scholarly journals Homogeneous Assay of rs4343, anACEI/D Proxy, and an Analysis in the British Women’s Heart and Health Study (BWHHS)

2008 ◽  
Vol 24 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Mohammad Reza Abdollahi ◽  
Shuwen Huang ◽  
Santiago Rodriguez ◽  
Philip Alexander Isles Guthrie ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Linkage Disequilibrium ◽  
Liquid Phase ◽  
Diastolic Blood Pressure ◽  
Current Literature ◽  
Health Study ◽  
Insertion And Deletion ◽  
Homogeneous Assay ◽  
Post Hoc ◽  
Cardiovascular Traits

Current literature suggests thatACESNP rs4343,ACE2350A>G in exon 17, T202T, may be the best proxy for theACEAlu I/D whereas rs4363 and rs4362 may be slightly stronger predictors ofACElevels. Considering reported difficulties in genotypingACEI/D and stronger associations of rs4343 thanACEI/D with plasmaACElevels in Africans, and suitability of rs4343 for allelic mRNA (cDNA) studies, we developed and validated a liquid phase assay for rs4343, which has advantage on both functional and technical grounds. We confirmed that rs4343, is in near perfect linkage disequilibrium (D’=1, r2=0.88, n=64) withACEI/D in Europeans (A and G alleles of rs4343 marking insertion and deletion alleles ofACEI/D respectively).We then studied its association with metabolic and cardiovascular traits in 3253 British women (60–79 years old).Apart from a nominal trend of association with diastolic blood pressure (p anova=0.08; p trend=0.05), no other associations were observed. A post-hoc vascular and general phenome scan revealed no further associations.We conclude thatACEI/D is not a major determinant of metabolic and cardiovascular traits in this population. Liquid phase genotyping of SNP rs4343 may be preferable to gel basedACEI/D genotyping both for technical and functional reasons.

Abstract 469: Residential Lifestyle Interventions Reduce Blood Pressure in 18 Days

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Francisco E Ramirez ◽  
Jill Siebold ◽  
Linda Ivy ◽  
Kathelyn Antuna ◽  
Albert Sanchez ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Linear Trend ◽  
Lifestyle Interventions ◽  
Blood Pressure Medication ◽  
Significant Linear Trend ◽  
Time Points ◽  
Positive Effects ◽  
Significant Difference ◽  
Post Hoc

Background: Tight control of blood pressure can have long term positive effects, non-pharmacological interventions to achieve it are documented in this study. Hypothesis: Vegan diets together with other lifestyle changes can safely decrease blood pressure. Methods: Twelve years of data was used, 1196 patients participated in a lifestyle program in Weimar California. The intervention consisted in whole food plant based diet (WFPD), exercise, sleep hygiene, medical, psychological and spiritual therapies. Treatments of massage and hydrotherapy were also given. A physician monitored the progress of each patient during the 18 days. Blood pressure was measured at baseline, at the end of the first week (time 1) and at the end of the second week (time 2) and at the end of 18 days. Some patients need it to decrease their blood pressure medication during the 18 days. Data was process with SPSS statistics package. Results: From 1196 patients, 764 of them were females. Mean age at baseline was 60.7 SD 15. Both systolic and diastolic blood pressure were reduced throughout treatment. For systolic on average (in mm HG) at baseline: 132.21, at time 1: 125.3, at rime 2: 121.96, at the end : 121.4. For diastolic on average (in mm HG) at baseline: 76.1, time 1: 72.2, time 2: 70.86, at the end : 69.9. A repeated measures ANOVA determined that mean systolic blood pressure differed significantly between time points (F(3,3585) = 69.008, P < .001). Post hoc polynomial contrasts revealed a significant linear trend in the data from start to end (F(1,1195 = 206.474. p<.001, partial η 2 = .14)). A similar pattern was found for diastolic blood pressure. The overall ANOVA found a significant difference in time points (F(3,3585) = 34.738, P < .001). Post hoc polynomial contrasts also showed a significant linear trend (F(1,1195 = 109.031. p<.001, partial η 2 = .08). Participants lost 4.8 pounds on average by the end of the program. Conclusion: WFPD together with lifestyle interventions are associated with a significant reduction of systolic and diastolic blood pressures. Many patients reduced their blood pressure medication. Lifestyle interventions options should be offered to patients with hypertension.

Abstract 3113: Uncontrolled Hypertension, Systolic and Diastolic Blood Pressure and Development of Symptomatic Peripheral Arterial Disease in the Women’s Health Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Tiffany M Powell ◽  
Robert J Glynn ◽  
Mark A Creager ◽  
Paul M Ridker ◽  
Aruna D Pradhan
Keyword(s):  
Blood Pressure ◽  
Peripheral Arterial Disease ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Arterial Disease ◽  
Uncontrolled Hypertension ◽  
Health Study ◽  
Adjusted Risk ◽  
Treatment Status ◽  
Peripheral Arterial

Background : Prospective data pertaining to risk factors for peripheral arterial disease (PAD) in women are sparse. Few studies have evaluated blood pressure, including uncontrolled hypertension, and PAD onset in women. Methods and Results : We examined the relationship between blood pressure and development of confirmed symptomatic PAD (n=116 events) in a prospective cohort study of 39,261 female health professionals aged ≤ 45 years without diagnosed vascular disease at baseline. Median follow-up was 11.4 years. Women were first grouped according to baseline presence of uncontrolled hypertension, defined as reported systolic blood pressure (SBP)≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg, and pharmacologic treatment status. SBP and DBP were then modeled as continuous and categorical exposures irrespective of treatment status. Pulse pressure (PP) and mean arterial pressure (MAP) were also assessed. Age-adjusted and multivariable-adjusted risk estimates were derived from Cox proportional hazards models. Women with treated but uncontrolled hypertension had the highest risk of symptomatic PAD (0.67 events per 1000 person-years). Adjusted hazard ratios (HRs) compared to women without hypertension were 1.1 (95% CI, 0.5–2.3) for women who were treated and controlled, 1.7 (95% CI, 1.0 –3.0) for women untreated and uncontrolled, and 2.3 (95% CI, 1.4 – 4.0) for women treated and uncontrolled (p-trend<0.001). When hypertension was examined using continuous and categorical measures, there was a 33% increase in risk per 10 mmHg of SBP (95% CI, 18 to 47%) and a positive gradient in multivariable-adjusted risk according to SBP category (<120, 120 –139, 140 –159, and ≤ 160 mmHg); HRs were 1.0, 1.6, 2.8, and 4.3 (p-trend<0.001), respectively. We also considered DBP, PP, and MAP. While individually predictive, none was a stronger predictor than SBP with none adding predictive ability beyond SBP. Conclusions : Uncontrolled hypertension is associated with incident symptomatic PAD in women. Among blood pressure variables assessed, SBP is the best single predictor. These data support a strong prognostic role for systolic blood pressure in the development of peripheral atherosclerosis in women.

P1316PREDICTORS OF ARTERIO-VENOUS FISTULA FAILURE: A POST-HOC ANALYSIS OF THE FAVOURED STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Yong Pey See ◽  
Andrea Viecelli ◽  
David Voss ◽  
Trevor Mori ◽  
Peter Kerr ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Central Venous Catheter ◽  
Diastolic Blood Pressure ◽  
Vascular Access ◽  
Venous Catheter ◽  
Central Venous ◽  
Post Hoc Analysis ◽  
Factors Associated ◽  
Female Sex ◽  
Post Hoc

Abstract Background and Aims An autologous arteriovenous fistula (AVF) is the preferred haemodialysis vascular access but successful creation is hampered by high rates of AVF failure. This study aimed to evaluate patient and surgical factors associated with AVF failure to improve vascular access selection and outcomes. Method This is a post-hoc analysis of all participants of FAVOURED, a multi-centre, double-blind, multinational, randomized placebo-controlled trial evaluating the effect of fish oil and/or aspirin in preventing AVF failure in patients receiving haemodialysis. The primary outcome of AVF failure was a composite of fistula thrombosis and/or abandonment and/or cannulation failure at 12 months post AVF creation and secondary outcomes included individual outcome components. Patient data (demographics, comorbidities, medications and laboratory data) and surgical factors (surgical expertise, anaesthetic, intraoperative heparin use) were examined using multivariable logistic regression analyses to evaluate associations with AVF failure. Results Of 536 participants, 253 patients (47%) experienced AVF failure during the study period. The mean age was 55 ± 14.4 years, 64% were male, 45% were diabetic and 4% had peripheral vascular disease. Factors associated with AVF failure included female sex (odds ratio [OR] 1.78, 95% confidence interval [CI] 1.20-2.67), lower diastolic blood pressure (DBP; OR for higher DBP 0.98, 95% CI 0.97-0.99), presence of central venous catheter (OR 1.50, 95% CI 1.02-2.20, p=0.04) and aspirin requirement (OR 1.61, 95% CI 1.01-2.57). Conclusion Female sex, requirement for aspirin therapy, requiring haemodialysis via a central venous catheter and lower diastolic blood pressure were factors associated with higher odds of AVF failure. These associations have potential implications for vascular access planning and warrant further studies.

scholarly journals Slow Deep Breathing dan Alternate Nostril Breathing terhadap Penurunan Tekanan Darah pada Pasien Hipertensi

2019 ◽  
Vol 2 (2) ◽  
pp. 160-175
Author(s):  
Faradilla Miftah Suranata ◽  
Agung Waluyo ◽  
Wati Jumaiyah ◽  
Dhea Natashia
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Intervention Group ◽  
Deep Breathing ◽  
Test Results ◽  
Intervention Period ◽  
P Values ◽  
Group Design ◽  
Quasi Experimental ◽  
Post Hoc

The purpose of this study is to determine the effectiveness of slow deep breathing and alternate nostril breathing on reducing blood pressure in patients with hypertension. This study uses a quasi-experimental design with a pretest-posttest group design approach. Friedman test results showed that there were differences in systolic blood pressure (x2 = 34.09; p <0.001) and diastolic (x2 = 28.74; p <0.001) in the slow deep breathing intervention group. Based on the post hoc test, measurements from time to time obtained p values ​​(p = 0.001) for both systolic and diastolic blood pressure. Meanwhile there were differences in blood pressure in the alternate nostril systolic breathing group (x2 = 15.50; p <0.001), diastolic (x2 = 17.18; p <0.001). Post hoc test found a significant decrease in systolic and diastolic blood pressure from each measurement time during the intervention period with p values ​​0.005 and 0.025, respectively. Conclusion, in this study that slow deep breathing is much more effective in reducing blood pressure in hypertensive patients.   Keywords: Alternate Nostril Breathing, Hypertension, Decreased Blood Pressure, Slow Deep Breathing

Evaluation of the Relationship Between Depression, Anxiety, and Stress with Hypertension: Results of a Health Study in Yazd, Iran

2020 ◽  
Author(s):  
Mohammad Khajeh ◽  
Masoud Mirzaei ◽  
Azadeh Nadjarzadeh
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Large Population ◽  
Health Study ◽  
Healthy Individuals ◽  
Mild Depression ◽  
Cross Sectional ◽  
Symptoms Of Depression ◽  
The Relationship ◽  
Moderate Stress

Background and Aim: Over the past few decades, different epidemiological studies have been conducted on the relationship between mental disorders and hypertension. However, conflicting results have been reported. This research aimed to evaluate the relationship between symptoms of depression, anxiety and stress with hypertension in a large population. Materials and Methods: This cross-sectional analytic study was conducted using the results of in Yazd Health Study, Iran (N=9340). In addition, DASS-21 questionnaire was asked from the participants to assess depression, anxiety, and stress. Moreover, logistic regression was used to evaluate the relationship between symptoms of depression, anxiety and stress with hypertension. Results: A negative association was observed between systolic and diastolic blood pressure and symptoms of depression, anxiety, and stress, which were independent from other variables. Regarding systolic blood pressure, a significant and reverse relationship was found in individuals with moderate stress (OR: 0.81, 95% CI: 0.69-0.95) and mild depression (OR: 0.82, 95% CI: 0.68-0.99). In terms of diastolic blood pressure, subjects with moderate stress had a lower blood pressure, compared to healthy individuals (OR: 0.86, 95% CI: 0.75- 0.99). Furthermore, participants with depression had a lower chance of being diagnosed with hypertension, compared to healthy individuals. Conclusion: The present research did not confirm the previous assumptions about the relationship between depression, anxiety and stress with hypertension. Our findings showed that symptoms of depression, anxiety, and stress are correlated with a low blood pressure.

scholarly journals Variation of blood pressure during change of posture

2019 ◽  
Vol 51 (1-2) ◽  
pp. 16-20
Author(s):  
Md Nazrul Islam ◽  
SK Kamal ◽  
Md Sirajul Islam ◽  
Sk Amir Hossain
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Repeated Measures ◽  
Body Position ◽  
Standing Position ◽  
Specific Pattern ◽  
Healthy Adult Male ◽  
Pressure Changes ◽  
Post Hoc

Background: Many factors can influence blood pressure, one of which is body position. The aim of present study was to establish a specific pattern of blood pressure (BP) changes in accordance with posture changes in healthy adults. Objective: Aim of present study was to establish a specific pattern of blood pressure (BP) changes in accordance with posture changes in healthy adult male and females. Methods: Blood pressure was recorded by aneroid sphygmomanometer in supine, sitting and standing posture on both arms. Mean ± standard deviation of the observation for all the parameters were calculated and comparison in supine, sitting and standing position was done by repeated measures Analysis was done by ANOVA test and tukey's post hoc test. Results: Fifty healthy males and fifty healthy female took part in this study. BP varies according to body position. Both Systolic blood pressure and diastolic blood pressure was significantly decreased (P<0.05) while changing posture from supine to standing. But blood pressure changes during change of posture from supine to sitting or from sitting to standing was not significant (P>0.05). Conclusions: Change in body posture changes systolic blood pressure as well as diastolic blood pressure. Bang Med J (Khulna) 2018; 51 : 16-20

Lutein Complex Supplementation Increases Ocular Blood Flow Biomarkers in Healthy Subjects

2019 ◽  
Vol 89 (1-2) ◽  
pp. 5-12
Author(s):  
Alon Harris ◽  
Brent Siesky ◽  
Amelia Huang ◽  
Thai Do ◽  
Sunu Mathew ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Diastolic Blood Pressure ◽  
Healthy Subjects ◽  
Ocular Blood Flow ◽  
Capillary Blood ◽  
Post Treatment ◽  
Capillary Blood Flow ◽  
Doppler Imaging ◽  
Retinal Capillary

Abstract. Introduction: To investigate the effects of a lutein complex supplementation on ocular blood flow in healthy subjects. Materials and Methods: Sixteen healthy female patients (mean age 36.8 ± 12.1 years) were enrolled in this randomized, placebo-controlled, double-blinded, two-period crossover study. Subjects received daily an oral dose of the lutein with synergistic phytochemicals complex (lutein (10 mg), ascorbic acid (500 mg), tocopherols (364 mg), carnosic acid (2.5 mg), zeaxanthin (2 mg), copper (2 mg), with synergistic effects in reducing pro-inflammatory mediators and cytokines when administered together in combination) and placebo during administration periods. Measurements were taken before and after three-week supplementation periods, with crossover visits separated by a three-week washout period. Data analysis included blood pressure, heart rate, intraocular pressure, visual acuity, contrast sensitivity detection, ocular perfusion pressure, confocal scanning laser Doppler imaging of retinal capillary blood flow, and Doppler imaging of the retrobulbar blood vessels. Results: Lutein complex supplementation produced a statistically significant increase in mean superior retinal capillary blood flow, measured in arbitrary units (60, p = 0.0466) and a decrease in the percentage of avascular area in the superior (−0.029, p = 0.0491) and inferior (−0.023, p = 0.0477) retina, as well as reduced systolic (−4.06, p = 0.0295) and diastolic (−3.69, p = 0.0441) blood pressure measured in mmHg from baseline. Data comparison between the two supplement groups revealed a significant decrease in systemic diastolic blood pressure (change from pre- to post-treatment with lutein supplement (mean (SE)): −3.69 (1.68); change from pre- to post-treatment with placebo: 0.31 (2.57); p = 0.0357) and a significant increase in the peak systolic velocity (measured in cm/sec) in the central retinal artery (change from pre- to post-treatment with lutein supplement: 0.36 (0.19); change from pre- to post-treatment with placebo: −0.33 (0.21); p = 0.0384) with lutein complex supplement; data analyses from the placebo group were all non-significant. Discussion: In healthy participants, oral administration of a lutein phytochemicals complex for three weeks produced increased ocular blood flow biomarkers within retinal vascular beds and reduced diastolic blood pressure compared to placebo.

EFEKTIVITAS PEMBERIAN HYDROTHERAPI RENDAM KAKI PADA PENDERITA HIPERTENSI DI BANJAR SRI MANDALA, KELURAHAN DAUHWARU KABUPATEN JEMBRANA

2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Measurement ◽  
Reduce Blood Pressure ◽  
Second Grade ◽  
Control Group ◽  
Hypertensive Patients ◽  
First Category

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.

EVALUATION OF PITUITARY-ADRENAL FUNCTION IN CHILDREN

1965 ◽  
Vol 48 (1) ◽  
pp. 81-90 ◽  
Author(s):  
B. van der Wal ◽  
T. Wiegman ◽  
J. F. Janssen ◽  
A. Delver ◽  
D. de Wied
Keyword(s):  
Blood Pressure ◽  
Body Temperature ◽  
Diastolic Blood Pressure ◽  
Linear Increase ◽  
Significant Rise ◽  
Moderate Increase ◽  
Specific Stimulus ◽  
Lysine Vasopressin ◽  
Free Cortisol ◽  
Pituitary Adrenal Axis

ABSTRACT The reactivity of the hypothalamico-pituitary-adrenal axis was determined in 48 children, not suffering from any endocrine disorder. The free cortisol (F)- and corticosterone (B) content of plasma was determined in response to ACTH (clinical corticotrophin; A1 peptide), a corticotrophin releaser (lysine vasopressin) and a non specific stimulus (bacterial polysaccharide) as compared to saline. The two ACTH-preparations infused over one hour in a dose of 5 IU per child elicited a marked increase in both F and B. Lysine vasopressin in a dose of 0.5 IU per year of age similarly infused, exhibited a distinct linear increase in the two circulating cortical steroids, although the effect of this octapeptide was smaller than that of the two ACTH-preparations. Blood pressure was also measured during the infusion with vasopressin or saline. The systolic blood pressure was not significantly affected by vasopressin, but a significant rise in diastolic blood pressure was found. No correlation between the increase in diastolic blood pressure and in blood corticoids in response to vasopressin, was found. The intravenous administration of a relatively small amount of pyrifer caused a moderate increase in circulating F which was significant only at 4 and 6 hours after the injection of the pyrogen. The B content did not increase significantly above that of saline treated control children, presumably because of the relatively weak corticotrophic activity of the pyrogen under these conditions. A positive linear relation between body temperature and time was found. No correlation between increase in body temperature and increase in circulating F could be demonstrated.

EFFECT OF SUBMAXIMAL EXERCISE ON SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN YOUNG SEDENTARY NORMOTENSIVE NEPALESE MEDICAL STUDENTS

2003 ◽  
Vol 42 (149) ◽  
pp. 315-6
Author(s):  
Arijit Ghosh ◽  
T Pramanik
Keyword(s):  
Blood Pressure ◽  
Medical Students ◽  
Diastolic Blood Pressure ◽  
Submaximal Exercise ◽  
Muscular Exercise ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Standing Posture ◽  
Normal Range ◽  
Exercise Blood Pressure

Higher exercise blood pressure represents low cardiorespiratory status of an individual and vice versa. Thechanges in systolic and diastolic blood pressure in response to rhythmic isotonic muscular exercise in sedentaryyoung normotensive Nepalese students were assessed. Normal blood pressure in standing posture in maleand female subjects are about 115 / 75 mm of Hg. and 106 / 71 mm of Hg. respectively. Just after the exercisesystolic blood pressure increases moderately in both the sexes, whereas diastolic blood pressure remainsunchanged in most of the females. Diastolic blood pressure is found to be decreased slightly in the males,just after exercise. The present study indicates the cardiorespiratory status of the Napalese medical studentsis within normal range.

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