scholarly journals Traditional Chinese Medicines in Treatment of Patients with Type 2 Diabetes Mellitus

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Weidong Xie ◽  
Yunan Zhao ◽  
Yaou Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Action Mechanisms ◽  
Golden Thread ◽  
The Future ◽  
Antidiabetic Effects

Type 2 diabetes mellitus (T2DM) occurs in 95% of the diabetic populations. Management of T2DM is a challenge. Traditional Chinese medicines (TCM) are usually served as adjuvants used to improve diabetic syndromes in combination of routine antidiabetic drugs. For single-herb prescriptions, Ginseng, Bitter melon, Golden Thread, Fenugreek, Garlic, and Cinnamon might have antidiabetic effects in T2DM patients. Among 30 antidiabetic formulas approved by the State Food and Drugs Administrator of China, top 10 of the most frequently prescribed herbs are Membranous Milkvetch Root, Rehmannia Root, Mongolian Snakegourd Root, Ginseng, Chinese Magnoliavine Fruit, Kudzuvine Root, Dwarf Lilyturf Tuber, Common Anemarrhena Rhizome, Barbary Wolfberry Fruit, and India Bread, which mainly guided by the theory of TCM. Their action mechanisms are related to improve insulin sensitivity, stimulate insulin secretion, protect pancreatic islets, and even inhibit intake of intestinal carbohydrates. However, it is very difficult to determine antihyperglycemic components of TCM. Nevertheless, TCM are becoming popular complementary and alternative medicine in treatment of syndromes of T2DM. In the future, it requires further validation of phytochemical, pharmacological, and clinical natures of TCM in T2DM in the future studies, especially for those herbs with a high prescription frequency.

The future of protein biomarker research in type 2 diabetes mellitus

2018 ◽  
Vol 16 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Roel Tans ◽  
Lars Verschuren ◽  
Hans J. C. T. Wessels ◽  
Stephan J. L. Bakker ◽  
Cees J. Tack ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Protein Biomarker ◽  
The Future ◽  
Biomarker Research

Systematic investigation of the mechanism of Cichorium glandulosum on type 2 diabetes mellitus accompanied with non-alcoholic fatty liver rats

2019 ◽  
Vol 10 (5) ◽  
pp. 2450-2460 ◽  
Author(s):  
Huiyu Qin ◽  
Haijun Chen ◽  
Yang Zou ◽  
Xiaoyi Zhang ◽  
Changqing Wei ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Liver ◽  
Systematic Investigation ◽  
Systems Pharmacology ◽  
Active Compounds ◽  
Alcoholic Fatty Liver ◽  
Action Mechanisms

Strategy of this systems-pharmacology approach to investigate the active compounds and action mechanisms of CG on T2DM-NAFLD.

scholarly journals Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?

2006 ◽  
Vol 96 (2) ◽  
pp. 326-333 ◽  
Author(s):  
Cristovao F. Lima ◽  
Marisa F. Azevedo ◽  
Rita Araujo ◽  
Manuel Fernandes-Ferreira ◽  
Cristina Pereira-Wilson
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Glucose ◽  
Primary Cultures ◽  
Rat Hepatocytes ◽  
Salvia Officinalis ◽  
Diabetic Patients ◽  
Antidiabetic Effects

Common sage (Salvia officinalis L.) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals. In the present study, we aimed to verify the antidiabetic effects of an infusion (tea) of common sage, which is the most common form of this plant consumed. Replacing water with sage tea for 14d lowered the fasting plasma glucose level in normal mice but had no effect on glucose clearance in response to an intraperitoneal glucose tolerance test. This indicated effects on gluconeogenesis at the level of the liver. Primary cultures of hepatocytes from healthy, sage-tea-drinking rats showed, after stimulation, a high glucose uptake capacity and decreased gluconeogenesis in response to glucagon. Essential oil from sage further increased hepatocyte sensitivity to insulin and inhibited gluconeogenesis. Overall, these effects resemble those of the pharmaceutical drug metformin, a known inhibitor of gluconeogenesis used in the treatment and prevention of type 2 diabetes mellitus. In primary cultures of rat hepatocytes isolated from streptozotocin (STZ)-induced diabetic rats, none of these activities was observed. The present results seem to indicate that sage tea does not possess antidiabetic effects at this level. However, its effects on fasting glucose levels in normal animals and its metformin-like effects on rat hepatocytes suggest that sage may be useful as a food supplement in the prevention of type 2 diabetes mellitus by lowering the plasma glucose of individuals at risk.

scholarly journals Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2044
Author(s):  
Aisha Musaazi Sebunya Nakitto ◽  
John H. Muyonga ◽  
Yusuf Byenkya Byaruhanga ◽  
Anika E. Wagner
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Homeostasis ◽  
Low Income ◽  
Fruits And Vegetables ◽  
Low Income Countries ◽  
Glucose And Lipid Metabolism ◽  
Antidiabetic Effects

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder of glucose homeostasis associated with a status of insulin resistance, impaired insulin signaling, β-cell dysfunction, impaired glucose and lipid metabolism, sub-clinical inflammation, and increased oxidative stress. Consuming fruits and vegetables rich in phytochemicals with potential antidiabetic effects may prevent T2DM and/or support a conservative T2DM treatment while being safer and more affordable for people from low-income countries. Solanum anguivi Lam. fruits (SALF) have been suggested to exhibit antidiabetic properties, potentially due to the presence of various phytochemicals, including saponins, phenolics, alkaloids, ascorbic acid, and flavonoids. For the saponin fraction, antidiabetic effects have already been reported. However, it remains unclear whether this is also true for the other phytochemicals present in SALF. This review article covers information on glucose homeostasis, T2DM pathogenesis, and also the potential antidiabetic effects of phytochemicals present in SALF, including their potential mechanisms of action.

scholarly journals What is the Future of Therapeutic Education? The Italian Scenario and the Covid-19 Pandemic Lesson

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Riccio M ◽  
Memoli G
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Developing Countries ◽  
Type 2 Diabetes Mellitus ◽  
Progressive Failure ◽  
Therapeutic Education ◽  
Healthcare Facilities ◽  
Exponential Increase ◽  
The Future

The exponential increase in cases of Type 2 Diabetes Mellitus (T2DM), particularly in developing countries, is combined with the progressive failure of healthcare facilities to provide adequate assistance.

The Future of Thiazolidinedione Therapy in the Management of Type 2 Diabetes Mellitus

2013 ◽  
Vol 13 (3) ◽  
pp. 329-341 ◽  
Author(s):  
Hanford Yau ◽  
Kathya Rivera ◽  
Romina Lomonaco ◽  
Kenneth Cusi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
The Future

scholarly journals Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Qian Sun ◽  
Jingchao Liu ◽  
Lei Wu ◽  
Yue Sun ◽  
Jianrong Jin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
The Future ◽  
Low Hdl

Abstract Background Serum lipid abnormalities are generally considered as a major risk factor for type 2 diabetes mellitus (T2DM). However, evidence for the effect of long-term serum lipid fluctuations on future T2DM probability remains limited. Methods A total of 4475 nondiabetic participants who underwent annual health examinations between 2010 and 2013 were followed for the subsequent 5-year risk of T2DM. The Cox proportional hazards model was performed to evaluate the associations of visit-to-visit variabilities and trajectories of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) with T2DM probability. Results During the five-year follow-up, 223 newly developed T2DM cases were identified. Compared with the “Low” TG trajectory, “Moderate” and “Moderate-High” TG trajectories were significantly associated with T2DM incidence, with adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) of 1.51 (1.12-2.03) and 2.55 (1.62-4.03), respectively. Additionally, participants in the third and fourth quartiles of TG/standard deviation (SD) were associated with increased T2DM probability when compared with those in the lowest quartile. After excluding individuals with prediabetes, participants with “Moderate-High” TG trajectory still had a 2.43-fold greater risk of T2DM compared with those with “Low” TG trajectory (95 % CI: 1.28-4.63). In addition, compared with participants in “Low” HDL-c trajectory, the future T2DM probability was significantly reduced in those with “Moderate” and “High” HDL-c trajectories, with HR (95 % CI) of 0.52 (0.37-0.72) and 0.38 (0.18-0.80), respectively. After excluding individuals with prediabetes, the “Moderate” HDL-c trajectory remained associated with decreased T2DM probability when compared with “Low” HDL-c trajectory (HR: 0.55, 95 % CI: 0.35-0.88). However, the incidence of T2DM was not associated with the long-term fluctuations of TC and LDL-c. Conclusions Long-term visit-to-visit variability of TG, and the change trajectories of TG and HDL-c were significantly associated with future T2DM probability. Moreover, these associations were not affected after excluding individuals with prediabetes.

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