scholarly journals Tako-Tsubo Cardiomyopathy in a Patient with Advanced Colorectal Adenocarcinoma

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Yusuf Kasirye ◽  
Ihab B. Abdalrahman
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Colorectal Adenocarcinoma ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Advanced Malignancy ◽  
Coronary Syndrome ◽  
Triggering Factors ◽  
Tako Tsubo Cardiomyopathy ◽  
Postmenopausal Female

Transient left ventricular dysfunction syndrome (TLVDS), or Tako-Tsubo cardiomyopathy (TC), is a clinical entity in which patients present with features of acute coronary syndrome, electrocardiogram abnormalities, and transient left ventricular (apical or mid-ventricular) dysfunction. Patients usually recover from this condition four to six weeks after the event. The etiology or triggering factors of TC remains unknown. Various triggering factors have been associated with this syndrome, with one of the most recent being malignancies. In this case report we present a postmenopausal female with underlying advanced malignancy who presented with TC. This is consistent with a recent hypothesis that in addition to currently known triggering factors, malignancies might well trigger TC in the context of a stressor or paraneoplastic phenomenon.

scholarly journals Takotsubo Cardiomyopathy Due to Combined Use of Phentermine and Lisdexamfetamine

2020 ◽  
Author(s):  
Tara Burleigh ◽  
Khandalavala Birgit
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Left Ventricular ◽  
Ventricular Wall ◽  
Takotsubo Syndrome ◽  
Coronary Syndrome ◽  
First Case ◽  
Combined Use ◽  
Menopausal Women ◽  
Post Menopausal

Objectives: This is the first case report of iatrogenic Takotsubo syndrome (TS) due to a combination of lisdexamfetamine and phentermine. Background: TS is characterized by transient acute ballooning of the left ventricular wall. Typically, it occurs in extremely stressed post-menopausal women, however a few iatrogenic causes have been described recently. Results: A 55-year old woman prescribed lisdexamfetamine and phentermine, presented with acute substernal chest pain. Acute coronary syndrome was excluded. The echocardiogram was diagnostic of TS, and she recovered spontaneously, with supportive care. Conclusion: Caution with the use of sympathomimetic medications in post-menopausal women appears warranted.

Abstract 17575: Looking Beyond Left Ventricular Ejection Fraction: Investigating the Utility of Multi-factorial Computational Modeling to Predict Sudden Cardiac Death Following Acute Coronary Syndrome in the MERLIN-TIMI36 Trial

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Alex Van Esbroeck ◽  
Mohammed Saeed ◽  
Benjamin M Scirica ◽  
Collin M Stultz ◽  
John V Guttag ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Sudden Cardiac Death ◽  
Left Ventricular Ejection Fraction ◽  
Cardiac Death ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Clinical Parameters ◽  
Ventricular Ejection Fraction ◽  
Coronary Syndrome

Introduction: Guidelines to prevent sudden cardiac death (SCD) following acute coronary syndrome (ACS) are widely based on cutoffs defined on left ventricular ejection fraction (LVEF) with limited use of other available data. Methods: We investigated the improvement in predicting post-ACS SCD using a multi-factorial model that integrates an assessment of left ventricular dysfunction through echocardiography with a broader set of other parameters collected routinely during hospitalization for ACS. Patients in the MERLIN-TIMI36 trial were admitted within 48 hours of ischemic symptoms for non-ST-elevation ACS and followed for a median of 348 days. SCD was adjudicated by a blinded clinical events committee. Data from 4,404 patients with LVEF and other clinical parameters routinely collected during index hospitalization (demographic, comorbidity, history, laboratory, electrocardiographic, and medication variables) were used to train and validate a logistic regression model to predict SCD using stepwise backward elimination and leave-one-out cross-validation. Results: The stepwise elimination process retained age, history of congestive heart failure, ST depression, beta blocker use, BNP, LVEF, and ischemia and ventricular tachycardia on continuous ECG as variables in the model. The model achieved significant improvements in discrimination, calibration and reclassification relative to LVEF, and demonstrated further utility in stratifying patients with mild/moderate left ventricular dysfunction or normal systolic function (Table 1). The model also resulted in higher sensitivity without increasing false positives relative to the LVEF<=30% rule (38% increase in correct predictions of SCD). Conclusions: Risk stratification for post-ACS SCD is significantly improved using multi-factorial models to integrate information in LVEF with other clinical parameters routinely collected during hospitalization.

Left ventricular apical ballooning—A novel cardiac disease mimicking acute coronary syndrome: A case report in a Caucasian patient

2006 ◽  
Vol 106 (3) ◽  
pp. 398-400 ◽  
Author(s):  
Johann Auer ◽  
Michael Porodko ◽  
Robert Berent ◽  
Christian Punzengruber ◽  
Thomas Weber ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Report ◽  
Cardiac Disease ◽  
Apical Ballooning ◽  
Left Ventricular ◽  
Caucasian Patient ◽  
Coronary Syndrome
Sign in / Sign up

Export Citation Format

Share Document