scholarly journals Serum Cytokine Concentrations in a Patient with Rheumatoid Arthritis on Etanercept Therapy Who Subsequently Developed Pneumocystis Pneumonia: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Masao Sato ◽  
Masao Takemura ◽  
Ryuki Shinohe ◽  
Katsuji Shimizu
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Serum Levels ◽  
Pneumocystis Pneumonia ◽  
Tnf Alpha ◽  
Serum Cytokine ◽  
Initiation Of Therapy ◽  
Necrosis Factor

We report a rheumatoid arthritis patient who was treated with etanercept. Serum levels of tumor-necrosis-factor- (TNF-)alpha, soluble-tumor-necrosis-factor receptor- (sTNFR-) I and -II, interleukin- (IL-) 6, and IL-1 beta were measured by ELISA before and during the course of therapy. While the serum levels of IL-6 and IL-1 beta dropped rapidly following the initiation of therapy, the concentrations of TNF-alpha and sTNFR-II steadily increased to a plateau. Although significant clinical efficacy was observed, etanercept had to be discontinued when after 12 weeks of therapy the patient was found to have pneumocystis pneumonia.

scholarly journals Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Arzu Ataseven ◽  
Recep Kesli ◽  
Gulcan Saylam Kurtipek ◽  
Perihan Ozturk
Keyword(s):  
Uric Acid ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Severity Index ◽  
Serum Levels ◽  
Lipocalin 2 ◽  
Pasi Score ◽  
Necrosis Factor

Background. Chronic inflammation may play a role in psoriasis pathogenesis. Lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1 (sTNFR-1), interleukin-6, homocysteine, and uric acid are inflammatory and/or biochemical markers. However, both the roles of these markers and the pathogenesis of psoriasis are unknown.Objective. The aim of this study was to investigate serum levels of lipocalin 2, clusterin, sTNFR-1, interleukin-6, homocysteine, and uric acid in patients and controls groups.Methods. Fifty-six patients with psoriasis and 33 healthy controls were included in the study. Serum concentrations of the markers were evaluated by ELISA. The Psoriasis Area and Severity Index (PASI) was evaluated in all psoriasis patients. Body mass index (BMI) was calculated by dividing weight (kg) by height (m) squared.Results. The serum value of lipocalin and sTNFR-1 were significantly higher in psoriasis patients than in controls (resp.,P<0.001,P<0.05). The others showed no significant differences between psoriasis and the control groups (all of themP>0.05). The mean PASI score in the patient group was8.3±6.5.Conclusions. These findings suggest that lipocalin 2 and sTNFR-1 might play a role in the pathogenesis of psoriasis and can be used as markers of the disease.

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