scholarly journals Studies on NovelN4-[4,6-Diaryl-2-pyrimidinyl]-7-chloro-4-quinolinamine and their Microbicidal Efficacy

2009 ◽  
Vol 6 (s1) ◽  
pp. S406-S412 ◽  
Author(s):  
Arvind G. Mehta ◽  
Avnish A. Patel
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
Guanidine Nitrate ◽  
Aryl Aldehyde ◽  
Antibacterial And Antifungal

The required chalcones1a-hwere prepared by reaction of substituted acetophenone with different aryl aldehyde, which in turn treated with guanidine nitrate, yielded 4-(substituted phenyl)-6-(substituted phenyl)-2-pyrimidinamine2a-h. Novel pyrimidine quinoline clubbed molecules3a-hhave been prepared by reaction of2a-hwith 4,7-dichloroquinoline. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

scholarly journals Synthesis and Studies of Novel Optically Active Schiff’s Base Derivatives and their Antimicrobial Activities

2010 ◽  
Vol 7 (2) ◽  
pp. 617-623 ◽  
Author(s):  
Ishwar J. Patel ◽  
Shailesh J. Parmar
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
Acid Catalyst ◽  
Antimicrobial Activities ◽  
Optically Active ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Base ◽  
Antibacterial And Antifungal

Several new Schiff’s base derivatives were prepared by condensing various substituted benzaldehyde with 1-(4-aminophenyl)-2-{4-[(S)-(4-chlorophenyl)(phenyl) methyl]-1-piperazinyl}ethanone in presence of acid catalyst under reflux condition. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

scholarly journals Synthesis and studies of the biological activity of novel pyrimido fused acridine derivatives

2006 ◽  
Vol 71 (10) ◽  
pp. 1015-1023 ◽  
Author(s):  
Bhavesh Patel ◽  
Ranjan Patel ◽  
Manish Patel
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Potassium Carbonate ◽  
Anthranilic Acid ◽  
Phosphorus Oxychloride ◽  
Type Ii ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

Anthranilic acid was reacted with various substituted 6-bromoquinazolinones in the presence of Cu-powder and anhydrous potassium carbonate in DMF to give acid intermediates (Ullmann Type-II condensation). All these acids were then cyclized in phosphorus oxychloride to give 11-chloropyrimido[4,5-b]acridin-4(3H)-ones. All the synthesized compounds were identified by conventional methods (1H-NMR, IR, elemental analysis) and were screened for their antimicrobial activity on some bacterial and fungal cultures. The results were compared with standard bactericides and fungicides. All the synthesized compounds exhibited moderate antibacterial and antifungal activity. .

scholarly journals Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety

2019 ◽  
Vol 9 (5-s) ◽  
pp. 44-49
Author(s):  
Purushottam R. Laddha ◽  
Kailash R. Biyani
Keyword(s):  
Acetic Acid ◽  
Antifungal Activity ◽  
Schiff Bases ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Primary Amines ◽  
Antibacterial And Antifungal Activity ◽  
Phenoxy Acetic Acid ◽  
Antibacterial And Antifungal

Schiff's bases are condensation products of primary amines with carbonyl compounds. Schiff bases (imines) possess wide variety of biological activities that include antibacterial and antifungal activity. In present work, Schiff bases from 3,5- Dimethoxyphenol (aryloxy moiety) as starting material synthesized. Esterification of 3,5- Dimethoxyphenol led to formation of (3,5-Dimethoxy-phenoxy)-acetic acid ethyl ester (1). (3,5-Dimethoxy-phenoxy)-acetic acid hydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield novel imines or Schiff bases (3A-I). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities. All the synthesized compounds had shown antibacterial and antifungal activity. Schiff bases 3C, 3D, 3E and 3I had shown good antimicrobial activity among all newly synthesized compounds. Keywords: Schiff base, aryloxy moiety, imines

SYNTHESIS OF SOME NEW 1, 3-DI METHYL SUBSTITUTED GUANIDINE WITH POSSIBLE ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY

2016 ◽  
Vol 2 (3) ◽  
pp. 138-140
Author(s):  
Bhupender Singh Rawat ◽  
S. C. Mehra
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Broad Spectrum ◽  
Nitrous Acid ◽  
Acid Oxidation ◽  
Antibacterial And Antifungal Activity ◽  
Acid Catalyzed ◽  
Antibacterial And Antifungal

The compounds containing thiazole, thiadiazole, oxazole, oxadiazole, imidazole, pyrimidine, pyridine & benzothiazole rings have been found to exhibit broad spectrum of biological activities.Derivatives of 1, 2, 4-thiadiazole and 1, 2, 4-thiadiazolidines exhibit antibacterial and antifungal activity1. Thiazolyl guanidines2 and various substituted aryl guanidine’s have been found to exhibit antibacterial & antifungal activities3.Keeping all these views in mind attempts were made to synthesized some new 1,3-di methyl Substituted Guanidine.In the present work 2,4 Dimethyl -3,5-(di Aryl imino)-1,2,4-thiadiazolidines were prepared by nitrous acid oxidation of N-methyl –N Aryl thiourea4 & 2,4 dimethyl-3,5-(diaryl imino)-1,2,4-thiazolidines were converted to corresponding 1,3 di methyl substituted guanidine’s by their acid catalyzed re-arrangment5.(Scheme-1)Antibacterial & Antifungal activity of the title compounds were evaluated against two bacteria, E.coli & lactobacillus & two fungi, A.Brassicicola & Aspergillus Niger. N=methyl-N`-Aryl thiourea (1-10) were prepared by refluxing a mixture of different 2-Amino Heterocyclic moieties with methyl iso thiocyanate in Ethanol.A mixture of compound (1-100 and conc. HCl, ethanol was added drop wise & under stirring to a solution of NaNO2 in water afforded 2, 4-dimethyl-3,5-(di Aryl imino)-1,2,4-thiadiazolidine (11-20) afforded 1,3 di methyl substituted guanidine’s (21-30). Structures of the compounds were established by elemental analysis & spectral data.

scholarly journals Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

2013 ◽  
Vol 63 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Priya V. Frank ◽  
Mahesha Manjunatha Poojary ◽  
Naral Damodara ◽  
Chandrashekhar Chikkanna
Keyword(s):  
Antifungal Activity ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Mannich Reaction ◽  
Mannich Bases ◽  
Antibacterial And Antifungal Activity ◽  
Antimicrobial Studies ◽  
Antibacterial And Antifungal

3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.

Synthesis of Coumarin Derivatives with Cytotoxic, Antibacterial and Antifungal Activity

2004 ◽  
Vol 19 (4) ◽  
pp. 373-379 ◽  
Author(s):  
Khalid Mohammed Khan ◽  
Zafar S. Saify ◽  
Muhammad Zarrar Khan ◽  
Zia-Ullah ◽  
M. Iqbal Choudhary ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Coumarin Derivatives ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal
Sign in / Sign up

Export Citation Format

Share Document