scholarly journals Lower Frequency of CD62Lhighand Higher Frequency of TNFR2+Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Monika Ryba ◽  
Karolina Rybarczyk-Kapturska ◽  
Katarzyna Zorena ◽  
Małgorzata Myśliwiec ◽  
Jolanta Myśliwska
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Regulatory T Cells ◽  
Lower Percentage ◽  
Diabetic Patients ◽  
Autoreactive T Cells ◽  
Inflammatory Conditions ◽  
Type 1 Diabetic Patients ◽  
Chronic Autoimmune Disease

Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. Human regulatory cells play important role in controlling autoimmunity, and their qualitative or quantitative dysfunctions may result in ineffective suppression of autoreactive T cells. CD62L is a surface molecule that plays role in homing capabilities of Tregs, and only cells with high expression of CD62L have high suppressive potential. Tregs are also characterized by the constant expression of TNFR2. The frequency of Tregs carrying TNFR2 is higher in inflammatory conditions. We investigated blood regulatory T cells with CD62L expression and regulatory T cells expressing TNFR2 in type 1 diabetic patients. We found differences in these populations when comparing to healthy individuals. We propose that these may be associated with inflammatory conditions that are present in patients with type 1 diabetes. The lower percentage of Tregs and Treg CD62Lhighmay contribute to ineffective suppression of proinflammatory cytokines production during type 1 diabetes.

Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis

Endocrine ◽  
2009 ◽  
Vol 35 (3) ◽  
pp. 420-428 ◽  
Author(s):  
Núria Alonso ◽  
María Jesús Martínez-Arconada ◽  
María Luisa Granada ◽  
Berta Soldevila ◽  
Ana Cantón ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Genetic Restoration of Heme Oxygenase-1 Expression Protects from Type 1 Diabetes in NOD Mice

2019 ◽  
Vol 20 (7) ◽  
pp. 1676 ◽  
Author(s):  
Julien Pogu ◽  
Sotiria Tzima ◽  
Georges Kollias ◽  
Ignacio Anegon ◽  
Philippe Blancou ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Heme Oxygenase ◽  
Transcriptional Activation ◽  
Critical Role ◽  
Nod Mice ◽  
Lower Percentage ◽  
Heme Oxygenase 1 ◽  
Autoreactive T Cells

Antigen-presenting cells (APCs) including dendritic cells (DCs) play a critical role in the development of autoimmune diseases by presenting self-antigen to T-cells. Different signals modulate the ability of APCs to activate or tolerize autoreactive T-cells. Since the expression of heme oxygenase-1 (HO-1) by APCs has been associated with the tolerization of autoreactive T-cells, we hypothesized that HO-1 expression might be altered in APCs from autoimmune-prone non-obese diabetic (NOD) mice. We found that, compared to control mice, NOD mice exhibited a lower percentage of HO-1-expressing cells among the splenic DCs, suggesting an impairment of their tolerogenic functions. To investigate whether restored expression of HO-1 in APCs could alter the development of diabetes in NOD mice, we generated a transgenic mouse strain in which HO-1 expression can be specifically induced in DCs using a tetracycline-controlled transcriptional activation system. Mice in which HO-1 expression was induced in DCs exhibited a lower Type 1 Diabetes (T1D) incidence and a reduced insulitis compared to non-induced mice. Upregulation of HO-1 in DCs also prevented further increase of glycemia in recently diabetic NOD mice. Altogether, our data demonstrated the potential of induction of HO-1 expression in DCs as a preventative treatment, and potential as a curative approach for T1D.

scholarly journals Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 ◽  
Vol 177 (12) ◽  
pp. 8338-8347 ◽  
Author(s):  
Manuela Battaglia ◽  
Angela Stabilini ◽  
Barbara Migliavacca ◽  
Jutta Horejs-Hoeck ◽  
Thomas Kaupper ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Healthy Subjects ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients
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