scholarly journals Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Frederic Delom ◽  
Delphine Fessart
Keyword(s):  
Protein Phosphorylation ◽  
G Protein ◽  
Adaptor Proteins ◽  
G Protein Coupled Receptors ◽  
Coated Vesicle ◽  
Receptor Endocytosis ◽  
Endocytic Machinery ◽  
Vesicle Cycle ◽  
G Protein Coupled

The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle.

scholarly journals The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension

2018 ◽  
Vol 5 ◽  
Author(s):  
Gayathri Viswanathan ◽  
Argen Mamazhakypov ◽  
Ralph T. Schermuly ◽  
Sudarshan Rajagopal
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricle ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
The Right ◽  
G Protein Coupled

scholarly journals The role of membrane curvature elastic stress for function of rhodopsin-like G protein-coupled receptors

Biochimie ◽  
2014 ◽  
Vol 107 ◽  
pp. 28-32 ◽  
Author(s):  
Olivier Soubias ◽  
Walter E. Teague ◽  
Kirk G. Hines ◽  
Klaus Gawrisch
Keyword(s):  
G Protein ◽  
Elastic Stress ◽  
Membrane Curvature ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

scholarly journals Atypical Chemokine Receptors in Cardiovascular Disease

2019 ◽  
Vol 119 (04) ◽  
pp. 534-541 ◽  
Author(s):  
Selin Gencer ◽  
Emiel van der Vorst ◽  
Maria Aslani ◽  
Christian Weber ◽  
Yvonne Döring ◽  
...  
Keyword(s):  
G Protein ◽  
Chemokine Receptors ◽  
Cellular Response ◽  
Current Knowledge ◽  
G Protein Coupled Receptors ◽  
Signalling Pathways ◽  
Atherosclerosis Development ◽  
G Protein Coupled ◽  
Precise Role

AbstractInflammation has been well recognized as one of the main drivers of atherosclerosis development and therefore cardiovascular diseases (CVDs). It has been shown that several chemokines, small 8 to 12 kDa cytokines with chemotactic properties, play a crucial role in the pathophysiology of atherosclerosis. Chemokines classically mediate their effects by binding to G-protein-coupled receptors called chemokine receptors. In addition, chemokines can also bind to atypical chemokine receptors (ACKRs). ACKRs fail to induce G-protein-dependent signalling pathways and thus subsequent cellular response, but instead are able to internalize, scavenge or transport chemokines. In this review, we will give an overview of the current knowledge about the involvement of ACKR1–4 in CVDs and especially in atherosclerosis development. In the recent years, several studies have highlighted the importance of ACKRs in CVDs, although there are still several controversies and unexplored aspects that have to be further elucidated. A better understanding of the precise role of these atypical receptors may pave the way towards novel and improved therapeutic strategies.

The Role of MC1R in Speciation & Phylogeny

2013 ◽  
Vol 75 (9) ◽  
pp. 670-676 ◽  
Author(s):  
Susan Offner
Keyword(s):  
G Protein ◽  
Point Mutation ◽  
Solomon Island ◽  
G Protein Coupled Receptors ◽  
Ancestral Population ◽  
Mc1r Gene ◽  
The Many ◽  
Evolutionary Consequences ◽  
G Protein Coupled

A point mutation in the MC1R gene, a G-protein-coupled receptor, has been found that could have led to the formation of two subspecies of Solomon Island flycatcher from a single ancestral population. I discuss the many roles that G-protein-coupled receptors play in vertebrate physiology and how one particular point mutation can have enormous evolutionary consequences.

New thoughts on the role of the βγ subunit in G protein signal transduction

2000 ◽  
Vol 78 (5) ◽  
pp. 537-550 ◽  
Author(s):  
Barbara Vanderbeld ◽  
Gregory M Kelly
Keyword(s):  
Signal Transduction ◽  
G Protein ◽  
G Proteins ◽  
G Protein Coupled Receptors ◽  
Limited Information ◽  
Α Subunit ◽  
Downstream Effectors ◽  
Receptor Signal ◽  
G Protein Coupled

Heterotrimeric G proteins are involved in numerous biological processes, where they mediate signal transduction from agonist-bound G-protein-coupled receptors to a variety of intracellular effector molecules and ion channels. G proteins consist of two signaling moieties: a GTP-bound α subunit and a βγ heterodimer. The βγ dimer, recently credited as a significant modulator of G-protein-mediated cellular responses, is postulated to be a major determinant of signaling fidelity between G-protein-coupled receptors and downstream effectors. In this review we have focused on the role of βγ signaling and have included examples to demonstrate the heterogeneity in the heterodimer composition and its implications in signaling fidelity. We also present an overview of some of the effectors regulated by βγ and draw attention to the fact that, although G proteins and their associated receptors play an instrumental role in development, there is rather limited information on βγ signaling in embryogenesis.Key words: G protein, βγ subunit, G-protein-coupled receptor, signal transduction, adenylyl cyclase.

scholarly journals Interactions between Two Different G Protein-Coupled Receptors in Reproductive Hormone-Producing Cells: The Role of PACAP and Its Receptor PAC1R

2016 ◽  
Vol 17 (10) ◽  
pp. 1635 ◽  
Author(s):  
Haruhiko Kanasaki ◽  
Aki Oride ◽  
Tomomi Hara ◽  
Tselmeg Mijiddorj ◽  
Unurjargal Sukhbaatar ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Reproductive Hormone ◽  
G Protein Coupled

scholarly journals Crucial Role of Neuron-enriched Endosomal Protein of 21 kDa in Sorting between Degradation and Recycling of Internalized G-protein-coupled Receptors

2004 ◽  
Vol 279 (34) ◽  
pp. 35687-35691 ◽  
Author(s):  
Colin Debaigt ◽  
Harald Hirling ◽  
Pascal Steiner ◽  
Jean-Pierre Vincent ◽  
Jean Mazella
Keyword(s):  
G Protein ◽  
Crucial Role ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

scholarly journals Role of Water in Transmembrane Domain of G Protein-Coupled Receptors

2011 ◽  
Vol 100 (3) ◽  
pp. 20a
Author(s):  
Roman Osman ◽  
Arnau Cordomi ◽  
Themis Lazaridis ◽  
Mihaly Mezei ◽  
Leonardo Pardo
Keyword(s):  
G Protein ◽  
Transmembrane Domain ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled
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