scholarly journals Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Joanna Rosalind Cunnington ◽  
Ramesh Jois ◽  
Ivan Zammit ◽  
David Scott ◽  
John Isaacs
Keyword(s):  
Pituitary Gland ◽  
Diabetes Insipidus ◽  
Wegener’S Granulomatosis ◽  
Standard Treatment ◽  
Rare Complication ◽  
Wegener's Granulomatosis ◽  
Biologic Agents ◽  
Response To Treatment ◽  
Biologic Therapies ◽  
Patients With Diabetes

Wegener's granulomatosis of the pituitary gland resulting in diabetes insipidus is a rare complication of the disease. Standard treatment for Wegener's granulomatosis involves a combination of prednisolone and cylophosphamide, however biologic agents are now being used in refractory cases. We report three cases of patients with diabetes insipidus as a complication of Wegener's granulomatosis who were treated with biologic agents. All three cases showed clinical response to treatment with biologic agents including rituximab and alemtuzumab and two cases demonstrated improvement in pituitary gland abnormalities by MRI. Clinicians should be aware that diabetes insipidus can present as a complication of Wegener's granulomatosis and that biologic therapies may be effective in refractory cases.

scholarly journals Aortitis with aneurysm formation as a rare complication of Wegener's granulomatosis

2011 ◽  
Vol 54 (5) ◽  
pp. 1485-1487 ◽  
Author(s):  
Çagdas Ünlü ◽  
Martine Willems ◽  
Ineke J.M. Ten Berge ◽  
Dink A. Legemate
Keyword(s):  
Wegener’S Granulomatosis ◽  
Rare Complication ◽  
Wegener's Granulomatosis ◽  
Aneurysm Formation

Wegener's Granulomatosis Presenting as Diabetes Insipidus

2006 ◽  
Vol 114 (09) ◽  
pp. 533-536 ◽  
Author(s):  
P. Dutta ◽  
M. HayatBhat ◽  
A. Bhansali ◽  
P. Bambery ◽  
N. Kakar
Keyword(s):  
Diabetes Insipidus ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis

Wegener's granulomatosis. First case report in Bahrain

1998 ◽  
Vol 112 (7) ◽  
pp. 664-666 ◽  
Author(s):  
Ahmed Jamal ◽  
Reda Ali Ebrahim ◽  
Nabeel Tammam ◽  
Sungam Kanekar
Keyword(s):  
Wegener’S Granulomatosis ◽  
Total Population ◽  
Standard Treatment ◽  
Wegener's Granulomatosis ◽  
Cytotoxic Agents ◽  
Radiological Findings ◽  
First Case ◽  
High Index Of Suspicion ◽  
Very High

AbstractFormerly a fatal condition, Wegener's granulomatosis is now treated with good results. Although the annual incidence of Wegener's granulomatosis in the general population is not known, most European and American studies revealed an incidence in the range of one for every 250,000 of the population. The estimated total population of Bahrain as of June 1997 is 586,110; here we report the first diagnosed case of Wegener's granulomatosis in Bahrain.Our patient presented with epistaxis, and from the clinical features, the very high ESR, the operative, histopathological and the radiological findings, and a high index of suspicion we could confirm the diagnosis along with the appropriate immunological test (positive cANCA). Standard treatment with cytotoxic agents and corticosteroids has been used. On follow-up the patient has shown a progressive improvement in her clinical and laboratory parameters.

scholarly journals Ruptured arterial aneurysm in Wegener’s granulomatosis: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
A. Gravos ◽  
K. Katsifa ◽  
P. Tselioti ◽  
V. Grammatikopoulou ◽  
K. Sakellaridis ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Rare Complication ◽  
Supportive Therapy ◽  
Wegener's Granulomatosis ◽  
Multiple Organ ◽  
Ruptured Aneurysm ◽  
Arterial Aneurysm ◽  
Life Threatening ◽  
Old Greek

Abstract Background Aneurysm formation is a possible, but rare, complication of granulomatosis with polyangiitis, known as Wegener’s granulomatosis. Urgent diagnosis and therapy is very important because a ruptured aneurysm could be life threatening. Case presentation We, therefore, present the case of a 63-year-old Greek man who was diagnosed with granulomatosis with polyangiitis and retroperitoneal hematoma due to ruptured aneurysm in renal artery and upper pancreaticoduodenal artery. His clinical course was complicated by acute renal failure and acute respiratory failure due to alveolar hemorrhage. Emergency coil embolization was performed. Postembolization recovery was uneventful; no bleeding occurred. The patient underwent mechanical ventilation and continuous veno-venous hemofiltration and received combined immunosuppression and supportive therapy, but eventually died 30 days after admission to hospital from severe septic shock and multiple organ failure. Conclusion Endovascular treatment is the therapy of choice, especially for patients with ruptured aneurysms that are hemodynamically stable. Early diagnosis is very important, as urgent embolization and early initiation of immunosuppression therapy are the treatment of choice.

scholarly journals Wegener's granulomatosis complicated by diabetes insipidus.

1983 ◽  
Vol 42 (5) ◽  
pp. 600-601 ◽  
Author(s):  
N P Hurst ◽  
N A Dunn ◽  
T M Chalmers
Keyword(s):  
Diabetes Insipidus ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis
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