scholarly journals Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
A. P. Mishra ◽  
Monika Soni
Keyword(s):  
Schiff Bases ◽  
Pathogenic Bacteria ◽  
Free Ligand ◽  
Physicochemical Characterization ◽  
Xrd Analysis ◽  
E Coli ◽  
Diffusion Technique ◽  
Tetragonal Crystal ◽  
Biological Studies ◽  
Degradation Pattern

New bidentate or tridentate Schiff bases and their VO(II) and Co(II) complexes formed by the condensation of methyl isobutyl ketone with nicotinamide (mna)/2-amino-4-chlorophenol (map) and 2-hydroxy acetophenone with nicotinamide (han)/isoniazide (hai). Physicochemical characterization has been carried out to determine the structure of the complexes. The FAB mass and thermal data show degradation pattern of the complexes. XRD analysis reveals that all the studied complexes crystallize as tetragonal crystal system. Some of the complexes have been screened for their antimicrobial activity by the well diffusion technique using DMSO as solvent on different species of pathogenic bacteria/fungi, that is, E. coli, S. aureus, S. fecalis, A. niger, T. polysporum, and their antimicrobial potency have been discussed. It has been found that all the complexes are antimicrobially active and show higher activity than the free ligand. Metal chelation affects significantly the antimicrobial/bioactive behavior of the organic ligands.

scholarly journals Biosynthesis and antibacterial potential of tectona grandis mediated magnesium oxide nanorods.

2019 ◽  
Vol 27 ◽  
pp. 109-120
Author(s):  
HA Maishera ◽  
FA Kuta ◽  
JO Tijani ◽  
NU Adabara ◽  
AS Adedeji ◽  
...  
Keyword(s):  
Magnesium Oxide ◽  
Pathogenic Bacteria ◽  
Tectona Grandis ◽  
Xrd Analysis ◽  
High Rate ◽  
Hydrodynamic Diameter ◽  
Magnesium Chloride Solution ◽  
E Coli ◽  
Oxide Nanorods ◽  
Average Size

The high rate of enteric bacterial infection and the increasing drug resistance by pathogenic bacteria have made the search for new antimicrobials inevitable. The aim of the study was to investigate the antibacterial potentials of Tectona grandis magnesium oxide (MgO) nanorods on clinical isolates of Escherichia coli Acj 213, Salmonella Typhi strain T8 and Pseudomonas aeruginosa strain DMI. Magnesium chloride solution (50 ml, 1M) was bio reduced to magnesium oxide nanorods using Tectona grandis leaves extract (10 ml). The biosynthesized nanoparticles were characterized using UV-visible spectroscopy (UV-vis), dynamic light scattering (DLS), high resolution transmission electron microscopy (HRTEM), surface area electron diffraction analysis (SAED) and X-ray diffraction techniques (XRD). Similarly, antibacterial effects of the MgO nanorods were determined using agar well diffusion technique. The biogenic MgO nanorods colloidal solution was fluffy brown in colour with UV-Vis absorbance peak occurring at 364 nm. The DLS analysis revealed monodispersed MgO nanorods with 90 nm hydrodynamic diameter. Furthermore, the XRD analysis showed that the crystalline nature had average size of 30 nm. HRTEM/SAED result revealed a rod shaped polycrystalline MgO nanorods with 29 nm average size. The results of the antibacterial test showed that MgO nanorods had the highest antimicrobial activity (21.75 ± 1.79 mm, 22.75 ± 1.70 mm and 19.75 ± 1.10 mm) at 500 mg/ml against E. coli Acj 213, S. Typhi strain T8 and P. aeruginosa strain DMI, respectively. The minimum inhibitory concentration for P. aeruginosa strain DMI, S. Typhi strain T8 and E. coli Acj 213 were 125 mg/ml, 62.5 mg/ml and 125 mg/ml, respectively. However, the minimum bacteriocidal concentration was 250 mg/ml, 125 mg/ml and 250 mg/ml, respectively. The results of this study indicate that the synthesized MgO nanorods could be a potential antibacterial agent with broad spectrum activities. J. bio-sci. 27: 109-120, 2019

Synthesis and Characterization of Tris(nicotinohydroxamato) Vanadium(III) Complex

2020 ◽  
Vol 12 (5) ◽  
pp. 695-701
Author(s):  
Sonika Sharma ◽  
Neeraj Sharma
Keyword(s):  
Pathogenic Bacteria ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Nitrogen Atmosphere ◽  
Spectral Studies ◽  
Mass Spectral ◽  
E Coli ◽  
Concentration Method ◽  
Elemental Analyses

The tris(nicotinohydroxamato) vanadium(III) complex of composition [V(C5H4NCONHO)3] have been synthesized by the reaction of VCl3 with three equivalents of potassium salts of nicotinohydroxamate in methanol medium under nitrogen atmosphere. The characterization of complex has been accomplished by elemental analyses, molar conductivity, magnetic moment measurements, IR, electronic and mass spectral studies. An octahedral geometry around vanadium, inferred from physicochemical and spectral studies has been proposed for complex. The antimicrobial activities of the newly synthesized complex, ligand and precursor VCl3 have been evaluated against some pathogenic bacteria as E. coli, S. aureus, S. typhi, S. paratyphi, S. epidermidis and K. pneumoniae and fungi such as A. niger, B. fulva and M. circinelloid by minimum inhibitory concentration method. The complex exhibited promising antimicrobial activity relative to free ligand and metal precursor.

scholarly journals Prevalence of Extended-Spectrum Beta-Lactamases-Producing Microorganisms in Patients Admitted at KRRH, Southwestern Uganda

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Baguma Andrew ◽  
Atek Kagirita ◽  
Joel Bazira
Keyword(s):  
Healthcare Workers ◽  
Pathogenic Bacteria ◽  
Regional Referral Hospital ◽  
Beta Lactamases ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
Extended Spectrum ◽  
Diffusion Technique ◽  
Extended Spectrum Beta Lactamases ◽  
Southwestern Uganda

The emergence of extended-spectrum beta-lactamase- (ESBL-) producing pathogenic bacteria at Kabale Regional Referral Hospital (KRRH), located in southwestern Uganda, is of great concern: a phenomenon that worries clinicians and other healthcare workers due to the serious threat they pose to patients. This current study aimed at determining the phenotypic detection of ESBL-producing strains ofE. coli, Klebsiellasp., andProteussp. isolated from clinical specimens and their prevalence in patients admitted at KRRH. We used combined disc diffusion technique to detect and establish the presence of ESBLs-producing bacteria. Of the 100 tested bacterial isolates, 89 (89%) were identified as ESBL-producing bacteria.Klebsiellasp. predominated in the samples (46 (52%)), presenting the highest frequency of ESBLs producing followed byE. coli(39 (44%)) andProteus mirabilis(4 (4.5%)) from the combined disk diffusion.

scholarly journals Conductivity, Surface Tension, and Comparative Antibacterial Efficacy Study of Different Brands of Soaps of Nepal

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Narendra Kumar Chaudhary ◽  
Arush Bhattarai ◽  
Biswash Guragain ◽  
Ajaya Bhattarai
Keyword(s):  
Escherichia Coli ◽  
Pathogenic Bacteria ◽  
Efficacy Study ◽  
Antibacterial Efficacy ◽  
Solution Properties ◽  
Disc Diffusion ◽  
Proteus Vulgaris ◽  
E Coli ◽  
Diffusion Technique ◽  
Bioactive Ingredients

The current study aims to evaluate the solution properties and antibacterial efficacy study of five different brands of toilet soaps of Nepal such as Okhati (OKT), Lifebuoy (LFBY), Lux (LX), Liril (LRL), and Chiuree Neem (NM). The evaluation of critical micelle concentration (CMC) and their thermodynamics and surface properties are also reported. This study was further extended to evaluate antibacterial efficacy against three pathogenic bacteria such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Proteus vulgaris (P. vulgaris) by disc diffusion technique, and it was done at four different concentrations of soap. The bioactive ingredients present in them provide antibacterial potency to cure various skin problems caused by bacterial pathogens. Similarly, the antibacterial potency of LFBY was found higher than other soaps. Based on these studies, we can simply take LFBY soap at the highest rank in regards to antibacterial sensitivity.

scholarly journals Synthesis, Structural Characterization, Thermal and Biological Studies of Some Metal Complexes with Aroyl Hydrazone Based Ligand

2020 ◽  
Vol 32 (8) ◽  
pp. 2021-2027
Author(s):  
A.S. Aswar ◽  
K.A. Thakare
Keyword(s):  
Metal Complexes ◽  
Pathogenic Bacteria ◽  
Condensation Reaction ◽  
Free Ligand ◽  
Sem Analysis ◽  
Central Metal ◽  
Magnetic Studies ◽  
Hydrazone Ligand ◽  
Biological Studies ◽  
Bacteria And Fungi

The metal complexes of Ti(III), Cr(III), Fe(III), VO(IV), MoO2(VI), WO2(VI), Th(IV) have been synthesized with hydrazone ligand. The mononucleating hydrazone ligand has been synthesized via condensation reaction between pyrazine-2-carbohydrazide and 2,4-dihydroxy benzophenone in 1:1 ratio. The ligand and its complexes were studied on the basis of elemental analysis, magnetic susceptibility measurements, IR and electronic spectra, TGA, XRD, 1H NMR, mass spectroscopy and SEM analysis. Spectroscopic and magnetic studies suggest coordination of most of the metal complexes in a regular octahedral around the central metal ions except vanadium which is square pyramidal. Free ligand as well as its metal complexes were screened against the growth of pathogenic bacteria. The inhibition data revealed that metal complexes exhibit higher inhibition potential against growth of bacteria and fungi than free ligand.

scholarly journals Antibacterial Activities of Soft Coral Extract Lobophytum sp. towards Pathogenic Bacteria (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa)

2020 ◽  
Vol 25 (2) ◽  
pp. 151
Author(s):  
May Juna putri Tanjung ◽  
Dessy Yoswaty ◽  
Irwan Effendi
Keyword(s):  
Escherichia Coli ◽  
Research Method ◽  
Pathogenic Bacteria ◽  
Soft Coral ◽  
Antibacterial Activities ◽  
Inhibitory Effect ◽  
E Coli ◽  
Activity Test ◽  
Diffusion Technique ◽  
West Sumatra

Soft coral extract of Lobophytum sp. can inhibit the growth of pathogenic bacteria with a weak to very strong category. The purpose of this study was to determine the activity of Lobophytum sp. against pathogenic bacteria E. coli, S. aureus, and P. aeruginosa and analyze the concentration of Lobophytum sp. effective against pathogenic bacteria E. coli, S. aureus, and P. aeruginosa. Sampling was carried out in the waters of Pigago Island, West Pasaman Regency, West Sumatra. This research method is an experimental method and antibacterial activity test is carried out with agar diffusion diffusion technique. This soft coral extract has the potential to inhibit pathogenic bacteria. The highest inhibitory effect on E. coli bacteria was the highest yield at a concentration of 100% with a yield of 13.95 mm, in the S. aureus bacteria the highest yield at a concentration of 100% with a yield of 12.53 mm and in P.aureginosa bacteria at a concentration of 100% was 23.87 mm.

scholarly journals Synthetic, structural and biological studies of organosilicon(IV) complexes of Schiff bases derived from pyrrole-2-carboxaldehyde

2010 ◽  
Vol 75 (7) ◽  
pp. 917-927 ◽  
Author(s):  
Kiran Singh ◽  
Dharam Pal
Keyword(s):  
Schiff Bases ◽  
Pathogenic Bacteria ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Central Metal Atom ◽  
Central Metal ◽  
Biological Studies

Selected new organosilicon(IV) complexes having the general formula R2SiCl[L] and R2Si[L]2 were synthesized by the reactions of Me2SiCl2 with Schiff bases [5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole, 5-mercapto-3-methyl-4-(2-pyrrolecarboxalidene amino)-s-triazole and 3-ethyl-5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole] in 1:1 and 1:2 molar ratios. All of the compounds were characterized by elemental analysis, molar conductance, and IR, UV, 1H-, 13C- and metal-NMR spectral studies. All the spectral data suggest an involvement with an azomethine nitrogen in coordination to the central metal atom. With the help of above-mentioned spectral studies, penta and hexacoordinated environments around the central metal atoms in the 1:1 and 1:2 complexes, respectively, are proposed. Finally, the free ligands and their metal complexes were tested in vitro against some pathogenic bacteria and fungi to assess their antimicrobial properties.

scholarly journals Synthesis, characterization, and biological studies of some biometal complexes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Vinay Kumar Srivastava
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Anticancer Agents ◽  
Anthranilic Acid ◽  
Pathogenic Bacteria ◽  
Free Ligand ◽  
Binding Studies ◽  
Metal Acetate ◽  
Biological Studies

Abstract Background Metal complexes Cu[C13H8O4N]22, Ni[Cl3H8O4N]23, and Co[C13H8O4N]24 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1. All the complexes are well characterized by various spectral and physical methods. The antimicrobial activity of the complexes has been studied against some of the pathogenic bacteria and fungi. Results Results indicate that complexes have higher antimicrobial activity than the free ligand. This would suggest that chelation reduces considerably the polarity of the metal ions in the complexes which in turn increases the hydrophobic character of the chelate and thus enables permeation, through the lipid layer of microorganisms. All the complexes were assessed for their anticancer studies against a panel of selected cancer cells HOP62 and BT474 respectively. Results showed that the complexes are promising chemotherapeutic alternatives in the search of anticancer agents. The fluorescence quenching phenomenon is observed in the Schiff base metal complexes. Conclusion The octahedral transition metal complexes 2, 3, and 4 have been obtained by treatment of ligand 2-furylglyoxal-anthranilic acid (FGAA) 1 with metal acetate. Complexes under investigations have shown antimicrobial, potential anticancer, and the DNA binding studies. Graphical abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES

2018 ◽  
Vol 7 (6) ◽  
Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Fungal Strain ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Gram Negative ◽  
E Coli

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.

Probiotics Slow the Growth of Pathogenic Bacteria

2019 ◽  
Vol 14 (1) ◽  
pp. 28-31 ◽  
Author(s):  
Rowles H. L.
Keyword(s):  
Growth Rate ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Diarrheal Disease ◽  
Growth Curves ◽  
Mortality Rates ◽  
Controlled Delivery ◽  
E Coli ◽  
Multiple Strains ◽  
Commercial Probiotics

Probiotics are live microorganisms, which when ingested in sufficient amounts, confer health benefits to the host by improving the gut microflora balance. The purpose of this research was to determine whether commercial probiotic products containing multitude of commensal bacteria would reduce the growth rate of pathogenic bacteria, specifically Escherichia coli and Salmonella typhimurium. Growth curves were established, and the growth rates were compared for samples of E. coli, S. typhimurium, Nature’s Bounty Controlled Delivery probiotic, Sundown Naturals Probiotic Balance probiotic, and cocultures of the pathogenic bacteria mixed with the probiotics. The findings of this research were that the commercial probiotics significantly reduced the growth rate of E. coli and S. typhimurium when combined in cocultures. Probiotics containing multiple strains may be taken prophylactically to reduce the risk of bacterial infections caused by E. coli and S. typhimurium. Probiotics could be used to reduce the high global morbidity and mortality rates of diarrheal disease.

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