions.— Melanotic neuroectodermal tumor of infancy most commonly occurs in the bones of the head and neck region during the first year of life, but it can also present in other locations, including the central nervous system, testes, ovaries, and subcutaneous soft tissues. Histologically, it is composed of a biphasic population of cells, consisting of epithelioid melanin-producing cells and primitive neurogenic cells in a fibrocollagenous stroma. These microscopic findings, especially in small biopsies, can lead to a broad differential diagnosis that includes malignant small round blue cell tumors and malignant melanoma. Melanotic neuroectodermal tumor of infancy commonly has an infiltrative growth pattern, and anatomic constraints often lead to incomplete resection and local recurrence, requiring multiple surgical operations. Because melanotic neuroectodermal tumor of infancy can mimic a more aggressive and aggressively treated malignancy, recognition of this rare tumor is very crucial for pathologists.

scholarly journals A rare case of primitive neuroectodermal tumor of the right lung.

1996 ◽  
Vol 35 (5) ◽  
pp. 460-465 ◽  
Author(s):  
Mayumi UENO ◽  
Junzo FUJIYAMA ◽  
Tadashi IDEI ◽  
Kunishi KAWAMATA ◽  
Yukitoshi SATOH ◽  
...  
Keyword(s):  
Rare Case ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
The Right

scholarly journals The Adventitia Resection in Treatment of Liver Hydatid Cyst: A Case Report of a 15-Year-Old Boy

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Zhenhua Ma ◽  
Wei Yang ◽  
Yingmin Yao ◽  
Qingguang Liu
Keyword(s):  
Hydatid Cyst ◽  
Bile Leakage ◽  
Virtual Space ◽  
Liver Hydatid Cyst ◽  
Computed Tomographic ◽  
History Of ◽  
Right Lobe ◽  
Upper Abdominal ◽  
The Right ◽  
Significant Health

Human hydatid disease is a significant health problem in endemic regions caused by the larval form ofEchinococcus granulosus. In this paper, we report a case of liver hydatid cyst. The patient, a 15-year-old boy, presented with a history of intermittent upper abdominal pain of a few-month duration was referred to our hospital for investigation. Computed tomographic scan and laboratory test suggested a hydatid cyst in the right lobe of liver. The adventitia resection of hydatid cyst was smoothly performed as there was a less bloody virtual space between adventitia and outer membrane. Our diagnosis was made using an imaging approach and was confirmed during surgery. We proposed the adventitia resection of hydatid cyst could be safe and easy to perform with low risk of bleeding and bile leakage.

scholarly journals Primitive neuroectodermal tumor of thyroid: a rare presentation

2017 ◽  
Vol 4 (1) ◽  
pp. 276
Author(s):  
Shravan S. Shetty ◽  
Dhairyasheel N. Savant ◽  
Hozefa Lokhandwala ◽  
Akanksha Chichra
Keyword(s):  
Head And Neck ◽  
Multimodal Treatment ◽  
Primitive Neuroectodermal Tumor ◽  
Soft Tissues ◽  
Neck Region ◽  
Neuroectodermal Tumor ◽  
Rare Presentation ◽  
Term Survival ◽  
Complete Surgical Excision ◽  
Response To Chemotherapy

<p>Extraskeletal Ewing’s sarcoma (EES) commonly arises in the soft tissues of trunk or extremities. EES is rare in the head and neck region; most having been documented in nasal cavity, paranasal sinuses and neck. Head and neck PNETs have an intermediate prognosis. We report the case of a 12 year old boy who presented with primitive neuroectodermal tumor of the thyroid and was treated with multimodal treatment including surgery, chemotherapy and radiotherapy. The patient is alive and fit with a functional larynx. Major drug regimens use vincristine, doxorubicin, ifosfamide or cyclophosphamide, dactinomycin and/or etoposide. Complete surgical excision is undertaken whenever possible to improve long-term survival. However, the relative radiosensitivity of tumors of the Ewing family, suggest multimodal treatment including adjuvant radiotherapy in case of positive margins or poor response to chemotherapy rather than resection with 2-3 cm margins, which would imply laryngeal sacrifice for thyroid tumors.</p>

scholarly journals Anti-PD-1 Immunotherapy Combined With Antiangiogenic Therapy as Salvage Therapy in a Patient With Refractory Metastatic Peripheral Primitive Neuroectodermal Tumor: A Case Report and Literature Review

2021 ◽  
Author(s):  
Qiaoyun Chen ◽  
Ronghui Jin ◽  
Xu Li ◽  
Qifan Wu ◽  
Gaili An
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Kinase Inhibitor ◽  
Treatment Plan ◽  
Antiangiogenic Therapy ◽  
Malignant Neoplasm ◽  
Neuroectodermal Tumor ◽  
Comprehensive Treatment ◽  
Peripheral Primitive Neuroectodermal Tumor ◽  
New Ideas ◽  
The Right

Abstract Background: Peripheral primitive neuroectodermal tumor (pPNET) is a relatively rare malignant neoplasm that usually occurs in children and young adults,associated with poor prognosis. However, standard treatment for refractory pPNET has not been determined.Case presentation: A case of a 38-year-old woman with pPNET on the right shoulder and back,she had gained up to seven-and-a-half years suvival undergoing these comprehensive treatment including surgery, radiotherapy, chemotherapy, antiangiogenic treatment. However, the tumor eventually progressed after receiving multiline treatment.With the patient's strong desire to receive immunotherapy, we finally adjusted the treatment plan to " anti-angiogenic tyrosine kinase inhibitor Lenvatinib combined with PD-1 inhibitor Toripalimab" for 2 cycles.Unfortunately,she developed grade 2-3 immune pneumonia after treatment.Conclusions: To our knowledge, this is the first report of immunotherapy combined with antiangiogenic therapy in pPNET,which provides new ideas for the treatment of refractory pPNET.

scholarly journals Primitive Neuroectodermal Tumor in the Spinal Cord of a Brahman Crossbred Calf

2005 ◽  
Vol 42 (6) ◽  
pp. 834-836 ◽  
Author(s):  
A. Berrocal ◽  
D. L. Montgomery ◽  
J. T. Mackie ◽  
R. W. Storts
Keyword(s):  
Spinal Cord ◽  
Immunohistochemical Staining ◽  
Primitive Neuroectodermal Tumor ◽  
Neuron Specific Enolase ◽  
Neuroectodermal Tumor ◽  
Lumbosacral Junction ◽  
Embryonal Tumors ◽  
S 100 ◽  
The Central Nervous System ◽  
Ependymal Differentiation

A variety of embryonal tumors of the central nervous system, typically malignant and occurring in young individuals, are recognized in humans and animals. This report describes an invasive subdural but predominantly extramedullary primitive neuroectodermal tumor developing at the lumbosacral junction in a 6-month-old Brahman crossbred calf. The tumor was composed of spindloid embryonal cells organized in interlacing fascicles. The cells had oval to elongate or round hyperchromic nuclei, single to double nucleoli, and scant discernible cytoplasm. Immunohistochemical staining for neuron-specific enolase, synaptophysin, and S-100 protein and formation of pseudorosettes suggested neuronal and possibly ependymal differentiation.

scholarly journals Snoring as main symptoms of peripheral primitive neuroectodermal tumor in oropharynx:a case report with review of literature

2021 ◽  
Author(s):  
Xin-xiang Ma ◽  
Chuan-xin Zhang ◽  
Yi-fan Ren ◽  
Yu-lin Zhang ◽  
Ji-ai Zheng
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Soft Tissues ◽  
Wilms Tumor ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Neuroectodermal Tumor ◽  
Lower Limbs ◽  
Peripheral Primitive Neuroectodermal Tumor ◽  
Magnetic Resonance Imaging Mri ◽  
Histology And Immunohistochemistry

Abstract IntroductionIn children, snoring is often associated with hypertrophied tonsils and adenoids. There was a case in a girl who did not suffer from hypertrophy adenoids, but from a peripheral primitive neuroectodermal tumor (pPNET) in the oropharynx. pPNET often occurs in the deep soft tissues of the trunk, paravertebral, lower limbs and retroperitoneum. It is rarely located in children's oropharynx and makes snoring.Patient concernsWe report a case of a 4-years-old girl who complained of slurred speech and snoring. Her serum showed normal results, computed tomography (CT) and magnetic resonance imaging (MRI) revealed a mass lesion in oropharynx. By using histology and immunohistochemistry, cluster of differentiation 99 (CD99), vimentin, friend leukemia integration 1 (FLI-1), integrase interactor-1 and α-smooth muscle actin were positive, but epithelial membrane antigen, erythroblast transformation-specific (ETS) related gene (ERG), NK homeobox 2.2, Wilms’ tumor 1 and S100-protein were negative. And the rearrangement of the Ewing sarcoma breakpoint region 1 (EWSR1) gene was proved in the test of fluorescent.DiagnosisShe was diagnosed as a peripheral primitive neuroectodermal tumor.Interventions and outcomeThe girl had been treated with surgery and chemotherapy. She has been well for 24 months without any signs of disease.ConclusionIn children who snore, we should not only think of hypertrophied adenoids, but also the possibility of pPNETs in oropharynx. CT scan or MRI should be conducted in time, as well as histology and immunohistochemistry to avoid misdiagnosis.

scholarly journals Supratentorial primitive neuroectodermal tumor presenting with intracranial hemorrhage in adult

2014 ◽  
Vol 5 (02) ◽  
pp. 176-179 ◽  
Author(s):  
Bashar Abuzayed ◽  
Wiam Khreisat ◽  
William Maaiah ◽  
Saoud Agailat
Keyword(s):  
Female Patient ◽  
Intracranial Hemorrhage ◽  
Radiation Oncology ◽  
Primitive Neuroectodermal Tumor ◽  
Histopathological Examination ◽  
Neuroectodermal Tumor ◽  
Loss Of Consciousness ◽  
Postoperative Course ◽  
Supratentorial Primitive Neuroectodermal Tumor ◽  
The Right

ABSTRACTA 24-year-old female patient presented with complaints of nausea, vomiting and of loss of consciousness lasted for 15 minutes with left sided weakness. Neuroradiological evaluation revealed a hemorrhagic mass lesion in the right frontal lobe. The patient was operated and intraoperative findings showed a cortical-subcortical hematoma including hemorrhagic and disrupted tissue with a pathologic purple tissue on the periphery of the hematoma. Postoperative course was uneventful and postoperative histopathological examination revealed primitive neuroectodermal tumor. The patient was then referred to medical and radiation oncology clinics for further evaluation and treatment.

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