scholarly journals MR Spectroscopy in Gliomatosis: Is there a Sensitivity Issue?

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
M. Szewczyk-Bieda ◽  
A. K. Kanodia ◽  
G. Main ◽  
M. S. Eljamel
Keyword(s):  
Chemical Shift ◽  
Mr Spectroscopy ◽  
Brain Tumours ◽  
Progressive Disease ◽  
Good Prognosis ◽  
Short Term ◽  
Tumour Grading ◽  
Normal Limits ◽  
Single Voxel ◽  
Highly Sensitive

Objective.1H MR spectroscopy (MRS) is widely performed for assessment of brain tumours and is considered a highly sensitive technique capable of differentiating benign from malignant conditions and tumour grading.Method. We present a case of a 69 year old woman who was suspected to have gliomatosis on MRI.Results. MRS performed using single voxel and chemical shift/multivoxel techniques was within normal limits. A repeat scan 6 months later showed progressive disease, and biopsy was performed that proved the diagnosis of glioblastoma.Conclusion. Normal MRS in a patient with suspicion of gliomatosis on MRI should not reassure clinicians into assuming a benign aetiology or a good prognosis in short term.

scholarly journals SPectroscOpic prediction of bRain Tumours (SPORT): study protocol of a prospective imaging trial

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Pamela Franco ◽  
Urs Würtemberger ◽  
Karam Dacca ◽  
Irene Hübschle ◽  
Jürgen Beck ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Mr Spectroscopy ◽  
Brain Tumours ◽  
Patient Characteristics ◽  
Who Grade ◽  
Target Sequencing ◽  
Molecular Stratification ◽  
1H Mr Spectroscopy ◽  
Cns Tumours ◽  
Grade Ii

Abstract Background The revised 2016 WHO-Classification of CNS-tumours now integrates molecular information of glial brain tumours for accurate diagnosis as well as for the development of targeted therapies. In this prospective study, our aim is to investigate the predictive value of MR-spectroscopy in order to establish a solid preoperative molecular stratification algorithm of these tumours. We will process a 1H MR-spectroscopy sequence within a radiomics analytics pipeline. Methods Patients treated at our institution with WHO-Grade II, III and IV gliomas will receive preoperative anatomical (T2- and T1-weighted imaging with and without contrast enhancement) and proton MR spectroscopy (MRS) by using chemical shift imaging (MRS) (5 × 5 × 15 mm3 voxel size). Tumour regions will be segmented and co-registered to corresponding spectroscopic voxels. Raw signals will be processed by a deep-learning approach for identifying patterns in metabolic data that provides information with respect to the histological diagnosis as well patient characteristics obtained and genomic data such as target sequencing and transcriptional data. Discussion By imaging the metabolic profile of a glioma using a customized chemical shift 1H MR spectroscopy sequence and by processing the metabolic profiles with a machine learning tool we intend to non-invasively uncover the genetic signature of gliomas. This work-up will support surgical and oncological decisions to improve personalized tumour treatment. Trial registration This study was initially registered under another name and was later retrospectively registered under the current name at the German Clinical Trials Register (DRKS) under DRKS00019855.

Clinical value of amino acid imaging in paediatric brain tumours

2005 ◽  
Vol 44 (04) ◽  
pp. 131-136 ◽  
Author(s):  
K. Lang ◽  
S. Kloska ◽  
R. Straeter ◽  
C. H. Rickert ◽  
G. Goder ◽  
...  
Keyword(s):  
Amino Acid ◽  
Brain Tumours ◽  
Photon Emission ◽  
Diagnostic Tools ◽  
Emission Computed Tomography ◽  
Gadolinium Enhancement ◽  
Tumour Grading ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Paediatric Brain Tumours

Summary Purpose: To evaluate single photon emission computed tomography (SPECT) using the amino acid l-3-[123I]-α-methyl tyrosine (IMT) and contrast enhanced magnetic resonance imaging (MRI) as diagnostic tools in primary paediatric brain tumours in respect of non-invasive tumour grading. Patients, materials, methods: 45 children with primary brain tumours were retrospectively evaluated. IMT uptake was quantified as tumour/nontumour- ratio, a 4-value-scale was used to measure gadolinium enhancement on contrast enhanced MRI. Statistical analyses were performed to evaluate IMT uptake and gadolinium enhancement in low (WHO I/II) and high (WHO III/ IV) grade tumours and to disclose a potential relationship of IMT uptake to disruption of blood brain barrier as measured in corresponding MRI scans. Results: IMT uptake above background level was observed in 35 of 45 patients. IMT uptake was slightly higher in high grade tumours but the difference failed to attain statistical significance. Grading of individual tumours was neither possible by IMT SPECT nor by gadolinium enhanced MRI. Conclusion: IMT is accumulated in most brain tumours in children. Tumour grading was not possible using IMT or contrast enhancement as determined by MRI. Neither morphological nor functional imaging can replace histology in paediatric brain tumours.

In Vivo Single Voxel 1H MR Spectroscopy in Cerebral Glioma

1996 ◽  
Vol 35 (3) ◽  
pp. 307 ◽  
Author(s):  
In Chan Song ◽  
Kee Hyun Chang ◽  
Moon Hee Han ◽  
Hee Won Jung ◽  
Dong Sung Kim ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Cerebral Glioma ◽  
1H Mr Spectroscopy ◽  
Single Voxel

Single-voxel proton MR spectroscopy of right versus left hippocampi in PTSD

2003 ◽  
Vol 123 (2) ◽  
pp. 101-108 ◽  
Author(s):  
P. Mohanakrishnan Menon ◽  
Henry A. Nasrallah ◽  
Judith A. Lyons ◽  
Mertis F. Scott ◽  
Vincent Liberto
Keyword(s):  
Mr Spectroscopy ◽  
Proton Mr Spectroscopy ◽  
Single Voxel

scholarly journals Selective and Irreversible Induction of Necroptotic Cell Death in Lung Tumorspheres by Short-Term Exposure to Verapamil in Combination with Sorafenib

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Juan Sebastian Yakisich ◽  
Yogesh Kulkarni ◽  
Neelam Azad ◽  
Anand Krishnan V. Iyer
Keyword(s):  
Cancer Cells ◽  
Culture Conditions ◽  
Serum Starvation ◽  
Adherent Cells ◽  
Key Factors ◽  
Short Term ◽  
Short Term Exposure ◽  
Highly Sensitive ◽  
Free Media ◽  
Drug Free

The presence of highly resistant cancer cells and the toxicity to normal cells are key factors that limit chemotherapy. Here, we used two models of highly resistant lung cancer cells: (1) adherent cells growing under prolonged periods of serum starvation (PPSS) and (2) cells growing as floating tumorspheres (FTs) to evaluate the effect of Verapamil (VP) in combination with Sorafenib (SF). Compared to cells growing under routine culture conditions (RCCs), PPPS cells or FTs were highly sensitive to short-term exposure (24 h) to VP 100 μM + SF 5 μM (VP100 + SF5). Recovery experiments exposing cells to VP100 + SF5 for 24 h followed by incubation in drug-free media for 48 h demonstrated that while PPSS as well as FT cells were unable to recover, cancer cells and the noncancerous cell line Beas-2B growing under RCCs were less sensitive and were also able to recover significantly. VP100 + SF5 induced significant changes in the expression of protein associated with apoptosis, autophagy, and to a lesser extent necroptosis. Coincubation experiments with z-VAD-FMK, necrostatin 1, or chloroquine showed evidence that necroptosis played a central role. Our data demonstrates that highly resistant cancer cells can be selectively eliminated by VP + SF and that necroptosis plays a central role.

scholarly journals Glacier dynamics at Helheim and Kangerdlugssuaq glaciers, southeast Greenland, since the Little Ice Age

2014 ◽  
Vol 8 (4) ◽  
pp. 1497-1507 ◽  
Author(s):  
S. A. Khan ◽  
K. K. Kjeldsen ◽  
K. H. Kjær ◽  
S. Bevan ◽  
A. Luckman ◽  
...  
Keyword(s):  
Mass Balance ◽  
Little Ice Age ◽  
Ice Age ◽  
Short Term ◽  
Velocity Change ◽  
Outlet Glacier ◽  
Episodic Events ◽  
Highly Sensitive ◽  
Decadal Scale ◽  
Speed Up

Abstract. Observations over the past decade show significant ice loss associated with the speed-up of glaciers in southeast Greenland from 2003, followed by a deceleration from 2006. These short-term, episodic, dynamic perturbations have a major impact on the mass balance on the decadal scale. To improve the projection of future sea level rise, a long-term data record that reveals the mass balance beyond such episodic events is required. Here, we extend the observational record of marginal thinning of Helheim and Kangerdlugssuaq glaciers from 10 to more than 80 years. We show that, although the frontal portion of Helheim Glacier thinned by more than 100 m between 2003 and 2006, it thickened by more than 50 m during the previous two decades. In contrast, Kangerdlugssuaq Glacier underwent minor thinning of 40–50 m from 1981 to 1998 and major thinning of more than 100 m after 2003. Extending the record back to the end of the Little Ice Age (prior to 1930) shows no thinning of Helheim Glacier from its maximum extent during the Little Ice Age to 1981, while Kangerdlugssuaq Glacier underwent substantial thinning of 230 to 265 m. Comparison of sub-surface water temperature anomalies and variations in air temperature to records of thickness and velocity change suggest that both glaciers are highly sensitive to short-term atmospheric and ocean forcing, and respond very quickly to small fluctuations. On century timescales, however, multiple external parameters (e.g. outlet glacier shape) may dominate the mass change. These findings suggest that special care must be taken in the projection of future dynamic ice loss.

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