scholarly journals DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions

2009 ◽  
Vol 2009 ◽  
pp. 1-10 ◽  
Author(s):  
Wojciech Szczepanik ◽  
Marzena Kucharczyk-Klamińska ◽  
Piotr Stefanowicz ◽  
Anna Staszewska ◽  
Zbigniew Szewczuk ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Damage ◽  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Stable Complex ◽  
The Novel ◽  
Complex Species ◽  
Peptide Derivatives ◽  
Derivatives Of

Three model dipeptides containing 3-(2,3-di(pyridin-2-yl)quinoxalin-6-yl)alanine, 3-(dipyrido[3,2-a:2,3-c]phenazin-11-yl)alanine, and 3-(2,3-diphenylquinoxalin-6-yl)alanine were studied with respect to their ability to bind selected transition metal ions, such as Cu(II), Fe(II), Ni(II), Co(II), Mn(II), and Cr(III). It was found that only Cu(II) and Fe(II) ions could form stable complex species with the studied compounds. The ability to form the complexes correlated well with DNA damage experiments. Only the ferrous and cupric complexes are capable of generating both single- and double-strand scissions. However, double-strand breakages appear to be dominating lesions in the presence of hydrogen peroxide, especially for copper(II) containing systems. The quantity of breakage products in the presence ofN-(3-(dipyrido[3,2-a:2,3-c]phenazine-11-yl)alanyl)glycine complexes was the highest as compared to the complexes of the remaining compounds. Moreover, this ligand was the only one that cleaved DNA in the absence of either Cu(II) or Fe(II) ions.

Fluorescence Enhancement of Polyamine Derivatives of 1,8-Naphthalimide with Transition Metal Ions

2006 ◽  
Vol 19 (6) ◽  
pp. 506-510 ◽  
Author(s):  
Guo-tao Wen ◽  
Man-zhou Zhu ◽  
Zhuo Wang ◽  
Xiang-ming Meng ◽  
Hui-yuan Hu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Fluorescence Enhancement ◽  
Transition Metal Ions ◽  
Derivatives Of ◽  
Polyamine Derivatives

Synthesis, Characterization and Electrochemistry of the Novel Dawson-Type Tungstophosphate [H4PW18O62]7- and First Transition Metal Ions Derivatives.

ChemInform ◽  
2004 ◽  
Vol 35 (16) ◽  
Author(s):  
Israel-Martyr Mbomekalle ◽  
Bineta Keita ◽  
Yu Wei Lu ◽  
Louis Nadjo ◽  
Roland Contant ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
The Novel

Synthesis, Characterization and Electrochemistry of the Novel Dawson-Type Tungstophosphate [H4PW18O62]7− and First Transition Metal Ions Derivatives

2004 ◽  
Vol 2004 (2) ◽  
pp. 276-285 ◽  
Author(s):  
Israel-Martyr Mbomekalle ◽  
Bineta Keita ◽  
Yu Wei Lu ◽  
Louis Nadjo ◽  
Roland Contant ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
The Novel

scholarly journals Study of DNA damage caused by dipyrone in presence of some transition metal ions

2017 ◽  
Vol 25 (7) ◽  
pp. 961-966
Author(s):  
Bruna Corrêa Roriz ◽  
Horacio Dorigan Moya
Keyword(s):  
Dna Damage ◽  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions

Stabilization and Protection of Biomaterial through Biomineralization via Surface Interaction: An Astrobiological Approach

2018 ◽  
Author(s):  
Preeti Bhatt ◽  
Chandra Kala Pant ◽  
Pramod Pandey ◽  
Yogesh Pandey ◽  
Satish Chandra Sati ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Metal Ion ◽  
Transition Metal Ions ◽  
Living System ◽  
Stable Complex ◽  
Adsorption Parameters ◽  
Spectral Techniques ◽  
Prebiotic Chemical ◽  
Free Environment

A Cytosine (CYN), core constituent of both RNA and DNA, is a well-known functional biomaterial of living system. Adsorption of such molecule on primigenial mineral surfaces transacts a very specific and selective role in biocompatibility and biomineralization. The adsorption behaviour of CYN, with change in pH, concentration, time and temperature on siliceous Montmorillonite (MMT) surface, a prominent nanoclay of smectite group with specific surface area, was studied systematically and methodically using different spectral techniques (viz. UV, FTIR, SEM and XRD). Biogenic metal dication [M2+= Mg2+, Ca2+, Fe2+ and Cu2+] entrapped nanocomposites of MMT were prepared separately by cation-exchange approach. The results reveal significant role of MMT and biogenic metal ions on the quantity of CYN adsorbed. The adsorption isotherm elegantly evinces monolayer formation of the biomaterial on the surface of MMT and MMT-M2+. The Langmuir adsorption parameters (KL & Xm) delineated appreciable interaction of CYN on MMT-Fe2+ surface as compared to MMT alone and other metal confined MMTs. The present work throws light on affinity of MMT nanoclay (having multifarious applications in biological systems) involving biogenic metal ions on stabilization and protection of biomaterials through biomineralization during prebiotic chemical evolution of biomolecules. The results embarks better adsorption capability of transition metal ion incorporated MMT than the clay without metal ion and with alkaline Earth dications due to better coordination properties of transition metal ions involving their d-orbitals for stable complex formation with negative sites of cytosine molecules as ligands. Since metal ions are key components of various enzymes which can catalyse a number of biochemical reactions in the living systems, the present study give better understanding regarding the pathways of aggregation of biomonomers on solid surfaces which themselves might have catalysed the formation of complex biomolecules via polymerization and condensation in enzyme free environment of early Earth and also influences implant biocompatibility.

scholarly journals Effect of magnesium-salts on hydrogen peroxide bleaching of non-wood pulps

2016 ◽  
Vol 51 (4) ◽  
pp. 291-296
Author(s):  
N Das ◽  
SK Bose ◽  
D Biswas
Keyword(s):  
Hydrogen Peroxide ◽  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Peroxide Bleaching ◽  
Lower Viscosity ◽  
Pulp Viscosity ◽  
Acid Washing ◽  
Mg Addition ◽  
Wood Pulps

Transition metal ions present in pulp, cause wasteful decomposition of hydrogen peroxide, a pulp brightener, and thus significantly affect the delignification selectivity of hydrogen peroxide bleaching. The metal ions also affect the brightness and optical properties of pulp. The free radicals generated during the decomposition degrade carbohydrates resulting in lower viscosity and yield. It is reported in the literature that magnesium sulfate successfully adsorbs transition metal ions and thus decrease their activity. This study dealt with the effect of Mg salts in hydrogen peroxide bleaching of jute caddies pulp. It was observed that prior bleaching treatments like chelation and acid washing of pulp were efficient in removing transition metal ions as indicated by lower consumption of hydrogen peroxide. However EDTA chelation seemed better compared to acid washing. The inclusion of Mg salts improved pulp brightness. The pulp viscosity was the highest with 0.3% Mg addition for both treated kraft and soda-AQ pulps. Considering both pulp viscosity and pulp brightness, it appeared that a 0.3% Mg dose on EDTA chelated pulp, was enough in hydrogen peroxide bleaching of pulps obtained from jute caddies. Bangladesh J. Sci. Ind. Res. 51(4), 291-296, 2016

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