scholarly journals Synthesis of Bioactive Fluorinated 10H-Phenothiazines and their Sulfone Derivatives

2008 ◽  
Vol 5 (s1) ◽  
pp. 1063-1068 ◽  
Author(s):  
Yogesh Dixit ◽  
Rahul Dixit ◽  
Naveen Gautam ◽  
D. C. Gautam
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Spectroscopic Data ◽  
Halogen Atom ◽  
Glacial Acetic Acid ◽  
Present Communication ◽  
Smiles Rearrangement ◽  
Antimicrobial Studies ◽  
Sulfone Derivatives

The present communication deals with the synthesis of a series of fluorinated 10H-phenothiazines. 10H-phenothiazines is prepared by Smiles rearrangement of substituted 2-foramido-2´-nitrodiphenylsulfide. Substituted 2-foramido-2´-nitrodiphenylsulfide were obtained by the reaction of 2-amino-3-fluorobenzenethiol witho-halonitrobenzenes followed by formylation and 1-nitro/1-halo-10H-phenothiazines have been prepared by the reaction of substituted 2-aminobenzenethiols with reactiveo-halonitrobenzene containing a nitro group or halogen atom ato-position to the reactive halogen atom directly yielded 1-nitro/1-halo-10H-phenothiazines in situ. 10H-phenothiazine sulfone derivatives have been synthesized by the oxidation of 10H-phenothiazines by 30% hydrogen peroxide in glacial acetic acid. The structure of the synthesized compounds has been characterized by spectroscopic data and elemental analysis. Antimicrobial studies of the synthesized compounds have also been included.

Response Surface Methodology for Optimization of Epoxidized Trimethylolpropane Ester Synthesis from Palm Oil

2011 ◽  
Vol 9 (1) ◽  
Author(s):  
Ferra Naidir ◽  
Robiah Yunus ◽  
Irmawati Ramli ◽  
Tinia I. Mohd. Ghazi
Keyword(s):  
Hydrogen Peroxide ◽  
Response Surface Methodology ◽  
Acetic Acid ◽  
Regression Model ◽  
Palm Oil ◽  
Iodine Value ◽  
Glacial Acetic Acid ◽  
Oxirane Oxygen ◽  
Dependent Variables

To improve the oxidative stability of the palm oil-based biolubricant, the fatty acid double bonds in palm oil-based trimethylolpropane ester (TMP ester) was converted into an oxirane ring via an in-situ epoxidation method. The epoxidized TMP ester was produced from a reaction between TMP ester and peracetic acid which was prepared in-situ by reacting glacial acetic acid with hydrogen peroxide in the presence of concentrated sulphuric acid. The response surface methodology was applied using a central composite design technique to optimize the conditions of the epoxidation reaction to produce the epoxidized TMP ester. The effects of four independent variables namely concentration of acetic acid (0-2 mol), concentration of hydrogen peroxide (1.5-9.5 mol), temperature of reaction (30-110°C) and reaction time (0.5-26.5 h) on the three dependent variables; percentage of oxirane oxygen, iodine value, and hydroxyl value were studied. A second-order polynomial multiple regression model was employed to predict the three dependent variables under optimum conditions of 0.59 mol of glacial acetic acid, 7.5 mol of hydrogen peroxide concentration, at temperature of 50°C and reaction times of 7 h. The optimum values of percentage of oxirane oxygen, iodine value, and hydroxyl value were 4.01%, 1.94%, and 0.43% respectively. The analysis of variance yielded a high coefficient of determination value of 0.9395-0.9880, hence indicating the fitness of the second-order regression model to the experimental data.

scholarly journals Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff's Base Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Nermien M. Sabry ◽  
Eman M. Flefel ◽  
Mohamed A. Al-Omar ◽  
Abd El-Galil E. Amr
Keyword(s):  
Acetic Acid ◽  
Fusidic Acid ◽  
Spectroscopic Data ◽  
Glacial Acetic Acid ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
Antimicrobial Screening ◽  
Positive Controls

A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine(2a,b)and corresponding Schiff's bases(3a–j)were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines(1a,b)as starting materials. The compounds1a,bwere reacted with 2,3,4,5-tetrachlorophthalic anhydride in glacial acetic acid to give the corresponding bis-imides(2a,b). But they are treated with aromatic aldehydes in refluxing ethanol to afford the Schiff’s base derivatives(3a–j). The antimicrobial screening showed that many of these newly synthesized compounds had good antimicrobial activities comparable to streptomycin and fusidic acid as positive controls. The detailed synthesis, spectroscopic data, and antimicrobial activities of the synthesized compounds were reported.

A new method for the preparation of peroxymonophosphoric acid

2003 ◽  
Vol 81 (2) ◽  
pp. 156-160 ◽  
Author(s):  
Tian Zhu ◽  
Hou-min Chang ◽  
John F Kadla
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Carbon Tetrachloride ◽  
Glacial Acetic Acid ◽  
Acid Synthesis ◽  
Conversion Ratio ◽  
New Method ◽  
Phosphorous Pentoxide ◽  
Preparation Conditions ◽  
Peroxy Acids

A new method for the preparation of peroxymonophosphoric acid (H3PO5) has been developed. It utilizes a biphasic solution to moderate the vigorous reaction between phosphorous pentoxide (P2O5) and hydrogen peroxide (H2O2). P2O5 is suspended in carbon tetrachloride (CCl4), and concentrated H2O2 is slowly added while being vigorously stirred at low temperature. Careful control of the reaction temperature through the slow addition of H2O2 is critical. Using typical preparation conditions (P2O5:H2O2 = 0.5:1, H2O2 70 wt %, 2°C, 120–180 min), ~70% of the H2O2 is effectively converted to H3PO5. Increasing the concentration of H2O2, as well as the mole ratio of P2O5:H2O2, leads to an even higher % conversion of H2O2 to H3PO5. The addition of glacial acetic acid to the P2O5:H2O2 suspension at the end of the 120–180 min reaction (P2O5:H2O2:CH3COOH = 0.5:1:0.3) leads to the formation of peracetic acid in addition to H3PO5, and to an overall increase in the conversion ratio of total peroxy acids based on H2O2 (>95%).Key words: peroxymonophosphoric acid, synthesis, stability, conversion ratio.

scholarly journals Synergistic Extraction and Characterization of Fulvic Acid by Microwave and Hydrogen Peroxide–Glacial Acetic Acid to Oxidize Low-Rank Lignite

ACS Omega ◽  
2020 ◽  
Vol 5 (12) ◽  
pp. 6389-6394
Author(s):  
Yingjie Zhang ◽  
Guanqun Gong ◽  
Honglei Zheng ◽  
Xin Yuan ◽  
Liangwei Xu
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Fulvic Acid ◽  
Glacial Acetic Acid ◽  
Synergistic Extraction ◽  
Low Rank

scholarly journals PERACETIC ACID OXIDATION OF HALOGENATED AZOBENZENES

1959 ◽  
Vol 37 (2) ◽  
pp. 366-369 ◽  
Author(s):  
Paul E. Gagnon ◽  
Brian T. Newbold
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Peracetic Acid ◽  
Glacial Acetic Acid ◽  
Acid Oxidation ◽  
Azoxy Compounds

A series of dihalogenated and five tetrachloroazobenzenes were oxidized to the corresponding azoxy compounds by means of 30% hydrogen peroxide in glacial acetic acid, the reaction being carried out at about 60–70 °C, for 24 hoursAs expected, the yields, in general, obtained from azobenzenes containing substituents in the 2,2′-positions were lower than those from compounds having substituents in the 3,3′- and 4,4′-positions, which gave very good results.

Catalytic oxidation of benzoic acid in acetic acid: Aromatic hydroxylation with in situ-generated hydrogen peroxide

1991 ◽  
Vol 69 (2) ◽  
pp. 215-222 ◽  
Author(s):  
Akikazu Itoh ◽  
Yasushi Kuroda ◽  
Tomoyuki Kitano ◽  
Guo Zhi-Hu ◽  
Atsutaka Kunai ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Benzoic Acid ◽  
Catalytic Oxidation ◽  
Aromatic Hydroxylation

scholarly journals Synthesis of Epoxidizedcardanol from CNSL Vietnam by Glacial Acetic Acid and Hydrogen Peroxide

2017 ◽  
Vol Volume-1 (Issue-6) ◽  
pp. 1271-1275
Author(s):  
Bach Trong Phuc ◽  
Vu Van Hai ◽  
Nguyen Thi Hien | Nguyen Thanh Liem ◽  
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Glacial Acetic Acid

Localization of H-2Kk in developing mouse palates using monoclonal antibody

Development ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 45-60
Author(s):  
Melnick Melnick ◽  
Tina Jaskoll ◽  
Mary Marazita
Keyword(s):  
Monoclonal Antibody ◽  
Acetic Acid ◽  
Monoclonal Antibodies ◽  
Glacial Acetic Acid ◽  
Corticosteroid Treatment ◽  
Basement Membranes ◽  
Spatiotemporal Distribution ◽  
Embryonic Tissue ◽  
Epithelial Fusion

Using monoclonal antibodies to H-2Kk antigen, we sought to develop a reproduceable method of in situ localization in embryonic tissue and to determine whether there are specific patterns of H-2 localization in time and space in the developing palatal tissues of B10.A(H-2a) embryonic mice, with and without corticosteroid pretreatment at 12 days gestation. Our procedure employs ethanol-glacial acetic acid fixation, paraplast embedding, and enzymatic predigestion with purified hyaluronidase and neuraminidase. H-2 antigens were detected in palatal mesenchyme as well as basement membranes but not in oral or nasal epithelium. The pattern of distribution in mesenchyme of untreated embryos changed with progressive shelf development: vertical → horizontal → epithelial fusion → epithelial seam degeneration → mesenchymal confluence. Although the palatal shelves of treated embryos remained vertical, corticosteroid treatment does not appear to alter the detectable spatiotemporal distribution of H-2 antigens in developing palates of embryonic B10.A mice.

Synthesis, characterization and biological activity of Pyrazoline derivatives

2021 ◽  
pp. 6223-6227
Author(s):  
Saras Kumar Jain ◽  
Rohit Singhal ◽  
Neetesh K. Jain
Keyword(s):  
Crystal Structure ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Acetic Acid ◽  
Biological Activity ◽  
Spectroscopic Data ◽  
Glacial Acetic Acid ◽  
Retardation Factor ◽  
Physical Parameters ◽  
Pyrazoline Derivative

Pyrazoline is dihydropyrazole having only one endocyclic double bond. Synthesis of pyrazoline derivatives from chalcones is an active arena of investigation due to established pharmacological result. In present study, chalcones were prepared by reacting of acetophenone with benzaldehyde. Then prepared chalcones react with isoniazid in the presence of glacial acetic acid results pyrazoline derivative. Physical parameters such as color, crystal structure, solubility, melting point, retardation factor (Rf) and % yield was evaluated. Confirmations of structures of all synthesized derivatives, were done by spectroscopic data of IR, 1HNMR and Mass spectroscopy. Also, all synthesized compounds were evaluated for antibacterial activity against B. subtilis, S. aureus, P.aeruginosa and E.coli, and antifungal activity was accomplished against C. albicans and A. niger at the different conc. and concluded that some compounds have excellent antimicrobial activity and most of the synthesized compounds exhibits moderate antimicrobial activity.

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