scholarly journals Tetrodotoxin Detection by a Surface Plasmon Resonance Sensor in Pufferfish Matrices and Urine

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Allen D. Taylor ◽  
Hana Vaisocherová ◽  
Jonathan Deeds ◽  
Stacey DeGrasse ◽  
Shaoyi Jiang
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Matrix Effects ◽  
Mouse Bioassay ◽  
Animal Testing ◽  
Live Animal ◽  
Multiple Reactions ◽  
Muscle Extract ◽  
Resonance Sensor

Tetrodotoxin (TTX) poisoning is most commonly associated with consumption of pufferfish. TTX is a low molecular weight (~319 Da) neurotoxin that selectively blocks voltage-sensitive Na+-gated ion channels. The standard method accepted worldwide for monitoring TTX toxicity in food matrices is the mouse bioassay. Ethical concerns from live animal testing, low sample throughput, and analytical inaccuracies have led to the need for an alternative method. We have previously established that surface plasmon resonance (SPR) sensors can quantify TTX in aqueous buffer samples by an antibody-based inhibition assay. In this paper, we report the extension of the assay for the detection of TTX in both clinical- and food-relevant matrices. The assay was optimized for application to three relevant complex matrices: pufferfish liver extract, pufferfish muscle extract, and human urine. Matrix effects are discussed and calibration curves are presented. Naturally contaminated pufferfish liver and muscle extracts were analyzed by the SPR method, and the data is compared to liquid-chromatography electrospray-ionization multiple reactions monitoring mass spectrometry (LC/ESI/MRM/MS) data. Ten samples, including three from a poisoning incident, two control monkfish samples, and five toxic pufferfish samples, were analyzed using this method, and the data is compared to LC/ESI/MRM/MS analysis of the samples.

scholarly journals Microstructured Surface Plasmon Resonance Sensor Based on Inkjet 3D Printing Using Photocurable Resins with Tailored Refractive Index

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2518
Author(s):  
Nunzio Cennamo ◽  
Lorena Saitta ◽  
Claudio Tosto ◽  
Francesco Arcadio ◽  
Luigi Zeni ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
3D Printing ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Optical Sensor ◽  
Low Cost ◽  
3D Print ◽  
Spr Sensor ◽  
Resonance Sensor ◽  
3D Printed

In this work, a novel approach to realize a plasmonic sensor is presented. The proposed optical sensor device is designed, manufactured, and experimentally tested. Two photo-curable resins are used to 3D print a surface plasmon resonance (SPR) sensor. Both numerical and experimental analyses are presented in the paper. The numerical and experimental results confirm that the 3D printed SPR sensor presents performances, in term of figure of merit (FOM), very similar to other SPR sensors made using plastic optical fibers (POFs). For the 3D printed sensor, the measured FOM is 13.6 versus 13.4 for the SPR-POF configuration. The cost analysis shows that the 3D printed SPR sensor can be manufactured at low cost (∼15 €) that is competitive with traditional sensors. The approach presented here allows to realize an innovative SPR sensor showing low-cost, 3D-printing manufacturing free design and the feasibility to be integrated with other optical devices on the same plastic planar support, thus opening undisclosed future for the optical sensor systems.

scholarly journals Design and validation of fiber optic localized surface plasmon resonance sensor for thyroglobulin immunoassay with high sensitivity and rapid detection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyeong-Min Kim ◽  
Dae Hong Jeong ◽  
Ho-Young Lee ◽  
Jae-Hyoung Park ◽  
Seung-Ki Lee
Keyword(s):  
Surface Plasmon Resonance ◽  
Optical Fiber ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Localized Surface Plasmon Resonance ◽  
Optical Fiber Sensor ◽  
Fiber Sensor ◽  
Localized Surface Plasmon ◽  
Simple Method ◽  
Resonance Sensor

AbstractA simple optical fiber sensor based on localized surface plasmon resonance was constructed for direct and rapid measurement of thyroglobulin (Tg). Specific tests for Tg in patients that have undergone thyroidectomy are limited because of insufficient sensitivity, complicated procedures, and in some cases, a long time to yield a result. A sensitive, fast, and simple method is necessary to relieve the psychological and physical burden of the patient. Various concentrations of Tg were measured in a microfluidic channel using an optical fiber sensor with gold nanoparticles. The sensor chip has a detection limit of 93.11 fg/mL with no specificity for other antigens. The potential applicability of the Tg sensing system was evaluated using arbitrary samples containing specific concentrations of Tg. Finally, the sensor can be employed to detect Tg in the patient’s serum, with a good correlation when compared with the commercial kit.

scholarly journals An Enhanced Plastic Optical Fiber-Based Surface Plasmon Resonance Sensor with a Double-Sided Polished Structure

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1516
Author(s):  
Lian Liu ◽  
Shijie Deng ◽  
Jie Zheng ◽  
Libo Yuan ◽  
Hongchang Deng ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Optical Fiber ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Low Cost ◽  
Fiber Axis ◽  
Plastic Optical Fiber ◽  
Au Film ◽  
Spr Sensor ◽  
Resonance Sensor

An enhanced plastic optical fiber (POF)-based surface plasmon resonance (SPR) sensor is proposed by employing a double-sided polished structure. The sensor is fabricated by polishing two sides of the POF symmetrically along with the fiber axis, and a layer of Au film is deposited on each side of the polished region. The SPR can be excited on both polished surfaces with Au film coating, and the number of light reflections will be increased by using this structure. The simulation and experimental results show that the proposed sensor has an enhanced SPR effect. The visibility and full width at half maximum (FWHM) of spectrum can be improved for the high measured refractive index (RI). A sensitivity of 4284.8 nm/RIU is obtained for the double-sided POF-based SPR sensor when the measured liquid RI is 1.42. The proposed SPR sensor is easy fabrication and low cost, which can provide a larger measurement range and action area to the measured samples, and it has potential application prospects in the oil industry and biochemical sensing fields.

Dual-mode surface plasmon resonance sensor chip using a grating 3D-printed prism

2021 ◽  
Vol 1147 ◽  
pp. 23-29
Author(s):  
Chutiparn Lertvachirapaiboon ◽  
Akira Baba ◽  
Kazunari Shinbo ◽  
Keizo Kato
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Sensor Chip ◽  
Surface Plasmon Resonance Sensor ◽  
Dual Mode ◽  
Resonance Sensor ◽  
3D Printed

scholarly journals Nanocrystalline TiO2 Sensitive Layer for Plasmonic Hydrogen Sensing

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1490
Author(s):  
Enrico Gazzola ◽  
Michela Cittadini ◽  
Marco Angiola ◽  
Laura Brigo ◽  
Massimo Guglielmi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Localized Surface Plasmon ◽  
Surface Plasmon Resonance Sensor ◽  
Sensitive Layer ◽  
Plasmonic Sensor ◽  
Nanocrystalline Tio2 ◽  
Resonance Sensor

Solution processed TiO2 anatase film was used as sensitive layer for H2 detection for two plasmonic sensor configurations: A grating-coupled surface plasmon resonance sensor and a localized surface plasmon resonance sensor with gold nanoparticles. The main purpose of this paper is to elucidate the different H2 response observed for the two types of sensors which can be explained considering the hydrogen dissociation taking place on TiO2 at high temperature and the photocatalytic activity of the gold nanoparticles.

Rigorous Coupled Wave Analysis of Surface Plasmon Resonance Sensor Based on Metallic Grating

2011 ◽  
Vol 211-212 ◽  
pp. 465-468
Author(s):  
De Wei Chen
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Diffraction Order ◽  
Wave Analysis ◽  
Metallic Grating ◽  
Rigorous Coupled Wave Analysis ◽  
Resonance Sensor ◽  
Rigorous Coupled Wave ◽  
Coupled Wave

Since the development almost a decade ago of the first biosensor based on surface plasmon resonance (SPR), the use of this technique has increased steadily. In this study, we theoretically investigated the sensing character of SPR sensor with reflection type metallic with Rigorous Coupled Wave Analysis (RCWA) method, and the mechanism is analyzed by the field distribution. It is found that the sensitivity of negative diffraction order, which goes higher quickly as the resonant angle increases, is much greater than that of positive diffraction order.

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