scholarly journals Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Nobuhiko Takahashi ◽  
Miho Nagamine ◽  
Mitsuko Fukuda ◽  
Wataru Motomura ◽  
Atsuko Abiko ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Female Patient ◽  
Hyperinsulinemic Hypoglycemia ◽  
Fasting Test ◽  
Glucose Profiles ◽  
Leg Edema ◽  
Calcium Injection ◽  
Diabetes Patients

Occurrence of hypoglycemia in diabetes patients is very rare. We report here a case of frequent hypoglycemic attacks caused by inappropriate endogenous hyperinsulinemia in a female patient with poorly controlled diabetes and protein-losing gastroenteropathy. The blood glucose profiles of the patient were unstable. Results of the fasting test performed to investigate the cause of hypoglycemia suggested endogenous hyperinsulinism. Repeated selective arterial calcium injection tests suggested that hyperinsulinemia might be extrapancreatic in origin. However, efforts to detect a responsible lesion such as insulinoma were unsuccessful. Octreotide was used for the treatment of hypoglycemia and protein-losing gastroenteropathy. After treatment, although her leg edema caused by hypoalbuminemia persisted, hypoglycemia almost disappeared.

scholarly journals Appetite and blood glucose profiles in humans after glycogen-depleting exercise

1999 ◽  
Vol 87 (3) ◽  
pp. 947-954 ◽  
Author(s):  
Kathleen J. Melanson ◽  
Margriet S. Westerterp-Plantenga ◽  
L. Arthur Campfield ◽  
Wim H. M. Saris
Keyword(s):  
Blood Glucose ◽  
Respiratory Quotient ◽  
Moderate Exercise ◽  
High Fat ◽  
High Carbohydrate ◽  
Low Carbohydrate ◽  
Glucose Profiles ◽  
Regulatory Functions ◽  
Glycogen Stores ◽  
The Relationship

Regulatory functions of glycogen stores and blood glucose on human appetite, particularly relating to exercise, are not fully understood. Ten men (age 20–31 yr) performed glycogen-depleting exercise in an evening, ate a low-carbohydrate dinner, and stayed overnight in the laboratory. The next day, blood glucose was monitored continuously for 517 ± 23 (SE) min. Subjects had access to high-fat and high-carbohydrate foods after baseline glucose and respiratory quotient were determined. In the afternoon, 1 h of moderate exercise was performed. Baseline respiratory quotient was 0.748 ± 0.008, plasma free fatty acids were 677 ± 123 μmol/l, insulin was 4.8 ± 0.5 μU/ml, and leptin was 1.9 ± 0.3 ng/ml. Postabsorptively, 8 of 10 meals were initiated during stability in blood glucose. Postprandially, the association between meal initiation and blood glucose declines became significant (χ2 = 7.82). During moderate exercise, blood glucose initially decreased but recovered before completion. When the glycogen buffer is depleted, meal initiation can occur during blood glucose stability; the relationship between blood glucose declines and meal initiation reestablishes with refeeding.

scholarly journals Triangulating evidence for the causal impact of single-dose zinc supplement on glycemic control for type-2 diabetes

2021 ◽  
Author(s):  
Zhiyang Wang ◽  
Carine Ronsmans ◽  
Benjamin Woolf
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Fasting Glucose ◽  
Causal Effect ◽  
Fasting Blood Glucose ◽  
Zinc Supplement ◽  
Diabetes Patients

Background: Although previous studies suggested the protective effect of zinc for type-2 diabetes, the unitary causal effect remains inconclusive. Objective: We investigated the causal effect of zinc as a single intervention on glycemic control in type-2 diabetes patients, using a systematic review of RCTs and two-sample Mendelian randomization (MR). Methods: Four outcomes were identified: fasting blood glucose/fasting glucose, hemoglobin A1c (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), and serum insulin/fasting insulin level. In the systematic review, four databases were searched up to June 2021. Results were synthesized through the random-effects meta-analysis. Single nucleotide polymorphisms (SNPs) that are independent and are strongly related to zinc supplements were selected from MR-base to perform the two-sample MR with inverse-variance weighted (IVW) coefficient. Results: In the systematic review, 14 trials were included. The zinc supplement led to a significant reduction in the post-trial mean of fasting blood glucose (mean difference (MD): -26.52, 95%CI: -35.13, -17.91), HbA1C (MD: -0.52, 95%CI: -0.90, -0.13), and HOMA-IR (MD: -1.65, 95%CI: -2.62, -0.68), compared to the control group. In the two-sample MR, zinc supplement with 2 SNPs associated with lower fasting glucose (IVW coefficient: -2.04, 95%CI: -3.26, -0.83), but not specified type-2 diabetes. Conclusion: Although the study was limited by the few trials (review) and SNPs (two-sample MR), we demonstrated that the single zinc supplementary improved glycemic control among type-2 diabetes patients with causal evidence to a certain extent.

scholarly journals Effect of glucose on reduced glutathione level in Malay uncomplicated type 2 diabetes patients

2021 ◽  
pp. 13
Author(s):  
Subandrate ◽  
Raafqi Ranasasmita
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Free Radical ◽  
Reduced Glutathione ◽  
Normal Subjects ◽  
Random Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetes Patients

Background: Increasing blood sugar level may increase free radical compounds in type 2 diabetes. Free radical compounds can cause oxidative stress, thereby decreasing endogenous antioxidants such as reduced glutathione (GSH). Objective: This study aimed to determine whether random blood glucose levels affect GSH in type 2 diabetes patients within the Malay race. Methods: This study was observational with case-control, involving 25 patients with uncomplicated type 2 diabetes (receiving metformin and/or glimipiride) and 25 healthy controls. Random blood glucose levels were determined using ACCU-CHECK® Kit. Blood GSH levels were determined by Sigma GSH Assay Kit. Results: Results show that type 2 diabetes patients have a significantly lower random blood glucose level compared with those of age-matched normal subjects (p<0.0001). Type 2 diabetic patients had significantly lower levels of GSH (p=0.00) than those of age-matched normal subjects. We found a moderate negative correlation (r=-0.437 and p=0.02) between the level of random blood glucose and the level of GSH. Conclusion: The depletion of GSH during hyperglycemia may neutralize the free radicals indirectly generated by the abundant of glucose.  

Diurnal blood glucose profiles in women with gestational diabetes with or without hypertension

2004 ◽  
Vol 21 (11) ◽  
pp. 1181-1184 ◽  
Author(s):  
A. Leinonen ◽  
V. Hiilesmaa ◽  
H. Andersen ◽  
K. Teramo ◽  
R. Kaaja
Keyword(s):  
Blood Glucose ◽  
Gestational Diabetes ◽  
Glucose Profiles

Blood Glucose Awareness Training in Dutch Type 1 diabetes patients. Short-term evaluation of individual and group training

2002 ◽  
Vol 19 (2) ◽  
pp. 157-161 ◽  
Author(s):  
S. Broers ◽  
S. Le Cessie ◽  
K. P. Van Vliet ◽  
Ph. Spinhoven ◽  
N. C. W. Van Der Ven ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Group Training ◽  
Awareness Training ◽  
Short Term ◽  
Short Term Evaluation ◽  
Term Evaluation ◽  
Diabetes Patients

scholarly journals Results of a Study Comparing Glycated Albumin to Other Glycemic Indices

2019 ◽  
Vol 105 (3) ◽  
pp. 677-687 ◽  
Author(s):  
Cyrus V Desouza ◽  
Richard G Holcomb ◽  
Julio Rosenstock ◽  
Juan P Frias ◽  
Stanley H Hsia ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glycemic Control ◽  
Diabetes Management ◽  
Pearson Correlation ◽  
Glycated Albumin ◽  
Individual Subject ◽  
Glycemic Indices ◽  
Glucose Profiles ◽  
The Individual ◽  
Pearson Correlations

Abstract Context Intermediate-term glycemic control metrics fulfill a need for measures beyond hemoglobin A1C. Objective Compare glycated albumin (GA), a 14-day blood glucose measure, with other glycemic indices. Design 24-week prospective study of assay performance. Setting 8 US clinics. Participants Subjects with type 1 (n = 73) and type 2 diabetes (n = 77) undergoing changes to improve glycemic control (n = 98) or with stable diabetes therapy (n = 52). Interventions GA, fructosamine, and A1C measured at prespecified intervals. Mean blood glucose (MBG) calculated using weekly self-monitored blood glucose profiles. Main Outcome Measures Primary: Pearson correlation between GA and fructosamine. Secondary: magnitude (Spearman correlation) and direction (Kendall correlation) of change of glycemic indices in the first 3 months after a change in diabetes management. Results GA was more concordant (60.8%) with changes in MBG than fructosamine (55.5%) or A1C (45.5%). Across all subjects and visits, the GA Pearson correlation with fructosamine was 0.920. Pearson correlations with A1C were 0.655 for GA and 0.515 for fructosamine (P &lt; .001) and with MBG were 0.590 and 0.454, respectively (P &lt; .001). At the individual subject level, Pearson correlations with both A1C and MBG were higher for GA than for fructosamine in 56% of subjects; only 4% of subjects had higher fructosamine correlations with A1C and MBG. GA had a higher Pearson correlation with A1C and MBG in 82% and 70% of subjects, respectively. Conclusions Compared with fructosamine, GA correlates significantly better with both short-term MBG and long-term A1C and may be more useful than fructosamine in clinical situations requiring monitoring of intermediate-term glycemic control (NCT02489773).

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