scholarly journals Well-Differentiated Thyroid Carcinomas: Management of the Central Lymph Node Compartment and Emerging Biochemical Markers

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Meei J. Yeung ◽  
Janice L. Pasieka
Keyword(s):  
Lymph Node ◽  
Good Prognosis ◽  
Specific Information ◽  
Central Lymph Node ◽  
Blood Marker ◽  
Lymph Node Compartment ◽  
Well Differentiated ◽  
Central Lymph ◽  
Definition Of ◽  
Differentiated Thyroid Cancers

Well-differentiated thyroid cancers (WDTCs) are generally indolent cancers that are associated with a low mortality. Although the incidence of these tumors is increasing, there has not been an associated increase in the mortality rates. As we gain a greater understanding and more experience with these good prognosis cancers, the way in which we treat these tumors is evolving. The definition of persistent or recurrent disease has seen a shift from being a clinical and/or radiological diagnosis to now one based on a biochemical blood marker, thyroglobulin. Central lymph node metastases are a very common problem in WDTC, being present in up to 90% of patients. The optimal surgical management of the central lymph node compartment remains a hotly debated topic. This paper identifies these controversies and presents available data surrounding these issues. Biochemical tumor markers are gaining wider use in practice and in time hopefully provide more specific information with which surgical decision-making can be based. A summary of the clinically available markers is presented.

scholarly journals Recent Advances in the Surgical Treatment of Differentiated Thyroid Cancer: A Comprehensive Review

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Raghunandan Venkat ◽  
Marlon A. Guerrero
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Thyroid Surgery ◽  
Node Dissection ◽  
Central Lymph Node ◽  
Thyroid Cancers ◽  
Perioperative Morbidity ◽  
Central Lymph Node Dissection ◽  
Central Lymph ◽  
Differentiated Thyroid Cancers

Differentiated thyroid cancers have become one of the fastest growing malignancies in the world. While surgery has remained the cornerstone of management of these tumors, the surgical approach has seen numerous innovations over the past few decades. The use of video-assistance and robotics has revolutionized thyroid surgery. This paper provides a comprehensive evaluation of the different approaches to thyroid surgery, the utility of prophylactic and therapeutic lymph node dissection, and evidence-based guidelines in the treatment of differentiated thyroid cancers. Minimally invasive video-ssisted thyroidectomy is both safe and effective in the hands of the trained surgeon and, in selected patient populations, has comparative perioperative morbidity and better cosmesis as compared to conventional open thyroidectomy. It is universally accepted that therapeutic central lymph node dissection should be performed when metastatic lymph nodes are identified on physical exam, ultrasound, or intraoperatively. In the absence of overt nodal metastasis, the role of elective prophylactic central lymph node dissection remains a matter of debate and prospective, randomized studies are warranted to evaluate the utility of this procedure.

scholarly journals Prevalence of Central Compartment Lymph Node Metastases in Papillary Thyroid Micro-Carcinoma: A Retrospective Evaluation of Predictive Preoperative Features

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6028
Author(s):  
Marta Tagliabue ◽  
Gioacchino Giugliano ◽  
Maria Cecilia Mariani ◽  
Manila Rubino ◽  
Enrica Grosso ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Binary Logistic Regression ◽  
Central Compartment ◽  
Good Prognosis ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
Node Metastases ◽  
Central Lymph

Papillary thyroid micro-carcinomas are considered relatively indolent carcinomas, often occult and incidental, with good prognosis and favorable outcomes. Despite these findings, central lymph node metastases are common, and are related to a poor prognosis for the patient. We performed a retrospective analysis on patients treated with surgery for stage pT1a papillary thyroid micro-carcinomas. One hundred ninety-five patients were included in the analyses. The presence of central lymph node metastases was identified and studied. A multivariate analysis employing binary logistic regression was used to calculate adjusted odds ratios with 95% confidence intervals of possible central lymph node metastases risk factors. In the performed multivariate analysis, male gender, younger age, and histopathological characteristics, such as a tumor sub-capsular localization, were significantly associated with central lymph node metastases in pT1a patients. Central compartment lymph node metastases are present in a non-negligible number of cases in patients with papillary thyroid micro-carcinoma undergoing surgical resection. Studying these factors could be an effective tool for predicting patients’ central lymph node metastases in papillary thyroid micro-carcinomas, defining a tailored surgical treatment in the future.

Predictive factors of central lymph node involvement in differentiated thyroid cancers

2021 ◽  
Author(s):  
Mohamed Masmoudi ◽  
Mehdi Hasnaoui ◽  
Thabet Wadii ◽  
Marwa Ben Njima ◽  
Zitouni Chaima ◽  
...  
Keyword(s):  
Lymph Node ◽  
Predictive Factors ◽  
Lymph Node Involvement ◽  
Central Lymph Node ◽  
Thyroid Cancers ◽  
Node Involvement ◽  
Central Lymph ◽  
Differentiated Thyroid Cancers
Sign in / Sign up

Export Citation Format

Share Document