scholarly journals Selective Digestive Tract Decontamination: A Tough Pill to Swallow

2009 ◽  
Vol 20 (1) ◽  
pp. 9-11 ◽  
Author(s):  
Kevin B Laupland ◽  
David N Fisman
Keyword(s):  
Digestive Tract ◽  
Selective Digestive Tract Decontamination

scholarly journals Reply to “Colistin Resistance during Selective Digestive Tract Decontamination Is Uncommon”

2013 ◽  
Vol 58 (1) ◽  
pp. 627-627 ◽  
Author(s):  
Teysir Halaby ◽  
Nashwan al Naiemi ◽  
Jan Kluytmans ◽  
Job van der Palen ◽  
Christina M. J. E. Vandenbroucke-Grauls
Keyword(s):  
Digestive Tract ◽  
Colistin Resistance ◽  
Selective Digestive Tract Decontamination

Selective digestive tract decontamination in critically ill patients

2012 ◽  
Vol 13 (8) ◽  
pp. 1113-1129 ◽  
Author(s):  
Luciano Silvestri ◽  
Hendrick KF van Saene ◽  
Andy J Petros
Keyword(s):  
Digestive Tract ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Selective Digestive Tract Decontamination

scholarly journals Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects

Microbiome ◽  
2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Elena Buelow ◽  
Teresita d. j. Bello González ◽  
Susana Fuentes ◽  
Wouter A. A. de Steenhuijsen Piters ◽  
Leo Lahti ◽  
...  
Keyword(s):  
Intensive Care ◽  
Gut Microbiota ◽  
Digestive Tract ◽  
Healthy Subjects ◽  
Intensive Care Patients ◽  
Selective Digestive Tract Decontamination

scholarly journals Reducing the dosing frequency of selective digestive tract decontamination to three times daily provides effective decontamination of Gram-negative bacteria

2021 ◽  
Author(s):  
Jara R. de la Court ◽  
Kim C. E. Sigaloff ◽  
Thomas Groot ◽  
Johan I. van der Spoel ◽  
Rogier P. Schade
Keyword(s):  
Clinical Outcome ◽  
Digestive Tract ◽  
Rank Test ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Log Rank Test ◽  
Significant Difference ◽  
Selective Digestive Tract Decontamination ◽  
Dosing Frequency ◽  
Before And After

AbstractThis study evaluated the effectiveness of selective digestive tract decontamination (SDD) application three times daily (t.i.d.) compared to the standard four times daily (q.i.d.). Retrospective equivalence (combined non-inferiority and non-superiority design) study with a before-and-after design on a tertiary ICU in which the SDD frequency was reduced from q.i.d. to t.i.d. All patients with ICU admissions ≥72h and with ≥2 surveillance cultures collected on different dates were included in this study. We compared successful decontamination of Gram-negative bacteria (GNB). Furthermore, time to decontamination, ICU-acquired GNB bacteraemia and 28-day mortality were compared between the two groups. In total 1958 ICU admissions (1236 q.i.d., 722 t.i.d). Decontamination was achieved during the first week of admission in 77% and 76% of patients receiving SDD q.i.d and t.i.d., respectively. Successful decontamination within 14 days (without consecutive acquisition of Gram-negative bacteria) was achieved in 69.3% of the admissions with q.i.d. versus 66.8% in t.i.d. SDD (p-value = 0.2519). The proportions of successful decontamination of GNB were equivalent in both groups (−0.025, 98% CI: −0.087; 0.037). There was no significant difference in time to decontamination between the two regimens (log-rank test p-value = 0.55). Incidence (episodes/1000 days) of ICU-acquired GNB bacteraemia was 0.9 in both groups, and OR for death at day 28 in the t.i.d. group compared to the q.i.d. group was 0.99 (95% confidence interval, 0.80–1.21). This study shows that a t.i.d. application regimen achieves similar outcomes to the standard q.i.d. regime, for both microbiological and clinical outcome measures.

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