scholarly journals Synthesis, Characterization, Theoretical Crystal Structure, and Antibacterial Activities of Some Transition Metal Complexes of the Thiosemicarbazone (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed A. Al-Amiery ◽  
Yasmien K. Al-Majedy ◽  
Haziem Abdulreazak ◽  
Hussain Abood
Keyword(s):  
Metal Complexes ◽  
Twist Angle ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Heat Of Formation ◽  
Antibiotic Drugs ◽  
Visible Spectra ◽  
Ft Ir

Problem Statement. In Iraq like most third world countries, attempts discovered new antibiotic drugs derived from thiosemicarbazide and its metal complexes and developed the branch of applied in organic chemistry.Approach. New (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) was synthesized in a good yield by the reaction of pyrrolidone with thiosemicarbazide. Co(II), Ni(II), and Cu(II) complexes of (L) were prepared and characterized by FT-IR, UV/visible spectra,1HNMR, and CHN analyses. Moreover, charge, bond length, bond angle, twist angle, heat of formation, and steric energy were calculated by using of the ChemOffice program, and the DFT calculations for the complexes were done. The free ligand and its metal complexes were testedin vitroagainst several microorganisms (Staphylococcus aurous,E. coli,Proteus vulgaris,Pseudomonas, andKlebsiella pneumoniae) to assess their antimicrobial properties.Results. The study shows that these complexes have octahedral geometry; in addition, it has high activity against tested bacteria.Conclusion/Recommendations. Based on the reported results, it may be concluded that ligand acts as bidentate, neutral ligand, coordinating through one of the nitrogen and sulfur atoms.

scholarly journals Synthesis and Bioassay of Novel Quinozolins

2019 ◽  
Vol 17 (72) ◽  
pp. 129-138
Author(s):  
Yasmine Kadom. Al-Majedy
Keyword(s):  
Twist Angle ◽  
Antimicrobial Properties ◽  
Heat Of Formation ◽  
Gram Negative Bacteria ◽  
The Novel ◽  
Gram Positive Bacteria ◽  
Visible Spectra ◽  
Ft Ir ◽  
Uv Visible

Novel Quinozolins were synthesized in a good yield through convert lacton to lactam and study the biological activity of the synthesized compounds. Quinozolins were characterized by elemental analysis, FT-IR and UV/visible spectra. The novel Quinozolins have been tested in vitro against (gram positive bacteria Staphylococcus aureus and against other gram negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus vulgaris; in order to assess their antimicrobial properties. Moreover, charge, bond length, bond angle, twist angle, heat of formation and steric energy were calculated by using of the ChemOffice program. The study indicates that these Quinozolins have high activity against tested bacteria. Based on the reported results, it may be concluded that the coumarin act as synthons for synthesis of new Quinozolins derivatives through the replacement of oxygen atom by nitrogen atom.

scholarly journals Synthesis and Antibacterial Studies of Novel Phosphorus Ligand 5-(2-diphenylphosphino) phenyl-1,2-dihydro-1,2,4-triazole-3-thione and its Metal Complexes with some Transition Metals

2010 ◽  
Vol 4 (2) ◽  
pp. 37-45
Author(s):  
Matheel D. Al-Sabti ◽  
Ahmed A. H. Al-Amiery ◽  
Thorria R. Marzoog ◽  
Yasmien K. Al-Majedy
Keyword(s):  
Metal Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Cadmium Complex ◽  
Gram Positive Bacteria ◽  
Visible Spectra ◽  
Number Of Microorganisms ◽  
Ft Ir ◽  
The Stability

This study involves the chemical synthesis of the novel ligand 5-(2-diphenylphosphino) phenyl-1,2-dihydro-1,2,4-triazole-3-thione (DPDTT) by the reaction of 2-diphenylphosphino benzoic acid with absolute ethanol that yield ethyl 2-diphenylphosphino benzoate and by cyclization of this compound with thiosemicarbazide, DPDTT will be produced. The chelating complexes of this ligand with Cr(III), Co(II), Ni(II), Cu(II) and Cd(II) were also prepared and studied. The new complexes were characterized by FT-IR, UV/visible spectra, and room temperature magnetic susceptibility. The stability for the prepared complexes was also measured using the density function theory and it was found that the cadmium complex is the most stable and the chromium complex is the least stable. Free ligand and its metal complexes have been tested in vitro against a number of microorganisms, like gram positive bacteria Staphylococcus aureus and gram negative bacteria E. coli, Proteus vulgaris, Pseudomonas and Klebsiella in order to assess their antimicrobial properties. All complexes showed considerable activity against all the studied bacteria.

scholarly journals Antimicrobial Studies of novel metal complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one

2009 ◽  
Vol 3 (2) ◽  
pp. 1-12
Author(s):  
Matheel D. Al-Sabti ◽  
Ahmed A. H. Al-Amiery ◽  
Yasmien K. Al-Majedy ◽  
Amel Ali
Keyword(s):  
Metal Complexes ◽  
Room Temperature ◽  
Antimicrobial Properties ◽  
Cadmium Complex ◽  
Antimicrobial Studies ◽  
Visible Spectra ◽  
Number Of Microorganisms ◽  
Ft Ir ◽  
Uv Visible

Chromium )III), cobalt (II), nickel (II), copper (II) and cadmium (II) complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one have been synthesized and characterized by elemental analysis, FT-IR, UV/visible spectra, and room temperature magnetic susceptibility. Cadmium complex is expected to have tetrahedral structure while the other complexes are expected to have octahedral structure. The free ligands and their metal complexes have been tested in vitro against a number of microorganisms (Staphylococcus aurous, E.coli, Proteus vulgaris, Pseudomonas, and Klebsiella) in order to assess their antimicrobial properties.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Sulekh Chandra ◽  
Smriti Raizada ◽  
Monika Tyagi ◽  
Archana Gautam
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Copper Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Zinc and Mercury Complexes of 2-Formylpyridine Thiosemicarbazone

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Sulekh Chandra ◽  
Shikha Parmar ◽  
Yatendra Kumar
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Tetrahedral Geometry ◽  
Antimicrobial Studies

A series of metal complexes of Zn(II) and Hg(II) having the general composition [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = , and ] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Studies on the Spectral, Anti-Bacterial and Anti-Fungal Activities of 1-((Dicyclohexylamino) (Phenyl) Methyl) Pyrrolidine-2, 5-Dione and Few of its Metal Complexes

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3124-3136
Author(s):  
Rajeswari S ◽  
Harindran Suhana ◽  
Kalaivizhi R
Keyword(s):  
Metal Complexes ◽  
Mannich Base ◽  
Micrococcus Luteus ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Spectral Studies ◽  
Aspergillus Fumigates ◽  
Ft Ir ◽  
Anti Fungal

1-((dicyclohexylamino)(phenyl)methyl) pyrrolidine-2,5-dione (SDB) has been synthesized as a result of succinimide, benzaldehyde and dicyclohexylamine Mannich base condensation and its CoII, NiII and CuII complexes were prepared. The structure of the Mannich Base ligand (SDB) was elucidated on the basis of FT-IR, 1H NMR, 13C NMR and Mass spectral studies. The monomeric and non-electrolytic nature of the metal complexes is evidenced by their magnetic susceptibility and low conductance data studies. Spectral tests, mainly FT-IR studies as well as elemental analysis, were carried out to verify the structures of the newly synthesized compounds. All the metal complexes possess a six-coordinate geometry. The synthesized ligand and its metal complexes have been tested against Gram-positive strains (Staphylococcus aureus and Micrococcus luteus), Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa) and fungal strains (Aspergillus niger and Aspergillus fumigates) for their in vitro anti-bacterial and anti-fungal activities. Preliminary antimicrobial studies of the ligand and their metal complexes have also been carried out in order to understand the toxic effect of ligands and metal complexes against the selective microbes. The results showed that the metal chelates of the ligands showed higher antimicrobial activities than the free ligand SDB and CoII  complexes possess higher activity than the other metal complexes. 

scholarly journals Synthesis and Spectral Investigations of Polymeric Hydrazone Schiff Base and its Transition Metal Complexes with Promising Antimicrobial, Anti-Angeogenic and DNA Photo-Cleavage Activities

2019 ◽  
Vol 31 (10) ◽  
pp. 2331-2336 ◽  
Author(s):  
Manoj Kumar ◽  
Anita Rani ◽  
Hardeep Singh Tuli ◽  
Rajshree Khare ◽  
Vinit Parkash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Free Ligand ◽  
Ft Ir ◽  
Bacteria And Fungi

This report describes the synthesis and exploration of novel Schiff base ligand in the form of a polymer (heptamer) which was prepared by reaction between 3,4-diacetyl-2,5-hexanedione and hydrazine hydrate in ethanol. On further reaction of Schiff base with transition metals ions (Co and Cu) leads to formation of its transition metal complexes. The structural identification of Schiff base ligand and its transition metal complexes were characterized by classical structural techniques like FT-IR, NMR and mass spectra. The free ligand and its transition metal complexes have been screened for in vitro biological activities against various strains of bacteria and fungi. The prepared Schiff base and its metal complexes were also screened for antiangiogenic activity. The results have shown the remarkable antimicrobial and antiangiogenic activities of the Schiff base and its metal complexes.

scholarly journals Structural Elucidation, 3D Molecular Modeling and Antibacterial Activity of Ni (II), Co (II), Cu (II) and Mn (II) Complexes Containing Salophen Ligand

2019 ◽  
pp. 1-15
Author(s):  
Md. Ali Asraf ◽  
Md. Mahbubur Rahman ◽  
D. C. Kabiraz ◽  
Rezaul H. Ansary ◽  
Md. Faruk Hossen ◽  
...  
Keyword(s):  
Experimental Data ◽  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Molecular Modeling ◽  
Metal Complexes ◽  
Metal Ion ◽  
Magnetic Measurements ◽  
Free Ligand ◽  
Antibacterial Activities ◽  
Ft Ir

The salophen ligand and its complexes of Ni(II), Co(II), Cu(II), and Mn(II) are explored in terms of synthesis, conductivity; magnetic measurements, elemental analysis, FT-IR; electronic spectra, and antibacterial activities. The 3D molecular modeling structures of the ligand and its metal complexes are obtained by using Argus lab software. The experimental data shows that the ligand is tetradentate and bonded to the metal ion via N2O2 donor atoms. Antibacterial activity of the synthesized compounds are checked against the microbes Bacillus cereus and Escherichia coli. The metal complexes exhibit antibacterial activity higher than that of the free ligand. This works contributes to the science of Schiff base compounds, in addition to stimulating the synthesis of new ligands and its complexes for the future advancement of coordination chemistry.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

scholarly journals Synthesis, characterization and biological activity of a Schiff base derived from o-amino benzoic acid and its Co(II), Cd(II) and Ni(II) complexes

2020 ◽  
Vol 11 (1) ◽  
pp. 15-20
Author(s):  
Tasneem Ibrahim Hussein ◽  
Musa Abduelrahman Ahmed ◽  
Ismail Adam Arbab ◽  
Awad Salim Ibrahim ◽  
Mohamed Al-Bratty ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Mass Spectra ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Proton Nuclear Magnetic Resonance ◽  
Complexing Agent ◽  
Diffusion Technique ◽  
Nuclear Magnetic Resonance Spectra

Equimolar amounts of imidazoleacetophenone and 2-aminobenzoic acid were combined together and the Schiff base 4(1H-imidazole-yl)acetophenoneanthranilic acid was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with cobalt(II), cadmium(II), and nickel(II) ions yielding air stable complexes. For quantification and characterization purposes, elemental analysis, infrared spectra, electronic spectra, proton nuclear magnetic resonance spectra and mass spectra studies were carried out on the obtained complexes and ligand. Thermogravimetric analysis and magnetic susceptibility measurements were also used for characterization. The ligand IR spectrum showed that the ligand acts as a bidentate coordinates to the metal ions through the nitrogen and oxygen atoms.Measurements of magnetic susceptibility for Ni(II) and Co(II) complexes were found to be 3.4 and 3.8 B.M., respectively, in the range normal for the octahedral geometry. The conductivity measurements revealed that the chelates are non-electrolytes. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against a number of bacterial and fungal strains, to assess their antimicrobial properties by diffusion technique. Antimicrobial activity of the prepared complexes showed higher activity than the free ligand.

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