scholarly journals On the Complexity of Electrostatic Suspension Stabilization of Functionalized Silica Nanoparticles for Biotargeting and Imaging Applications

2008 ◽  
Vol 2008 ◽  
pp. 1-9 ◽  
Author(s):  
Lotta Bergman ◽  
Jessica Rosenholm ◽  
Anna-Brita Öst ◽  
Alain Duchanoy ◽  
Pasi Kankaanpää ◽  
...  
Keyword(s):  
Fluorescent Dyes ◽  
Relative Concentration ◽  
Particle Surface ◽  
Silica Particles ◽  
Special Focus ◽  
Suspension Stability ◽  
Functionalized Silica ◽  
Ethylene Imine ◽  
Biologically Relevant ◽  
Covalently Linked

Different means of attaching streptavidin to surface functionalized silica particles with a diameter of 240 nm were investigated with special focus on suspension stability for electrostatically stabilized suspensions. The influence of two different fluorescent dyes covalently linked to the streptavidin on suspension stability was also studied. The results clearly show that the stability of the suspensions is crucially dependent on all functional groups present on the surface. The surface functions may either directly affect the effective surface charge if the functions contain charged groups, or indirectly by affecting the relative concentration of charged groups on the particle surface. Poly(ethylene imine)-functionalized silica particles, where the polymer is grown by surface hyperbranching polymerization, are shown to be promising candidates for bioapplications, as the zeta-potential can remain strongly positive even under biologically relevant conditions.

Preparation of porous cellulose 3,5-dimethylphenylcarbamate hybrid organosilica particles for chromatographic applications

2015 ◽  
Vol 3 (4) ◽  
pp. 620-628 ◽  
Author(s):  
Xilun Weng ◽  
Zongbi Bao ◽  
Zhiguo Zhang ◽  
Baogen Su ◽  
Huabin Xing ◽  
...  
Keyword(s):  
Silica Particles ◽  
Chiral Selector ◽  
High Loading ◽  
Loading Capacity ◽  
Functionalized Silica

Organic–inorganic hybrids incorporating cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC)-functionalized silica particles can exhibit a high loading capacity with high loadings of the chiral selector.

High Internal Phase Emulsions Stabilized Solely by Functionalized Silica Particles

2009 ◽  
Vol 48 (4) ◽  
pp. 632-632 ◽  
Author(s):  
Vivian O. Ikem ◽  
Angelika Menner ◽  
Alexander Bismarck
Keyword(s):  
Silica Particles ◽  
Functionalized Silica ◽  
Internal Phase

scholarly journals Development of A Flexible Cell Targeting System Based on Silica Nanoparticles

1998 ◽  
Vol 530 ◽  
Author(s):  
T. Schiimstel ◽  
H. Schirra ◽  
J. Gerwann ◽  
C. Lesniak ◽  
A. Kalaghi-Nafchi ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Electrostatic Interactions ◽  
Particle Concentration ◽  
Biological Function ◽  
Particle Surface ◽  
Cell Types ◽  
Silica Particles ◽  
Hydrodynamic Diameter ◽  
Reaction Conditions ◽  
Physiological Conditions

AbstractCommercially available and synthesized silica particles were fluorescently labeled with FITC and modified to get a wide variety of particle systems with defined size and surface charge. By a variation of reaction conditions particles with diameters of 10 and 80 nm determined with TEM and with zetapotentials between -50 to +30 mV under physiological conditions (pH: 7.4, PBS-buffer) were available.A further molecular shell consisiting of avidin was obtained by binding the molecules to negatively charged particle surfaces through electrostatic interactions. The amount of avidin coupled to the silica particles was 1.7 μg per mg particle. Starting with particles with an hydrodynamic diameter determined with PCS of 260 nm, the size increased to 500 nm, while the zeta potential was altered to -8 mV under physiological conditions.Biotinylated wheat germ agglutinin (bio-WGA) can be bonded to such particles through avidin / biotin complex formation. Up to 2.8 μg lectin per mg particles could be coupled to the particle surface. This leads to a further increase of hydrodynamic diameter to 650 nm. It could be shown by hemagglutination test, that the bonded lectin is still active. No toxic effects of the silica particles were found at 1 wt.-% particle concentration with various cell types (Caco-2, L132). The binding of lectin-particle complexes to cells was increased by a factor of 4.4 in comparison to uncoated particles.In addition it was found that WGA can directly be coupled to the particle surface. An amount of 1.8 μg Lectin per mg particle was determined. The hydrodynamic diameter increases from 260 nm to 432 rm, while a zetapotential of-28 mV was found under physiological conditions.It could be shown, that negatively charged silica nanoparticles are suitable systems to couple various biomolecules retaining their biological function.

One-step synthesis of golf ball-like thiol-functionalized silica particles

Soft Matter ◽  
2020 ◽  
Vol 16 (39) ◽  
pp. 9113-9120
Author(s):  
Ruixue Liang ◽  
Xia Fang ◽  
Biwei Qiu ◽  
Hua Zou
Keyword(s):  
Sol Gel ◽  
Silica Particles ◽  
Golf Ball ◽  
Functionalized Silica ◽  
One Step ◽  
First Time

Golf ball-like thiol-functionalized silica particles were synthesized for the first time by a one-step sol–gel reaction using 3-mercaptopropyl trimethoxysilane (MPTMS) and tetraethoxysilane (TEOS) as the precursors.

Synthesis of Functionalized Silica Particles for Label‐free Detection of PTP1B Using FRET

2019 ◽  
Vol 40 (12) ◽  
pp. 1172-1177
Author(s):  
Trishaladevi Durgannavar ◽  
Dohee Ahn ◽  
Ji Young Hwang ◽  
Sun‐Young Yoon ◽  
Hyo Jin Kang ◽  
...  
Keyword(s):  
Silica Particles ◽  
Functionalized Silica ◽  
Label Free ◽  
Label Free Detection

scholarly journals Size-selective separation of DNA fragments by using lysine-functionalized silica particles

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Lingling Liu ◽  
Zilong Guo ◽  
Zhenzhen Huang ◽  
Jiaqi Zhuang ◽  
Wensheng Yang
Keyword(s):  
Silica Particles ◽  
Selective Separation ◽  
Dna Fragments ◽  
Functionalized Silica

Physisorption and chemisorption of T4 bacteriophages on amino functionalized silica particles

2018 ◽  
Vol 532 ◽  
pp. 68-76 ◽  
Author(s):  
Stephanie Bone ◽  
Absar Alum ◽  
Jasmina Markovski ◽  
Kiril Hristovski ◽  
Edo Bar-Zeev ◽  
...  
Keyword(s):  
Silica Particles ◽  
Functionalized Silica

Properties of anion exchange membrane based on polyamine: Effect of functionalized silica particles prepared by sol–gel method

2018 ◽  
Vol 322 ◽  
pp. 85-92 ◽  
Author(s):  
Narges Ataollahi ◽  
Elisa Cappelletto ◽  
Keti Vezzù ◽  
Vito Di Noto ◽  
Gianni Cavinato ◽  
...  
Keyword(s):  
Anion Exchange ◽  
Sol Gel ◽  
Silica Particles ◽  
Anion Exchange Membrane ◽  
Functionalized Silica ◽  
Gel Method ◽  
Sol Gel Method ◽  
Exchange Membrane

Covalent Immobilization of (−)-Riboflavin on Polymer Functionalized Silica Particles: Application in the Photocatalytic E →Z Isomerization of Polarized Alkenes

2018 ◽  
Vol 24 (17) ◽  
pp. 4228-4233 ◽  
Author(s):  
Jan B. Metternich ◽  
Sven Sagebiel ◽  
Anne Lückener ◽  
Sebastian Lamping ◽  
Bart Jan Ravoo ◽  
...  
Keyword(s):  
Silica Particles ◽  
Covalent Immobilization ◽  
Functionalized Silica
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