scholarly journals Prognostic Factors for Tumor Recurrence after a 12-Year, Single-Center Experience of Liver Transplantations in Patients with Hepatocellular Carcinoma

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Matteo Cescon ◽  
Matteo Ravaioli ◽  
Gian Luca Grazi ◽  
Giorgio Ercolani ◽  
Alessandro Cucchetti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Microvascular Invasion ◽  
Proportional Hazard ◽  
Single Center ◽  
Tumor Treatment ◽  
Factors Affecting ◽  
Single Center Experience ◽  
Liver Transplantations

Background. Factors affecting outcomes after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) have been extensively studied, but some of them have only recently been discovered or reassessed.Methods. We analyzed classical and more recently emerging variables with a hypothetical impact on recurrence-free survival (RFS) in a single-center series of 283 patients transplanted for HCC between 1997 and 2009.Results. Five-year patient survival and RFS were 75% and 86%, respectively. Thirty-four (12%) patients had HCC recurrence. Elevated preoperative alpha-fetoprotein (AFP) levels, preoperative treatments of HCC, unfulfilled Milan and up-to-seven criteria at final histology, poor tumor differentiation, and tumor microvascular invasion negatively affected RFS by univariate analysis. Milan and up-to-seven criteria applied preoperatively, and the use of m-TOR inhibitors did not reach statistical significance. Cox's proportional hazard model showed that only elevated AFP levels (Odds ; 95% –5.80; ), preoperative tumor treatments (Odds ; 95% –16.42; ), and microvascular invasion (Odds ; 95% –12.41; ) were predictors of lower RFS.Conclusions. Biological aggressiveness and preoperative tumor treatment, rather than traditional and expanded dimensional criteria, conditioned the outcomes in patients transplanted for HCC.

Preoperative Albumin-to-Globulin Ratio Predicts Prognosis in Hepatocellular Carcinoma: A Cohort Study Including Non-Hepatitis Virus-Infected Patients

2021 ◽  
pp. 1-9
Author(s):  
Masashi Utsumi ◽  
Koji Kitada ◽  
Naoyuki Tokunaga ◽  
Toru Narusaka ◽  
Ryosuke Hamano ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis Virus ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Microvascular Invasion ◽  
The Relationship ◽  
Clinicopathological Variables ◽  
Preoperative Albumin ◽  
Albumin To Globulin Ratio

<b><i>Introduction:</i></b> We evaluated the prognostic significance of the preoperative albumin-to-globulin ratio (AGR) in patients with hepatocellular carcinoma (HCC) with various liver etiologies. <b><i>Methods:</i></b> We retrospectively analyzed 157 patients with HCC between July 2010 and February 2021. The relationship between clinicopathological variables was investigated using univariate and multivariate analyses. Statistical significance was set at <i>p</i> &#x3c; 0.05. <b><i>Results:</i></b> The mean overall survival (OS) was 24.5 months. The 1-, 3-, and 5-year OS rates were 90.4%, 81.2%, and 68.7%, respectively. Patients were classified into 2 groups: AGR &#x3c;1.16 (low-AGR group; <i>n</i> = 43) and AGR ≥1.16 (high-AGR group; <i>n</i> = 114). In univariate analysis, OS was significantly reduced in patients with a low AGR (AGR &#x3c;1.16), an alpha-fetoprotein level ≥25 ng/mL, a tumor size ≥3.5 cm, microvascular invasion, and poor tumor differentiation. In multivariate analysis, a low AGR (hazard ratio [95% confidence interval]) (2.394 [1.092–5.213]; <i>p</i> = 0.030) and microvascular invasion (2.268 [1.019–5.169]; <i>p</i> = 0.045) were independent predictors of OS. <b><i>Discussion/Conclusion:</i></b> A low AGR was significantly associated with poor OS in patients with HCC, regardless of liver etiology. This may assist in treatment stratification and better management of patients with HCC.

Liver transplantation for hepatocellular carcinoma: A single center experience

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
V Stadlbauer ◽  
S Schaffellner ◽  
D Kniepeiss ◽  
E Jakoby ◽  
F Iberer ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Single Center ◽  
Single Center Experience

Abstract 16884: Evaluating the Effectiveness of Atrial Fibrillation Ablation Guided by Spatiotemporal Electrogram Dispersion

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Brian Liu ◽  
Arismendy Nunez-Garcia ◽  
Cao Tran ◽  
Michael Wu
Keyword(s):  
Atrial Fibrillation ◽  
Atrial Tachycardia ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
External Validation ◽  
Posterior Wall ◽  
High Rate ◽  
Single Center Experience ◽  
The Mean

Introduction: Catheter ablation of atrial fibrillation (AF) guided by spatiotemporal dispersion (SD) of electrograms has been proposed as an ablation strategy to treat patients with persistent AF. However, external validation of this technique is lacking. Here we report a single center experience using ablation by SD. Hypothesis: Targeting regions with SD is associated with a high rate of termination and favorable freedom from AF among patients with persistent AF. Methods: Patients with persistent AF who underwent SD from November 2018 to January 2020 were included in this study. All patients underwent pulmonary vein isolation (PVI) in addition to targeting areas of SD. Lesions on areas of electrogram dispersion were anchored to the PVI or to mitral or posterior wall lines where appropriate. EKG, Holter, event monitors or device interrogations were obtained at 3 and 6 months to assess for arrhythmia recurrence. Results: 44 patients met the inclusion criteria and were included in the study. The patients had a mean age of 69±8 years and were 68 % male. The prevalence of comorbidities was as follows: hypertension (89%), diabetes (21%), OSA (37%) and CAD (26%). Average CHADSVASC score was 2.9±1.4, LVEF was 53±11% and left atrium (LA) diameter was 5.2±1 cm. The recurrence rate of AF at 6 months was 14% whereas the recurrence of atrial tachycardia was 20%. Acute AF termination was observed in 73% of the patients. Termination to sinus occurred in 38% of the patients and the remaining terminated to atrial tachycardia which was subsequently ablated to sinus. The mean procedure duration was 240±90 minutes. Univariate analysis showed recurrence was associated with LA diameter (r=.52; p<.001). No recurrences were observed among patients with a LA diameter < 5 cm. Termination rates were higher among patients with LA diameter < 5 cm when compared to LA diameter ≥ 5 cm. However, it did not reach statistical significance (80% vs. 60%; p=.21). Conclusions: The target of electrograms with SD during AF ablation added to PVI was associated with a high termination rate and a good freedom from AF recurrence at 6 months. The ideal candidate for this procedure may be those with LA diameter < 5 cm among persistent AF. The long-term efficacy of this technique merits further studies in larger populations.

Abstract P220: Hemorrhagic Stroke Patients Admitted to Inpatient Rehabilitation Facilities Improve Differently Based on Their Involvement of Corticospinal Tract

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Shayandokht Taleb ◽  
Dorothea Parker ◽  
Lamya Ibrahim ◽  
Billie Hsieh ◽  
Muhammad E Haque ◽  
...  
Keyword(s):  
Corticospinal Tract ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Inpatient Rehabilitation ◽  
Functional Improvement ◽  
Volume Estimate ◽  
Factors Affecting ◽  
Rehabilitation Facilities ◽  
And Gender ◽  
Time Of Admission

Introduction: We asked whether intracerebral hemorrhage (ICH) patients admitted to inpatient rehabilitation facilities(IRF) improve differently based on their involvement of the corticospinal tract(CST). Aim: To predict associating radiological factors affecting discharge FIM score. Methods: We reviewed the patients’ characteristics and their respective imaging findings presenting with ICH between 4/17 to 8/19. The ICH volume and edema around the ICH were measured using analyze software. The main outcome measure was FIM score at time of discharge. Statistical significance was set at 0.05. Results: Among the 53 patients included, 49% were female. The median age of the patients was 62 years (IQR 25,89). The median length of stay at IRF was 22days (IQR 14,26). In univariate analysis, FIM score at the time of discharge FIM score at the time of discharge admission were significantly associated with NIHSS (estimate -1.26, p<0.001), and ICH volume (estimate -3.45, p=0.01). However, the univariate analysis did not reveal an association of age (estimate -0.15, p=0.4) and gender (estimate 0.207, p=0.97) with FIM score at the time of discharge.Multiple regression analysis reflected that the CST involvement had a decrement in functional improvement on FIM in comparison with patients with intact CST when adjusting for age ( p = 0.008), gender ( p <0.01), NIHSS at the time of admission ( p <0.01), and the ICH volume ( p =0.02). Conclusion: This preliminary study suggests that functional improvement declines in ICH patients with CST involvement.

Biliary Complications After 52 Adult Living Donor Liver Transplantations: A Single-Center Experience

2008 ◽  
Vol 40 (8) ◽  
pp. 2539-2541 ◽  
Author(s):  
H. Iwamoto ◽  
K. Hama ◽  
Y. Nakamura ◽  
K. Osamu ◽  
T. Yokoyama ◽  
...  
Keyword(s):  
Living Donor ◽  
Biliary Complications ◽  
Single Center ◽  
Donor Liver ◽  
Single Center Experience ◽  
Liver Transplantations

scholarly journals Factors affecting successful colonoscopy procedures: Single-center experience

2018 ◽  
Author(s):  
Ramazan Kozan ◽  
◽  
Tonguc Utku Yilmaz ◽  
Uygar Bastugral ◽  
Umut Kerimoglu ◽  
...  
Keyword(s):  
Single Center ◽  
Factors Affecting ◽  
Single Center Experience

scholarly journals Single-center experience on actual mid-term (≥5 years) and long-term (≥10 years) survival outcome in patients with hepatocellular carcinoma after curative hepatectomy

Medicine ◽  
2020 ◽  
Vol 99 (48) ◽  
pp. e23358
Author(s):  
Andrew K.Y. Fung ◽  
Nicole M.Y. Cheng ◽  
Charing C.N. Chong ◽  
Kit-Fai Lee ◽  
John Wong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Survival Outcome ◽  
Single Center ◽  
Single Center Experience ◽  
Curative Hepatectomy
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