scholarly journals Nanotechnologies for Curcumin: An Ancient Puzzler Meets Modern Solutions

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Shengpeng Wang ◽  
Miao Tan ◽  
Zhangfeng Zhong ◽  
Meiwan Chen ◽  
Yitao Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Curcuma Longa ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Protective Agent ◽  
Natural Polyphenol ◽  
Preclinical Trials ◽  
High Doses

Curcumin, a low-molecular-weight natural polyphenol mainly found in the plantCurcuma longa(turmeric), is widely used as a food colorant and as a potential protective agent against several chronic diseases including cancer, HIV-infection, neurological, cardiovascular, and skin diseases. Moreover, evidences from long-term use process and preclinical trials have demonstrated low toxicity of curcumin, even at relatively high doses. However, it has been well known that the application of curcumin was limited owing to its water insolubility, instability, and poor bioavailability. For decades, many attempts have been made to compensate for these disadvantages, with the development of improved delivery platforms as the feasible approaches. The past ten years witnessed the encouraging progress in the use of nanoscale drug delivery systems on curcumin such as loading curcumin into liposomes or nanoparticles, forming self-microemulsifying drug delivery systems (SMEDDS), cyclodextrin inclusions, and solid dispersions, as well as the latest reported technologies such as nadodisks and nanotubes. This paper summarizes the recent works on the design and development of nanoscale delivery systems of curcumin, with the goal of harnessing the true difficulties of this multifunctional agent in the clinical arena.

Development and Evaluation of Sustained Release Lipid Nanocarriers for Curcumin

2020 ◽  
Vol 5 (3) ◽  
pp. 224-235
Author(s):  
Harshal A. Pawar ◽  
Bhagyashree D. Bhangale
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Research Work ◽  
Elimination Rate ◽  
Delivery Systems ◽  
Physicochemical Stability ◽  
Wide Range

Background: Lipid based excipients have increased acceptance nowadays in the development of novel drug delivery systems in order to improve their pharmacokinetic profiles. Drugs encapsulated in lipids have enhanced stability due to the protection they experience in the lipid core of these nano-formulations. Phytosomes are newly discovered drug delivery systems and novel botanical formulation to produce lipophilic molecular complex which imparts stability, increases absorption and bioavailability of phytoconstituent. Curcumin, obtained from turmeric (Curcuma longa), has a wide range of biological activities. The poor solubility and wettability of curcumin are responsible for poor dissolution and this, in turn, results in poor bioavailability. To overcome these limitations, the curcumin-loaded nano phytosomes were developed to improve its physicochemical stability and bioavailability. Objective: The objective of the present research work was to develop nano-phytosomes of curcumin to improve its physicochemical stability and bioavailability. Methods: Curcumin-loaded nano phytosomes were prepared by using phospholipid Phospholipon 90 H using a modified solvent evaporation method. The developed curcumin nano phytosomes were evaluated by particle size analyzer and differential scanning calorimetry (DSC). Results: Results indicated that phytosomes prepared using curcumin and lipid in the ratio of 1:2 show good entrapment efficiency. The obtained curcumin phytosomes were spherical in shape with a size less than 100 nm. The prepared nano phytosomal formulation of curcumin showed promising potential as an antioxidant. Conclusion: The phytosomal complex showed sustained release of curcumin from vesicles. The sustained release of curcumin from phytosome may improve its absorption and lowers the elimination rate with an increase in bioavailability.

Nanotechnology-Based Drug Delivery Systems for Treatment of Hyperproliferative Skin Diseases - A Review

2013 ◽  
Vol 9 (1) ◽  
pp. 159-167
Author(s):  
Fernanda Kolenyak dos Santos ◽  
Marcia Helena Oyafuso ◽  
Charlene Priscila Kiill ◽  
Maria Palmira Daflon- Gremiao ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Delivery Systems

A general approach on the surfactants use and their properties in drug delivery systems

2021 ◽  
Vol 27 ◽  
Author(s):  
Mysrayn Yargo de Freitas Araújo Reis ◽  
Renaly Ivyna de Araújo Rêgo ◽  
Beatriz Patrício Rocha ◽  
Gabryella Garcia Guedes ◽  
Ízola Morais de Medeiros Ramalho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Epithelial Cells ◽  
Stratum Corneum ◽  
Chain Length ◽  
Formation Process ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Dissolution Profile ◽  
Amphiphilic Molecules

: Surfactants are amphiphilic molecules of great interest in the pharmaceutical field due to their use in combination with other adjuvants to solubilize poor soluble drugs, improve their dissolution profile, promote permeation, increase drug delivery systems stabilization, among other characteristics. Literature shows that surfactants are included in several pharmaceutical forms composition: tablets, solid dispersions, emulsions, microemulsions, nanoemulsions, liposomes, and niosomes. This review aims to elucidate the different classes of surfactants based on their charges (cationic, anionic, nonionic, zwitterionic, and dimeric), the micelles formation process, and how surfactants molecules geometry can affect this phenomenon. Moreover, current studies regarding the benefits of surfactants in the development of formulations are presented. Finally, a discussion on how charges and chain length of surfactants can interact with the stratum corneum epithelial cells leading to increased permeation or skin irritability is reported.

scholarly journals Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Samatha Akula ◽  
Aravind Kumar Gurram ◽  
Srinivas Reddy Devireddy
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Oral Route ◽  
Delivery Systems ◽  
Water Soluble ◽  
Lymphatic Transport ◽  
Water Soluble Drugs ◽  
Solubilized Form

Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs with minimum dose. Although many formulation approaches like solid dispersions, complexation, pH modification, and cocrystals exist, lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug. Among lipid based formulations, self-microemulsifying formulations (droplet size < 100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Various components that are used to formulate these dosage forms like surfactants and lipids contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be surmounted. The present paper gives exhaustive information on the formulation design and characterization of SMEDDS along with the probable mechanisms by which the bioavailability can be improved with SMEDDS.

scholarly journals Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1968
Author(s):  
Mina Zare ◽  
Karolina Dziemidowicz ◽  
Gareth R. Williams ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Strong Electric Field ◽  
Solid Dispersions ◽  
Electrospun Nanofibers ◽  
Amorphous Solid ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
Biological And Medical Applications

Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.

Investigation of novel supersaturating drug delivery systems of chlorthalidone: The use of polymer-surfactant complex as an effective carrier in solid dispersions

2018 ◽  
Vol 111 ◽  
pp. 142-152 ◽  
Author(s):  
Maria Terezinha França ◽  
Rafael Nicolay Pereira ◽  
Manoela Klüppel Riekes ◽  
Juliana Munari Oliveira Pinto ◽  
Hellen Karine Stulzer
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Surfactant Complex ◽  
Polymer Surfactant ◽  
Effective Carrier

scholarly journals The main potentialities of resveratrol for drug delivery systems

2015 ◽  
Vol 51 (3) ◽  
pp. 499-513 ◽  
Author(s):  
Joana Ruivo ◽  
Cátia Francisco ◽  
Rita Oliveira ◽  
Ana Figueiras
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Physicochemical Properties ◽  
Drug Delivery Systems ◽  
Mechanisms Of Action ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
Natural Polyphenol ◽  
Prevention And Therapy ◽  
Novel Therapeutic

Resveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.

Nanotechnology-Based Drug Delivery Systems for Treatment of Hyperproliferative Skin Diseases - A Review

2013 ◽  
Vol 9 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Fernanda Kolenyak dos Santos ◽  
Marcia Helena Oyafuso ◽  
Charlene Priscila Kiill ◽  
Maria Palmira Daflon- Gremiao ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Delivery Systems

Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

2020 ◽  
Vol 26 (36) ◽  
pp. 4569-4579 ◽  
Author(s):  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Srividya Gorantla ◽  
Ranendra Narayan Saha ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Skin Permeation ◽  
Clinical Status ◽  
Age Groups ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Skin Disorders

Background: Skin diseases affect all the age groups of people and have an impact on patients’ physical, mental, and emotional status. Conventional topical preparation is limited with its efficacy due to low permeation, frequent application, and poor adherence to the therapy for prolong time. Objective: The objective of this review article is to address the emerging trends of nanotechnology derived lipidic carrier systems for an effective treatment for skin disorders. Methodology: Various research and review articles from reputed international journals were referred and compiled. Results and Discussion: opical drug delivery systems were found to be more effective than oral and parenteral drug delivery systems for treating skin diseases due to targeted localized applications with reduced side effects. Lipid-based nanoparticles have been found to have the potential in treating skin diseases due to the biocompatibility and the versatility of the lipids. Nanostructured lipid carriers (NLCs) have gained much attention in treating skin diseases due to improved stability of the drugs, enhanced skin permeation, retention, and better therapeutic efficacy. The review summarizes the NLCs characteristics and their application for topical delivery of various therapeutics in skin disorders. NLCs have shown great potential in effective drug delivery for the treatment of psoriasis, dermatitis, bacterial infections, and skin cancer. Its cosmetic application has opened a new area for skincare. Furthermore, safety and clinical status revealed its future commercial acceptability. Conclusion: NLCs have been found as effective lipid nanocarriers for the delivery of topical therapeutics.

scholarly journals Drug Delivery Systems for Topical treatment of Inflammatory Skin Diseases

2021 ◽  
Vol 5 (1) ◽  
pp. 59-64
Author(s):  
Shadeed Gad ◽  
Mohamed Desoqi ◽  
Hossam El-Sawy ◽  
Elsayed Khafagy ◽  
Mamdouh Ghourab
Keyword(s):  
Drug Delivery ◽  
Topical Treatment ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Delivery Systems ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin
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