scholarly journals Nocardia FarcinicaLung Abscess Presenting in the Context of Advanced HIV Infection: Spontaneous Resolution in Response to Highly Active Antiretroviral Therapy Alone

2009 ◽  
Vol 20 (3) ◽  
pp. e103-e106 ◽  
Author(s):  
Arienne S King ◽  
Jose G Castro ◽  
Gordon CK Dow
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Opportunistic Pathogen ◽  
Cd4 Cell Count ◽  
Highly Active ◽  
Metastatic Infection ◽  
History Of ◽  
Cd4 Cell ◽  
The Impact

A 43-year-old man, known to be HIV-positive, presented with a six-week history of symptoms including cough, hemoptysis, anterior chest pain, fever and wasting. His CD4 cell count was 46 cells/μL, and his chest x-ray showed a cavitating lesion in the left upper lobe. Sputum culture was positive forNocardia farcinica. His infection resolved following initiation of antiretroviral therapy.Nocardiais an uncommon opportunistic pathogen in patients with HIV infection and is usually associated with advanced CD4 depletion, cavitary pneumonia, metastatic infection and high mortality. The impact of antiretroviral therapy onNocardiainfection in the setting of HIV has not been clearly elucidated. The current report is the first to present a case in which a complete clinical cure ofNocardiapneumonia has been documented, primarily in response to highly active antiretroviral therapy alone.

Pulmonary cryptosporidiosis in an AIDS patient: successful treatment with paromomycin plus azithromycin

2005 ◽  
Vol 16 (7) ◽  
pp. 515-517 ◽  
Author(s):  
F Palmieri ◽  
S Cicalini ◽  
N Froio ◽  
E B Rizzi ◽  
D Goletti ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Combination Therapy ◽  
Respiratory Tract ◽  
Highly Active Antiretroviral Therapy ◽  
Favourable Outcome ◽  
Antimicrobial Treatment ◽  
Cd4 Cell Count ◽  
Highly Active ◽  
Intestinal Involvement ◽  
Cd4 Cell

Extra-intestinal cryptosporidiosis, especially of the biliary and respiratory tract, is likely in the course of an intestinal involvement, whereas it is rare without such a localization. We report a case of pulmonary cryptosporidiosis without apparent intestinal involvement in an AIDS patient, with favourable outcome after antimicrobial combination therapy with paromomycin plus azithromycin. The successful response to antimicrobial treatment was subsequently maintained by effective highly active antiretroviral therapy (HAART). We suggest that respiratory cryptosporidiosis should be investigated in HIV-infected patients with pulmonary symptoms and low CD4 cell count, and, if detected, treatment should include HAART plus the combination of paromomycin and azithromycin.

Hodgkin’s disease and HIV infection (HD-HIV): Prognostic factors in 596 patients (pts) within the group of European Cooperation on AIDS and Tumors (GECAT).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 8058-8058
Author(s):  
Michele Spina ◽  
Josep-Maria Ribera ◽  
Jean Gabarre ◽  
Christoph Wyen ◽  
Silvia Montoto ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Cd4 Cell Count ◽  
Highly Active ◽  
Cd4 Cell

8058 Background: Hodgkin’s disease (HD) is the most common non-AIDS defining tumour diagnosed in HIV setting. The introduction of highly active antiretroviral therapy (HAART) has opened a new prospective in the treatment of pts with HD-HIV as the better control of the underlying HIV infection allows the use of more aggressive chemotherapy regimens, including high dose chemotherapy. However, up to now prognostic factors on overall survival (OS) or time to treatment failure (TTF) have not yet been identified. Methods: In order to identify prognostic factors, we analyzed data on 596 pts with HD-HIV diagnosed and treated in 90 different Institution of 6 European countries from October 1983 to March 2010. All factors were analyzed for OS and TTF. Results: 86% of pts were male and the median CD4 cell count was 224/dl (range 3-1274); 52% of pts had mixed cellularity subtype, stages III-IV were diagnosed in 72% of cases and 55% of pts had extranodal involvement (bone marrow 35%, spleen 21%, liver 14%). The table summarizes the results of multivariate analysis. Conclusions: We identified a new “European Score” for HD-HIV able to predict different outcomes in these patients. This score should be considered for future prospective studies. [Table: see text]

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