scholarly journals Cerebral Sinovenous Thrombosis in a Child with Idiopathic Nephrotic Syndrome

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
L. Ghedira Besbes ◽  
S. Haddad ◽  
A. Gabsi ◽  
M. Hassine ◽  
Ch. Ben Meriem ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Magnetic Resonance ◽  
Cranial Computed Tomography ◽  
Renal Disorder ◽  
Heavy Proteinuria ◽  
Steroid Dependent ◽  
Cerebral Sinovenous Thrombosis ◽  
Sinovenous Thrombosis ◽  
Life Threatening ◽  
Nephrotic Children

Nephrotic syndrome (NS) is a renal disorder characterized by heavy proteinuria, hypoalbuninemia, edema and hypercholesterolemia. Nephrotic syndrome in children is known to be associated with an hypercoagulable state and thromboembolic complications. However cerebral sinovenous thrombosis (CSVT) is very rare. Here we report a seven-year-old child with steroid-dependent idopathic nephrotic syndrome resulting from a minimal change disease, developed multiple cerebral sinovenous thrombosis, presenting with headache, left sixth nerve palsy, and papilledema. The diagnosis of CSVT was established by cranial computed tomography, magnetic resonance imaging, and magnetic resonance angiography. He gradually recovered after anticoagulant therapy. CSVT is very rare in nephrotic children. The diagnosis of CSVT should be considered in any patient with nephrotic syndrome who develops neurologic symptoms. This report highlights the importance of suspecting and recognizing this potentially life threatening complication and initiating early treatment.

scholarly journals Analysis of 10 Pediatric Nephrotic Syndrome Cases With Complications of Cerebral Sinovenous Thrombosis

2020 ◽  
Vol 8 ◽  
Author(s):  
Liping Rong ◽  
Lizhi Chen ◽  
Zhi Dong ◽  
Hongjie Zhuang ◽  
Zhilang Lin ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Magnetic Resonance ◽  
Clinical Manifestations ◽  
Elevated Pressure ◽  
Cerebral Sinovenous Thrombosis ◽  
Treatment Data ◽  
Cerebral Computed Tomography ◽  
Sinovenous Thrombosis ◽  
Steroid Sensitive ◽  
Magnetic Resonance Imaging Mri

Background: To analyze the clinical characteristics of nephrotic syndrome (NS) with complications of cerebral sinovenous thrombosis (CSVT) in children.Method: Clinical, radiographic, laboratory, and treatment data obtained from 10 confirmed cases of NS with complications of CSVT were analyzed. All patients were followed up for at least 18 months. CSVT was diagnosed by cerebral computed tomography (CT) and/or magnetic resonance imaging (MRI) with or without magnetic resonance venography (MRV) of the cerebral vessels.Results: Among 10 cases reported, 4 were steroid-sensitive NS with frequent relapse, 5 were steroid-resistant (three of them had renal biopsies showing two minimal change disease and one IgA nephropathy), and 1 was steroid-sensitive with one relapse. Common clinical manifestations were headache or ophthalmodynia complicated by vomiting, dizziness, convulsion, and coma. Neuropathologic signs were positive in some cases. Papilledema appeared in only one case with winding of vein. Cerebrospinal fluid was examined in three cases with elevated pressure but normal cytological and biochemical results. D dimer and fibrinogen levels were elevated while prothrombin time and activated partial thromboplastin time were shortened. Five out of seven cases who had performed cranial CT were suspicious for cerebral thrombosis. Nine cases had cranial MRI with abnormal signs in seven cases. All of the cases received MRV, confirming the diagnosis of CVST.Conclusion: Clinical manifestations of NS with CSVT are not specific but varied. Therefore, CSVT should be considered once nervous manifestations present. MRV is a better method in the diagnosis of CSVT.

scholarly journals Cerebral sinovenous thrombosis in a nephrotic child

2003 ◽  
Vol 61 (4) ◽  
pp. 1026-1029 ◽  
Author(s):  
Marcelo Masruha Rodrigues ◽  
Lilian Rocha Zardini ◽  
Maria Cristina de Andrade ◽  
Cristina Malzoni Ferreira Mangia ◽  
João Tomas de Abreu Carvalhaes ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Anticoagulation Therapy ◽  
Signs And Symptoms ◽  
Successful Outcome ◽  
Review Of The Literature ◽  
Cranial Ct ◽  
Cerebral Sinovenous Thrombosis ◽  
Infancy And Childhood ◽  
Sinovenous Thrombosis ◽  
Ct And Mri

Nephrotic syndrome in infancy and childhood is known to be associated with a hypercoagulable state and thromboembolic complications, but cerebral sinovenous thrombosis (CST) is a very rare and serious one, with only a few isolated reports in the literature. A case is presented of a 9-year-old boy with nephrotic syndrome that acutely developed signs and symptoms of intracranial hypertension syndrome. CST was diagnosed on cranial CT and MRI and he gradually recovered after treatment with anticoagulants. The diagnosis of CST should be considered in any patient with nephrotic syndrome who develops neurologic symptoms. The discussion of this case, coupled with a review of the literature, emphasizes that early diagnosis is essential for institution of anticoagulation therapy and a successful outcome. This report also illustrates the difficulties that may be encountered in managing such a patient.

scholarly journals Pediatric Stroke: Clinical Findings and Radiological Approach

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Giuseppe Lanni ◽  
Alessia Catalucci ◽  
Laura Conti ◽  
Alessandra Di Sibio ◽  
Amalia Paonessa ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Hemorrhagic Stroke ◽  
Clinical Findings ◽  
Pediatric Stroke ◽  
Arterial Ischemic Stroke ◽  
Venous Circulation ◽  
Cerebral Sinovenous Thrombosis ◽  
First Choice ◽  
Sinovenous Thrombosis

This paper focuses on radiological approach in pediatric stroke including both ischemic stroke (Arterial Ischemic Stroke and Cerebral Sinovenous Thrombosis) and hemorrhagic stroke. Etiopathology and main clinical findings are examined as well. Magnetic Resonance Imaging could be considered as the first-choice diagnostic exam, offering a complete diagnostic set of information both in the discrimination between ischemic/hemorrhagic stroke and in the identification of underlying causes. In addition, Magnetic Resonance vascular techniques supply further information about cerebral arterial and venous circulation. Computed Tomography, for its limits and radiation exposure, should be used only when Magnetic Resonance is not available and on unstable patients.

Cerebral sinovenous thrombosis during asparaginase treatment

2003 ◽  
Vol 23 (03) ◽  
pp. 109-112
Author(s):  
A. Hirt ◽  
C. Zwicky ◽  
W.A. Wuillemin ◽  
K. Leibundgut
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Induction Treatment ◽  
Pathogenic Mechanisms ◽  
Cerebral Sinovenous Thrombosis ◽  
Haemorrhagic Infarction ◽  
Sinovenous Thrombosis

SummaryA boy (age: 71/12 years) with acute lymphoblastic leukaemia developed thrombosis of the sinus sagitalis superior with secondary haemorrhagic infarction while on induction treatment with vincristine, prednisone, and asparaginase. Based on this report, the potential pathogenic mechanisms are discussed with respect to congenital prothrombotic defects as well as to the role of antileukaemic treatment. Current hypotheses on mechanisms for thromboembolism in children and proposed prophylactic strategies are briefly summarized.

A case of a 7-year-old boy with steroid-dependent nephrotic syndrome who developed severe neutropenia three months after the administration of rituximab

2009 ◽  
Vol 22 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Ryugo Hiramoto ◽  
Shinsuke Matsumoto ◽  
Hironobu Eguchi ◽  
Yoshitaka Miyoshi ◽  
Isao Komori ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Severe Neutropenia ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome
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