scholarly journals Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Monika Conchon ◽  
Sabri S. Sanabani ◽  
Mariana Serpa ◽  
Mafalda M. Y. Novaes ◽  
Luciana Nardinelli ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Unplanned Pregnancy ◽  
Single Patient ◽  
Successful Pregnancy ◽  
Cesarean Section Delivery ◽  
Male Baby ◽  
Pregnancy And Delivery ◽  
Complete Hematological Response ◽  
Hematological Remission

Here we report the case of an 18-year-old woman with chronic myeloid leukemia (CML) who became pregnant while undergoing treatment with dasatinib. Before pregnancy, she received imatinib mesylate therapy but could not tolerate the treatment. The regimen was then changed to dasatinib at a dose of 70 mg b.i.d. While she was in hematological remission and on dasatinib therapy, she became pregnant. The unplanned pregnancy was identified after the patient had experienced four weeks of amenorrhea. Because the patient elected to continue the pregnancy to term, dasatinib was stopped immediately. Meanwhile, CML hematological relapse occurred and then she was treated with interferon- (IFN-) (9 million IU/day) throughout the pregnancy without a complete hematological response. She successfully gave birth to a male baby at 33 weeks by cesarean section delivery with no sequelae or malformations. Although this experience is limited to a single patient, it provides a useful contribution for counselling patients inadvertently exposed to dasatinib during pregnancy.

scholarly journals Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Sasha Mikhael ◽  
Ashlee Pascoe ◽  
Joseph Prezzato
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Animal Studies ◽  
Kinase Inhibitors ◽  
Adverse Outcomes ◽  
High Dose ◽  
Molecular Remission ◽  
Successful Pregnancy ◽  
Pregnancy And Delivery ◽  
Reproductive Aged Women

The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) in reproductive-aged women poses major dilemmas concerning its associated teratogenicity as observed in many animal studies. Much controversy exists regarding continuation versus discontinuation of its use in pregnancy with some studies suggesting safety of TKIs before and during pregnancy and others reporting toxicity and adverse outcomes. TKIs have become a well-established treatment option for CML, significantly improving prognosis, and yet have been reported to be fetotoxic. We present a case of a 25-year-old woman who achieved successful pregnancy and delivery after withholding treatment, meanwhile relapsing, eventually achieving complete molecular remission after reinitiation of high dose dasatinib.

Successful pregnancy and delivery during α-interferon therapy for chronic myeloid leukemia

1992 ◽  
Vol 40 (3) ◽  
pp. 238-239 ◽  
Author(s):  
Michael Crump ◽  
Xing-Hua Wang ◽  
Matthew Sermer ◽  
Armand Keating
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Interferon Therapy ◽  
Successful Pregnancy ◽  
Pregnancy And Delivery

Pregnancy outcome in chronic myeloid leukemia patients on imatinib therapy.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 7114-7114
Author(s):  
Swati Dasgupta ◽  
Ashis Mukhopadhyay ◽  
Ujjal Kanti Ray ◽  
Firoj Hossain Gharami ◽  
Chinmay Kumar Basu ◽  
...  
Keyword(s):  
Congenital Anomaly ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Unplanned Pregnancy ◽  
First Trimester ◽  
Imatinib Therapy ◽  
Spontaneous Abortions ◽  
Male And Female ◽  
Increased Risk ◽  
Male Patients

7114 Background: Now that imatinib is being used to treat thousands of chronic myeloid leukemia (CML) patients for more than 10 year it is highly probable that many patients will get pregnant during its use. Company warns against any such use. But the fact remains that there is need for planned pregnancies in indicated cases. So we selected few cases both male and female for such pregnancies by interrupting treatment and following the pregnancy closely. Their outcome was studied so that we have an idea about what best could be suggested in such instance. Methods: From November 2002 to May 2010, 634 patients with CML in any stage of the disease were treated with imatinib at our tertiary cancer research institute. We selected 22 (12 females and 10 males) cases of pregnancies by interrupting treatment. We reported 9 accidental pregnancies and 13 planned pregnancies involving 22 patients who or their wives conceived while receiving imatinib for the treatment of CML. Results: Among 22 pregnancies there were 3 spontaneous abortions and 4 elective abortions. In case of 7 female patients, 3 and 4 were male and female babies respectably and in case of six male patients 4 and 4 were male and female babies. Two babies were with congenital anomaly such as one Hypospandium and one Mild-Hydrocephalus (in case of unplanned pregnancies and imatinib exposure during the first trimester of organogenesis). Conclusions: In conclusion, exposure to Imatinib during pregnancy might result in an increased risk of serious fetal abnormalities or spontaneous abortions. Women of childbearing potential should use adequate contraception while using Imatinib. We can suggest that planned pregnancy during therapy should be encouraged but imatinib therapy in unplanned pregnancy can cause spontaneous abortion or minor congenital anomaly.

scholarly journals Successful Pregnancy in a Patient with Chronic Myeloid Leukemia under Treatment with Imatinib

2009 ◽  
Vol 48 (16) ◽  
pp. 1433-1435 ◽  
Author(s):  
Motohiro Tsuzuki ◽  
Youko Inaguma ◽  
Kousuke Handa ◽  
Akio Hasegawa ◽  
Yukiya Yamamoto ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Successful Pregnancy

Successful pregnancy involving a man with chronic myeloid leukemia on dasatinib

2010 ◽  
Vol 283 (1) ◽  
pp. 133-134 ◽  
Author(s):  
Houssam Oweini ◽  
Zaher K. Otrock ◽  
Rami A. R. Mahfouz ◽  
Ali Bazarbachi
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Successful Pregnancy
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