scholarly journals Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Urszula Grzybowska-Chlebowczyk ◽  
Halina Woś ◽  
Aleksander L. Sieroń ◽  
Sabina Więcek ◽  
Aleksandra Auguściak-Duma ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Food Allergy ◽  
Small Bowel ◽  
Blood Serum ◽  
Bowel Disease ◽  
Older Age ◽  
Elisa Method ◽  
Allergic Colitis ◽  
Inflammatory Bowel ◽  
Frequent Localization

The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA. Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD was established on the basis of Porto criteria. Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. We did not observe any relation between the occurrence of FA and the frequency and ASCA titre. p-ANCA were significantly more frequent in the group of children with UC. The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis. Conclusions. Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age. We observed a connection between the occurrence of antibodies and the examined mutations of gene NOD2/CARD15.

scholarly journals A186 OLDER AGE IS ASSOCIATED WITH INCREASED EXTRAINTESTINAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 201-202
Author(s):  
Z Chattha ◽  
R Chattha ◽  
S Reza ◽  
M Moradshahi ◽  
M Fadida ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Regression Analysis ◽  
Bowel Disease ◽  
Multivariate Regression Analysis ◽  
Older Age ◽  
Extraintestinal Manifestations ◽  
Forward Selection ◽  
Increased Risk ◽  
Inflammatory Bowel

Abstract Background The relationship between older age and extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) remains unknown. Aims This study aims to determine whether older age is associated with increased risk of EIMs in IBD patients. Methods This was a retrospective study of IBD patients seen at the McMaster University Medical Centre, in Hamilton, ON, Canada from 2012–2020. Patients were identified to have the primary outcome of interest if their gastroenterologist documented the presence of any EIM either during the baseline assessment or during the period of follow up. The independent variable, age at start of follow-up, was dichotomized into two categories age >=40 vs. <40.Prior knowledge in combination with forward selection was used to develop a logistic regression model. The variables utilized for the forward selection model included gender, disease duration, and current biologic use. Results A total of 995 IBD patients (625 with CD) were considered for the regression analysis, all for whom the EIM status was recorded. Out of the 995 patients, 270 patients reported at least one EIM – 99 with arthritis/arthralgia, 79 with dermatologic manifestations, 16 with ophthalmic manifestations, 30 with liver manifestations, and 116 with other EIMs. A univariate regression analysis foundincreased odds of EIMs in older patientsas compared to younger patients (odds ratio (OR) 1.41 (95% CI, 1.05 – 1.89)). In the multivariate regression analysis, current biologic use was found to have a significant relationship with odds of having EIMs (OR 1.49; 95% CI, 1.06 – 2.09). After adjustment for biologic use, patients aged 40 or over had 1.46 times higher odds of having EIMs (95% CI 1.03 – 2.05). A sub-analysis of individual EIM categoriesdid not show a significant association with older age. Conclusions Older age is associated with increased risk of EIMs in IBD patients. Patients with EIMs were also more likely to be treated with biological therapies. Clinicians should inquire about the presence of EIMs in older IBD patients. Funding Agencies None

scholarly journals Food allergy among Iranian children with inflammatory bowel disease: A preliminary report

2015 ◽  
Vol 20 (9) ◽  
pp. 855 ◽  
Author(s):  
Peiman Nasri ◽  
Farid Imanzadeh ◽  
Somayeh Sadeghi ◽  
Aliakbar Sayyari ◽  
Naghi Dara ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Food Allergy ◽  
Bowel Disease ◽  
Preliminary Report ◽  
Inflammatory Bowel ◽  
Iranian Children

Diffuse Filiform Polyposis With Unique Histology Mimicking Familial Adenomatous Polyposis in a Patient Without Inflammatory Bowel Disease

2007 ◽  
Vol 131 (12) ◽  
pp. 1821-1824
Author(s):  
Gerard J. Oakley III ◽  
Wolfgang H. Schraut ◽  
Robert Peel ◽  
Alyssa Krasinskas
Keyword(s):  
Inflammatory Bowel Disease ◽  
Small Bowel ◽  
Familial Adenomatous Polyposis ◽  
Bowel Disease ◽  
Nerve Fibers ◽  
Normal Colonic Mucosa ◽  
Adenomatous Polyposis ◽  
Inflammatory Bowel ◽  
Filiform Polyposis ◽  
Vascular Hamartoma

Abstract Filiform polyposis is an uncommon entity that is most often encountered in the colon of patients with a history of inflammatory bowel disease (IBD). Filiform polyposis is characterized by a large number of “wormlike” polyps lined by histologically normal colonic mucosa. These polyps can mimic adenomatous polyps. Only rare cases without a history or evidence of IBD have been reported. Neuromuscular and vascular hamartoma of the small bowel is a rare, focal disorder characterized by disorganized smooth muscle fascicles throughout the submucosa accompanied by fibrosis, nerve fibers, ganglion cells, and vessels. To our knowledge, there is only one report of this lesion in the large bowel (cecum), where it presented as a mass. Here we report the case of a 50-year-old man with no known history or symptoms of IBD presenting with filiform polyposis involving the entire colon, clinically mimicking familial adenomatous polyposis, and showing histologic features similar to neuromuscular and vascular hamartoma of the small bowel.

The role of MRI small bowel in the assessment of inflammatory bowel disease: a single-centre prospective study

2010 ◽  
Vol 95 (Suppl 1) ◽  
pp. A48.1-A48 ◽  
Author(s):  
G Eunson ◽  
S McGurk ◽  
D Wilson ◽  
P Gillett ◽  
P Rogers ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Small Bowel ◽  
Prospective Study ◽  
Bowel Disease ◽  
Single Centre ◽  
Inflammatory Bowel
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