scholarly journals Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory EffectIn Vitro

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Sudha Ponnusamy ◽  
Remya Ravindran ◽  
Smita Zinjarde ◽  
Shobha Bhargava ◽  
Ameeta Ravi Kumar
Keyword(s):  
Medicinal Plants ◽  
Curcuma Longa ◽  
Hot Water ◽  
Phytochemical Analysis ◽  
Tribulus Terrestris ◽  
Pancreatic Amylase ◽  
Glucose Levels ◽  
Isopropanol Extract ◽  
Dependent Inhibition ◽  
Inhibitory Potential

Pancreaticα-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown. Eleven Ayurvedic Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested forα-amylase inhibition, in order to assess and evaluate their inhibitory potential on pancreaticα-amylase. Analysis of 91 extracts, showed that 10 exhibited strong Human Pancreatic Amylase (HPA) inhibitory potential. Of these, 6 extracts showed concentration dependent inhibition withIC50values, namely, cold and hot water extracts fromFicus bengalensisbark (4.4 and 125 μgmL-1),Syzygium cuminiseeds (42.1 and 4.1 μgmL-1), isopropanol extracts ofCinnamomum verumleaves (1.0 μgmL-1) andCurcuma longarhizome (0.16 μgmL-1). The other 4 extracts exhibited concentration independent inhibition, namely, methanol extract ofBixa orellanaleaves (49 μgmL-1), isopropanol extract fromMurraya koenigiileaves (127 μgmL-1), acetone extracts fromC. longarhizome (7.4 μgmL-1) andTribulus terrestrisseeds (511 μgmL-1). Thus, the probable mechanism of action of the above fractions is due to their inhibitory action on HPA, thereby reducing the rate of starch hydrolysis leading to lowered glucose levels. Phytochemical analysis revealed the presence of alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins and steroids as probable inhibitory compounds.

PRELIMINARY PHYTOCHEMICAL ANALYSIS OF SELECTED MEDICINAL PLANTS OF NORTH EASTERN REGION OF INDIA

2018 ◽  
Vol 7 (4) ◽  
pp. 88-97
Author(s):  
MELAKYRKHU NIANGMIH ◽  
SAMIRAN CHUTIA ◽  
DAS BANYASHREE ◽  
SARKAR BAPI ROY ◽  
DEY BIPLAB KUMAR ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Phytochemical Analysis ◽  
Eastern Region ◽  
North Eastern

scholarly journals A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production

2017 ◽  
Vol 6 ◽  
Author(s):  
Ryusei Uchio ◽  
Yohei Higashi ◽  
Yusuke Kohama ◽  
Kengo Kawasaki ◽  
Takashi Hirao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Oral Administration ◽  
Alanine Aminotransferase ◽  
Curcuma Longa ◽  
Water Extract ◽  
Hot Water ◽  
Hepatic Tissue ◽  
Hot Water Extract ◽  
Acute Ethanol

AbstractTurmeric (Curcuma longa) is a widely used spice that has various biological effects, and aqueous extracts of turmeric exhibit potent antioxidant activity and anti-inflammatory activity. Bisacurone, a component of turmeric extract, is known to have similar effects. Oxidative stress and inflammatory cytokines play an important role in ethanol-induced liver injury. This study was performed to evaluate the influence of a hot water extract of C. longa (WEC) or bisacurone on acute ethanol-induced liver injury. C57BL/6 mice were orally administered WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol was given by oral administration (3·0 g/kg BW). Plasma levels of aspartate aminotransferase and alanine aminotransferase were markedly increased in ethanol-treated mice, while the increase of these enzymes was significantly suppressed by prior administration of WEC. The increase of alanine aminotransferase was also significantly suppressed by pretreatment with bisacurone. Compared with control mice, animals given WEC had higher hepatic tissue levels of superoxide dismutase and glutathione, as well as lower hepatic tissue levels of thiobarbituric acid-reactive substances, TNF-α protein and IL-6 mRNA. These results suggest that oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of bisacurone.

Screening for Rho-kinase 2 inhibitory potential of Indian medicinal plants used in management of erectile dysfunction

2012 ◽  
Vol 144 (3) ◽  
pp. 483-489 ◽  
Author(s):  
Sumanta Kumar Goswami ◽  
Pandre Manoj Kumar ◽  
Rohitash Jamwal ◽  
Shekhar Dethe ◽  
Amit Agarwal ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Medicinal Plants ◽  
Rho Kinase ◽  
Inhibitory Potential ◽  
Indian Medicinal Plants

Antiviral and Immunity-modulating Natural Herbs in the Prevention of COVID-19

2021 ◽  
pp. 81-94
Author(s):  
Sonali S Gadge
Keyword(s):  
Immune System ◽  
Medicinal Plants ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Antiviral Drug ◽  
Herbal Medicines ◽  
Echinacea Purpurea ◽  
Black Pepper ◽  
Tinospora Cordifolia ◽  
Ocimum Sanctum

The COVID-19 has spread all over the world and there is no single drug or medicine for the prevention and the treatment of this deadly disease. One can get prevention from this disease by boosting the immune system. Persons with weak immune system e.g. children, elder patients or patients with preexisting diseases affect rapidly due to coronavirus. This novel coronavirus attacks mainly on the person immunity. For the centuries the herbal medicinal plants have many beneficial effects against deadly viruses. Herbal medicines provide a rich resource for new antiviral drug development. These natural agents interact with the life cycle of virus such as virus entry, replication, assembly and release. In this review, the importance, immunomodulator, antiviral and pharmacological activities of some medicinal plants, namely, Allium Sativum, Zingiber Officinalis, Cinnamomum zeylanicum, Curcuma longa, Ocimum sanctum, Glycyrrhiza glabra, Ginseng, Black pepper, Emblica officinalis, Withania somnifera, Tinospora cordifolia, Echinacea purpurea, Azadirachta indica, Piper betel, Eugenia caryophyllata, Cinchona calisaya, Nigella sativa, Cuminum cyminum are highlighted. These medicinal plants have many phytoconstituents like alkaloids, glycosides, terpenoids, flavonoids, lactones, polysaccharides, volatile oils, tannins, resins, etc which are helpful for boosting immunity and will help in the prevention and in the management of COVID-19. Several types of research attempted to use herbal medicines against COVID-19.

scholarly journals Evaluation of antimycobacterial rhamnolipid production from non-cytotoxic strains of Pseudomonas aeruginosa isolated from rhizospheric soil of medicinal plants

2016 ◽  
Vol 4 (2) ◽  
pp. 112 ◽  
Author(s):  
Alok K Mishra ◽  
Rikesh K Dubey ◽  
Shivraj M Yabaji ◽  
Swati Jaiswal
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Medicinal Plants ◽  
Biochemical Characterization ◽  
Rhizospheric Soil ◽  
Rhamnolipid Production ◽  
Medicinal Value ◽  
Wide Range ◽  
Rrna Sequencing ◽  
Inhibitory Potential ◽  
Potent Inhibitory Activity

Rhamnolipids (RLs) are the bacterial derived biosurfactants and known for a wide range of industrial and therapeutic applications. They exhibit potent anti-bacterial activity against various gram positive, gram negative and acid fast bacteria including Mycobacterium tuberculosis. Since, Pseudomonas is one of the largest known genuses containing a variety of rhamnolipid producing strains. Therefore, in this study, we selectively isolated the Pseudomonas aeruginosa strains from the rhizospheric soil of the Indian plants of medicinal value, e.g. Azadirachta Indica and Ficus spp., and evaluated them for their natural ability to produce antibacterial rhamnolipids. The bacteria were identified on the basis of 16s rRNA sequencing and biochemical characterization. Among 33 of P. aeruginosa isolates from different soil samples, four isolates showed potent inhibitory activity against methicillin resistant Staphylococcus aureus (MRSA) and fast grower mycobacterial spp. The inhibitory potential of the isolates was found to be correlated with their ability to produce RLs in the medium. The industrial viability of the strains was assessed on the basis of cytotoxicity determining alternative allele, exoS/exoU and cell mediated cytotoxicity against murine macrophages J774.1. The newly isolated strains harbor exoS allele and exhibits lower cell mediated cytotoxicity on macrophage cell line as compared to the clinical strains PA-BAA-427 and PA-27853 used as a control in this study.Evaluation of antimycobacterial rhamnolipid production from non-cytotoxic strains of Pseudomonas aeruginosa isolated from rhizospheric soil of medicinal plants

scholarly journals PHYSICO AND PHYTO-CHEMICAL ANALYSIS OF PLUMBAGO ZEYLANICA L. - A POTANT INDIAN HERB

2014 ◽  
Vol 1 (2) ◽  
pp. 105-108
Author(s):  
Sharmila S ◽  
Kalaichelvi K ◽  
Jayanthi G
Keyword(s):  
Medicinal Plants ◽  
Chemical Analysis ◽  
Large Body ◽  
Phytochemical Analysis ◽  
Cancer Treatments ◽  
Plumbago Zeylanica ◽  
Traditional System ◽  
Tropical Plant ◽  
Inorganic Matter ◽  
Physico Chemical

Medicinal plants are an integral component of alternative medical care. For millennia, Indian people traditionally played an important role in the management of biological resources and were custodians of related knowledge that they acquired through trial and error over centuries. India has a rich wealth ofmedicinal plants and the potential to accept the challenge to meet the global demand for them. In recent time, focus on plant research has increased all over the world and a large body evidence has collected to show immense potential of medicinal plants used in various traditional system. Plumbago zeylanica L.(Plumbaginaceae) is a tropical plant and the source for the well known ayurvedic drug ‘chitrakah’. Different parts of this plant are widely used for variety of medicinal treatments. Especially used for appetite, indigestion, piles, worms, liver diseases and cancer treatments. The present study was therefore carried outto provide pharmacognostic details of root of Plumbago zeylanica. The physico-chemical analysis of ash content indicated the presence of inorganic matter and siliceous matter in the drug. The phytochemical analysis indicated the presence of alkaloids, phenols, flavonoids, tannins and terpenoids. Plumbagin is anaturally occurring yellow pigment, produced by member of plumbaginaceae that can be obtained from roots

scholarly journals Antifeedant Activity of Leaf Aqueous Extracts of Selected Medicinal Plants on VI Instar Larva of Helicoverpa Armigera (Hubner)

2020 ◽  
Vol 8 (05) ◽  
pp. 62-66
Author(s):  
G. Ravi ◽  
Dr.G. Sundararajan
Keyword(s):  
Mortality Rate ◽  
Medicinal Plants ◽  
Aqueous Extract ◽  
Helicoverpa Armigera ◽  
Botanical Insecticides ◽  
Tribulus Terrestris ◽  
Aqueous Extracts ◽  
Antifeedant Activity ◽  
Leaf Aqueous Extract ◽  
Helicoverpa Armígera

Phytochemicals, especially botanical insecticides are currently of interest because of their successful application in plant protection as biocontrol agents. Biological activity of leaf aqueous extract of ten selected medicinal plants were evaluated against the fourth-instar larvae of gram pod borer Helicoverpa armigera (H¨ubner), (Lepidoptera: Noctuidae). Antifeedant activity of leaf aqueous extracts of Abutilon indicum L., Achyranthus aspera L., Aerva lanata L., Albiziz amara (Roxb), Andrographis paniculata Ness., Cardiospermum halicacabum L., Cassia tora L., Catharanthus roseus L (G) Don., Datura metal L. and Tribulus terrestris L. were evaluated in this study. Preliminary screening after 24 h of exposure with leaf aqueous extracts of the selected plants at a concentration of 1,000 ppm exhibited significant larval mortality rate. The percentage mortality rate ranged considerably from 10.8 to 72.8. The mortality rate was observed in the decreasing order of A. paniculata > C. roseus > D. metal > A. amara > C. halicacabum > A. indicum > C. tora > T. terrestris > A. aspera >A. lanata against the larvae of H. armigera. The results imply that leaf aqueous extract of A. paniculata, C. roseus and D. metal can potentially be used as eco-friendly pest control agents against the larva of H. armigera.

scholarly journals Pharmacognostic Evaluation of Curcuma longa L. Rhizome and Standardization of its Formulation by HPLC Using Curcumin as Marker

2018 ◽  
Vol 10 (01) ◽  
Author(s):  
Abraham A ◽  
Samuel S ◽  
Mathew L
Keyword(s):  
Cross Section ◽  
Curcuma Longa ◽  
Microscopic Analysis ◽  
Fluorescence Analysis ◽  
Phytochemical Analysis ◽  
Diagnostic Features ◽  
Starch Grains ◽  
Qualitative And Quantitative ◽  
Polyherbal Formulation ◽  
Laboratory Procedures

Objective: To evaluate Curcuma longa rhizome by pharmacognostic and phytochemical analysis and standardize one of its formulations by HPLC. The present work includes macroscopic study, microscopic analysis of cross section and powder of rhizome, fluorescence analysis, qualitative and quantitative phytochemical assay and chromatographic fingerprinting of its polyherbal formulation, Pathyashadangam kwath using curcumin as marker carried out as per standard laboratory procedures. The study helps to provide both diagnostic features for identification and preventing adulteration of Curcuma longa L and HPLC chromatogram for standardisation of its formulation. Results: Microscopic analysis revealed the presence of a broad parenchymatous cortex with abundant starch grains in the cross section, spiral vessels, starch grains having hilum towards the narrower end, fibres and cells with oleo resin in powder microscopy. HPLC analysis revealed the presence of three peaks corresponding to curcuminoids in the formulation. Conclusion: Pharmacognostic and phytochemical evaluation can be used for confirming the identity of Curcuma longa rhizome and HPLC using curcumin as marker can be used for standardisation of its formulations.

Sign in / Sign up

Export Citation Format

Share Document