scholarly journals Acanthosis Nigricans in a Patient with Lung Cancer: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Duru Serap ◽  
Sever Özlem ◽  
Yüceege Melike ◽  
Dilli Alper ◽  
Albayrak Aynur ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Acanthosis Nigricans ◽  
Fiberoptic Bronchoscopy ◽  
Skin Lesions ◽  
Punch Biopsy ◽  
Left Lobe ◽  
Thoracic Computed Tomography ◽  
Malignant Acanthosis Nigricans ◽  
Paraneoplastic Dermatosis ◽  
Histopathologic Analysis

Some skin lesions may accompany malignancies. Acanthosis nigricans, one such lesion, is a paraneoplastic dermatosis characterized by hyperpigmented and velvety verrucose plaques observed as symetric eruptions. With this report, we aim to present a rare case of concomitant lung cancer and acanthosis nigricans. Malignant acanthosis nigricans is most commonly associated with intra-abdominal malignancies. A 65-year-old patient who had hyperpigmented, hypertrophic and symmetric verrucose lesions at the flexor surfaces of the lower and upper extremities, face, palms and the axillary region. Thoracic computed tomography demonstrated a hypodense mass lesion with a dimension of  cm at the center of basal segment bronchi of the left pulmonary lobe. Fiberoptic bronchoscopy showed that the access to the lower left lobe was almost completely obstructed by the endobronchial lesion. The result of the histopathologic examination of the endobronchial tissue biopsy was reported as non-small cell (adenocarcinoma) lung cancer. Result of the histopathologic analysis of the punch biopsy of the skin lesions was reported as acanthosis nigricans .There are no pathognomonic dermatological findings for lung cancer. In conclusion, there are skin lesions that accompany lung cancer and we believe that these should be considered for differential diagnosis.

scholarly journals Malignant Acanthosis Nigricans, Florid Cutaneous Papillomatosis and Tripe Palms Syndrome Associated with Gastric Adenocarcinoma - a Case Report

2015 ◽  
Vol 7 (1) ◽  
pp. 5-14
Author(s):  
Mirjana Paravina ◽  
Dragana Ljubisavljević
Keyword(s):  
Gastric Adenocarcinoma ◽  
Cancer Diagnosis ◽  
Acanthosis Nigricans ◽  
Fatal Outcome ◽  
Detailed Examination ◽  
Sudden Onset ◽  
Seborrheic Keratosis ◽  
Malignant Acanthosis Nigricans ◽  
Paraneoplastic Dermatosis ◽  
The Moment

Abstract Malignant acanthosis nigricans is a rare obligate paraneoplastic dermatosis which accounts for 20% of all acanthosis nigricans cases. The clinical features of the disease are the same as in the benign forms: symmetrical, hyperpigmented, velvety papillomatous lesions mostly involving the axillae, neck, groins, periumbilical cubital and popliteal areas, mammary areolae and less often mucous membranes. However, unlike other forms, it is characterized by sudden onset and rapid spread, commonly (80%) after the age of 40, which may be a marker of malignancy and a key to early diagnosis, indicating the need for a detailed examination. It is a disorder that has no gender differences. Most cases are detected at the moment of cancer diagnosis (61.3%), in fewer cases (about 20%) prior to cancer diagnosis, and in 21% at a later stage of malignant disease. Acanthosis nigricans is usually associated with one of the three or all three forms of paraneoplastic lesions: florid cutaneous papillomatosis, acanthosis palmaris (tripe palms, pachydermatoglyphia) involving the palms and soles, as well as multiple seborrheic keratosis (sign of Leser-Trélat). We report on a female patient with clinically established three paraneoplastic syndromes: malignant acanthosis nigricans, florid cutaneous papillomatosis, and acanthosis palmaris, which appeared before the diagnosis of advanced gastric adenocarcinoma, leading to fatal outcome.

scholarly journals Comprehensive Perspective for Lung Cancer Characterisation Based on AI Solutions Using CT Images

2020 ◽  
Vol 10 (1) ◽  
pp. 118
Author(s):  
Tania Pereira ◽  
Cláudia Freitas ◽  
José Luis Costa ◽  
Joana Morgado ◽  
Francisco Silva ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapies ◽  
Treatment Plan ◽  
Personalised Medicine ◽  
Growth Factor Receptor ◽  
Accurate Diagnosis ◽  
Cancer Development ◽  
Thoracic Computed Tomography ◽  
Plan Selection ◽  
Ct Image Analysis

Lung cancer is still the leading cause of cancer death in the world. For this reason, novel approaches for early and more accurate diagnosis are needed. Computer-aided decision (CAD) can be an interesting option for a noninvasive tumour characterisation based on thoracic computed tomography (CT) image analysis. Until now, radiomics have been focused on tumour features analysis, and have not considered the information on other lung structures that can have relevant features for tumour genotype classification, especially for epidermal growth factor receptor (EGFR), which is the mutation with the most successful targeted therapies. With this perspective paper, we aim to explore a comprehensive analysis of the need to combine the information from tumours with other lung structures for the next generation of CADs, which could create a high impact on targeted therapies and personalised medicine. The forthcoming artificial intelligence (AI)-based approaches for lung cancer assessment should be able to make a holistic analysis, capturing information from pathological processes involved in cancer development. The powerful and interpretable AI models allow us to identify novel biomarkers of cancer development, contributing to new insights about the pathological processes, and making a more accurate diagnosis to help in the treatment plan selection.

scholarly journals Malignant acanthosis nigricans, florid cutaneous papillo matosis and tripe palms syndrome associated with gastric adenocarcinoma

2014 ◽  
Vol 1 ◽  
pp. 56-58 ◽  
Author(s):  
Marta Stawczyk-Macieja ◽  
Aneta Szczerkowska-Dobosz ◽  
Roman Nowicki ◽  
Hanna Majewska ◽  
Michał Dubowik ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Acanthosis Nigricans ◽  
Malignant Acanthosis Nigricans

scholarly journals Comparison of Symptom Score and Bronchoscopy-Based Assessment With Conventional Computed Tomography–Based Assessment of Response to Chemotherapy in Lung Cancer

2017 ◽  
Vol 3 (4) ◽  
pp. 370-379 ◽  
Author(s):  
Lakshimikant Baburao Yenge ◽  
Digambar Behera ◽  
Mandeep Garg ◽  
Ashutosh Nath Aggarwal ◽  
Navneet Singh
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Symptom Score ◽  
Fiberoptic Bronchoscopy ◽  
Symptom Burden ◽  
Response Evaluation ◽  
European Respiratory Society ◽  
Perfect Agreement ◽  
Who Criteria ◽  
Response To Chemotherapy

Purpose There is a paucity of literature on symptom score (SS) plus fiberoptic bronchoscopy (FOB) –based response evaluation (RE) to chemotherapy for lung cancer. This study aimed to compare the reliability of RE by SS, chest radiograph (CXR), and FOB with computed tomography (CT) –based assessment (Response Evaluation Criteria in Solid Tumors (RECIST) and WHO criteria) for lung cancer chemotherapy. Methods This was a prospective observational study involving treatment-naïve patients with lung cancer planned for chemotherapy, with one or more lesions on FOB and CT. Patients underwent assessment twice by SS, CXR, FOB, and CT (at baseline and after chemotherapy). Six symptoms (dyspnea, cough, chest pain, hemoptysis, anorexia, and weight loss) were noted on visual analog scale. Respiratory symptom burden (RSB) and total symptom burden (TSB) were calculated from the first four and all six symptoms, respectively, as the mean of individual SS. Bronchoscopic findings were recorded as per European Respiratory Society classification for tracheobronchial stenosis. Responses were classified as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD) by each method. For FOB and SS, improvement or worsening by ≥ 20% was taken as PR or PD, respectively, whereas < 20% change was considered SD. Agreements were tested using Cohen’s κ statistic. Results All individual SS, RSB, and TSB scores, and the number and distribution of FOB lesions improved significantly after chemotherapy. Individually, CXR and SS had no or minimal agreement with FOB-based and CT-based responses. RECIST and WHO criteria had strong agreement overall (Cohen’s κ = 0.872) and perfect agreement for PD (Cohen’s κ = 1.000). Cohen’s κvalues for FOB-based assessment with RECIST and WHO were 0.324 and 0.349, respectively for overall RE, and 0.462 and 0.501 for differentiating responders (CR and PR) from nonresponders (SD and PD), respectively. Cohen’s κvalues for PD were 0.629 (FOB alone), 0.672 (FOB and RSB), 0.739 (FOB and TSB), and 0.764 (FOB and CXR). Conclusion CT-based assessment should remain the reference for objective RE of chemotherapy in lung cancer. A combination of FOB and CXR may be used as a surrogate to diagnose PD if CT is not feasible.

Histomorphological Study of Skin Lesions in Punch Biopsy Specimens with Special References to Neoplastic Lesions

2018 ◽  
Vol 7 (7) ◽  
pp. 841-846
Author(s):  
Mamatha K. ◽  
◽  
S. Susmitha ◽  
Sathyashree K.V. ◽  
Rama Devi P. ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Punch Biopsy ◽  
Biopsy Specimens ◽  
Neoplastic Lesions
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