scholarly journals Determinants of Intravascular Resistance in Indian Diabetic Nephropathy Patients: A Hospital-Based Study

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
Anubhav Thukral ◽  
Manish Mishra ◽  
Vaibhava Srivastava ◽  
Hemant Kumar ◽  
Amit Nandan Dhar Dwivedi ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
High Risk ◽  
Vascular Resistance ◽  
Color Doppler ◽  
Renal Vascular Resistance ◽  
Metabolic Dysregulation ◽  
Duration Of Disease ◽  
Incipient Diabetic Nephropathy ◽  
Raas Inhibitors ◽  
Renal Vascular

Aims and Objectives. Metabolic dysregulation has failed to explain clinical variability of patients with diabetic nephropathy and hence a renewed interest emerged in haemodynamic factors as determinant of progression and development of diabetic nephropathy. We therefore studied for various factors which can correlate with raised renal vascular resistance in diabetic nephropathy.Material and Methods. Renal vascular resistance was measured in patients with established and incipient diabetic nephropathy and compared with controls using noninvasive color Doppler examinations of intrarenal vasculature.Results. Renal vascular resistance correlated with age, duration of disease, GFR, serum creatinine, and stage of retinopathy. Renal vascular resistance was significantly reduced in patients on treatment with RAAS inhibitors and insulin, than those on OHA and antihypertensives other than RAAS inhibitors.Conclusion. The study implies that renal vascular resistance may help identify diabetics at high risk of developing nephropathy, and these set of patients could be candidates for RAAS inhibition and early insulin therapy even in patients without albuminuria.

Renal vascular resistance in diabetic nephropathy: duplex Doppler US evaluation.

Radiology ◽  
1994 ◽  
Vol 192 (2) ◽  
pp. 549-554 ◽  
Author(s):  
B Brkljacić ◽  
V Mrzljak ◽  
I Drinković ◽  
D Soldo ◽  
M Sabljar-Matovinović ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Vascular Resistance ◽  
Renal Vascular Resistance ◽  
Doppler Us ◽  
Duplex Doppler ◽  
Renal Vascular

Diabetic nephropathy

1997 ◽  
Vol 38 (2) ◽  
pp. 296-302 ◽  
Author(s):  
D. Soldo ◽  
B. Brkljacic ◽  
V. Bozikov ◽  
I. Drinkovic ◽  
M. Hauser
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Vascular Resistance ◽  
Renal Vascular Resistance ◽  
Diabetic Patients ◽  
Renal Changes ◽  
Duplex Doppler ◽  
Renal Vascular ◽  
Parenchymal Thickness ◽  
Renal Length

Background: the purposes of this study were: to compare conventional and duplex Doppler ultrasonography in the detection of renal changes in diabetes mellitus; to investigate whether a correlation was found with various clinical stages; and to assess whether increased renal vascular resistance in asymptomatic patients correlated with mild renal functional impairment. Material and Methods: in 190 diabetic patients and 85 controls, conventional ultrasonography was used to assess renal length, parenchymal thickness, and cortical echo-genicity. Renal vascular resistance was estimated by duplex Doppler measurements of intrarenal arterial resistive indices. According to clinical stage, the patients were classified into 3 groups. Resistive indices were compared between controls and patient groups and correlated with age and renal function. Results: in asymptomatic diabetic nephropathy, renal length and parenchymal thickness were significantly increased compared to that of controls, reflecting hyperfiltra-tion-induced nephromegaly. Differences between controls and patients with clinically manifest nephropathy were insignificant; only in advanced renal disease were both values significantly decreased. Cortical hyperechogenicity was noted only in very advanced disease. Resistive indices correlated well with renal function, and pathologic values (i. e. ≥ 0.70) were observed in 15% in the asymptomatic group and in 87% in the group with advanced nephropathy. Conclusion: Renal changes in diabetic patients are detectable by conventional ultrasound only in very advanced stages of the disease. Pathologic resistive indices, however, may be detected in the earlier stages. Resistive indices correlate with serum cre-atinine levels and creatinine clearance rates. However, it remains unclear as to whether a diagnostic or prognostic benefit can be expected as compared to standard laboratory examinations.

Effects of endothelin ETA receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits

1997 ◽  
Vol 321 (3) ◽  
pp. 295-300 ◽  
Author(s):  
Diane P Ignasiak ◽  
Thomas B McClanahan ◽  
Lori J Saganek ◽  
Ronald E Potoczak ◽  
Hussein Hallak ◽  
...  
Keyword(s):  
Vascular Resistance ◽  
Renal Vascular Resistance ◽  
Receptor Antagonism ◽  
Eta Receptor ◽  
Renal Vascular

scholarly journals Associations of renal vascular resistance with albuminuria in adolescents and young adults

2011 ◽  
Vol 26 (12) ◽  
pp. 3943-3949 ◽  
Author(s):  
C.-W. Tsai ◽  
C.-C. Kuo ◽  
C.-F. Wu ◽  
K.-L. Chien ◽  
V.-C. Wu ◽  
...  
Keyword(s):  
Young Adults ◽  
Vascular Resistance ◽  
Renal Vascular Resistance ◽  
Adolescents And Young Adults ◽  
Renal Vascular
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