scholarly journals The Consequence of Immune Suppressive Cells in the Use of Therapeutic Cancer Vaccines and Their Importance in Immune Monitoring

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Matteo Vergati ◽  
Jeffrey Schlom ◽  
Kwong Y. Tsang
Keyword(s):  
Cancer Vaccines ◽  
T Regulatory Cells ◽  
Suppressor Cells ◽  
Immune Monitoring ◽  
Regulatory Cells ◽  
Phenotypic Characteristics ◽  
And Function ◽  
Immunosuppressive Cells ◽  
Therapeutic Cancer Vaccines

Evaluating the number, phenotypic characteristics, and function of immunosuppressive cells in the tumor microenvironment and peripheral blood could elucidate the antitumor immune response and provide information to evaluate the efficacy of cancer vaccines. Further studies are needed to evaluate the correlation between changes in immunosuppressive cells and clinical outcomes of patients in cancer vaccine clinical trials. This paper focuses on the role of T-regulatory cells, myeloid-derived suppressor cells, and tumor-associated macrophages in cancer and cancer immunotherapy and their role in immune monitoring.

scholarly journals Increased Levels of Granulocytic Myeloid-Derived Suppressor Cells in Peripheral Blood and Tumour Tissue of Pancreatic Cancer Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yazan S. Khaled ◽  
Basil J. Ammori ◽  
Eyad Elkord
Keyword(s):  
Pancreatic Cancer ◽  
Suppressor Cells ◽  
Blood Levels ◽  
Myeloid Derived Suppressor Cells ◽  
Arginase 1 ◽  
Hla Dr ◽  
Healthy Donors ◽  
And Function ◽  
Immunosuppressive Cells

Pancreatic cancer (PC) often presents late with poor survival. While role of immunosuppressive cells in preclinical studies provided help to develop immunotherapeutic agents, these cells remain under investigation in PC. The aim of this study was to characterise the different subsets of myeloid-derived suppressor cells (MDSCs) and evaluate their level and function in the circulation and tissue of PC patients. Significant increases in circulating and tumour-infiltrating granulocytic (Lin-HLA-DR-CD33+CD11b+CD15+), but not monocytic (Lin-HLA-DR-CD14+), MDSCs were detected in PC patients when compared with healthy donors and patients with chronic pancreatitis. The circulating MDSCs from PC patients expressed arginase 1, which represents their functional state. Blood levels of MDSCs showed no association with PC stage or preoperative levels of tumour markers. These findings provide a first characterisation of the phenotype of different subsets of peripheral and local MDSCs in PC patients and suggest that the frequency and contribution of these cells are predominantly granulocytic. This information demonstrates that MDSCs play a role in pancreatic cancer and future large validation studies may help in the development of new immunotherapeutic strategies to inhibit or eliminate MDSC function.

scholarly journals Myeloid-Derived Suppressor Cells Protect Islet Transplants by B7-H1 Mediated Enhancement of T Regulatory Cells

2012 ◽  
Vol 93 (3) ◽  
pp. 272-282 ◽  
Author(s):  
Hong-Shiue Chou ◽  
Ching-Chuan Hsieh ◽  
Ronald Charles ◽  
Lianfu Wang ◽  
Timothy Wagner ◽  
...  
Keyword(s):  
T Regulatory Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Regulatory Cells ◽  
Islet Transplants

scholarly journals CD18 Is Required for Optimal Development and Function of CD4+CD25+ T Regulatory Cells

2005 ◽  
Vol 175 (12) ◽  
pp. 7889-7897 ◽  
Author(s):  
Marissa Marski ◽  
Sravanthi Kandula ◽  
Jerrold R. Turner ◽  
Clara Abraham
Keyword(s):  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Optimal Development ◽  
And Function

scholarly journals Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Aleksandra Pyzik ◽  
Ewelina Grywalska ◽  
Beata Matyjaszek-Matuszek ◽  
Jacek Roliński
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
T Regulatory Cells ◽  
Hashimoto Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Regulatory Cells ◽  
Review Of Literature ◽  
Immune Disorders ◽  
Cd4 Cells ◽  
Immune Defect

This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors. The frequency of Hashimoto’s disease is a growing trend and among Caucasians it is estimated at approximately 5%. The dysfunction of the gland may be clinically evident (0.1–2% of the population) or subclinical (10–15%). The pathology is diagnosed five to ten times more often in women than men and its incidence increases with the age (the peak of the number of cases is between 45 and 65); however, it can also be diagnosed in children. The pathogenesis of Hashimoto’s thyroiditis is still not fully comprehended. In the etiology of Hashimoto thyroiditis excessively stimulated T CD4+ cells are known to play the most important role. Recent research has demonstrated an increasing role of newly discovered cells such as Th17 (CD4+IL-17+) or T regulatory cells (CD4+CD25+highFoxP3+) in the induction of autoimmune disorders. The process of programmed cell death also plays an equally important role in the pathogenesis and the development of hypothyroidism.

scholarly journals Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome

2015 ◽  
Vol 5 (2) ◽  
pp. e1062208 ◽  
Author(s):  
Astrid Olsnes Kittang ◽  
Shahram Kordasti ◽  
Kristoffer Evebø Sand ◽  
Benedetta Costantini ◽  
Anne Marijn Kramer ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Disease Progression ◽  
T Regulatory Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Regulatory Cells

Dexamethasone affects day/night development and function of thymus-derived T regulatory cells

Immunobiology ◽  
2019 ◽  
Vol 224 (5) ◽  
pp. 614-624
Author(s):  
Ewelina Kiernozek ◽  
Anna Bieńkowska ◽  
Magdalena Markowska ◽  
Ewa Kozlowska ◽  
Nadzieja Drela
Keyword(s):  
T Regulatory Cells ◽  
Regulatory Cells ◽  
And Function

scholarly journals Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Irina Lyadova Vladimirovna ◽  
Ekaterina Sosunova ◽  
Alexander Nikolaev ◽  
Tatiana Nenasheva
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Responses ◽  
Immune Regulation ◽  
T Regulatory Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Regulatory Cells ◽  
B Regulatory Cells ◽  
Immature Cells

To protect host against immune-mediated damage, immune responses are tightly regulated. The regulation of immune responses is mediated by various populations of mature immune cells, such as T regulatory cells and B regulatory cells, but also by immature cells of different origins. In this review, we discuss regulatory properties and mechanisms whereby two distinct populations of immature cells, mesenchymal stem cells, and myeloid derived suppressor cells mediate immune regulation, focusing on their similarities, discrepancies, and potential clinical applications.

Sign in / Sign up

Export Citation Format

Share Document