scholarly journals IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group BStreptococcusInfection

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Luciana Tissi ◽  
Francesco Bistoni ◽  
Manuela Puliti
Keyword(s):  
Mortality Rates ◽  
Group B Streptococci ◽  
Chemokine Production ◽  
Severe Arthritis ◽  
Invasive Infections ◽  
Group B ◽  
Experimental Group ◽  
Anti Inflammatory Cytokine ◽  
Local Levels

IL-4 is an anti-inflammatory cytokine that inhibits the onset and severity in different experimental arthritis models. Group B streptococci (GBS) have been recognized as an ever-growing cause of serious invasive infections in nonpregnant adults. Septic arthritis is a clinical manifestation of GBS infection. To investigate the role of IL-4 in experimental GBS infection, IL-4 deficient or competent mice were inoculated with1×107GBS/mouse. Mortality, appearance of arthritis, GBS growth in the organs, and local and systemic cytokine and chemokine production were examined. IL-4–/– mice showed lower mortality rates but increased severity of arthritis and exhibited a lower microbial load in blood, kidneys, and joints than wt mice. Increased local levels of IL-1β, IL-6, TNF-α, MIP-1α, and MIP-2 accompanied the more severe arthritis in IL-4–/– mice. Our results suggest a detrimental role of IL-4 in GBS sepsis, whereas it plays a beneficial effect on GBS-induced arthritis.

scholarly journals Inhibition of Nitric Oxide Synthase Exacerbates Group B Streptococcus Sepsis and Arthritis in Mice

2004 ◽  
Vol 72 (8) ◽  
pp. 4891-4894 ◽  
Author(s):  
Manuela Puliti ◽  
Christina von Hunolstein ◽  
Francesco Bistoni ◽  
Graziella Orefici ◽  
Luciana Tissi
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Group B Streptococcus ◽  
Mortality Rates ◽  
Interleukin 1Β ◽  
Severe Arthritis ◽  
Group B ◽  
Oxide Synthase

ABSTRACT The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with aminoguanidine (AG). AG-treated mice displayed higher mortality rates and more frequent and severe arthritis than controls. Worsening of arthritis correlated with a higher number of GBS cells in the joints and local interleukin-1β production.

scholarly journals Trends in molecular characteristics and antimicrobial resistance of group B streptococci: a multicenter study in Serbia, 2015–2020

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dusan Kekic ◽  
Ina Gajic ◽  
Natasa Opavski ◽  
Milan Kojic ◽  
Goran Vukotic ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Late Onset ◽  
Group B Streptococcus ◽  
Neonatal Morbidity ◽  
Disease Rate ◽  
Molecular Characteristics ◽  
Group B Streptococci ◽  
Live Births ◽  
Invasive Infections ◽  
Group B

AbstractGroup B Streptococcus (GBS) is a major cause of neonatal morbidity and mortality. Serbia has not fully implemented preventive measures against GBS neonatal diseases. Therefore, we aimed to assess the maternal GBS colonisation and invasive neonatal disease rate, to reveal the trends of antimicrobial resistance and serotype distribution of GBS from various patient groups. Randomly selected non-invasive (n = 991) and all invasive GBS (n = 80) collected throughout Serbia from 2015 to 2020 were tested for antimicrobial susceptibility, capsular typing, and hvgA detection. Overall, 877/5621 (15.6%) pregnant women were colonised with GBS. Invasive GBS infections incidence in infants (0.18/1000 live births) showed a decreasing trend (0.3 to 0.1/1000 live births). Type III was overrepresented in infants with invasive infections (n = 35, 58.3%), whereas type V predominated among colonised adults (n = 224, 25.5%) and those with noninvasive (n = 37, 32.5%) and invasive infections (n = 8, 40%). The hypervirulent clone III/ST17 was highly associated with invasive infections (n = 28, 35%), particularly late-onset disease (n = 9, 47.4%), showing an increase from 12.3 to 14.8%. The GBS resistance to erythromycin and clindamycin was 26.7% and 22.1%, respectively, with an upward trend. The emergence of the hypervirulent clone III/ST17 and the escalation in GBS resistance highlight an urgent need for continuous monitoring of GBS infections.

Assembly and role of pili in group B streptococci

2006 ◽  
Vol 60 (6) ◽  
pp. 1401-1413 ◽  
Author(s):  
Shaynoor Dramsi ◽  
Elise Caliot ◽  
Isabelle Bonne ◽  
Stephanie Guadagnini ◽  
Marie-Christine Prevost ◽  
...  
Keyword(s):  
Group B Streptococci ◽  
Group B

scholarly journals Role of L-Ficolin/Mannose-Binding Lectin-Associated Serine Protease Complexes in the Opsonophagocytosis of Type III Group B Streptococci

2004 ◽  
Vol 174 (1) ◽  
pp. 418-425 ◽  
Author(s):  
Youko Aoyagi ◽  
Elisabeth E. Adderson ◽  
Jin G. Min ◽  
Misao Matsushita ◽  
Teizo Fujita ◽  
...  
Keyword(s):  
Serine Protease ◽  
Mannose Binding Lectin ◽  
Group B Streptococci ◽  
Type Iii ◽  
Mannose Binding ◽  
Group B ◽  
Binding Lectin

scholarly journals Correction for Six et al., Molecular Characterization of Nonhemolytic and Nonpigmented Group B Streptococci Responsible for Human Invasive Infections

2016 ◽  
Vol 54 (7) ◽  
pp. 1932-1932
Author(s):  
Anne Six ◽  
Arnaud Firon ◽  
Céline Plainvert ◽  
Camille Caplain ◽  
Abdelouhab Bouaboud ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Group B Streptococci ◽  
Invasive Infections ◽  
Group B
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