scholarly journals Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Treated by Mohs Micrographic Surgery—A Case Report with Literature Review

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Yaohui G. Xu ◽  
Molly Hinshaw ◽  
B. Jack Longley ◽  
Humza Ilyas ◽  
Stephen N. Snow
Keyword(s):  
Literature Review ◽  
Adenoid Cystic Carcinoma ◽  
Perineural Invasion ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Mohs Surgery ◽  
Adenoid Cystic ◽  
Infiltrative Growth Pattern ◽  
Ideal Method

We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery. The patient remained tumor-free at 24-month follow-up. To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery. Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurrence after excision. We propose that Mohs surgery is an ideal method to achieve margin-free removal of cutaneous adenoid cystic carcinoma. A brief literature review is provided.

Adenoid Cystic Carcinoma of the Gingiva: A Case Report and Literature Review

2021 ◽  
pp. 000348942110555
Author(s):  
Gabriella T. Seo ◽  
Monica H. Xing ◽  
Neil Mundi ◽  
Ammar Matloob ◽  
Azita S. Khorsandi ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Literature Review ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Adjuvant Radiation ◽  
Minor Salivary Glands ◽  
Adjuvant Radiation Therapy ◽  
Adenoid Cystic ◽  
Left Mandible

Objectives: Adenoid cystic carcinoma (ACC) is a commonly encountered salivary gland malignancy. However, it rarely occurs in the gingiva, an area generally thought to be devoid of minor salivary glands. We present a case occurring in this unusual site and review other reported cases. Methods: A 56 year-old male presented with a right-sided mandibular toothache for 1 year and underwent dental extraction. Due to persistent pain, follow up examination revealed a large gingival lesion. A biopsy was positive for adenoid cystic carcinoma. Results: The patient underwent a complete right segmental mandibulectomy and was reconstructed with a fibular osteocutaneous free flap. Three months postoperatively, during the planning for adjuvant radiation therapy, the patient developed pain in the left mandible. Imaging revealed extensive involvement of the left native mandible. Deep bone biopsies in several areas of the left mandible revealed ACC. He then underwent a complete left hemi-mandibulectomy and reconstruction with a fibular osteocutaneous free flap. Tensor fascia lata suspension slings were placed due to concern for an open mouth deformity attributable to disruption of bilateral masticator slings. He will undergo adjuvant radiation therapy. Our review of the literature revealed 50 cases of gingival ACC published since 1972. Disease recurrence and distant metastases were noted in several patients, occurring at the latest after 30 years follow-up. Conclusions: Given its indolent behavior, high proclivity for late recurrence and metastasis, and overall infrequency, ACC represents a pathology that requires early diagnosis and comprehensive long-term surveillance. While ACC is well described in oral cavity sites with high densities of minor salivary glands, it is not commonly seen in the gingiva. As such, gingival ACC may display a unique biological and/or clinical character. We offer the first literature review of this rare entity.

Recurrent Adenoid Cystic Carcinoma of the Scalp Treated With Mohs Micrographic Surgery

2003 ◽  
Vol 29 (6) ◽  
pp. 647-649 ◽  
Author(s):  
Aleksandar L. Krunic ◽  
Sang Kim ◽  
Maria Medenica ◽  
Anne E. Laumann ◽  
Keyoumars Soltani ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Adenoid Cystic

Recurrent Adenoid Cystic Carcinoma of the Scalp Treated With Mohs Micrographic Surgery

2003 ◽  
Vol 29 (6) ◽  
pp. 647-649
Author(s):  
ALEKSANDAR L. KRUNIC ◽  
SANG KIM ◽  
MARIA MEDENICA ◽  
ANNE E. LAUMANN ◽  
KEYOUMARS SOLTANI ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Adenoid Cystic

scholarly journals Polymorphous Low-Grade Adenocarcinoma

2014 ◽  
Vol 29 (2) ◽  
pp. 39-40
Author(s):  
Joy B. Bernido ◽  
Jose M. Carnate
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Growth Pattern ◽  
Perineural Invasion ◽  
Salivary Gland Tumor ◽  
Nodal Metastasis ◽  
Low Grade ◽  
Adenoid Cystic ◽  
Infiltrative Growth Pattern

A 60-year-old woman with a 3-year history of a gingivoalveopalatal mass underwent an incision biopsy. Microscopically, the lesion centered in the stroma is infiltrative (Fig. 1) and architecturally diverse, having cystic (Fig. 2), linear or “Indian file” (Fig. 3), solid, and tubular (Fig. 4) patterns.  The cells are uniform in size, round to oval, and have bland cytologic features, with vesicular nuclei and inconspicuous nucleoli (Figure 4). The clinical data and histomorphologic features characterized by architectural diversity yet cytologic blandness lead us to the diagnosis of polymorphous low-grade adenocarcinoma.   Polymorphous low-grade adenocarcinoma (PLGA) is a malignant epithelial tumor characterized by cytologic uniformity, morphologic diversity, an infiltrative growth pattern, and low metastatic potential.1 It is the second most common intraoral malignant salivary gland tumor 1 following mucoepidermoid carcinoma.  The tumor is found almost exclusively in minor salivary glands and is rare in extraoral locations, including major salivary glands.2 The tumor affects a wide age range (16 – 95 years; mean 60 years), with only 2 pediatric cases reported,1 and has a female predilection.3,4  It usually presents as a painless mass located within the oral cavity,3 60% of which are located in the palate.1  They are characteristically unencapsulated, although well-circumscribed.3    This entity is architecturally diverse (“polymorphous”) even within a single tumor, with solid, tubular, trabecular, cribriform, papillary and linear patterns being described. Perineural invasion is common although it was not seen in this case.  The tumor cells are small to medium sized, and uniformly round to polygonal.  The nuclei are bland and vesicular, with occasional small inconspicuous nucleoli. Mitotic figures can be found occasionally but are never numerous.3, 8   The morphologic heterogeneity in small biopsies and frozen section samples can be confused with pleomorphic adenoma and adenoid cystic carcinoma.6,7 Glial fibrillary acid protein may help as PLGA is typically non-reactive in contrast to pleomorphic adenoma.2  De Araujo and others site that uniformly positive vimentin, CK7, and S100 staining favors PLGA over adenoid cystic carcinoma.6  Tumor cytology and histology are quite characteristic - recognizing the constant cytological appearance despite the diversity of architectural tumor patterns should aid one in diagnosing PLGA. PLGA, despite its infiltrative growth pattern and propensity for perineural invasion, usually runs an indolent course.  Nodal metastasis and distant spread are rare, occurring in less than 1% of cases.4 Seethala and others report that extrapalatal location is associated with a more aggressive clinical course.5 Complete surgical excision is the primary treatment with neck dissection reserved for nodal metastasis.1 One-third of patients may have a local recurrence and lifelong monitoring is suggested. Re-excision is amenable in these cases.5,6  

Adenoid cystic carcinoma of the labium oris with rare metastasis to the pleural cavity

2021 ◽  
Vol 14 (1) ◽  
pp. e237622
Author(s):  
Osama Mosalem ◽  
Anas Alsara ◽  
Fawzi Abu Rous ◽  
Borys Hrinczenko
Keyword(s):  
Side Effects ◽  
Adenoid Cystic Carcinoma ◽  
Pleural Cavity ◽  
Epigastric Pain ◽  
Asian Woman ◽  
Upper Lip ◽  
Adenoid Cystic ◽  
History Of ◽  
The Right

A 57-year-old Southeast Asian woman with a remote history of adenoid cystic carcinoma (ACC) of the right labium superius oris (upper lip) presented to the hospital with vague epigastric pain. On workup, she was found to have multiple pleural nodules. Histopathology confirmed the diagnosis of metastatic ACC. After 8 months of active surveillance, evidence of disease progression was found and the patient was started on pembrolizumab. Follow-up after starting pembrolizumab showed stable disease with no significant side effects.

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