scholarly journals Erratum to “Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis”

2011 ◽  
Vol 2011 ◽  
pp. 1-1
Author(s):  
Laura Ridolfi ◽  
Massimiliano Petrini ◽  
Laura Fiammenghi ◽  
Anna Maria Granato ◽  
Valentina Ancarani ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Clinical Outcome ◽  
Subgroup Analysis ◽  
Response Rate ◽  
High Response Rate ◽  
Advanced Melanoma ◽  
High Response ◽  
Traditional Therapy ◽  
Dendritic Cell Based Vaccine

A Follow-up Investigation with High Response Rate

1988 ◽  
Vol 16 (3) ◽  
pp. 137-137
Author(s):  
Henrik Toft Sørensen ◽  
Bo Christensen ◽  
Erling Kjærulff
Keyword(s):  
Response Rate ◽  
High Response Rate ◽  
High Response

scholarly journals High response rate with T-VEC in early metastatic melanoma (stage IIIB/C-IVM1a)

2018 ◽  
Vol 29 ◽  
pp. viii447
Author(s):  
V. Franke ◽  
D.M.S. Berger ◽  
W.M.C. Klop ◽  
B. van der Hiel ◽  
B.A. van de Wiel ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Response Rate ◽  
High Response Rate ◽  
High Response ◽  
Stage Iiib

scholarly journals High-risk germ cell tumors in men high response rate and severe toxicity with cisplatin, vinblastine, bleomycin, and etoposide

Cancer ◽  
1993 ◽  
Vol 71 (7) ◽  
pp. 2351-2357 ◽  
Author(s):  
Douglas W. Blayney ◽  
David A. Goldberg ◽  
Lucille A. Leong ◽  
Kim A. Margolin ◽  
Jerome S. Burke ◽  
...  
Keyword(s):  
High Risk ◽  
Germ Cell ◽  
Response Rate ◽  
Germ Cell Tumors ◽  
High Response Rate ◽  
High Response ◽  
Severe Toxicity

New cisplatin schedule in combination with aclarubicin (ACR) with high response rate in recurrent gynecological adenocarcinomas

1990 ◽  
Vol 38 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Jui-Tung Chen ◽  
Yasuo Hirai ◽  
Yoshio Shimizu ◽  
Katsuhiko Hasumi ◽  
Kazumasa Masubuchi
Keyword(s):  
Response Rate ◽  
High Response Rate ◽  
High Response

Interferon alpha with or without rituximab achieves a high response rate and durable responses in relapsed FL: 17 years’ experience in a single centre

2013 ◽  
Vol 93 (1) ◽  
pp. 147-156 ◽  
Author(s):  
Sinziana Radesi-Sarghi ◽  
Flavie Arbion ◽  
Caroline Dartigeas ◽  
Martine Delain ◽  
Lotfi Benboubker ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Response Rate ◽  
High Response Rate ◽  
High Response ◽  
Single Centre

Combining Decitabine With Plerixafor Yields a High Response Rate In Newly Diagnosed Older Patients With AML

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 621-621 ◽  
Author(s):  
Gail J. Roboz ◽  
Joseph M. Scandura ◽  
Ellen Ritchie ◽  
Yulia Dault ◽  
Linda Lam ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Clinical Response ◽  
Median Survival ◽  
Older Patients ◽  
Response Rate ◽  
High Response Rate ◽  
High Response ◽  
Newly Diagnosed ◽  
Median Response ◽  
Overall Response

Abstract Acute myeloid leukemia (AML) carries a dismal prognosis in older patients, with median survival 8-12 months and especially poor outcomes in patients with unfavorable cytogenetics and/or poor performance status. Decitabine (5-aza-2’-deoxycytidine) has single-agent efficacy in older AML patients, with 40-50% CR (Blum et al, Proc Natl Acad Sci,107(16):7473-8,2010; Ritchie et al Leuk Lymphoma, 2013). AML originates from a rare population of leukemia stem cells (LSCs) that are capable of self-renewal, proliferation and differentiation into malignant blasts. LSCs may persist after treatment and contribute to disease relapse. Drugs that release LSCs from their protective microenvironment may leave them more vulnerable to therapy, as they are strongly dependent on the niche for proliferation and survival. Plerixafor blocks SDF1-mediated CXCR4 signaling and significantly decreases the survival of AML cells in vitro. The objective of this study was to investigate the safety and efficacy of decitabine combined with plerixafor in newly diagnosed older patients with AML and to evaluate the clinical and biological effects of plerixafor on LCSs. Patients were treated with repeated monthly cycles of decitabine 20 mg/m2 days 1-10 combined with escalating doses of plerixafor (320-810 μg/kg) days 1-5. Plerixafor was administered every other cycle so patients could serve as their own control when assessing the effects of CXCR4 blockade. Two cohorts of patients were treated at each dose level: cohort A received plerixafor only during even-numbered cycles and cohort B received plerixafor only during odd-numbered cycles. Patients achieving a clinical response received ongoing monthly maintenance cycles with 5 days of decitabine and plerixafor during alternate cycles. Sixty-nine patients were treated. Baseline patient characteristics were 55% male with a median age of 73 (56-87) yrs; ECOG 0 17%, 1 64%, 2 19%; cytogenetics intermediate 57%, adverse 44%; antecedent hematologic disorder 44%; secondary AML 45%; prior hypomethylating agent treatment (HMA) 20%. The overall response rate was 43% (36% CR, 7% CRi), with median time to response 1.9 mos (2 cycles) and median response duration 4.5 mos. Adverse karyotype did not predict overall response (P=0.31) and 53% of patients with adverse cytogenetics responded to treatment (43% CR, 7% CRi). Median overall survival (OS) for responders was significantly longer (18 mos) than for nonresponders (5 mos, P<0.0001). Prior HMA treatment was the strongest independent predictor of OS (HR=3.1; 95% CI 1.3-7.3; P=0.008). Whereas 52% of HMA treatment naive patients achieved CR (46%/6% CR/CRi), only 14% of patients previously treated with an HMA achieved response (0% CR, 14% CRi, P=0.002). Accordingly, the median survival of patients with prior HMA was much shorter (2.5 mos) than for HMA-naive patients (12.6 mos, P=0.001). We observed no significant differences in ORR or OS linked to plerixafor dose or treatment cohort (A vs B), but the study was not powered for these comparisons. Toxicities were predictable and typical of older AML patients. Cytopenias and infections were the most common adverse events. There was no clinically significant hyperleukocytosis with plerixafor. Fourteen (56%) patients treated with 810 ug/kg plerixafor experienced reversible, treatment-associated insomnia. Immunophenotypically-defined leukemia stem and progenitor cells (LSPCs) were mobilized in a subset of patients as a consequence of CXCR4 blockade. Importantly, increased proliferation of LSPCs was also observed by Ki-67 staining. Decitabine-induced hypomethylation of AML-specific DNA methylation biomarker regions was observed in LSPCs of responders, but not in non-responders. Interestingly, this biochemical response preceded clinical response by at least one month in the subset of 7 patients analyzed to date. The combination of decitabine and plerixafor resulted in a high response rate with a favorable toxicity profile in poor-prognosis elderly AML patients. The MTD of plerixafor was 810 ug/kg and results from ongoing translational studies suggest that measures to optimize the regimen based on LSPC mobilization and DNA methylation may be feasible. Disclosures: Off Label Use: decitabine for AML.

Correlation of clinical outcome with natural killer (NK) response to an anti-cancer, dendritic cell-based vaccine

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 2585-2585
Author(s):  
M. Morse ◽  
T. Osada ◽  
A. Hobeika ◽  
S. Chui ◽  
T. Clay ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Clinical Outcome ◽  
Natural Killer ◽  
Anti Cancer ◽  
Dendritic Cell Based Vaccine
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