scholarly journals Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals

2009 ◽  
Vol 21 (1-2) ◽  
pp. 77-91 ◽  
Author(s):  
Maija Pihlajamäki ◽  
Reisa A. Sperling
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Functional Imaging ◽  
Default Mode Network ◽  
Cognitive Task ◽  
Memory Function ◽  
Brain Regions ◽  
Older Individuals ◽  
Default Mode

Alzheimer’s disease (AD) is the most common form of dementia in old age, and is characterized by prominent impairment of episodic memory. Recent functional imaging studies in AD have demonstrated alterations in a distributed network of brain regions supporting memory function, including regions of the default mode network. Previous positron emission tomography studies of older individuals at risk for AD have revealed hypometabolism of association cortical regions similar to the metabolic abnormalities seen in AD patients. In recent functional magnetic resonance imaging (fMRI) studies of AD, corresponding brain default mode regions have also been found to demonstrate an abnormal fMRI task-induced deactivation response pattern. That is, the relative decreases in fMRI signal normally observed in the default mode regions in healthy subjects performing a cognitive task are not seen in AD patients, or may even be reversed to a paradoxical activation response. Our recent studies have revealed alterations in the pattern of deactivation also in elderly individuals at risk for AD by virtue of their APOE e4 genotype, or evidence of mild cognitive impairment (MCI). In agreement with recent reports from other groups, these studies demonstrate that the pattern of fMRI task-induced deactivation is progressively disrupted along the continuum from normal aging to MCI and to clinical AD and more impaired in e4 carriers compared to non-carriers. These findings will be discussed in the context of current literature regarding functional imaging of the default network in AD and at-risk populations.

scholarly journals Shared effects of the clusterin gene on the default mode network among individuals at risk for Alzheimer's disease

2017 ◽  
Vol 23 (5) ◽  
pp. 395-404 ◽  
Author(s):  
Qing Ye ◽  
Fan Su ◽  
Hao Shu ◽  
Liang Gong ◽  
Chun-Ming Xie ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Default Mode Network ◽  
Default Mode

scholarly journals Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

2019 ◽  
Vol 15 (7) ◽  
pp. 940-950 ◽  
Author(s):  
Patrizia A. Chiesa ◽  
Enrica Cavedo ◽  
Andrea Vergallo ◽  
Simone Lista ◽  
Marie-Claude Potier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Default Mode Network ◽  
Default Mode ◽  
Asymptomatic Individuals

scholarly journals Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease

2013 ◽  
Vol 34 (3) ◽  
pp. 641-649 ◽  
Author(s):  
Heather Kenna ◽  
Fumiko Hoeft ◽  
Ryan Kelley ◽  
Tonita Wroolie ◽  
Bevin DeMuth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Default Mode Network ◽  
Plasma Insulin ◽  
Default Mode ◽  
Fasting Plasma ◽  
Fasting Plasma Insulin

scholarly journals The Default Mode Network in Healthy Aging and Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Katell Mevel ◽  
Gaël Chételat ◽  
Francis Eustache ◽  
Béatrice Desgranges
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Default Mode Network ◽  
Healthy Aging ◽  
Brain Regions ◽  
Amnestic Mild Cognitive Impairment ◽  
Default Mode ◽  
The Past ◽  
Populations At Risk ◽  
Increased Activity

In the past decade, a “default mode network” (DMN) has been highlighted in neuroimaging studies as a set of brain regions showing increased activity in task-free state compared to cognitively demanding task, and synchronized activity at rest. Changes within this network have been described in healthy aging as well as in Alzheimer's disease (AD) and populations at risk for AD, that is, amnestic Mild Cognitive Impairment (aMCI) patients and APOE-ε4 carriers. This is of particular interest in the context of early diagnosis and more generally for our understanding of the physiopathological mechanisms of AD. This paper gives an overview of the anatomical and physiological characteristics of this network as well as its relationships with cognition, before focusing on changes in the DMN over normal aging and Alzheimer's disease. While perturbations of the DMN have been consistently reported, especially within the posterior cingulate, further studies are needed to understand their clinical implication.

scholarly journals Race modifies default mode network connectivity in Alzheimer’s disease

2018 ◽  
Author(s):  
Maria B. Misiura ◽  
Junjie Wu ◽  
Deqiang Qiu ◽  
Jennifer C. Howell ◽  
Monica W. Parker ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
African Americans ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Medial Temporal Lobe ◽  
Memory Function ◽  
Default Mode ◽  
Neuropsychological Profile ◽  
Older African Americans

AbstractObjectiveTo determine if resting state functional MRI biomarkers of Alzheimer’s disease (AD) differ between older African Americans and Caucasians.MethodsWe analyzed MRI profiles from 78 individuals (31 African Americans, 47 Caucasians) with normal cognition (n=36) or mild cognitive impairment/mild AD dementia (MCI/AD, n=42). We compared AD-associated intra-network functional connectivity of the default mode network (DMN) according to race, and correlated domain-specific cognitive functions with functional connectivity which differed between the racial groups.ResultsWe identified key differences in DMN functional connectivity associated with AD between the races. Whereas MCI/AD was associated with decreased functional connectivity within the midline core DMN subsystem in older Caucasians, MCI/AD was instead associated with increased functional connectivity within the same subsystem of older African Americans. This is despite decreased functional connectivity in the medial temporal lobe DMN subsystem in both races. Memory function was also positively associated with connectivity between the precuneus and the posterior cingulate/inferior parietal lobule within the midline core subsystem, in keeping with a less amnestic-profile in older African Americans with MCI/AD.ConclusionsThese findings provide structural support that race modifies the AD phenotypes downstream from cerebral amyloid deposition, and suggests a rsf-MRI correlate of African American’s less amnestic neuropsychological profile in MCI/AD.

Spectral dynamic causal modelling of resting-state fMRI: an exploratory study relating effective brain connectivity in the default mode network to genetics

2020 ◽  
Vol 19 (3) ◽  
Author(s):  
Yunlong Nie ◽  
Eugene Opoku ◽  
Laila Yasmin ◽  
Yin Song ◽  
Jie Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Default Mode Network ◽  
Resting State ◽  
Brain Connectivity ◽  
Parametric Bootstrap ◽  
Imaging Genetics ◽  
Nucleotide Polymorphisms ◽  
Mixed Effect ◽  
Default Mode

AbstractWe conduct an imaging genetics study to explore how effective brain connectivity in the default mode network (DMN) may be related to genetics within the context of Alzheimer’s disease and mild cognitive impairment. We develop an analysis of longitudinal resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data obtained from a sample of 111 subjects with a total of 319 rs-fMRI scans from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. A Dynamic Causal Model (DCM) is fit to the rs-fMRI scans to estimate effective brain connectivity within the DMN and related to a set of single nucleotide polymorphisms (SNPs) contained in an empirical disease-constrained set which is obtained out-of-sample from 663 ADNI subjects having only genome-wide data. We relate longitudinal effective brain connectivity estimated using spectral DCM to SNPs using both linear mixed effect (LME) models as well as function-on-scalar regression (FSR). In both cases we implement a parametric bootstrap for testing SNP coefficients and make comparisons with p-values obtained from asymptotic null distributions. In both networks at an initial q-value threshold of 0.1 no effects are found. We report on exploratory patterns of associations with relatively high ranks that exhibit stability to the differing assumptions made by both FSR and LME.

IC-P-133: Music as a probe of default mode network function in young-onset Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_2) ◽  
pp. P91-P91
Author(s):  
Catherine F. Slattery ◽  
Jennifer L. Agustus ◽  
Ross W. Paterson ◽  
Mark J. White ◽  
Alexander J.M. Foulkes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Default Mode Network ◽  
Default Mode ◽  
Young Onset ◽  
Network Function
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