scholarly journals Evaluation of anti-osteoporosis in ovariectomized Wistar rats treated with antler blood by synchrotron radiation X-ray fluorescence microprobe

2009 ◽  
Vol 23 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Jianhong Yang ◽  
Ruilin Wang ◽  
Yi Cao ◽  
Yurong Fei ◽  
Yuying Huang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Synchrotron Radiation ◽  
Wistar Rats ◽  
Dual Energy ◽  
Relative Content ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
X Ray ◽  
Female Wistar Rats ◽  
The Relationship

To evaluate the anti-osteoporotic effect of antler blood, the relationship between the change of element content and the bone mineral density (BMD) increase in femur was investigated. Female Wistar rats were randomly divided into three groups: sham-operated group (SHAM,n=5), ovariectomized group (OVX,n=5) and ovariectomized group with antler blood treatment (n=5). The femoral BMD was analyzed by dual-energy X-ray absorptiometry (DXA) and the element relative content was determined by synchrotron radiation X-ray fluorescence (SRXRF) microprobe. The results showed that the femoral BMD in ovariectomized rats was significantly lower than that of sham-operated rats (p<0.05) but reversed by antler blood treatment (p<0.05). A further study demonstrated that the relative contents of phosphorus (P), calcium (Ca), zinc (Zn) and strontium (Sr) were obviously lower in ovariectomized rats compared to sham-operated rats but only the relative contents of P, Ca and Zn were normalized by antler blood treatment (p<0.05). Our experiments revealed that loss of element Ca, P, Zn and Sr was closely related to the BMD reduction in ovariectomized rats and the anti-osteoporotic effect of antler blood was mediated by increasing the contents of P, Ca and Zn.

scholarly journals Peri-prosthetic Bone Remodeling of Hydroxyapatite-coated Compaction Short Stem was Not Affected by Stem Alignment

2021 ◽  
Author(s):  
Shinya Hayashi ◽  
Yuichi Kuroda ◽  
Naoki Nakano ◽  
Tomoyuki Matsumoto ◽  
Tomoyuki Kamenaga ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Remodeling ◽  
Retrospective Cohort ◽  
Dual Energy ◽  
Short Stem ◽  
Mineral Density ◽  
X Ray ◽  
Ct Data ◽  
The Relationship

Abstract Background: We aimed to investigate the relationship between stem insertion alignment and postoperative bone mineral density (BMD) changes in patients with full hydroxyapatite-coated (HA) compaction short stem and short tapered-wedge stem. Methods: This retrospective cohort study enrolled 115 consecutive patients (115 joints) undergoing total hip arthroplasty (THA) using the full HA compaction short (n=59) and short tapered-wedge (n=56) stems. Stem alignment including anteversion, valgus, and anterior tilt were measured by 3D-template using computed tomography (CT) data. Post-operative peri-prosthetic BMD was measured by dual-energy X-ray absorptiometry (DEXA). The relationship between stem alignment and BMD changes in the stems were analyzed.Results: Both groups showed similar patterns of peri-prosthetic BMD changes. Stem insertion alignments of anteversion, valgus, and anterior tilt were different between the two types of stems. Stem alignment of valgus and anterior tilt did not affect peri-prosthetic BMD in either type of stem. An absolute anteversion difference between stem anteversion and original canal anteversion caused significant peri-prosthetic BMD loss in Gruen zones 1 and 7 in the tapered-wedge stem. However, stem alignment of absolute anteversion difference did not affect BMD changes in the HA compaction stem.Conclusion: Peri-prosthetic bone remodeling remained unaffected by stem alignment after THA with the new short full HA compaction stem.

scholarly journals POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 227.2-228
Author(s):  
D. Claire ◽  
M. Geoffroy ◽  
L. Kanagaratnam ◽  
C. Isabelle ◽  
A. Hittinger ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
General Population ◽  
Bone Mineral ◽  
Bone Densitometry ◽  
Dual Energy ◽  
Mineral Density ◽  
Least Significant Change ◽  
X Ray ◽  
Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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