scholarly journals Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Sumadhya Deepika Fernando ◽  
Chaturaka Rodrigo ◽  
Senaka Rajapakse
Keyword(s):  
Current Evidence ◽  
Endosymbiotic Bacterium ◽  
Infection Rates ◽  
Bancroftian Filariasis ◽  
Drug Management ◽  
Treatment Regimens ◽  
Long Term Impact ◽  
Followup Studies

Many trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis. Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-established microfilaricidal and some macrofilaricidal effects. Ivermectin (IVM) is highly microfilaricidal but minimally macrofilaricidal. The role of albendazole (ALB) in treatment regimens is not well established though the drug has a microfilaricidal effect. The combination of DEC+ALB has a better long-term impact than IVM+ALB. Recent trials have shown that doxycycline therapy againstWolbachia, an endosymbiotic bacterium of the parasite, is capable of reducing microfilaria rates and adult worm activity. Followup studies on mass drug administration (MDA) are yet to show a complete interruption of transmission, though the infection rates are reduced to a very low level.

Considering a Potential Role of Linalool as a Mood Stabilizer for Bipolar Disorder

2020 ◽  
Vol 26 (40) ◽  
pp. 5128-5133
Author(s):  
Kate Levenberg ◽  
Wade Edris ◽  
Martha Levine ◽  
Daniel R. George
Keyword(s):  
Bipolar Disorder ◽  
Treatment Options ◽  
Mood Stabilizer ◽  
Well Being ◽  
Epidemiologic Studies ◽  
Treatment Regimens ◽  
Bipolar Spectrum Disorders ◽  
Short And Long Term

Epidemiologic studies suggest that the lifetime prevalence of bipolar spectrum disorders ranges from 2.8 to 6.5 percent of the population. To decrease morbidity and mortality associated with disease progression, pharmacologic intervention is indicated for the majority of these patients. While a number of effective treatment regimens exist, many conventional medications have significant side effect profiles that adversely impact patients’ short and long-term well-being. It is thus important to continue advancing and improving therapeutic options available to patients. This paper reviews the limitations of current treatments and examines the chemical compound Linalool, an alcohol found in many plant species, that may serve as an effective mood stabilizer. While relatively little is known about Linalool and bipolar disorder, the compound has been shown to have antiepileptic, anti-inflammatory, anxiolytic, anti-depressive, and neurotrophic effects, with mechanisms that are comparable to current bipolar disorder treatment options.

The Role of UBI in Mitigating the Effects of Psychosocial Stressors: A Review and Proposal

2021 ◽  
pp. 003329412110051
Author(s):  
Rashmi Gupta ◽  
Jemima Jacob ◽  
Gaurav Bansal
Keyword(s):  
Role Stress ◽  
Psychosocial Stressors ◽  
Basic Income ◽  
Economic Stability ◽  
The Past ◽  
Individual Outcomes ◽  
Long Term Impact ◽  
The Impact

Psychosocial stressors and social disadvantages contribute to inequalities in opportunities and outcomes. In the current paper, we use an epidemiological perspective and highlight the role stress plays on individuals by reviewing the outcomes of major stressors such as poverty and unemployment. We further analyzed the psychological and physical cost of these stressors and their long-term impact. We examined the role of universal basic income and closely looked at income experiments that were implemented in the past, in terms of their effectiveness in enhancing the community as well as individual outcomes and propose the UBI as a tool for alleviating the impact of these stressors. At a time when a major pandemic (e.g., COVID-19) threatens economic stability and health globally, we believe the UBI is relevant now, more than ever.

scholarly journals Sinabung volcano: how culture shapes community resilience

2019 ◽  
Vol 28 (3) ◽  
pp. 290-303
Author(s):  
Marta Mori ◽  
Ronan McDermott ◽  
Saut Sagala ◽  
Yasmina Wulandari
Keyword(s):  
Structured Interviews ◽  
Content Type ◽  
Aid Dependency ◽  
Relief Operations ◽  
Long Term Impact ◽  
Cultural Experts ◽  
Practical Implications

Purpose The purpose of this paper is to explore how culture, including traditions and social structures, can influence resilience and how culturally sensitive relief operations can put affected people and their context at the core of any interventions. Design/methodology/approach A case study of the Mt Sinabung volcano area in Indonesia was undertaken. As part of the case study, an analysis of interventions was conducted, which was complemented by semi-structured interviews with Karo cultural experts and humanitarian organisations. Findings Culture influences the manner in which the Karo people react to volcano eruptions with varying implications for recovery. In addition, relief organisations which understand people’s actions through a cultural lens have better managed to tailor programs with long-term impact, thereby avoiding aid dependency. Practical implications Practical examples of disaster management activities that adequately account for the beneficiaries’ way of living prior to the eruptions are provided. Aid actors are provided with guidance concerning how to better tailor their activities in line with a cultural lens. Originality/value The study provides empirical grounding for claims concerning the role of culture in planning interventions in Indonesia and other similar contexts.

Increasing Access or Widening Choice: The Role of Resold Public-Sector Dwellings in the Housing Market

1992 ◽  
Vol 24 (11) ◽  
pp. 1585-1598 ◽  
Author(s):  
N J Williams ◽  
F E Twine
Keyword(s):  
Public Sector ◽  
Housing Market ◽  
Housing Policy ◽  
Housing Association ◽  
Lower Income ◽  
General Government ◽  
Policy Shift ◽  
Long Term Impact

British housing policy has, since 1979, been dominated by a shift from collectivist to market-oriented strategies. The single most important element of this policy shift has been the sale of public-sector dwellings to sitting tenants. The patterns of such sales have been well documented, but the longer-term effects on the broader housing market are less well understood. This paper is a report of the results of a research project into the resale by purchasing tenants of Scottish Special Housing Association dwellings over the period 1979–90. The findings are placed in the broader context of the general government housing policy aimed at widening the access to owner occupation for lower-income households. The authors conclude that the long-term impact of the sale of public-sector dwellings is more likely to widen choice for existing owners rather than to increase access to owner occupation.

“Poor Peasant, Poor Country”?

2020 ◽  
pp. 112-134
Author(s):  
Steven J. Ericson
Keyword(s):  
Foreign Trade ◽  
Government Spending ◽  
Poor Country ◽  
Rural Sector ◽  
Short And Long Term ◽  
Poor Peasant ◽  
Long Term Impact

This chapter discusses the Matsukata deflation and its impact on domestic agriculture and industry and on foreign trade. Regardless of whether scholars hold negative or positive views of the Matsukata reform, they have tended to overstate both the short- and long-term impact of the deflation-induced depression as well as the role of the reform itself in bringing about the “Matsukata deflation” in the first place. If Matsukata had strictly followed an orthodox program of financial stabilization, the depression would likely have been as severe as most accounts claim. But his deviations from orthodoxy—boosting government spending, promoting exports of commodities from the rural sector, and the like—helped to buffer the economy and abridge the downturn. In short, the chapter asserts that one needs to qualify the commonly held view that the Matsukata reform was “a devastating experience for millions of people.”

The Role of the Researcher in New Information Infrastructure Research

2012 ◽  
pp. 196-217
Keyword(s):  
Critical Reflection ◽  
Information Infrastructure ◽  
Methodological Choices ◽  
Is Research ◽  
New Information ◽  
Reflective Development ◽  
Long Term Impact ◽  
Research Choices

In this chapter, the role of the researcher in new information infrastructure research is explored. The key ideas informing this chapter are drawn from a critical reflection on trends in information systems (IS) research and the need for a more pragmatic approach (Constantinides et al., 2012). The focus is on developing a better understanding of the consequences of research choices by drawing on the notion of phronesis – the reflective development of prudent knowledge that is continuously shaped by and imbued with situated values and interests (Flyvberg, 2001). Specifically, it is argued that, IS researchers must recognize that research involves not just choices about how to conduct a study (i.e. theoretical and methodological choices), but also about why we study what we study and who is affected by our work (i.e. the desirable outcomes and long-term impact of research).

Silvio Berlusconi and the Italian presidency: accordions, triangles and constitutional change

Modern Italy ◽  
2015 ◽  
Vol 20 (1) ◽  
pp. 77-90 ◽  
Author(s):  
Paul Furlong
Keyword(s):  
The Political ◽  
Constitutional Change ◽  
Party Leaders ◽  
Political Role ◽  
The Status ◽  
Long Term Impact ◽  
The Impact ◽  
Silvio Berlusconi

This article considers the changed role of the Italian presidency and the impact and legacy of Silvio Berlusconi on this. After consideration of some of the methodological difficulties raised by these issues, the article looks at the role of the presidency up to 1992, when the presidency was interpreted in narrow terms set by the framers of the 1948 constitution and by the predominance of the party leaders of the period over the political direction of the State. The article considers how presidents from Sandro Pertini (1978–85) on, sought in different ways to expand the political role of their office. The article analyses the different ways that Oscar Luigi Scalfaro, Carlo Azeglio Ciampi and Giorgio Napolitano used their formal and informal powers both to maintain the status of the office and to promote political goals, and concludes with an assessment of the likely long-term impact of these changes and of Berlusconi's role in them.

The future of gout management

2016 ◽  
Author(s):  
Nicola Dalbeth
Keyword(s):  
Coronary Artery Disease ◽  
Models Of Care ◽  
Common Condition ◽  
Lowering Therapy ◽  
Artery Disease ◽  
Long Term Impact ◽  
Effective Use ◽  
Morbid Conditions

At present, despite the increasing prevalence of the disease, gout is poorly treated. Alternative models of care within primary care offer new opportunities for effective gout management. In addition to more effective use of approved agents, future gout management will be improved with increasing availability of new urate-lowering drugs. The role of urate-lowering therapy for asymptomatic hyperuricaemia, particularly in the context of co-morbid conditions such as chronic kidney disease, hypertension, and coronary artery disease is currently unknown; large clinical trials are needed to address this key question. Wider and earlier adoption of urate-lowering therapy in those with established gout is likely to reduce the long-term impact of this common condition.

Treat registry: Examination of the long-term impact of various Crohn's disease treatment regimens

2000 ◽  
Vol 118 (4) ◽  
pp. A1094
Author(s):  
William J. Sandborn ◽  
Gary L. Lichtenstein ◽  
Brian G. Feagan ◽  
Stephen B. Hanauer ◽  
Jeffrey S. Hyams ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Treatment ◽  
Treatment Regimens ◽  
Long Term Impact
Sign in / Sign up

Export Citation Format

Share Document