scholarly journals Rhabdomyolysis-Induced Acute Renal Failure Following Fenofibrate Therapy: A Case Report and Literature Review

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Ramazan Danis ◽  
Sami Akbulut ◽  
Sehmus Ozmen ◽  
Senay Arikan
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Metabolic Disorders ◽  
Cell Damage ◽  
Pathological Condition ◽  
Skeletal Muscle Cell ◽  
Fibric Acid Derivative ◽  
Alcohol And Drug Use ◽  
Laboratory Examinations

Fenofibrate, a fibric acid derivative, is used to treat diabetic dyslipidemia, hypertriglyceridemia, and combined hyperlipidemia, administered alone or in combination with statins. Rhabdomyolysis is defined as a pathological condition involving skeletal muscle cell damage leading to the release of toxic intracellular material into circulation. Its major causes include muscle compression or overexertion; trauma; ischemia; toxins; cocaine, alcohol, and drug use; metabolic disorders; infections. However, rhabdomyolysis associated with fenofibrate is extremely rare. Herein we report a 45-year-old female patient who was referred to our department because of generalized muscle pain, fatigue, weakness, and oliguria over the preceding 3 weeks. On the basis of the pathogenesis and clinical and laboratory examinations, a diagnosis of acute renal failure secondary to fenofibrate-induced rhabdomyolysis was made. Weekly followups for patients who are administered fenofibrate are the most important way to prevent possible complications.

Rhabdomyolysis and myoglobinuric renal failure

1990 ◽  
Vol 10 (3) ◽  
pp. 32-36 ◽  
Author(s):  
J Harper
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Critical Care ◽  
Patient Population ◽  
Clinical Syndrome ◽  
Skeletal Muscle Cell ◽  
Critical Care Nurses ◽  
Precipitating Factors ◽  
Optimal Function

Rhabdomyolysis, a clinical syndrome resulting from the release of skeletal muscle cell contents into the plasma, is causally connected to up to 25 percent of all cases of acute renal failure. Critical care nurses need to be aware of precipitating factors and proper interventions in order to assure optimal function in this patient population.

Plasma and Skeletal Muscle Free Aminoacids in Acute Renal Failure

1987 ◽  
pp. 93-98
Author(s):  
Almerico Novarini ◽  
Isabella Simoni ◽  
Rossana Colla ◽  
Antonio Trifirò ◽  
Achille Guariglia ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Free Aminoacids

Alcohol Related Non-traumatic Rhabdomyolysis and Compartment Syndrome

2007 ◽  
Vol 6 (1) ◽  
pp. 33-34
Author(s):  
JPL Ong ◽  
◽  
LA Thomas ◽  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Lower Extremity ◽  
Compartment Syndrome ◽  
Early Recognition ◽  
Clinical Entity ◽  
Threatening Condition ◽  
Life Threatening ◽  
Renal Support

Rhabdomyolysis is a serious and life-threatening condition in which skeletal muscle is damaged, commonly resulting in acute renal failure. The causes of this clinical entity can be traumatic and non-traumatic. In the latter group, alcohol is the commonest cause. This report describes the case of a 25 year old man who presented with rhabdomyolysis leading to acute renal failure after an alcohol binge. He presented with painful legs and lower extremity compartment syndrome. The patient recovered with surgical fasciotomy and renal support. This case illustrates the importance of early recognition and treatment of alcohol related non-traumatic rhabdomyolysis and compartment syndrome.

Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure

2005 ◽  
Vol 289 (6) ◽  
pp. R1770-R1776 ◽  
Author(s):  
David P. Basile ◽  
Deborah L. Donohoe ◽  
Shane A. Phillips ◽  
Jefferson C. Frisbee
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Pressor Response ◽  
Gracilis Muscle ◽  
Ang Ii ◽  
Sprague Dawley

In addition to the long-term renal complications, previous studies suggested that after acute renal failure (ARF), rats manifest an increased pressor response to an overnight infusion of ANG II. The present study tested whether recovery from ARF results in alterations in sensitivity to the peripheral vasculature. ARF was induced in Sprague-Dawley rats by 45 min of bilateral renal ischemia and reperfusion. Animals were allowed to recover renal structure and function for 5–8 wk, after which the acute pressor responses to ANG II were evaluated either in vivo in in situ skeletal muscle arterioles or in isolated gracilis muscle arteries in vitro. Baseline arterial pressure was not different in ARF rats vs. sham-operated controls, although ARF rats exhibited an enhanced pressor response to bolus ANG II infusion compared with control rats. Steady-state plasma ANG II concentration and plasma renin activity were similar between ARF and control rats. Constrictor reactivity of in situ cremasteric arterioles from ARF rats was enhanced in response to increasing concentrations of ANG II; however, no difference was observed in arteriolar responses to elevated Po2, norepinephrine, acetylcholine, or sodium nitroprusside. Isolated gracilis muscle arteries from ARF rats also showed increased vasoconstriction in response to ANG II but not norepinephrine. In conclusion, recovery from ischemic ARF is not associated with hypertension but is associated with increased arteriolar constrictor reactivity to ANG II. Although the mechanisms of this altered responsiveness are unclear, such changes may relate, in part, to cardiovascular complications in patients with ARF and/or after renal transplant.

scholarly journals Recent Updates on Mesenchymal Stem Cell Based Therapy for Acute Renal Failure

2019 ◽  
Vol 13 (4) ◽  
pp. 189-199 ◽  
Author(s):  
Asmaa Missoum
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Epithelial Cells ◽  
Adult Stem Cells ◽  
Pathological Condition ◽  
Organ Transplant ◽  
Kidney Injury ◽  
Cell Based Therapy ◽  
Toxic Damage

Acute kidney injury, formerly known as acute renal failure, is a pathological condition in which ischemia or toxic damage contributes to the loss of renal proximal tubule epithelial cells. Pathophysiological events such as oxidative stress, mitochondrial dysfunction, and direct renal tubular epithelial cells toxicity are responsible for the progression of the disease. This devastating decline in renal function affects mostly patients in the intensive care units and requires costly and invasive treatments such as dialysis and organ transplant. Fortunately, recent therapies such as the use of mesenchymal stem cells (MSCs) were proven to be effective in ameliorating renal failure via paracrine and immunomodulatory mechanisms. These fibroblast-like adult stem cells that differentiate multilineagely can be isolated from dental pulps, umbilical cords, amniotic fluids, adipose tissues, and bone marrows. Depending on their sources, the therapeutical application of each MSC type has its own capacities, advantages, and drawbacks. The review discusses and compares the latest research studies on the use of different MSCs sources to treat renal failure. Concerns about the future clinical application of MSCs such as homing, toxicity, and the risk of immune rejection are also highlighted.

scholarly journals D+ hemolytic uremic syndrome

2016 ◽  
Vol 44 (2) ◽  
pp. 80
Author(s):  
Ni Made Sumiartini ◽  
I Nyoman Lila ◽  
I Ketut Suarta
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Endothelial Cell ◽  
Hemolytic Uremic Syndrome ◽  
Cell Damage ◽  
Endothelial Cell Damage ◽  
Uremic Syndrome

Hemolytic uremic syndrome (HUS) is characterized by anemia microangiopathy, thrombocytopenia, and acute renalfailure, predominantly occurs in childrenyounger than 4 years of age. It is the most commoncause of acute renal failure in children.1,2 HUS is dividedinto two categories, the epidemic type which isaccompanied by enteritis (D+HUS) and the sporadictype which is not accompanied by enteritis (D-HUS).The pathogenesis is unknown, but available evidencestrongly suggests endothelial cell damage in the organs.

scholarly journals Renal Replacement Therapy in Acute Kidney Failure due to Rhabdomyolysis

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
G. Maggi ◽  
F. Quinteros Hinojosa ◽  
M. J. Villagran ◽  
E. Guasch Arévalo ◽  
F. Gilsanz Rodríguez
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Kidney Failure ◽  
The Usa ◽  
Prolonged Immobilization ◽  
Myoglobinuric Acute Renal Failure ◽  
Main Complication

Rhabdomyolysis is a syndrome caused by skeletal muscle cells destruction which can occur for many reasons, including prolonged immobilization. The main complication of the syndrome is the development of acute renal failure. Rhabdomyolysis and myoglobinuria are responsible for approximately 5% of all causes of acute renal failure in the USA. The cause of rhabdomyolysis is often multifactorial, and approximately 8–20% of such patients develop myoglobinuric acute renal failure.

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