scholarly journals Gait and Equilibrium in Subcortical Vascular Dementia

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Rita Moretti ◽  
Paola Torre ◽  
Rodolfo M. Antonello ◽  
Francesca Esposito ◽  
Giuseppe Bellini
Keyword(s):  
White Matter ◽  
Vascular Dementia ◽  
Clinical Entity ◽  
Drug Intake ◽  
Men And Women ◽  
Imbalance Problem ◽  
Subcortical Vascular Dementia

Subcortical vascular dementia is a clinical entity, widespread, even challenging to diagnose and correctly treat. Patients with this diagnosis are old, frail, often with concomitant pathologies, and therefore, with many drugs in therapy. We tried to diagnose and follow up for three years more than 600 patients. Study subjects were men and women, not bedridden, aged 68–94 years, outpatients, recruited from June, 1st 2007 to June, 1st 2010. We examined them clinically, neurologically, with specific consideration on drug therapies. Our aim has been to define gait and imbalance problem, if eventually coexistent with the pathology of white matter and/or with the worsening of the deterioration. Drug intake interference has been detected and considered.

scholarly journals A mouse model of subcortical vascular dementia reflecting degeneration of cerebral white matter and microcirculation

2017 ◽  
Vol 39 (1) ◽  
pp. 44-57 ◽  
Author(s):  
Eek-Sung Lee ◽  
Jin-Hui Yoon ◽  
Jiye Choi ◽  
Faris R Andika ◽  
Taekwan Lee ◽  
...  
Keyword(s):  
Working Memory ◽  
White Matter ◽  
Recognition Memory ◽  
Mouse Model ◽  
Vascular Dementia ◽  
Spatial Working Memory ◽  
Cerebral Hypoperfusion ◽  
Cerebral Microcirculation ◽  
White Matter Damage ◽  
Subcortical Vascular Dementia

Subcortical vascular dementia(SVaD) is associated with white matter damage, lacunar infarction, and degeneration of cerebral microcirculation. Currently available mouse models can mimic only partial aspects of human SVaD features. Here, we combined bilateral common carotid artery stenosis (BCAS) with a hyperlipidaemia model in order to develop a mouse model of SVaD; 10- to 12-week-old apolipoprotein E (ApoE)-deficient or wild-type C57BL/6J mice were subjected to sham operation or chronic cerebral hypoperfusion with BCAS using micro-coils. Behavioural performance (locomotion, spatial working memory, and recognition memory), histopathological findings (white matter damage, microinfarctions, astrogliosis), and cerebral microcirculation (microvascular density and blood–brain barrier (BBB) integrity) were investigated. ApoE-deficient mice subjected to BCAS showed impaired locomotion, spatial working memory, and recognition memory. They also showed white matter damage, multiple microinfarctions, astrogliosis, reduction in microvascular density, and BBB breakdown. The combination of chronic cerebral hypoperfusion and ApoE deficiency induced cognitive decline and cerebrovascular pathology, including white matter damage, multiple microinfarctions, and degeneration of cerebral microcirculation. Together, these features are all compatible with those of patients with SVaD. Thus, the proposed animal model is plausible for investigating SVaD pathophysiology and for application in preclinical drug studies.

Is Subcortical Vascular Dementia a Clinical Entity for Clinical Drug Trials?

1999 ◽  
Vol 13 (Supplement 3) ◽  
pp. S66-S68 ◽  
Author(s):  
Domenico Inzitari ◽  
Timo Erkinjuntti ◽  
Anders Wallin ◽  
Teodoro del Ser ◽  
Leonardo Pantoni
Keyword(s):  
Vascular Dementia ◽  
Clinical Entity ◽  
Drug Trials ◽  
Subcortical Vascular Dementia ◽  
Clinical Drug Trials ◽  
Clinical Drug

White matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementia

2015 ◽  
Vol 22 (4) ◽  
pp. 709-716 ◽  
Author(s):  
Y. J. Kim ◽  
H. K. Kwon ◽  
J.-M. Lee ◽  
Y. J. Kim ◽  
H. J. Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Vascular Dementia ◽  
Microstructural Changes ◽  
Subcortical Vascular Dementia

scholarly journals Remote Ischemic Conditioning Improves Cognition in Patients with Subcortical Ischemic Vascular Dementia

2019 ◽  
Author(s):  
Zhangyuan Liao ◽  
Yali Bu ◽  
Meijie Li ◽  
Ranran Han ◽  
Nan Zhang ◽  
...  
Keyword(s):  
White Matter ◽  
Vascular Dementia ◽  
Upper Limb ◽  
Verbal Learning ◽  
Control Group ◽  
Lesion Volume ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Hs Crp

Abstract Background ： Subcortical ischemic vascular dementia (SIVD) is very common among the older people, but has no approved treatment. Preclinical trials show that remote ischemic conditioning (RIC) reduces recurrence of ischemic stroke. We hypothesize that RIC may also be an effective therapy for patients with SIVD. Methods ： Thirty-seven consecutive SIVD cases were enrolled in this randomized control study. Eighteen RIC patients underwent five brief cycles of conditioning (bilateral upper limb compression at 200 mmHg) followed by reperfusion twice daily over 6 consecutive months. Nineteen control patients underwent the same process, but at a pressure of 60 mmHg which caused no restriction on the blood flow of the upper limb. The primary outcome measures were changes in neuropsychological assessments. The secondary outcomes included the changes in high-sensitive C-reactive protein (hs-CRP) concentration, white matter lesion volume (WMLV), diffusion tension imaging (DTI) metrics of white matter. All data were collected at baseline and follow-up. Results ： A significant treatment difference favoring RIC at 6 months was observed on performance of Hopkins Verbal Learning Test-Revised (HVLT-R), Controlled Oral Word Association Test(COWAT), Trail Making Test A and B (TMT-A & TMT-B), and Judgment of Line Orientation (JLO) (p<0.05). The control group did not show much improvement after the treatment, and only with a slight change in HVLT-R and TMT-R(p<0.05). Covariance analysis of efficacy between the two groups suggested that RIC patients performed better on JLO than control patients at the 6-month follow-up (RIC 23.10 vs. control 18.56; p=0.013). Although DTI metrics were comparable, Hs-CRP levels and WMLV in RIC patients showed a declining trend. Conclusions： Over the 6-month treatment period, we found that RIC was safe and effective for improving cognitive function in SIVD patients.

Is Subcortical Vascular Dementia a Clinical Entity for Clinical Drug Trials?

1999 ◽  
Vol 13 (Supplement) ◽  
pp. S66-68 ◽  
Author(s):  
Domenico Inzitari ◽  
Timo Erkinjuntti ◽  
Anders Wallin ◽  
Teodoro del Ser ◽  
Leonardo Pantoni
Keyword(s):  
Vascular Dementia ◽  
Clinical Entity ◽  
Drug Trials ◽  
Subcortical Vascular Dementia ◽  
Clinical Drug Trials ◽  
Clinical Drug
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