scholarly journals DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone

2011 ◽  
Vol 8 (s1) ◽  
pp. S309-S317
Author(s):  
M. S. Surendra Babu ◽  
T. B. Patrudu ◽  
K. Hussain Reddy
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Magnetic Moments ◽  
Nuclease Activity ◽  
Molar Conductance ◽  
Electrochemical Behaviors ◽  
Voltammetric Studies ◽  
Binuclear Metal ◽  
Cyclic Voltammetric Studies ◽  
Dna Binding And Cleavage

Transition metal complexes of copper(II), nickel(II), cobalt(II) and iron(II) with benzil-α-monoxime thiosemicarbazone (BMOT) have been synthesized and characterized by molar conductance, magnetic moments, IR, electronic and ESR spectroscopy. Electrochemical behaviors of these complexes were investigated by cyclic voltammetric studies. The nuclease activity of these complexes has been investigated on double-stranded pBR322 circular plasmid DNA by using the gel electrophoresis experiments in presence and absence of oxidant (H2O2). In the absence of oxidant DNA cleavage by hydrolytically was observed a less discernable, whereas in presence of oxidant (H2O2) all complexes showed increased nuclease activity.

scholarly journals Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Palakuri Kavitha ◽  
K. Laxma Reddy
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Spectroscopic Data ◽  
Nuclease Activity ◽  
Molar Conductance ◽  
Agarose Gel Electrophoresis ◽  
Tridentate Ligands ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Bacteria And Fungi

Ni(II) and Zn(II) complexes were synthesized from tridentate 3-formyl chromone Schiff bases such as 3-((2-hydroxyphenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino)benzoic acid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3), and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL4). All the complexes were characterized in the light of elemental analysis, molar conductance, FTIR, UV-VIS, magnetic, thermal, powder XRD, and SEM studies. The conductance and spectroscopic data suggested that, the ligands act as neutral and monobasic tridentate ligands and form octahedral complexes with general formula [M(L1–4)2]·nH2O (M = Ni(II) and Zn(II)). Metal complexes exhibited pronounced activity against tested bacteria and fungi strains compared to the ligands. In addition metal complexes displayed good antioxidant and moderate nematicidal activities. The cytotoxicity of ligands and their metal complexes have been evaluated by MTT assay. The DNA cleavage activity of the metal complexes was performed using agarose gel electrophoresis in the presence and absence of oxidant H2O2. All metal complexes showed significant nuclease activity in the presence of H2O2.

scholarly journals Synthesis, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from 4-Nitrobenzene-1,2-diamine and 5-Chloroisatin

2020 ◽  
Vol 32 (9) ◽  
pp. 2324-2328
Author(s):  
NETRA PAL SINGH ◽  
KAUSHAL KUMAR ◽  
GAJENDRA KUMAR ◽  
ANUROOP KUMAR
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Magnetic Moments ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi

A series of transition metal complexes of the type [MLX2], where M = Mn(II), Fe(II), Co(II), Ni(II), X = Cl–/CH3COO– and L = Schiff base derived from 4-nitrobenzene-1,2-diamine and 5-chloroisatin have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-visible, magnetic moments measurement, 1H & 13C NMR and mass spectral studies. On the basis of physico-chemical studies and spectral evaluation, an octahedral geometry have been proposed for all metal(II) complexes. The antimicrobial activity of ligand and its metal complexes have been additionally screened against bacteria and fungi. Metal(II) complexes show good activity as compared to ligand towards studied microorganisms and also metal complexes checked for their catalytic properties for benzoylation of phenol.

scholarly journals Synthesis, Structural Investigations and Antimicrobial Activities of Homo Binuclear Complexes Derived from 2-Amino-4-chlorophenol

2020 ◽  
Vol 32 (4) ◽  
pp. 759-764
Author(s):  
K. Savitha ◽  
S. Vedanayaki
Keyword(s):  
Metal Complexes ◽  
Magnetic Moment ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Azomethine Nitrogen ◽  
Planar Geometry ◽  
Binuclear Complexes ◽  
Central Metal

Co(II), Ni(II) and Cu(II) homo binuclear Schiff base metal complexes were synthesized from terephthalaldehyde and 2-amino-4-chlorophenol in methanol using template method. The structure of the ligand and its metal complexes were established by elemental, molar conductance, UV, magnetic moment, IR, 1H & 13C NMR, EPR, mass, thermal and PXRD. Molar conductance values showed that all complexes were non-electrolytic in nature. The IR spectral data provides the coordination of azomethine nitrogen and oxygen with central metal ion. UV, ESR and magnetic moment values suggest square planar geometry for Co(II), Ni(II) and Cu(II) complexes. TGA and DSC analysis data show the thermal stability of the ligand and its metal complexes. The crystalline nature of ligand and its metal complexes were investigated by powder-XRD. The DNA cleavage activities of all the complexes assayed on PUC18 DNA shows nuclease ability.

scholarly journals Preparation and Characterisation of Some Transition Metal Complexes of Niacinamide (Vitamin B3)

2015 ◽  
Vol 58 (2) ◽  
pp. 59-65
Author(s):  
Md. Mahmudul Hasan ◽  
Md. Elius Hossain ◽  
M. Ershad Halim ◽  
Md. Qamrul Ehsan
Keyword(s):  
Metal Complexes ◽  
Thermo Gravimetric Analysis ◽  
Calculated Data ◽  
Gravimetric Analysis ◽  
Vitamin B3 ◽  
Thermo Gravimetric ◽  
Ftir Spectral Analysis ◽  
Voltammetric Studies ◽  
Physicochemical Methods ◽  
Cyclic Voltammetric Studies

Niacinamide forms metal complexes of general formula [M(C6H6N2O)2]Cl2; where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) in the aqueous medium. The complexes were formulated by comparing the experimental and calculated data for C, H, N and metal. The prepared complexes were characterised by different physicochemical methods. The UV-vis, FTIR spectral analysis and thermo gravimetric analysis(TGA). TGA of these complexes have been discussed. Magnetic susceptibility values indicate that all complexes except Zn complex are paramagnetic in nature. The redox properties of the metal ions in the Mn, Cu and Zn complexes have been discussed from the cyclic voltammetric studies. In all cases the systems are quasi reversible.

scholarly journals Synthesis, structural characterization and DNA studies of trivalent cobalt complexes of (2E)-4N-substituted-2-[4-(propan-2-yl)benzylidene]hydrazinecarbothioamide

2017 ◽  
Vol 6 (3) ◽  
pp. 88-97 ◽  
Author(s):  
Murali Krishna Panchangam ◽  
Hussain Reddy K
Keyword(s):  
Magnetic Susceptibility ◽  
Dna Cleavage ◽  
Binding Constants ◽  
Cobalt Complexes ◽  
Nuclease Activity ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Susceptibility Data ◽  
Calf Thymus ◽  
Chemical Nucleases

This paper describes trivalent cobalt complexes of hydrazinecarbothioamides derived from 4-(propan-2-yl) benzaldehyde and substituted thiosemicarbazides NH2NHC(S)NHR, where R = H (1), Me (2), Et (3) or Ph (4) have been synthesized and characterized. The prepared ligands and complexes were characterized using various physicochemical techniques viz. elemental analysis, molar conductance, magnetic susceptibility measurements, IR, electronic absorption spectral studies and cyclic voltammetry. The electronic spectra in DMSO solvent and magnetic susceptibility data of complexes reveal that the complexes are diamagnetic with low spin octahedral cobalt(III) complexes. The absorption titration studies revealed that each of these complexes is an avid binder to calf thymus-DNA. The apparent binding constants are in the order of 107–108 M-1 . The nucleolytic cleavage activities of the ligands and their complexes were assayed on pUC18 plasmid DNA using gel electrophoresis in the presence and absence of H2O2. The ligands showed increased nuclease activity when administered as cobalt complexes. All the complexes behave as efficient chemical nucleases with hydrogen peroxide activation. These studies revealed that the complexes exhibit both oxidative and hydrolytic chemistry in DNA cleavage.

scholarly journals Synthesis, characterization and DNA cleavage activity of nickel(II) adducts with aromatic heterocyclic bases

2010 ◽  
Vol 75 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Surendra Babu ◽  
Pitchika Krishna ◽  
Hussain Reddy ◽  
G.H. Philip
Keyword(s):  
Dna Cleavage ◽  
Magnetic Moments ◽  
Nuclease Activity ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Cleavage Activity ◽  
Redox Couples ◽  
Dna Cleavage Activity ◽  
Calf Thymus ◽  
Heterocyclic Bases

Mixed ligand complexes of nickel(II) with 2,4-dihydroxyacetophenone oxime (DAPO) and 2,4-dihydroxybenzophenone oxime (DBPO) as primary ligands, and pyridine (Py) and imidazole (Im) as secondary ligands were synthesized and characterized by molar conductivity, magnetic moments measurements, as well as by electronic, IR, and 1H-NMR spectroscopy. Electrochemical studies were performed by cyclic voltammetry. The active signals are assignable to the NiIII/II and NiII/I redox couples. The binding interactions between the metal complexes and calf thymus DNA were investigated by absorption and thermal denaturation. The cleavage activity of the complexes was determined using double-stranded pBR322 circular plasmid DNA by gel electrophoresis. All complexes showed increased nuclease activity in the presence of the oxidant H2O2. The nuclease activities of mixed ligand complexes were compared with those of the parent copper(II) complexes.

scholarly journals Magnetic and Spectroscopic Studies of the Synthesized Metal Complexes of Bis(Pyridine-2-carbo) Hydrazide and Their Antimicrobial Studies

2012 ◽  
Vol 9 (4) ◽  
pp. 1835-1842 ◽  
Author(s):  
Netra Pal Singh ◽  
Anu ◽  
Jagvir Singh
Keyword(s):  
Staphylococcus Aureus ◽  
Metal Complexes ◽  
Magnetic Moments ◽  
Bacterial Species ◽  
Spectroscopic Studies ◽  
Fungal Species ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Antimicrobial Studies

Cobalt(II), Nickel(II), Copper(II) and Manganese(II) complexes, having the general composition {M(L)2X2}, have been synthesized [where L= bis(pyridine-2-carbo) hydrazide(L), and X = Cl–]. All the Metal complexes reported here have been characterized by elemental analysis, molar conductance, magnetic moments, IR, electronic and mass spectral studies. All the complexes were found to have magnetic moments corresponding to unpaired electrons. The possible geometries of the complexes were assigned on the basis of electronic and infrared spectral studies. On the basis of molar conductance values the complexes show 1:2 electrolytic nature. Newly synthesized ligand and its Metal complexes have been screened againstStaphylococcus aureus(ATCC 25923),Staphylococcus aureus(ATCC 3160) bacterial species andCandida albicans(227) and Staphylococcus cereviscae (361) fungal species.

scholarly journals Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe(II), Mn(II), Zn(II), and Ru(II) ions: Catalytic activity of ruthenium(II) complex

2018 ◽  
Vol 9 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Nevin Turan ◽  
Kenan Buldurun
Keyword(s):  
Antioxidant Activity ◽  
Metal Complexes ◽  
Antioxidant Activities ◽  
Magnetic Moments ◽  
Antioxidant Properties ◽  
Molar Conductance ◽  
Transfer Hydrogenation ◽  
Spectral Studies ◽  
Ft Ir

The synthesis, spectral, catalytic and antioxidant properties of ethyl-2-(2-hydroxy-3-methoxybenzylideneamino)-6-methyl-4,5,6-tetrahydrobenzo[b]thiophene-3-carboxylate (L) substituted iron(II), manganese(II), zinc(II), and ruthenium(II)-arene chlorides are described for the first time. The ligand and its metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, and spectral (1H NMR, 13C NMR, FT-IR, UV-Vis and Mass) techniques. The FT-IR spectra showed that the ligand can act as bidentate or tridentate. Magnetic moments and electronic spectral studies revealed an octahedral geometry for all the complexes obtained. The thermal behavior of the complexes showed that the water molecules were separated in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. Ru(II) complex was used as catalysts for the transfer hydrogenation of ketones. At the same time, the effect of various bases such as NaOH, KOH, KOBut and NaOAc as organic base were investigated in the transfer hydrogenation of ketones by 2-propanol as the hydrogen source. The complexes and ligand were tested in vitro for their antioxidant activity. The experimental results showed that Ru(II) complex had more potent antioxidant activities than Zn(II), Fe(II), Mn(II) complexes and parent ligand.

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