scholarly journals Peripartum Cardiomyopathy: A Current Review

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Katie M. Twomley ◽  
Gretchen L. Wells
Keyword(s):  
African American Women ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Treatment Options ◽  
The United States ◽  
Current Treatment ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Objective Evidence ◽  
A Current

Peripartum cardiomyopathy (PPCM) is a rare but potentially lethal complication of pregnancy occurring in approximately 1 : 3,000 live births in the United States although some series report a much higher incidence. African-American women are particularly at risk. Diagnosis requires symptoms of heart failure in the last month of pregnancy or within five months of delivery in the absence of recognized cardiac disease prior to pregnancy as well as objective evidence of left ventricular systolic dysfunction. This paper provides an updated, comprehensive review of PPCM, including emerging insights into the etiology of this disorder as well as current treatment options.

scholarly journals Peripartum Cardiomyopathy

1970 ◽  
Vol 24 (2) ◽  
pp. 67-70
Author(s):  
Shirin Akter Begum ◽  
SB Chowdhury ◽  
Begum Nasrin ◽  
Jannatul Ferdous ◽  
Zillur Rahman Bhuiyan
Keyword(s):  
African American Women ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Function ◽  
Beta Blockers ◽  
Angiotensin Receptor Blockers ◽  
Systolic Dysfunction ◽  
The United States ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Objective Evidence

Peripartum cardiomyopathy (PPCM) is a rare but potentially lethal complication of pregnancy occurring in approximately 1in 3000 live births in the United States although some series report a much higher incidence. African-American women are particularly at risk. Diagnosis requires symptoms of heart failure in the last month of pregnancy or within five months of delivery in the absence of recognized cardiac disease prior to pregnancy as well as objective evidence of left ventricular systolic dysfunction. Obstetricians should suspect the diagnosis, particularly if the patient has risk factors. Evaluation should include an echocardiogram to assess the LV systolic function. Treatment includes ACE inhibitors or angiotensin receptor blockers, beta-blockers, and diuretics. Consideration should be given to anticoagulation. A number of causes are being investigated, including nutritional, infectious, and genetic, which, hopefully, lead to more targeted treatments. This paper provides an updated, comprehensive review of PPCM, including emerging insights into the etiology of this disorder as well as current treatment options. Bangladesh J Obstet Gynaecol, 2009; Vol. 24(2) : 67-70   DOI: http://dx.doi.org/10.3329/bjog.v24i2.8531

Peripartum Cardiomyopathy

2018 ◽  
Author(s):  
Kendra M Gray ◽  
Michael R Foley
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
The United States ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Left Ventricular Ejection ◽  
Ventricular Systolic Dysfunction ◽  
Ventricular Ejection Fraction

Peripartum cardiomyopathy (PPCM) is a serious and rare disease of late pregnancy or the early postpartum period. It is defined as idiopathic, nonfamilial, nongenetic, heart failure occurring in the absence of any other identifiable causes of heart disease within the last month of pregnancy or within the first 5 months postdelivery in otherwise previously healthy woman. The incidence in the United States is 1 per 3,000 to 4,000 live births. Left ventricular systolic dysfunction develops, almost always leading to a left ventricular ejection fraction of less than 45%. PPCM is unique in its rapid medical course and propensity to spontaneously resolve within 3 to 6 months of disease onset. The mortality rate is high, up to 10%, and the risk of relapse in subsequent pregnancies is also elevated. Treatment for PPCM varies slightly based on whether the woman is pregnant or postpartum. Conventional pharmacologic treatment includes diuretics, angiotensin-converting enzyme inhibitors (postpartum only), vasodilators such as hydralazine, digoxin, β-blockers, and anticoagulants. This review contains 5 figures, 5 tables, and 36 references. Key Words: critical care obstetrics, ejection fraction, heart failure, left ventricular systolic dysfunction, management, maternal mortality, peripartum cardiomyopathy, preeclampsia, pregnancy

Intersection of Heart Failure and Pregnancy: Beyond Peripartum Cardiomyopathy

2021 ◽  
Author(s):  
Ersilia M. DeFilippis ◽  
Jennifer H. Haythe ◽  
Mary Norine Walsh ◽  
Michelle M. Kittleson
Keyword(s):  
Heart Failure ◽  
Pregnant Women ◽  
De Novo ◽  
Systolic Dysfunction ◽  
The United States ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Ventricular Assist Devices ◽  
Left Ventricular Assist Devices ◽  
Common Diagnosis

Heart failure (HF) is a leading cause of morbidity and mortality in pregnant women in the United States. Although peripartum cardiomyopathy is the most common diagnosis for pregnant women with HF, women with preexisting cardiomyopathies and systolic dysfunction are also at risk as the hemodynamic demands of pregnancy can lead to decompensation, arrhythmia, and rarely death. The differential diagnosis of HF in pregnancy is broad and includes Takotsubo or stress cardiomyopathy, exacerbation of a preexisting cardiomyopathy, such as familial cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, or left ventricular noncompaction. This review will explore the implications of pregnancy in women with preexisting cardiomyopathies and de novo HF, risk assessment and preconception planning, decisions about contraception, the safety of HF medications and implantable cardioverter-defibrillators during pregnancy, pregnancy in women with left ventricular assist devices and following heart transplantation.

scholarly journals Sclerotherapy Induced Takotsubo Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-4 ◽  
Author(s):  
Sunny Patel ◽  
Sepideh Nabatian ◽  
Michael Goyfman
Keyword(s):  
Chest Pain ◽  
Troponin I ◽  
Left Ventricular Systolic Dysfunction ◽  
Varicose Veins ◽  
Systolic Dysfunction ◽  
The United States ◽  
Left Ventricular ◽  
Takotsubo Syndrome ◽  
T Wave ◽  
Patient Reported

A 66-year-old female was brought to the emergency department for acute-onset left-sided chest pain. Prior to arrival, she was at an outpatient appointment with a vascular surgeon for elective sclerotherapy treatment of her lower extremity varicose veins. After receiving an IV injection of polidocanol, she developed severe chest pain with left arm and jaw numbness for the first time in her life. Upon arrival to the ED, the patient reported that her symptoms had resolved. Electrocardiogram (ECG) on presentation was significant for T-wave inversions in leads V1-V3. An initial set of cardiac enzymes showed a troponin I level of 0.62 ng/mL, which subsequently increased to 2.26 ng/mL. Her echocardiogram was significant for mild left ventricular systolic dysfunction with apical hypokinesis (ejection fraction 50%). A repeat ECG showed new T-wave inversions compared to that from the time of admission. The patient eventually agreed to cardiac catheterization, which revealed patent vessels without coronary artery disease, supporting our diagnosis of Takotsubo syndrome and what is the first reported case of likely polidocanol-induced Takotsubo syndrome in the United States.

scholarly journals A Change of Heart: Case Series of Peripartum Cardiomyopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Sean Martin ◽  
Daniel Short ◽  
Chih Mun Wong ◽  
Dina McLellan
Keyword(s):  
Heart Failure ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Significant Proportion ◽  
Case Series ◽  
Decompensated Heart Failure ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Ventricular Systolic Dysfunction ◽  
Diagnostic Challenge

Peripartum cardiomyopathy (PPCM) is an uncommon disease of pregnancy, occurring in about 1 in 2000 live births, and is characterized by the development of heart failure, due to left ventricular systolic dysfunction. It is associated with high rates of maternal and neonatal mortality. Cardiac disease is the leading cause of maternal death in the UK: PPCM accounts for about 17% of these. Clinical findings of decompensated heart failure (HF) are often masked by the normal physiological changes seen in pregnancy making the diagnosis challenging. A high index of suspicion is essential—prompting referral for echocardiogram, which is crucial for diagnosis. Favourable prognosis is dependent on the early initiation of HF medications. Although full recovery occurs in around half of cases, left ventricular systolic dysfunction persists in a significant proportion of patients with PPCM and the risk of recurrence in subsequent pregnancies is high. The pathophysiology of PPCM is under intense research. We present four patients with PPCM and a review of the literature. Owing to the diagnostic challenge of PPCM and decompensated HF in pregnant mothers and its high mortality rate without treatment, prompt investigation and referral are key to improving maternal survival.

scholarly journals Peripartum Cardiomyopathy: A Review of Three Case Reports

2012 ◽  
Vol 4 (3) ◽  
pp. 164-166 ◽  
Author(s):  
Ankita Kumari ◽  
Mridul Chaturvedi
Keyword(s):  
Heart Failure ◽  
Left Ventricular Systolic Dysfunction ◽  
Case Reports ◽  
Systolic Dysfunction ◽  
Signs And Symptoms ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Idiopathic Cardiomyopathy ◽  
Maternal Morbidity And Mortality ◽  
Long Term Prognosis

ABSTRACT Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that presents with heart failure secondary to left ventricular systolic dysfunction toward the end of pregnancy or in the months after delivery. Incidence of PPCM ranges from 1:300 to 1:15,000 pregnancies. Causes and pathogenesis are poorly understood. Clinical presentation includes signs and symptoms of heart failure. PPCM remains a major cause of maternal morbidity and mortality. Many cases of PPCM improve or resolve completely but others progress to heart failure; as early diagnosis and medical treatment may affect the patient's long-term prognosis. The aim of this report is to make health professionals aware of the possibilities in a woman with dyspnoea in the postpartum period. How to cite this article Kumari A, Singh S, Singh S, Chaturvedi M. Peripartum Cardiomyopathy: A Review of Three Case Reports. J South Asian Feder Obst Gynae 2012;4(3):164-166.

Heart failure: left ventricular systolic dysfunction

2016 ◽  
Author(s):  
Erwan Donal ◽  
Elena Galli
Keyword(s):  
Heart Failure ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
The United States ◽  
Left Ventricular ◽  
Ventricular Systolic Dysfunction ◽  
Public Health Burden ◽  
Health Burden ◽  
Electromechanical Interaction ◽  
Heart Anatomy

Heart failure (HF) is a growing problem worldwide and poses an especially large public health burden. It represents a new epidemic of cardiovascular disease, affecting nearly 5.8 million people in the United States, and over 23 million worldwide. Nevertheless, in Europe, fears of an impending HF ‘epidemic’ could not be confirmed in this analysis of trends in prevalence for the period 1990-2007 in patients hospitalized with HF in Sweden. An overall slight decrease in age-adjusted prevalence was observed from 2002. The prevalence in patients under 65 years increased markedly. In absolute numbers, there was a substantial increase among the very old, consistent with demographic changes. The complexity of left ventricular function(s) assessment in HF patients is related to the complexity of heart anatomy, but also to the complexity of electromechanical interaction, and to the load dependency of all the parameters that could be applied in clinical practice.

scholarly journals Levosimendan treatment in a child with treatment-resistant left ventricular systolic dysfunction after scorpion sting

2019 ◽  
Vol 27 (4) ◽  
pp. 245-249
Author(s):  
Ahmet Yöntem ◽  
Rıza Dinçer Yıldızdaş ◽  
Özden Özgür Horoz ◽  
Nagehan Aslan ◽  
Merve Mısırlıoğlu ◽  
...  
Keyword(s):  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Pediatric Emergency ◽  
Current Treatment ◽  
Left Ventricular ◽  
Temperate Climate ◽  
Scorpion Sting ◽  
Low Cardiac Output Syndrome ◽  
Pediatric Emergency Care ◽  
Scorpion Stings

Background: Scorpion stings are common in countries dominated by rural and coastal settlements with temperate climate. Scorpion stings are usually harmless and can be seen in local findings, but in some cases, systemic, neurotoxic, and cardiotoxic findings can be seen. Case report: A 3 year 7 month old girl was referred to pediatric emergency care 2 h after yellow scorpion (species of Leiurus abdullahbayrami) sting. In our case, cardiac function insufficiently progressed in spite of the standard inotropic and milrinone treatment. On the third day of hospitalization, levosimendan was initiated with good clinical effect. Conclusion: In the literature, the use of levosimendan in pediatric patients has been limited to those with low cardiac output syndrome after cardiovascular surgery. The use of levosimendan in children with scorpion sting has been previously reported only in Banille et al.’s study. Scorpion antivenom should be administered intravenously as soon as possible in cases of systemic findings that develop after scorpion stings. This report suggests that levosimendan is temporally associated with improvement in patients who have severe cardiac dysfunction due to scorpion sting and refractory to current treatment.

scholarly journals Peripartum Cardiomyopathy

2014 ◽  
Vol 25 (2) ◽  
pp. 96-98
Author(s):  
Md Abdul Mahid Khan ◽  
Hasina Banoo ◽  
Sheikh Salahuddin Ahmed
Keyword(s):  
Left Ventricular Systolic Dysfunction ◽  
Post Partum ◽  
Systolic Dysfunction ◽  
Normal Pregnancy ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Ventricular Systolic Dysfunction ◽  
Idiopathic Cardiomyopathy ◽  
Medicine Today ◽  
High Degree

Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that presents with heart failure secondary to left ventricular systolic dysfunction. Onset is from the last trimester of pregnancy to 5 months postpartum. Diagnosis in the last trimester is complicated by the fact that the early symptoms of this disorder may mimic the symptoms of normal pregnancy. However, it is essential for the practitioner dealing with such population to have a high degree of clinical suspicion for early diagnosis and management. Echocardiography is used to diagnose this entity and monitor the therapy. We present a case report of a 40-year-old woman who presented two days post-partum with respiratory distress and early echocardiography helped in diagnosing PPCM. The aim of this report is to make health professionals aware of the possibilities of PPCM in a woman with dyspnoea in the postpartum period. DOI: http://dx.doi.org/10.3329/medtoday.v25i2.17930 Medicine Today 2013 Vol.25(2): 96-98

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