scholarly journals Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
Fahmideh Shabani ◽  
Shahriar Ghammamy ◽  
Khayroallah Mehrani ◽  
Mohammad Bagher Teimouri ◽  
Masoud Soleimani ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Elemental Analysis ◽  
Analysis Data ◽  
Molar Conductance ◽  
Carcinoma Cells ◽  
Elemental Analysis Data ◽  
Human T Lymphocyte ◽  
Ft Ir ◽  
Uv Visible

(6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile. Characterization of the ligand and its complexes was made by microanalyses, FT-IR,1HNMR,13CNMR, and UV-Visible spectroscopy. All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements. The elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation. The molar conductance measurements reveal the presence of 1:1 electrolytic nature complexes. These new complexes showed excellent antitumor activity against two kinds of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.

scholarly journals Synthesis and Characterisation of Co(II) Cu(II) Zn(III) and La(II) Complexes of Standard Antidiabetic Drugs

2014 ◽  
Vol 11 (1) ◽  
pp. 51-61
Author(s):  
Mohammad Tawkir
Keyword(s):  
Elemental Analysis ◽  
Analysis Data ◽  
Esr Spectra ◽  
Molar Conductance ◽  
Elemental Analysis Data ◽  
Water Molecules ◽  
Geometrical Structures ◽  
Conductance Data ◽  
Ft Ir ◽  
Hydrated Complexes

Metal complxes of Glimeperide drugs were prepared and characterized based on elemental analysis, FT-IR, Molar conductance and thermal analysis (TGA and DTG) technique. From elemental analysis data, the complexes were proposed to have general formulae (GLM)2Co2H2O, (GLM)2Cu, (GLM)2Zn,and (GLM)2La2H2O. The molar conductance data reveal that all the metal complexes are non-electrolytic, IR spectra shows that GLM are coordinated to metal ions in a neutral bidentate manner from the ESR spectra and XRD-spectra. It is found that the geometrical structures of these complexes are tetrahedral Cu(II) ,Zn(II) and octrahedral Co(II), La(II). The thermal behavior of these complexesstudied using thermogravimetric analysis (TGA and DTG) techniques. The results obtained shows that the hydrated complexes lose water molecules of hydration followed immediately by decomposition of the anions and ligand molecules in the successive unseparate steps.

scholarly journals The synthesis and characterization of some new diazoamino derivatives

2010 ◽  
Vol 16 (1) ◽  
pp. 89-95
Author(s):  
Mihaela Mocanu
Keyword(s):  
1H Nmr ◽  
Bioactive Compounds ◽  
Elemental Analysis ◽  
Analysis Data ◽  
Biological Properties ◽  
Synthesis And Characterization ◽  
Elemental Analysis Data ◽  
Spectral Measurements ◽  
Inflammatory Processes

The sulfonamidic moiety is much encountered in structures of bioactive compounds. In the present paper the studies on the sulfonamidated aryloxyalkylcarboxylic acids are extended by their attaching on certain substrata able to confer some special biological properties to the final products, such as anti-tumor and antioxidant actions useful in treating inflammatory processes, ulcer, convulsions and diabetes, as well as a herbicidal action. The stepwise syntheses of the sulfonamidated aryloxyalkylcarboxylic acid derivatives and their characterization by elemental analysis data and IR, 1H-NMR and UV-Vis spectral measurements are described. The newly obtained compounds could show potential pharmaceutical and herbicide properties.

scholarly journals Synthesis, Characterization and Antibacterial Activity of Schiff Base, 4-Chloro-2-{(E)-[(4-Fluorophenyl)imino]methyl}phenol Metal (II) Complexes

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
F. K. Ommenya ◽  
E. A. Nyawade ◽  
D. M. Andala ◽  
J. Kinyua
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Condensation Reaction ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Elemental Analysis Data ◽  
Ft Ir

A new series of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) complexes of the Schiff base ligand, 4-chloro-2-{(E)-[(4-fluorophenyl)imino]methyl}phenol (C13H9ClFNO), was synthesized in a methanolic medium. The Schiff base was derived from the condensation reaction of 5-chlorosalicylaldehyde and 4-fluoroaniline at room temperature. Elemental analysis, FT-IR, UV-Vis, and NMR spectral data, molar conductance measurements, and melting points were used to characterize the Schiff base and the metal complexes. From the elemental analysis data, the metal complexes formed had the general formulae [M(L)2(H2O)2], where L = Schiff base ligand (C13H9ClFNO) and M = Mn, Co, Ni, Cu, and Zn. On the basis of FT-IR, electronic spectra, and NMR data, “O” and “N” donor atoms of the Schiff base ligand participated in coordination with the metal (II) ions, and thus, a six coordinated octahedral geometry for all these complexes was proposed. Molar conductance studies on the complexes indicated they were nonelectrolytic in nature. The Schiff base ligand and its metal (II) complexes were tested in vitro to evaluate their bactericidal activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus typhi) using the disc diffusion method. The antibacterial evaluation results revealed that the metal (II) complexes exhibited higher antibacterial activity than the free Schiff base ligand.

SYNTHESIS AND CHARACTERIZATION OF TI (III), V (III),VO (IV), MOO (V),FE (II) AND FE (III) COMPLEXES OF BENZIL- 2,4-DINITROPHENYL HYDRAZONE P-BROMO ANILINE

2016 ◽  
Vol 2 (4) ◽  
pp. 177
Author(s):  
Raj Kamal Rastogi ◽  
Sonu Sharma ◽  
Gulshan Rastogi ◽  
Alok K. Singh
Keyword(s):  
Elemental Analysis ◽  
Magnetic Measurement ◽  
Measurement Data ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Synthesis And Characterization ◽  
Distorted Octahedral Geometry ◽  
Distorted Octahedral ◽  
Uv Visible

The complexes of Benzil-2, 4-dinitrophenyl hydrazone-p- bromo aniline with Ti(III),V(III), VO(IV),MoO (V), Fe(II), Fe(III) have synthesized and characterized by elemental analysis, magnetic measurement data, molar conductance, TGA,UV-visible and IR spectra data. The complexes of Ti (III), V (III), Fe (II) and Fe (III) have octahedral geometry while VO (IV) and MoO(V) have distorted octahedral geometry due to the presence of M=O moiety.

scholarly journals Synthesis, crystal structure and properties of [Co(L)2](ClO4)2 (L=1,3-bis(1H-benzimidazol-2-yl)-2-oxapropane)

2015 ◽  
Vol 80 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Aydin Tavman ◽  
Cigdem Sayil
Keyword(s):  
Thermogravimetric Analysis ◽  
Elemental Analysis ◽  
Analysis Data ◽  
Molar Conductivity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Coordination Bonding ◽  
Ft Ir ◽  
Uv Visible ◽  
Ethereal Oxygen

The reaction of 1,3-bis(1H-benzimidazol-2-yl)-2-oxapropane (L) with Co(ClO4)2?6H2O in absolute ethanol produces di[1,3-bis(1H-benzimidazol-2-yl)-2-oxapropane-k2N,N?]cobalt(II)diperchlorate chelate complex ([Co(L)2](ClO4)2, 1). The complex 1 was characterized by elemental analysis, magnetic moment, molar conductivity, thermogravimetric analysis, FT-IR, UV-visible, mass spectrometry, and its solid state structure was determined by single crystal X-ray diffraction. According to the thermogravimetric analysis data, there is no any water coordinated or uncoordinated in 1 as well as elemental analysis. The complex 1 has 1:2 M:L ionic characteristic according to the molar conductivity. In the complex, the distances between the cobalt and the ethereal oxygen atoms (Co1-O2: 2.805(3); Co2-O1: 2.752(2) ?) show the semi-coordination bonding and the Co(II) ion is six-coordinated with a N4O2 ligand set, resulting in a distorted octahedron.

scholarly journals SYNTHESIS AND CHARACTERIZATION OF COORDINATION COMPOUNDS OF 3d-METAL MALEATES WITH THIOSEMICARBAZIDE

2021 ◽  
Vol 26 (3(79)) ◽  
pp. 45-54
Author(s):  
T. V. Koksharova ◽  
T. V. Mandzii ◽  
A. Yu. Kovalyov ◽  
D. V. Kramarenko ◽  
T. Yu. Brazhnik ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Elemental Analysis ◽  
Coordination Compounds ◽  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Analysis Data ◽  
Reflectance Spectroscopy ◽  
Synthesis And Characterization ◽  
Elemental Analysis Data

Complexes of copper(II), nickel(II), cobalt(III), and zinc(II) maleates with thiosemicarbazide were synthesized. The resulting compounds were characterized by the elemental analysis data, infrared spectroscopy, diffuse reflectance spectroscopy, and thermogravimetry.

scholarly journals Synthesis and characterization of mixed ligand catecholato-bis (diamine-mono-dithiocarbamato) vanadium (IV) complexes

2017 ◽  
Vol 52 (2) ◽  
pp. 89-96
Author(s):  
B Begum ◽  
A Sarker ◽  
AKM Lutfor Rahman ◽  
NC Bhoumik
Keyword(s):  
1H Nmr ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Vanadium Complexes ◽  
Spectroscopic Techniques ◽  
Physico Chemical ◽  
Ft Ir ◽  
Uv Visible

Diamine-mono-dithiocarbamates are mono-basic bidentate ligand forming stable complexes with transition metals. Mixed ligand catecholato-bis (diamine-mono-dithiocarbamato) vanadium (IV) complexes were synthesized and characterized using FT-IR, UV-visible and 1H-NMR spectroscopic techniques. The formation of vanadium complexes was con?rmed by the disappearance of ?S-H band in the complexes which was present in the ligands and incidence of ?V-S and ?V-O band in FT-IR spectra of the complexes. The mono-dithiocarbamate with one uncoordinated ?NH/NH2 group was indicated by the presence of ?N-H vibrational band in both the ligands and complexes. In the 1H-NMR spectra, the peak for –SH proton of ligands disappeared in the complexes suggest the formation of [VL2Cat] complex. Non-electrolytic nature of the synthesized complexes was established by their low molar conductance values. The +4 oxidation state of vanadium was con?rmed by the electronic spectra of the complexes. On the basis of all physico-chemical data, a six-coordinated octahedral structure has been suggested for catecholato-bis (diamine-mono-dithiocarbamato) vanadium (IV) complexes.Bangladesh J. Sci. Ind. Res. 52(2), 89-96, 2017

Synthesis and Characterization of Complexes of New Derivative of Cyclopentaphenanthren-3-one with Manganese (II), Iron (II), Cobalt (II), Nickel (II), and Copper (II) Ions

2020 ◽  
Vol 38 (3B) ◽  
pp. 197-203
Author(s):  
Liblab S. Jassim
Keyword(s):  
Metal Ion ◽  
Molar Conductance ◽  
Spectral Measurements ◽  
Chemical Preparation ◽  
Electron Pairs ◽  
H Nmr ◽  
Absorption Studies ◽  
Ft Ir ◽  
Uv Visible

This work involves the chemical preparation from a series of metal Complexes having the general composition M(L)2(H2O)2, where M = [Mn+2, Fe+2, Co+2, Ni+2 and Cu+2]. The ligand used was 9-fluoro-17-(1-hydrazono-2-hydroxyethyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[α]phenanthren-3-one (FHDTCP), who was diagnosed by H-NMR spectra. These complexes have been prepared and characterized by the ligand to metal by molar conductance, spectral (UV-Visible and FT-IR), and atomic absorption studies. The IR spectral measurements forecast interference to oxygen, nitrogen in coordination from the electron pairs to the metal ion in the center. And suggested the complexes geometry be octahedral for all.

scholarly journals Preparation and Characterization of Some Metal Complexes with Heterocyclic Azo Ligand (4-SuBAI)

2015 ◽  
Vol 12 (3) ◽  
pp. 503-515 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Metal Complexes ◽  
Elemental Analysis ◽  
Analytical Data ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Chelate Complexes ◽  
Ft Ir ◽  
Metal Ligand ◽  
Azo Ligand

The preparation and characterization of the Cu (II), Co(II), Ni(II), Zn(II), Cd(II), and Hg(II) metal complexes of heterocyclic azo ligand 2-[(4`-sulphamide phenyl) azo] -4,5-diphenyl imidazole (4-SuBAI) have been studied by elemental analysis, FT-IR and UV-Vis Spectroscopic, magnetic moment and molar conductance methods. The analytical data showed that all chelate complexes were prepared with (metal-ligand) ratio of (1:2). The general formula of these complexes was [ML2X2]. nH2O [were L=2-[(4`-sulphamide phenyl) azo]-4,5-diphenyl imidazole and X=Cl, and the octahedral geometry were suggested for these complexes .

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