scholarly journals Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Ivaylo Gentschev ◽  
Ulrike Donat ◽  
Elisabeth Hofmann ◽  
Stephanie Weibel ◽  
Marion Adelfinger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vaccinia Virus ◽  
Human Prostate ◽  
Tumor Xenograft ◽  
Regional Lymph Nodes ◽  
Human Prostate Carcinoma ◽  
Xenograft Models ◽  
Proliferation Assays ◽  
Virus Strains ◽  
New Strategies

Virotherapy using oncolytic vaccinia virus strains is one of the most promising new strategies for cancer therapy. In the current study, we analyzed the therapeutic efficacy of the oncolytic vaccinia virus GLV-1h68 against two human prostate cancer cell lines DU-145 and PC-3 in cell culture and in tumor xenograft models. By viral proliferation assays and cell survival tests, we demonstrated that GLV-1h68 was able to infect, replicate in, and lyse these prostate cancer cells in culture. In DU-145 and PC-3 tumor xenograft models, a single intravenous injection with GLV-1h68 resulted in a significant reduction of primary tumor size. In addition, the GLV-1h68-infection led to strong inflammatory and oncolytic effects resulting in drastic reduction of regional lymph nodes with PC-3 metastases. Our data documented that the GLV-1h68 virus has a great potential for treatment of human prostate carcinoma.

Methylglyoxal–Induced Apoptosis in Human Prostate Carcinoma: Potential Modality for Prostate Cancer Treatment

2000 ◽  
Vol 37 (6) ◽  
pp. 728-734 ◽  
Author(s):  
Dan M. Milanesa ◽  
Muhammad S. Choudhury ◽  
Camille Mallouh ◽  
Hiroshi Tazaki ◽  
Sensuke Konno
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Prostate Carcinoma ◽  
Human Prostate ◽  
Prostate Cancer Treatment ◽  
Human Prostate Carcinoma ◽  
Induced Apoptosis

scholarly journals Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft

2007 ◽  
Vol 28 (12) ◽  
pp. 2567-2574 ◽  
Author(s):  
R. P. Singh ◽  
G. Deep ◽  
M.-J. Blouin ◽  
M. N. Pollak ◽  
R. Agarwal
Keyword(s):  
Prostate Carcinoma ◽  
Human Prostate ◽  
Tumor Xenograft ◽  
Human Prostate Carcinoma ◽  
In Vivo Growth

CCL2 INCREASES IN VIVO TUMOR GROWTH OF HUMAN PROSTATE CANCER PC-3 TUMOR XENOGRAFT

2009 ◽  
Vol 181 (4S) ◽  
pp. 264-264
Author(s):  
Kosuke Mizutani ◽  
Sudha Sud ◽  
Zachary Varsos ◽  
Hernan Roca ◽  
Kenneth J Pienta
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Human Prostate ◽  
Tumor Xenograft ◽  
Human Prostate Cancer

scholarly journals Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: Implications for xenograft models of human prostate cancer

2015 ◽  
Vol 333 (1) ◽  
pp. 136-146 ◽  
Author(s):  
J.E. Lisle ◽  
I. Mertens-Walker ◽  
C.R. Stephens ◽  
S.H. Stansfield ◽  
J.A. Clements ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Serine Protease ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Kallikrein 4 ◽  
Xenograft Models

scholarly journals MP07-19 NEW MOUSE XENOGRAFT MODELS FOR HUMAN PROSTATE CANCER BONE AND BRAIN METASTASES

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Qinlong Li ◽  
Lijuan Yin ◽  
Michael Lewis ◽  
Peng Duan ◽  
Lawrence W. Jones ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Brain Metastases ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Mouse Xenograft ◽  
Xenograft Models

scholarly journals Optimizing live‐animal bioluminescence imaging prediction of tumor burden in human prostate cancer xenograft models in SCID‐NSG mice

The Prostate ◽  
2019 ◽  
Vol 79 (9) ◽  
pp. 949-960
Author(s):  
Sangyub Kim ◽  
Yong Zhang ◽  
Suni Tang ◽  
Chongtao Qin ◽  
Deepkamal Karelia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bioluminescence Imaging ◽  
Tumor Burden ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Live Animal ◽  
Nsg Mice ◽  
Xenograft Models
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