scholarly journals Spectrophotometric Determination of Various Drugs Using Chloranilic Acid as Chromogenic Reagent - II

2010 ◽  
Vol 7 (2) ◽  
pp. 624-628 ◽  
Author(s):  
V. Annapurna ◽  
G. Jyothi ◽  
T. Rohini Kumari ◽  
B. B. V. Sailaja
Keyword(s):  
Regression Analysis ◽  
Charge Transfer ◽  
Spectrophotometric Method ◽  
Standard Error ◽  
Redox Reaction ◽  
Charge Transfer Complex ◽  
Molar Absorptivity ◽  
Method Of Least Squares ◽  
Chloranilic Acid

Simple, accurate and reproducible visible spectrophotometric method for the assay of drugs such as pyrilamine and fluvoxamine as maleates was established based on the formation of charge-transfer complex and redox reaction between the corresponding drug and substitutedp-benzoquinone (chloranilic acid). The optical characteristics such as Beer’s law limits, molar absorptivity and Sandell’s sensitivity are reported. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for each drug.

scholarly journals Sensitive Spectrophotometric Determinations of Paracetamol and Protriptyline HCl Using 3-Chloro-7-hydroxy-4-methyl-2H-chromen-2-one

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Kumble Divya ◽  
Badiadka Narayana ◽  
Majal Sapnakumari
Keyword(s):  
Charge Transfer ◽  
Spectrophotometric Method ◽  
Charge Transfer Complex ◽  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Pharmaceutical Samples ◽  
Chromogenic Reagent ◽  
Detection And Quantification

A new spectrophotometric method is developed for the determination of Paracetamol (PCT) and protriptyline HCl (PTP) in pure forms and in pharmaceutical formulations. The experiment involves the use of 3-chloro-7-hydroxy-4-methyl-2H-chromen-2-one as a novel chromogenic reagent for the determination of PCT and PTP. The method is based on the formation of charge transfer complex between the drugs and chromogenic reagent. Beer's law is obeyed in the concentration ranges 10.00–60.00 µg mL−1 for PCT at 545 nm and 40.00–160.00 µg mL−1 for PTP at 468 nm. The molar absorptivity, Sandell, sensitivity, and limit of detection and quantification are also calculated. The method has been successfully applied for the determination of both PCT and PTP in pharmaceutical samples with acceptable results.

scholarly journals Spectrophotometric Methods for the Assay of Fluvoxamine Using Chromogenic Reagents

2010 ◽  
Vol 7 (4) ◽  
pp. 1539-1545
Author(s):  
V. Annapurna ◽  
G. Jyothi ◽  
V. Nagalakshmi ◽  
B. B. V. Sailaja
Keyword(s):  
Ascorbic Acid ◽  
Regression Analysis ◽  
Standard Error ◽  
Oxidative Coupling ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Method Of Least Squares ◽  
Spectrophotometric Methods ◽  
Uv Visible

Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of FXA based on the oxidative coupling and condensation reactions. Condensation and coupling of the FXA with Ninhydrin-Ascorbic acid is proposed in method A. Method B includes complexation of FXA with cobalt thiocyanate. The ligating property of FXA with sodium nitro prusside is incorporated in method C. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system. Determination of FXA in bulk form and in pharmaceutical formulations were also incorporated.

scholarly journals Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents

2010 ◽  
Vol 7 (4) ◽  
pp. 1523-1529
Author(s):  
V. Annapurna ◽  
G. Jyothi ◽  
A. V. Subbayamma ◽  
B. B. V. Sailaja
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Charge Transfer Complex ◽  
Hydroxylamine Hydrochloride ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Method Of Least Squares ◽  
Spectrophotometric Methods ◽  
Formation Method

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay ofbuclizine(BUCZ) based on the formation of precipitation, charge transfer complex and inner complex formation. Method A involves the precipitation, charge transfer complex formation of BUCZ with tannic acid/p-N-methyl aminophenol sulphate (PMAP)-Cr(VI), the complex formation with cobalt thiocyanate (CTC) in method B and inner complex formation of BUCZ with sodium nitroprusside hydroxylamine hydrochloride and sodium carbonate in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system Determination of BUCZ in bulk form and in pharmaceutical formulations were also incorporated.

scholarly journals Spectrophotometric Methods for the Assay of Pyrilamine Maleate Using Chromogenic Reagents

2010 ◽  
Vol 7 (4) ◽  
pp. 1507-1513 ◽  
Author(s):  
V. Annapurna ◽  
G. Jyothi ◽  
V. Nagalakshmi ◽  
B. B. V. Sailaja
Keyword(s):  
Charge Transfer ◽  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Method Of Least Squares ◽  
Spectrophotometric Methods ◽  
Oxidative Coupling Reaction ◽  
Charge Transfer Complexation

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products. Method A includes the oxidative coupling reaction of PYRA with 3-methyl-2-benzathiazolinone hydrazone (MBTH) in presence of Ce(IV). The formation of oxidative coupling product with 4-amino phenazone (4-AP) in presence of K3Fe(CN)6is incorporated in method B. Precipitation/charge transfer complex formation of the PYRA with tannic acid (TA)/Metol-Cr(VI) in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for each system. Determination of pyrilamine in bulk form and in pharmaceutical formulations were also incorporated.

Determination of phenothiazines by charge-transfer complex formation with chloranilic acid

Talanta ◽  
1986 ◽  
Vol 33 (2) ◽  
pp. 111-114 ◽  
Author(s):  
N.A. Zakhari ◽  
M. Rizk ◽  
F. Ibrahim ◽  
M.I. Walash
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Charge Transfer Complex ◽  
Chloranilic Acid

scholarly journals Simple Methods for the Spectrophotometric Determination of Carvedilol

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Divya N. Shetty ◽  
B. Narayana
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Confidence Level ◽  
Charge Transfer Complex ◽  
Condensation Reaction ◽  
Pharmaceutical Preparations ◽  
Molar Absorptivity ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision

Two simple spectrophotometric methods are described for the determination of carvedilol (CAR). Method A is the condensation reaction of CAR with p-dimethylaminobenzaldehyde (PDAB), and the reaction mixture exhibits maximum absorbance at 601 nm. Method B is based on the charge transfer complex formation of CAR with p-chloranil; the color developed is measured at 662 nm. The calibration graphs are found to be linear over 50.00–250.00 and 20.00–100.0 μg mL−1 with molar absorptivity values of 0.92×103 and 0.257×104 L mol−1cm−1 for CAR-PDAB and CAR-p-chloranil, respectively. Statistical comparisons of the results are performed with regard to accuracy and precision using Student’s t-test and F-test at 95% confidence level. The methods are successfully employed for the determination of CAR in pharmaceutical preparations, and the results agree favorably with the reference and proposed methods.

scholarly journals The Use of 7,7′,8,8′-Tetracyanoquinodimethane for the Spectrophotometric Determination of Some Primary Amines Application to Real Water Samples

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Theia'a N. Al-Sabha ◽  
Najwa M. Al-Karemy
Keyword(s):  
Charge Transfer ◽  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Aromatic Amines ◽  
Molar Absorptivity ◽  
Primary Amines ◽  
Charge Transfer Complexes ◽  
Buffer Solution ◽  
Real Water Samples

A sensitive, simple, and accurate spectrophotometric method was developed for the quantitative determination of some primary aliphatic and aromatic amines, that is, ethylamine, 1,2-diaminopropane, aniline, p-aminophenol, and benzidine. The method is based on the interaction of these amines in aqueous medium with 7,7′,8,8′-tetracyanoquinodimethane (TCNQ) reagent in the presence of a buffer solution and surfactant (in the case of aromatic amines) to form charge-transfer complexes measurable at maximum wavelengths ranging between 323 and 511 nm. Beer’s law is obeyed over the concentration ranges of 0.025 and 3.0 μg/mL and the molar absorptivity is ranged between 8.977 × 103and 5.8034 × 104 L·mol−1·cm−1for these amines. The method was applied for the determination of benzidine in the river, sea, and tap waters. The TCNQ complexes with the previously mentioned amines were formed in the ratio of 1 : 1 amine : TCNQ, and their stability constants ranged between 8.78 × 104and 1.844 × 105 L·mol−1.

scholarly journals Two charge-transfer complex spectrophotometric methods for the determination of sulpiride in pharmaceutical formulations

2009 ◽  
Vol 7 (4) ◽  
pp. 870-875 ◽  
Author(s):  
Sayed Zayed
Keyword(s):  
Charge Transfer ◽  
Charge Transfer Complex ◽  
Standard Free Energy ◽  
Pharmaceutical Formulations ◽  
Association Constants ◽  
Official Method ◽  
Chloranilic Acid ◽  
Spectrophotometric Methods ◽  
Charge Transfer Complexation

AbstractTwo simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of sulpiride. They are based on charge transfer complexation between the drug as n-electron donor and p-chloranilic acid as π acceptor or iodine as σ-acceptor. These give highly coloured complexes with absorption maxima at 518 and 363, 294 nm, respectively. Beer’s law linear ranges were 13.7–341.4 and 1.7–20.5 µg mL−1 for the p-chloranilic acid and iodine methods. The methods were successfully applied to the determination of the drug in Dogmatil® Fort tablets and the results compared with the official method. The complex association constants and standard free energy changes were calculated using Benesi-Hildebrand plots.

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