scholarly journals Outcomes of Universal Access to Antiretroviral Therapy (ART) in Georgia

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Tengiz Tsertsvadze ◽  
Nikoloz Chkhartishvili ◽  
Lali Sharvadze ◽  
Natia Dvali ◽  
Otar Chokoshvili ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Injection Drug Users ◽  
Drug Users ◽  
Universal Access ◽  
Injection Drug ◽  
Cd4 Cell Count ◽  
Art Initiation ◽  
Incurable Disease ◽  
Art Program ◽  
Advanced Immunodeficiency

Since 2004, Georgia achieved universal access to free antiretroviral therapy (ART). A retrospective cohort study was conducted to evaluate the outcomes of Georgia's ART program. The study included adult patients enrolled in the ART program from 2004 through 2009. Of 752 patients, 76% were men, 60% were injection drug users (IDU), 59% had a history of an AIDS-defining illness, and 53% were coinfected with hepatitis C. The median baseline CD4 cell count was 141 cells/mm3. During followup, 152 (20%) patients died, with the majority of deaths occurring within 12 months of ART initiation. Mortality was associated with advanced immunodeficiency or the presence of incurable disease at baseline. Among patients remaining on treatment, the median CD4 gain was 216 cell/mm3and 86% of patients had viral load <400 copies/ml at the last clinical visit. The Georgia ART program has been successful in treating injection drug users infected with HIV.

scholarly journals Relationship between Food Insecurity and Mortality among HIV-Positive Injection Drug Users Receiving Antiretroviral Therapy in British Columbia, Canada

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e61277 ◽  
Author(s):  
Aranka Anema ◽  
Keith Chan ◽  
Yalin Chen ◽  
Sheri Weiser ◽  
Julio S. G. Montaner ◽  
...  
Keyword(s):  
British Columbia ◽  
Antiretroviral Therapy ◽  
Food Insecurity ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Hiv Positive

scholarly journals Predictors of Weight Change in Male HIV-Positive Injection Drug Users Initiating Antiretroviral Therapy in Hanoi, Vietnam

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Alice M. Tang ◽  
Heidi B. Sheehan ◽  
Michael R. Jordan ◽  
Dang Van Duong ◽  
Norma Terrin ◽  
...  
Keyword(s):  
Weight Gain ◽  
Antiretroviral Therapy ◽  
Tobacco Smoking ◽  
Weight Change ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Hiv Positive ◽  
Weight Changes ◽  
Negative Weight

We examined clinical and nutritional predictors of weight change over two consecutive 6-month intervals among 99 HIV-positive male injection drug users initiating antiretroviral therapy (ART) in Hanoi, Vietnam. The average weight gain was 3.1 ± 4.8 kg in the first six months after ART and 0.8 ± 3.0 kg in the following six months. Predictors of weight change differed by interval. In the first interval, CD4 < 200 cells/μL, excellent/very good adherence to ART, bothersome nausea, and liquid supplement use were all associated with positive weight changes. Moderate to heavy alcohol use and tobacco smoking were associated with negative weight changes. In the second interval, having a CD4 count <200 cells/μL at the beginning of the interval and tobacco smoking were the only significant predictors and both were associated with negative weight changes. We identified several potential areas for interventions to promote weight gain immediately after starting ART in this population. Studies are needed to determine whether improving weight prior to, or at, ART initiation will result in improved outcomes on ART.

Adherence and plasma HIV RNA response to antiretroviral therapy among HIV-seropositive injection drug users in a Canadian setting

AIDS Care ◽  
2011 ◽  
Vol 23 (8) ◽  
pp. 980-987 ◽  
Author(s):  
Seonaid Nolan ◽  
M-J. Milloy ◽  
Ruth Zhang ◽  
Thomas Kerr ◽  
Robert S. Hogg ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Hiv Rna ◽  
Canadian Setting ◽  
Hiv Seropositive

Patient-level outcomes and virologic suppression rates in HIV-infected patients receiving antiretroviral therapy in Rwanda

2018 ◽  
Vol 29 (9) ◽  
pp. 861-872
Author(s):  
David J Riedel ◽  
Kristen A Stafford ◽  
Peter Memiah ◽  
Modupe Coker ◽  
Cyprien Baribwira ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Universal Access ◽  
Scale Up ◽  
Virologic Suppression ◽  
Model Of Care ◽  
Prevalence Odds Ratio ◽  
Cd4 Cell Count ◽  
Art Initiation ◽  
Care And Support ◽  
Cd4 Cell

The Rwanda national HIV program has been successful at scaling up antiretroviral therapy (ART) to achieve universal access. The AIDSRelief Model of Care focuses on four key principles: (1) earlier initiation of ART; (2) use of durable, highly-potent, and sequence-friendly first-line ART regimens; (3) early detection of treatment failure; and (4) provision of community-based care and support to ensure optimal adherence and follow up/engagement in care. We conducted a retrospective cohort study of randomly-selected HIV-infected patients at AIDSRelief-supported sites using a stratified, random sample of 583 adults (>15 years) who initiated ART from 30 June 2008 to 1 February 2010. At ART initiation, the median patient age was 38 years, and 67% were female. The baseline median CD4+ cell count was 309 cells/mm3. Overall virologic suppression was 91%. Married/ever married status (adjusted prevalence odds ratio [aPOR] 3.75, 95% confidence interval [CI] 1.30–10.78) and self-reported adherence ≥95% in the past month (aPOR 2.76, 95% CI 1.00–7.62) were significantly associated with viral suppression in the multivariable model. Excellent virologic outcomes were achieved in Rwandan AIDSRelief sites utilizing the AIDSRelief Model of Care during the scale-up of ART in the country.

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