scholarly journals Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb: Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Alejandra Delgado ◽  
Erica H. Jaffé
Keyword(s):  
Olfactory Bulb ◽  
Immobilization Stress ◽  
Acute Stress ◽  
Endocannabinoid System ◽  
Gaba Release ◽  
Synaptic Function ◽  
The Other ◽  
Cb1 Antagonist ◽  
Per Se ◽  
Autocrine Mechanism

We studied the effects of cannabinoids and acute immobilization stress on the regulation of GABA release in the olfactory bulb. Glutamate-stimulated 3H-GABA release was measured in superfused slices. We report that cannabinoids as WIN55, 212-2, methanandamide, and 2-arachidonoylglycerol were able to inhibit glutamate- and KCl-stimulated 3H-GABA release. This effect was blocked by the CB1 antagonist AM281. On the other hand, acute stress was ableper seto increase endocannabinoid activity. This effect was evident since the inhibition of stimulated GABA release by acute stress was reversed with AM281 and tetrahydrolipstatin. Inhibition of the endocannabinoid transport or its catabolism showed reduction of GABA release, antagonized by AM281 in control and stressed animals. These results point to endocannabinoids as inhibitory modulators of GABA release in the olfactory bulb acting through an autocrine mechanism. Apparently, stress increases the endocannabinoid system, modulating GABAergic synaptic function in a primary sensory organ.

The Problem of the Typology of Rationality in Muslim Culture

2019 ◽  
Vol 62 (6) ◽  
pp. 88-99
Author(s):  
Andrey A. Lukashev
Keyword(s):  
Modern Philosophy ◽  
Theoretical Basis ◽  
Theoretical Models ◽  
The Other ◽  
Common Denominator ◽  
Islamic Culture ◽  
The Common ◽  
Per Se ◽  
The One ◽  
Muslim Culture

The typology of rationality is one of major issues of modern philosophy. In an attempt to provide a typology to Oriental materials, a researcher faces additional problems. The diversity of the Orient as such poses a major challenge. When we say “Oriental,” we mean several cultures for which we cannot find a common denominator. The concept of “Orient” involves Arabic, Indian, Chinese, Turkish and other cultures, and the only thing they share is that they are “non-Western.” Moreover, even if we focus just on Islamic culture and look into rationality in this context, we have to deal with a conglomerate of various trends, which does not let us define, with full confidence, a common theoretical basis and treat them as a unity. Nevertheless, we have to go on trying to find common directions in thought development, so as to draw conclusions about types of rationality possible in Islamic culture. A basis for such a typology of rationality in the context of the Islamic world was recently suggested in A.V. Smirnov’s logic of sense theory. However, actual empiric material cannot always fit theoretical models, and the cases that do not fit the common scheme are interesting per se. On the one hand, examination of such cases gives an opportunity to specify certain provisions of the theory and, on the other hand, to define the limits of its applicability.

HALF-WAY TECHNOLOGIES ARE PROFITABLE

PEDIATRICS ◽  
1995 ◽  
Vol 95 (5) ◽  
pp. 681-681
Keyword(s):  
The Other ◽  
Other Hand ◽  
Per Se ◽  
Commercial Organizations

Decisive interventions, like vaccines, can be quite inexpensive. But commercial organizations make money by selling commodities; they cannot produce and sell "health" per se. The most profitable commodities are those embodying the "half-way" technologies, for those with the means to pay for them-again and again and again. Vaccines, on the other hand, "may never prove as enticing as drugs for pharmaceutical makers. They can be quite expensive to develop, and they produce less income-repeated refills not required ... "

The relationship among freezing tolerance, vernalization requirement, Ppd alleles and winter hardiness in European wheat cultivars

2017 ◽  
Vol 155 (9) ◽  
pp. 1353-1370 ◽  
Author(s):  
A. GORASH ◽  
R. ARMONIENĖ ◽  
Ž. LIATUKAS ◽  
G. BRAZAUSKAS
Keyword(s):  
Molecular Markers ◽  
Western Europe ◽  
Complex Trait ◽  
Winter Hardiness ◽  
Photoperiod Sensitivity ◽  
The Other ◽  
Wheat Cultivars ◽  
Crucial Component ◽  
Per Se ◽  
The Relationship

SUMMARYWinter hardiness of wheat is a complex trait involving a system of structural, regulatory and developmental genes, which interact in a complex pathway. The objective of the present work was to study the relationship among the main traits determining the level of adaptation and the possibility for target manipulation of breeding material by using molecular markers and phenological parameters. Wheat cultivars from different ecoclimatic environments of Europe were included for analysis. Gene-specific assay showed that photoperiod sensitivity of the studied cultivars was determined by polymorphism in the Ppd-D1 allele. The study established the relationship among winter hardiness, LT50 (the temperature at which 50% of plants are killed), photoperiod sensitivity, vernalization duration and earliness per se genes in the environment of Lithuania. The cultivars from Northern and Western Europe exhibited stronger requirement for vernalization and photoperiod. Although the group of cultivars from the southern latitudes were characterized by earliness, they possessed a stronger level of LT50. The level of LT50 was found to be the most crucial component of winter hardiness, the other traits served as supplementary components.

Semantic Congruency Improves Recognition Memory Performance for Both Audiovisual and Visual Stimuli

2017 ◽  
Vol 30 (7-8) ◽  
pp. 763-781 ◽  
Author(s):  
Jenni Heikkilä ◽  
Kimmo Alho ◽  
Kaisa Tiippana
Keyword(s):  
Recognition Memory ◽  
Congruency Effect ◽  
Memory Performance ◽  
Visual Stimuli ◽  
The Other ◽  
Memory Encoding ◽  
Semantic Congruency ◽  
Recognition Memory Performance ◽  
Visual Encoding ◽  
Per Se

Audiovisual semantic congruency during memory encoding has been shown to facilitate later recognition memory performance. However, it is still unclear whether this improvement is due to multisensory semantic congruency or just semantic congruencyper se. We investigated whether dual visual encoding facilitates recognition memory in the same way as audiovisual encoding. The participants memorized auditory or visual stimuli paired with a semantically congruent, incongruent or non-semantic stimulus in the same modality or in the other modality during encoding. Subsequent recognition memory performance was better when the stimulus was initially paired with a semantically congruent stimulus than when it was paired with a non-semantic stimulus. This congruency effect was observed with both audiovisual and dual visual stimuli. The present results indicate that not only multisensory but also unisensory semantically congruent stimuli can improve memory performance. Thus, the semantic congruency effect is not solely a multisensory phenomenon, as has been suggested previously.

scholarly journals Rural as Periphery Per Se? Unravelling the Discursive Node

2016 ◽  
Vol 13 (2) ◽  
pp. 11-28 ◽  
Author(s):  
Bianka Plüschke-Altof
Keyword(s):  
Discourse Analysis ◽  
Conceptual Framework ◽  
Critical Discourse Analysis ◽  
Rural Areas ◽  
The Other ◽  
Critical Discourse ◽  
Hegemonic Discourse ◽  
Spatial Inequalities ◽  
Urban Rural ◽  
Per Se

Despite often being used interchangeably, the dominant equation of the rural with the peripheral is not self-evident. In order to critically scrutinize the discursive node, the aim of this article is twofold. On one hand, it argues for overcoming the prevalent urban‒rural divide and dominant structural approaches in sociological and geographical research by introducing discursive peripheralization as a conceptual framework, which allows the analysis of the discursive (re-)production of socio-spatial inequalities on and between different scales. On the other hand, this article explores how rural areas are constituted as peripheries within a hegemonic discourse naturalizing the ascription of development (non-)potentials. Following a critical discourse analysis approach, this will be illustrated in the case of periphery constructions in Estonian national print media.

scholarly journals A dominant role for the beta 4 nicotinic receptor subunit in nicotinic modulation of glomerular microcircuits in the mouse olfactory bulb

2018 ◽  
Vol 120 (4) ◽  
pp. 2036-2048 ◽  
Author(s):  
Michael S. Spindle ◽  
Pirooz V. Parsa ◽  
Spencer G. Bowles ◽  
Rinaldo D. D’Souza ◽  
Sukumar Vijayaraghavan
Keyword(s):  
Olfactory Bulb ◽  
Nicotinic Acetylcholine Receptors ◽  
Information Transfer ◽  
Time Course ◽  
Feedback Inhibition ◽  
Dominant Role ◽  
Receptor Gene ◽  
Gaba Release ◽  
Cell Types ◽  
Receptor Activation

Nicotinic acetylcholine receptors (nAChRs) regulate information transfer across the main olfactory bulb by instituting a high-pass intensity filter allowing for the filtering out of weak inputs. Excitation-driven inhibition of the glomerular microcircuit via GABA release from periglomerular cells appears to underlie this effect of nAChR activation. The multiplicity of nAChR subtypes and cellular locations raises questions about their respective roles in mediating their effects on the glomerular output. In this study, we address this issue by targeting heteromeric nAChRs using receptor knockouts (KOs) for the two dominant nAChR β-subunit genes known to be expressed in the central nervous system. KOs of the β2-nAChR subunit did not affect nAChR currents from mitral cells (MCs) but attenuated those from the external tufted (ET) cells. In slices from these animals, activation of nAChRs still effectively inhibited excitatory postsynaptic currents (EPSCs) and firing on MCs evoked by the olfactory nerve (ON) stimulation, thereby indicating that the filter mechanism was intact. On the other hand, recordings from β4-KOs showed that nAChR responses from MCs were abolished and those from ET cells were attenuated. Excitation-driven feedback was abolished as was the effect of nAChR activation on ON-evoked EPSCs. Experiments using calcium imaging showed that one possible consequence of the β2-subunit activation might be to alter the time course of calcium transients in juxtaglomerular neurons suggesting a role for these receptors in calcium signaling. Our results indicate that nAChRs containing the β4-subunit are critical in the filtering of odor inputs and play a determinant role in the cholinergic modulation of glomerular output. NEW & NOTEWORTHY In this study, using receptor gene knockouts we examine the relative contributions of heteromeric nAChR subtypes located on different cell types to this effect of receptor activation. Our results demonstrate that nAChRs containing the β4-subunit activate MCs resulting in feedback inhibition from glomerular interneurons. This period of inhibition results in the selective filtering of weak odor inputs providing one mechanism by which nAChRs can enhance discrimination between two closely related odors.

Tipos de Predicação em Aristóteles

2005 ◽  
Vol 13 (26) ◽  
pp. 7-34
Author(s):  
António Pedro Mesquita ◽  
Keyword(s):  
The Other ◽  
Specific Difference ◽  
Complex Entity ◽  
Posterior Analytics ◽  
Present Essay ◽  
Syntactic Position ◽  
Other Hand ◽  
The Subject ◽  
Per Se

Predication is a complex entity in Aristotelian thought. The aim of the present essay is to account for this complexity, making explicit the diverse forms it assumes. To this end, we tum to a crucial chapter of the Posterior Analytics (1 22), where, in the most complete and developed manner within the corpus, Aristotle proceeds to systematize this topic. From the analysis, it will become apparent that predication can assume, generically, five forms: 1) the predication of essence (τὸ αύτᾢ εἶναι κατηγορεἲσθαι), that is of the genus and the specific difference; 2) essential predication (τὸ αύτᾢ εἶναι κατηγορεἲσθαι), that is either of the genus or of the differences (or their genera); 3) the predication of accidents per se 4) and of simple accidents (ώς συμβεβηκότα κατηγορεἲσθαι); and 5) accidental predication (κατἁ συμβεβηκός κατηγορεἲσθαι). However, only types 2-4 are forms of strict predication (άπλὢς). In effect, the “predication” of essence is not a genuine predication, but a formula for identity, constituting, technically, the statement of the essence of the subject (or its definition). On the other hand, accidental “predication” can only be conceived of as such equivocally, since it results from a linguistic accident through which the ontological subject of the attribution suffers a displacement to the syntactic position of the predicate, which is not, by nature, its own. In neither case does the phrase bring about any legitimate predication. The study concludes with a discussion of Aristotle’s thesis according to which no substance can be a predicate, which is implied by its notion of accidental predication, a thesis which has been - and in our opinion wrongly so - challenged in modem times.

The Artful Politics of Trauma: Rancière’s Critique of Lyotard

2018 ◽  
pp. 121-141
Author(s):  
Tina Chanter
Keyword(s):  
The Other ◽  
Absolute Difference ◽  
The Sublime ◽  
The Holocaust ◽  
Singular Event ◽  
Privileged Status ◽  
Specific Meaning ◽  
Per Se ◽  
The Absolute

Just as Rancière challenges the absolute difference between politics and art, he resists the absolutization of the other that he sees as characteristic of the ethical turn in contemporary aesthetics. The tendency of Lyotard, however, remains turning alterity into the unrepresentable, the unassimilable, and the unthinkable. Its consequences are precisely what Rancière forebodes with the appropriation of the sublime: For all its talk of art witnessing that which is unrepresentable—and the holocaust as the unrepresentable per se—the ethical turn only manages to rejoin a discourse of purism. If everyone is traumatised, what specific meaning remains for trauma? This chapter explores the context of Rancière’s critique of Lyotard, particularly regarding the attenuation of any sense to trauma that accumulates a privileged status for its singular event; it subsequently interrogates the generalization of trauma to such an extent that one evacuates it of any significance.

When a Daring Chemistry Meets a Boring Chemistry: The Reception of Mendeleev’s Periodic System in Sweden

2015 ◽  
Author(s):  
Anders Lundgren
Keyword(s):  
Nineteenth Century ◽  
Periodic System ◽  
Initial Step ◽  
The Other ◽  
Experimental Science ◽  
History Of Chemistry ◽  
System P ◽  
History Of ◽  
Per Se

The reception of Mendeleev’s periodic system in Sweden was not a dramatic episode. The system was accepted almost without discussion, but at the same time with no exclamation marks or any other outbursts of enthusiasm. There are but a few weak short-lived critical remarks. That was all. I will argue that the acceptance of the system had no overwhelming effect on chemical practice in Sweden. At most, it strengthened its characteristics. It is actually possible to argue that chemistry in Sweden was more essential for the periodic system than the other way around. My results might therefore suggest that we perhaps have to reevaluate the role of Mendeleev’s system in the history of chemistry. Chemistry in Sweden at the end of the nineteenth century can be characterized as a classifying science, with chemists very skilled in analysis, and as mainly an atheoretical science, which treated theories at most only as hypothesis—the slogan of many chemists being “facts persist, theories vanish.” Thanks to these characteristics, by the end of the nineteenth century, chemistry in Sweden had developed into, it must be said, a rather boring chemistry. This is obviously not to say that it is boring to study such a chemistry. Rather, it gives us an example of how everyday science, a part of science too often neglected but a part that constitutes the bulk of all science done, is carried out. One purpose of this study is to see how a theory, considered to be important in the history of chemistry, influenced everyday science. One might ask what happened when a daring chemistry met a boring chemistry. What happened when a theory, which had been created by a chemist who has been described as “not a laboratory chemist,” met an atheoretical experimental science of hard laboratory work and, as was said, the establishment of facts? Furthermore, could we learn something about the role of the periodic system per se from the study of such a meeting? Mendeleev’s system has often been considered important for teaching, and his attempts to write a textbook are often taken as the initial step in the chain of thoughts that led to the periodic system.

Farmers’ Suicides and the Agrarian Crisis in Punjab: Some Sociological Observations

2020 ◽  
Vol 69 (2) ◽  
pp. 270-286
Author(s):  
Birinder Pal Singh
Keyword(s):  
Social Development ◽  
The Other ◽  
Liberal Theory ◽  
Economic Factors ◽  
Per Se ◽  
Agrarian Crisis

Farmers’ suicides have been a serious issue over the last three decades in Punjab and also in other states. Much debate has concentrated on the economic factors, especially debt. This article makes sociological observations of Durkheim in the context of Punjab’s society and culture that may help us see the other side of the problem. It argues that debt per se is not the cause of suicide always but that of the agrarian crisis, following the liberal theory of economic and social development. The culture of consumerism is like fuel to the fire.

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